PH29985A - Substituted quinolines and medicinal use thereof - Google Patents
Substituted quinolines and medicinal use thereofInfo
- Publication number
- PH29985A PH29985A PH37861A PH37861A PH29985A PH 29985 A PH29985 A PH 29985A PH 37861 A PH37861 A PH 37861A PH 37861 A PH37861 A PH 37861A PH 29985 A PH29985 A PH 29985A
- Authority
- PH
- Philippines
- Prior art keywords
- stands
- pct
- carboxy
- bond
- stand
- Prior art date
Links
- 229940111121 antirheumatic drug quinolines Drugs 0.000 title 1
- 150000003248 quinolines Chemical class 0.000 title 1
- 229910020008 S(O) Inorganic materials 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 cyano, nitro, amino, carboxy Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 abstract 1
- 239000000867 Lipoxygenase Inhibitor Substances 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000003199 leukotriene receptor blocking agent Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002577 pseudohalo group Chemical group 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical group OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
- Water Treatment By Sorption (AREA)
- Optical Transform (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Optical Head (AREA)
- Luminescent Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878728051A GB8728051D0 (en) | 1987-12-01 | 1987-12-01 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH29985A true PH29985A (en) | 1996-10-29 |
Family
ID=10627789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH37861A PH29985A (en) | 1987-12-01 | 1988-11-25 | Substituted quinolines and medicinal use thereof |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5110819A (de) |
| EP (1) | EP0420844B1 (de) |
| JP (1) | JPH03501477A (de) |
| KR (1) | KR900700454A (de) |
| AT (1) | ATE110364T1 (de) |
| CA (1) | CA1336602C (de) |
| DE (1) | DE3851232T2 (de) |
| ES (1) | ES2011919A6 (de) |
| GB (1) | GB8728051D0 (de) |
| GR (1) | GR1000422B (de) |
| IE (1) | IE64473B1 (de) |
| NZ (1) | NZ227003A (de) |
| PH (1) | PH29985A (de) |
| PT (1) | PT89118B (de) |
| WO (1) | WO1989005294A1 (de) |
| ZA (1) | ZA888763B (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4920132A (en) * | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
| GB8919504D0 (en) * | 1989-08-29 | 1989-10-11 | Leo Pharm Prod Ltd | Chemical compounds |
| US5021576A (en) * | 1989-10-27 | 1991-06-04 | American Home Products Corporation | 2-Anilino phenylacetic acid derivatives |
| US5281593A (en) * | 1990-07-31 | 1994-01-25 | Lilly Industries Limited | Certain indole derivatives useful as leukotriene antagonists |
| AU654140B2 (en) * | 1990-07-31 | 1994-10-27 | Lilly Industries Limited | N-benzyl indoles, processes for their preparation or pharmaceutical compositions containing them |
| WO1994014797A1 (en) * | 1992-12-23 | 1994-07-07 | Smithkline Beecham Corporation | Quinoline compounds and the treatment of leucotriene related diseases therewith |
| US5486612A (en) * | 1993-12-14 | 1996-01-23 | Eli Lilly And Company | N-benzyl dihydroindole LTD4 antagonists |
| GB9414590D0 (en) * | 1994-07-20 | 1994-09-07 | Leo Pharm Prod Ltd | Chemical compounds |
| ES2103180B1 (es) * | 1994-08-01 | 1998-04-01 | Menarini Lab | Fenilacetamidas con accion antagonista de los leucotrienos. |
| US5602110A (en) * | 1994-08-31 | 1997-02-11 | Case Western Reserve University | Method and composition for treating cystic fibrosis |
| EP0725063A1 (de) * | 1995-02-01 | 1996-08-07 | Ciba-Geigy Ag | Chinolin-Derivate |
| ES2117551B1 (es) * | 1995-12-29 | 1999-04-01 | Menarini Lab | Quinolinas naftalenicas con accion antagonista de los leucotrienos, procedimiento para su preparacion y utilizacion de las mismas. |
| US5756518A (en) * | 1996-04-02 | 1998-05-26 | Kowa Co., Ltd. | Phenylene derivatives |
| KR100563430B1 (ko) * | 1997-06-17 | 2006-03-22 | 가켄 세이야쿠 가부시키 가이샤 | 2-술파모일벤조산 유도체 |
| JP2004137284A (ja) * | 1997-06-17 | 2004-05-13 | Kaken Pharmaceut Co Ltd | ２−スルファモイル安息香酸誘導体 |
| US6376671B1 (en) | 1997-06-17 | 2002-04-23 | Kaken Pharmaceutical Co., Ltd. | 2-sulfamoylbenzoic acid derivatives |
| ES2176877T3 (es) * | 1997-09-26 | 2002-12-01 | Kowa Co | Derivados de tetrazol como antagonistas de ltd4 y h1. |
| PL351470A1 (en) | 1999-04-28 | 2003-04-22 | Aventis Pharma Gmbh | Tri-aryl acid derivatives as ppar receptor ligands |
| IL151517A0 (en) * | 2000-03-09 | 2003-04-10 | Aventis Pharma Gmbh | Therapeutic uses of ppar mediators |
| US7098241B2 (en) | 2002-12-16 | 2006-08-29 | Hoffmann-La Roche Inc. | Thiophene hydroxamic acid derivatives |
| JP4875978B2 (ja) * | 2004-03-15 | 2012-02-15 | 武田薬品工業株式会社 | アミノフェニルプロパン酸誘導体 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4625034A (en) * | 1985-02-04 | 1986-11-25 | Usv Pharmaceutical Corp. | 1,2-Dihydro; 1,2,3,4-tetrahydro; 5,8 dihydro; and 5,6,7,8-tetrahydroquinoline derivatives |
| IE58870B1 (en) * | 1985-03-08 | 1993-11-17 | Leo Pharm Prod Ltd | Pyridine derivatives |
| US4839369A (en) * | 1985-04-16 | 1989-06-13 | Rorer Pharmaceutical Corporation | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
| IE861607L (en) * | 1985-06-18 | 1986-12-18 | Bunce Roger A | 2-substituted quinolines |
| ATE68789T1 (de) * | 1985-10-16 | 1991-11-15 | Merck Frosst Canada Inc | 2-substituierte chinoline. |
| EP0219307A3 (de) * | 1985-10-16 | 1987-10-14 | Merck Frosst Canada Inc. | 2-Substituierte Chinoline |
| GB2185741B (en) * | 1986-01-27 | 1989-10-25 | American Home Prod | Heterocyclic sulphonamides |
| US4904786A (en) * | 1986-01-27 | 1990-02-27 | American Home Products Corporation | Quinoline compounds as antiallergic and antiinflammatory agents |
| IE59889B1 (en) * | 1986-02-14 | 1994-04-20 | Merck Frosst Canada Inc | 2-substituted quinoline dioic acids |
| EP0271287A3 (de) * | 1986-12-11 | 1990-06-13 | Merck Frosst Canada Inc. | Chinolindicarbonsäuren und ihre Amide |
| US4920132A (en) * | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
| DE3814504A1 (de) * | 1988-04-29 | 1989-11-09 | Bayer Ag | (alpha)-substituierte 4-(chinolin-2-yl-methoxy)phenylessigsaeuren und -ester, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
-
1987
- 1987-12-01 GB GB878728051A patent/GB8728051D0/en active Pending
-
1988
- 1988-11-15 IE IE341988A patent/IE64473B1/en not_active IP Right Cessation
- 1988-11-17 AT AT89900021T patent/ATE110364T1/de not_active IP Right Cessation
- 1988-11-17 DE DE3851232T patent/DE3851232T2/de not_active Expired - Fee Related
- 1988-11-17 EP EP89900021A patent/EP0420844B1/de not_active Expired - Lifetime
- 1988-11-17 US US07/476,403 patent/US5110819A/en not_active Expired - Fee Related
- 1988-11-17 JP JP1500028A patent/JPH03501477A/ja active Pending
- 1988-11-17 WO PCT/DK1988/000188 patent/WO1989005294A1/en not_active Ceased
- 1988-11-18 NZ NZ227003A patent/NZ227003A/xx unknown
- 1988-11-23 ZA ZA888763A patent/ZA888763B/xx unknown
- 1988-11-25 PH PH37861A patent/PH29985A/en unknown
- 1988-11-25 GR GR880100797A patent/GR1000422B/el unknown
- 1988-11-28 CA CA000584360A patent/CA1336602C/en not_active Expired - Fee Related
- 1988-11-30 PT PT89118A patent/PT89118B/pt not_active IP Right Cessation
- 1988-11-30 ES ES8803652A patent/ES2011919A6/es not_active Expired - Lifetime
-
1989
- 1989-07-22 KR KR1019890701385A patent/KR900700454A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| PT89118B (pt) | 1993-04-30 |
| JPH03501477A (ja) | 1991-04-04 |
| IE64473B1 (en) | 1995-08-09 |
| EP0420844A1 (de) | 1991-04-10 |
| ATE110364T1 (de) | 1994-09-15 |
| GR1000422B (el) | 1992-06-30 |
| GB8728051D0 (en) | 1988-01-06 |
| DE3851232T2 (de) | 1995-02-02 |
| IE883419L (en) | 1989-06-01 |
| EP0420844B1 (de) | 1994-08-24 |
| WO1989005294A1 (en) | 1989-06-15 |
| KR900700454A (ko) | 1990-08-13 |
| NZ227003A (en) | 1991-11-26 |
| PT89118A (pt) | 1988-12-01 |
| ZA888763B (en) | 1989-07-26 |
| DE3851232D1 (de) | 1994-09-29 |
| CA1336602C (en) | 1995-08-08 |
| US5110819A (en) | 1992-05-05 |
| ES2011919A6 (es) | 1990-02-16 |
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