PH27513A - Diazepine antiallergy agents - Google Patents

Diazepine antiallergy agents

Info

Publication number: PH27513A
Authority: PH; Philippines
Prior art keywords: optionally substituted; ring; optionally; diazepine; chem
Prior art date: 1989-03-23

Application number

PH40251A

Other languages

English (en)

Inventor

Kelvin Cooper

Michael Jonathan Fray

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-23

Filing date

1990-03-22

Publication date

1993-08-18

1989-03-23 Priority claimed from GB898906813A external-priority patent/GB8906813D0/en

1989-11-21 Priority claimed from GB898926246A external-priority patent/GB8926246D0/en

1990-03-22 Application filed by Pfizer filed Critical Pfizer

1993-08-18 Publication of PH27513A publication Critical patent/PH27513A/en

Links

LRANPJDWHYRCER-UHFFFAOYSA-N 1,2-diazepine Chemical compound N1C=CC=CC=N1 LRANPJDWHYRCER-UHFFFAOYSA-N 0.000 title 1
239000000043 antiallergic agent Substances 0.000 title 1
UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 5
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical class C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 3
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical class C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 abstract 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 2
YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical class C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 abstract 1
125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical class C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 abstract 1
WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical class C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
238000005054 agglomeration Methods 0.000 abstract 1
230000002776 aggregation Effects 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
150000001555 benzenes Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
ZLTPDFXIESTBQG-UHFFFAOYSA-N isothiazole Chemical class C=1C=NSC=1 ZLTPDFXIESTBQG-UHFFFAOYSA-N 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Chemical class COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
229930192474 thiophene Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

PH40251A 1989-03-23 1990-03-22 Diazepine antiallergy agents PH27513A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB898906813A GB8906813D0 (en)	1989-03-23	1989-03-23	Therapeutic agents
GB898926246A GB8926246D0 (en)	1989-11-21	1989-11-21	Therapeutic agents

Publications (1)

Publication Number	Publication Date
PH27513A true PH27513A (en)	1993-08-18

Family

ID=26295132

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH40251A PH27513A (en)	1989-03-23	1990-03-22	Diazepine antiallergy agents

Country Status (21)

Country	Link
US (1)	US5008263A (de)
EP (1)	EP0389189B1 (de)
JP (1)	JPH0684371B2 (de)
KR (1)	KR920003981B1 (de)
CN (1)	CN1045783A (de)
AT (1)	ATE105839T1 (de)
AU (1)	AU627286B2 (de)
CA (1)	CA2012666C (de)
DE (1)	DE69008906T2 (de)
DK (1)	DK0389189T3 (de)
ES (1)	ES2052172T3 (de)
FI (1)	FI98463C (de)
HU (1)	HUT61006A (de)
IE (1)	IE62857B1 (de)
IL (1)	IL93776A (de)
MY (1)	MY106322A (de)
NO (1)	NO175151C (de)
NZ (1)	NZ233047A (de)
PH (1)	PH27513A (de)
PT (1)	PT93526B (de)
YU (1)	YU47344B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9010404D0 (en) *	1990-05-09	1990-06-27	Pfizer Ltd	Therapeutic agents
GB9015524D0 (en) *	1990-07-13	1990-08-29	Pfizer Ltd	Therapeutic agents
GB9019409D0 (en) *	1990-09-05	1990-10-17	Pfizer Ltd	Therapeutic agents
GB9019833D0 (en) *	1990-09-11	1990-10-24	Pfizer Ltd	Therapeutic agents
US5939412A (en) *	1992-06-26	1999-08-17	Smithkline Beecham Corporation	Bicyclic fibrinogen antagonists
ATE228115T1 (de) *	1991-06-28	2002-12-15	Smithkline Beecham Corp	Bizyklische fibrinogenantagonisten
IL108524A0 (en) *	1993-02-03	1994-05-30	Gensia Inc	Imidazodiazepine analogs
US5500439A (en) *	1993-12-09	1996-03-19	Alteon Inc.	Aminopyrazoles
MA23420A1 (fr) *	1994-01-07	1995-10-01	Smithkline Beecham Corp	Antagonistes bicycliques de fibrinogene.
ATE224377T1 (de) *	1994-04-29	2002-10-15	Takeda Chemical Industries Ltd	Kondensierte heterocyclische verbindung, deren herstellung und verwendung als gnrh antagonisten
US6458784B1 (en)	1994-06-29	2002-10-01	Smithkline Beecham Corporation	Vitronectin receptor antagonists
FR2733749B1 (fr) *	1995-05-05	1997-06-13	Oreal	Compositions pour la teinture des fibres keratiniques contenant des diamino pyrazoles, procede de teinture, nouveaux diamino pyrazoles et leur procede de preparation
US5726171A (en) *	1995-06-07	1998-03-10	Merck & Co Inc	N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo B! 1,4!diazepin-3yl)-acetamides
US5977101A (en) *	1995-06-29	1999-11-02	Smithkline Beecham Corporation	Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity
US5935908A (en) *	1995-08-15	1999-08-10	Novartis Crop Protection, Inc.	Pesticidal indazole derivatives
US6172222B1 (en)	1998-06-08	2001-01-09	American Home Products Corporation	Diaminopyrazoles
US6458823B1 (en)	1998-06-08	2002-10-01	Wyeth	Diaminopyrazoles
US6949542B2 (en) *	2002-02-06	2005-09-27	Hoffman-La Roche Inc.	Dihydro-benzo[b][1,4]diazepin-2-one derivatives
US8546377B2 (en)	2009-04-23	2013-10-01	Abbvie Inc.	Modulators of 5-HT receptors and methods of use thereof
US8518933B2 (en)	2009-04-23	2013-08-27	Abbvie Inc.	Modulators of 5-HT receptors and methods of use thereof
WO2012061342A2 (en)	2010-11-01	2012-05-10	Arqule, Inc.	Substituted benzo-imidazo-pyrido-diazepine compounds
KR101675984B1 (ko)	2015-02-23	2016-11-14	한양대학교 에리카산학협력단	티에노디아제핀 유도체 또는 이의 약학적으로 허용가능한 염, 및 이를 유효성분으로 포함하는 약학적 조성물
CN105153195B (zh) *	2015-09-01	2017-09-26	汤文建	一种三环吡唑[1,5‑d][1,4]苯并氧氮杂卓酮衍生物及其制备方法与用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU527689B2 (en) *	1974-09-11	1983-03-17	F. Hoffmann-La Roche & Co.	Imidazodiazepine derivatives
DK476885D0 (da) *	1985-10-17	1985-10-17	Ferrosan As	Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
ES2037013T3 (es) *	1986-01-21	1993-06-16	Boehringer Ingelheim Kg	Procedimiento para preparar tieno-1,4-diazepinas.

1990
- 1990-03-15 AT AT90302826T patent/ATE105839T1/de not_active IP Right Cessation
- 1990-03-15 DK DK90302826.4T patent/DK0389189T3/da active
- 1990-03-15 ES ES90302826T patent/ES2052172T3/es not_active Expired - Lifetime
- 1990-03-15 EP EP90302826A patent/EP0389189B1/de not_active Expired - Lifetime
- 1990-03-15 DE DE69008906T patent/DE69008906T2/de not_active Expired - Fee Related
- 1990-03-16 IL IL9377690A patent/IL93776A/en not_active IP Right Cessation
- 1990-03-20 US US07/496,393 patent/US5008263A/en not_active Expired - Fee Related
- 1990-03-21 MY MYPI90000443A patent/MY106322A/en unknown
- 1990-03-21 CA CA002012666A patent/CA2012666C/en not_active Expired - Fee Related
- 1990-03-21 PT PT93526A patent/PT93526B/pt not_active IP Right Cessation
- 1990-03-22 IE IE105590A patent/IE62857B1/en not_active IP Right Cessation
- 1990-03-22 AU AU52148/90A patent/AU627286B2/en not_active Ceased
- 1990-03-22 NZ NZ233047A patent/NZ233047A/en unknown
- 1990-03-22 FI FI901441A patent/FI98463C/fi not_active IP Right Cessation
- 1990-03-22 NO NO901329A patent/NO175151C/no unknown
- 1990-03-22 YU YU56390A patent/YU47344B/sh unknown
- 1990-03-22 HU HU901794A patent/HUT61006A/hu unknown
- 1990-03-22 KR KR1019900003870A patent/KR920003981B1/ko not_active Expired
- 1990-03-22 PH PH40251A patent/PH27513A/en unknown
- 1990-03-23 CN CN90101559A patent/CN1045783A/zh not_active Withdrawn
- 1990-03-23 JP JP2075339A patent/JPH0684371B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IL93776A0 (en)	1990-12-23
JPH0684371B2 (ja)	1994-10-26
AU627286B2 (en)	1992-08-20
NO175151B (no)	1994-05-30
HU901794D0 (en)	1990-06-28
DE69008906D1 (de)	1994-06-23
IE901055L (en)	1990-09-23
US5008263A (en)	1991-04-16
ES2052172T3 (es)	1994-07-01
PT93526B (pt)	1996-08-30
EP0389189B1 (de)	1994-05-18
FI98463B (fi)	1997-03-14
PT93526A (pt)	1990-11-07
FI901441A0 (fi)	1990-03-22
KR900014387A (ko)	1990-10-23
NO901329L (no)	1990-09-24
NO901329D0 (no)	1990-03-22
DE69008906T2 (de)	1994-08-25
NZ233047A (en)	1992-06-25
KR920003981B1 (ko)	1992-05-21
CA2012666A1 (en)	1990-09-23
IL93776A (en)	1994-10-21
EP0389189A2 (de)	1990-09-26
MY106322A (en)	1995-05-30
JPH0314577A (ja)	1991-01-23
DK0389189T3 (da)	1994-06-20
CA2012666C (en)	1997-01-28
IE62857B1 (en)	1995-03-08
YU47344B (sh)	1995-01-31
AU5214890A (en)	1990-11-01
FI98463C (fi)	1997-06-25
ATE105839T1 (de)	1994-06-15
EP0389189A3 (de)	1991-08-21
CN1045783A (zh)	1990-10-03
YU56390A (sh)	1992-12-21
HUT61006A (en)	1992-11-30
NO175151C (no)	1994-09-07

Publication	Publication Date	Title
AU627286B2 (en)	1992-08-20	Diazepine antiallergy agents
IL75077A0 (en)	1985-09-29	N,3-disubstituted 2-oxindole-1-carboxamides and pharmaceutical compositions containing them
GR3005072T3 (de)	1993-05-24
IL76175A (en)	1989-08-15	N-substituted tricyclic oxindole carboxamides and pharmaceutical compositions containing them
ZA928418B (en)	1993-05-14	Oxime derivatives of formylpyridyl imidazolinones, the herbicidal use and methods for the preparation thereof.
DE69302035D1 (de)	1996-05-09	Pharmazeutische Zusammensetzung zur Hemmung der Thrombocytenaggregation
NZ225099A (en)	1990-09-26	Ergoline n-oxide derivatives and pharmaceutical compositions
DE68908761D1 (de)	1993-10-07	Monopersulfate von stickstoffenthaltenden heterocyclischen Polypercarbonsäuren.