PH30665A - Aminosulfonyl urea acat inhibitors - Google Patents

Aminosulfonyl urea acat inhibitors

Info

Publication number: PH30665A
Authority: PH; Philippines
Prior art keywords: acat inhibitors; aminosulfonyl; compounds; aminosulfonyl urea; urea acat
Prior art date: 1990-11-07

Application number

PH43413A

Other languages

English (en)

Inventor

Joseph A Picard

Drago R Sliskovic

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-07

Filing date

1991-11-06

Publication date

1997-09-16

1991-11-06 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1997-09-16 Publication of PH30665A publication Critical patent/PH30665A/en

Links

239000003112 inhibitor Substances 0.000 title abstract 3
OJXASOYYODXRPT-UHFFFAOYSA-N sulfamoylurea Chemical compound NC(=O)NS(N)(=O)=O OJXASOYYODXRPT-UHFFFAOYSA-N 0.000 title abstract 3
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
239000008280 blood Substances 0.000 abstract 1
210000004369 blood Anatomy 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000009877 rendering Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C307/04—Diamides of sulfuric acids
- C07C307/06—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C307/04—Diamides of sulfuric acids
- C07C307/08—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C307/04—Diamides of sulfuric acids
- C07C307/10—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to carbon atoms of six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Diabetes (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Furan Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PH43413A 1990-11-07 1991-11-06 Aminosulfonyl urea acat inhibitors PH30665A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US61028790A	1990-11-07	1990-11-07
US07/747,040 US5214206A (en)	1990-11-07	1991-08-19	Aminosulfonyl urea acat inhibitors

Publications (1)

Publication Number	Publication Date
PH30665A true PH30665A (en)	1997-09-16

Family

ID=27086230

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH43413A PH30665A (en)	1990-11-07	1991-11-06	Aminosulfonyl urea acat inhibitors

Country Status (16)

Country	Link
US (2)	US5214206A (de)
EP (1)	EP0556322B1 (de)
JP (2)	JP3256541B2 (de)
AT (1)	ATE139226T1 (de)
AU (1)	AU657928B2 (de)
CA (1)	CA2094806C (de)
DE (1)	DE69120287T2 (de)
DK (1)	DK0556322T3 (de)
ES (1)	ES2088128T3 (de)
GR (1)	GR3020355T3 (de)
IE (1)	IE75379B1 (de)
MX (1)	MX9101958A (de)
NZ (1)	NZ240481A (de)
PH (1)	PH30665A (de)
PT (1)	PT99435B (de)
WO (1)	WO1992008694A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1992012144A1 (en) *	1990-12-28	1992-07-23	Teijin Limited	Condensed benzoxa ring compound, production thereof, and pharmaceutical composition containing the same
US5576335A (en) *	1994-02-01	1996-11-19	Nisshin Flour Milling Co., Ltd.	Urea derivatives and their use as ACAT inhibitors
US5491170A (en) *	1994-12-19	1996-02-13	Warner-Lambert Company	β-carboxy sulfonamide ACAT inhibitors
US6103733A (en) *	1998-09-09	2000-08-15	Bachmann; Kenneth A.	Method for increasing HDL cholesterol levels using heteroaromatic phenylmethanes
CA2369967A1 (en) *	2001-02-12	2002-08-12	Joseph Anthony Cornicelli	Methods of treating nuclear factor-kappa b mediated diseases and disorders
EP1281399A3 (de) *	2001-08-01	2004-02-11	Warner-Lambert Company	Hemmer mit doppelter Wirkung auf Wachsester- und Cholesterylestersynthese zur Hemmung der Sebumproduktion
ES2677668T3 (es)	2010-11-16	2018-08-06	Texas Heart Institute	Agonistas que mejoran la unión de células que expresan integrina a receptores de integrina
CN103288749A (zh) *	2013-03-04	2013-09-11	盐城工学院	可作除草剂的氨基磺酰脲类化合物
ES2740907T3 (es) *	2014-10-03	2020-02-07	Synaffix Bv	Enlazador de sulfamida, conjugados de los mismos y métodos de preparación
HUE055755T2 (hu)	2015-02-16	2021-12-28	Univ Queensland	Szulfonolkarmabidok és rokon vegyületeik valamint felhasználásuk
HK1257569A1 (zh) *	2016-02-16	2019-10-25	The University Of Queensland	磺醯脲和相关化合物及其用途
KR102669722B1 (ko)	2017-07-07	2024-05-29	인플라좀 리미티드	신규한 설폰아마이드 카복스아마이드 화합물
GB201721185D0 (en)	2017-12-18	2018-01-31	Nodthera Ltd	Sulphonyl urea derivatives
CN112672995A (zh) *	2018-08-15	2021-04-16	英夫拉索姆有限公司	新型磺酰胺脲化合物
ES3056339T3 (en)	2019-06-12	2026-02-19	Nodthera Ltd	Sulfonylurea derivatives and uses thereof
SI3983387T1 (sl)	2019-06-12	2024-09-30	NodThera Limited	Derivati sulfoniluree in njihove uporabe

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2312404A (en) *	1939-11-22	1943-03-02	Haack Erich	Method of preparing n-sulphonylureas
CH396872A (de)	1959-08-13	1965-08-15	Ciba Geigy	Verfahren zur Herstellung neuer Harnstoffe
US3242174A (en) *	1962-02-06	1966-03-22	Pfizer & Co C	1-(tertiary aminosulfonyl)-3-(hydrocarbon) ureas
GB990860A (en) *	1962-02-08	1965-05-05	Pfizer & Co C	N,n-disubstituted sulfamylureas and compositions thereof
US3245982A (en)	1962-03-27	1966-04-12	Pfizer & Co C	Sulfamylsemicarbazides
DE1518541A1 (de) *	1965-03-16	1969-09-11	Boehringer Mannheim Gmbh	Verfahren zur Herstellung von Sulfonylharnstoffen und Sulfonylsemicarbaziden
FR2339694A1 (fr)	1976-01-30	1977-08-26	Martin Usines Fonderie Arthur	Machine a laver le linge comportant un dispositif de sechage par ventilation d'air chaud
CH649081A5 (de) *	1982-01-12	1985-04-30	Ciba Geigy Ag	Triaza-verbindungen.

1991
- 1991-08-19 US US07/747,040 patent/US5214206A/en not_active Expired - Lifetime
- 1991-11-05 WO PCT/US1991/008223 patent/WO1992008694A1/en not_active Ceased
- 1991-11-05 ES ES92900981T patent/ES2088128T3/es not_active Expired - Lifetime
- 1991-11-05 EP EP92900981A patent/EP0556322B1/de not_active Expired - Lifetime
- 1991-11-05 NZ NZ240481A patent/NZ240481A/xx not_active IP Right Cessation
- 1991-11-05 JP JP50093292A patent/JP3256541B2/ja not_active Expired - Fee Related
- 1991-11-05 AU AU89597/91A patent/AU657928B2/en not_active Ceased
- 1991-11-05 DK DK92900981.9T patent/DK0556322T3/da active
- 1991-11-05 DE DE69120287T patent/DE69120287T2/de not_active Expired - Fee Related
- 1991-11-05 AT AT92900981T patent/ATE139226T1/de not_active IP Right Cessation
- 1991-11-05 CA CA002094806A patent/CA2094806C/en not_active Expired - Fee Related
- 1991-11-06 IE IE387491A patent/IE75379B1/en not_active IP Right Cessation
- 1991-11-06 MX MX9101958A patent/MX9101958A/es not_active IP Right Cessation
- 1991-11-06 PH PH43413A patent/PH30665A/en unknown
- 1991-11-06 PT PT99435A patent/PT99435B/pt not_active IP Right Cessation
1993
- 1993-02-19 US US08/019,519 patent/US5288757A/en not_active Expired - Lifetime
1996
- 1996-06-27 GR GR960401724T patent/GR3020355T3/el unknown
2000
- 2000-06-14 JP JP2000177740A patent/JP2001026574A/ja active Pending

Also Published As

Publication number	Publication date
DE69120287T2 (de)	1996-10-10
AU8959791A (en)	1992-06-11
DE69120287D1 (en)	1996-07-18
MX9101958A (es)	1992-07-08
ATE139226T1 (de)	1996-06-15
DK0556322T3 (da)	1996-10-14
AU657928B2 (en)	1995-03-30
JP2001026574A (ja)	2001-01-30
PT99435A (pt)	1992-12-31
JP3256541B2 (ja)	2002-02-12
WO1992008694A1 (en)	1992-05-29
US5214206A (en)	1993-05-25
CA2094806A1 (en)	1992-05-08
NZ240481A (en)	1994-06-27
IE913874A1 (en)	1992-05-20
ES2088128T3 (es)	1996-08-01
EP0556322B1 (de)	1996-06-12
JPH06501707A (ja)	1994-02-24
GR3020355T3 (en)	1996-09-30
IE75379B1 (en)	1997-09-10
CA2094806C (en)	2004-11-02
PT99435B (pt)	1999-04-30
EP0556322A1 (de)	1993-08-25
US5288757A (en)	1994-02-22

Publication	Publication Date	Title
NO971889L (no)	1997-06-23	Forbindelser og sammensetninger for levering av aktive midler
TR199901172T2 (xx)	1999-08-23	Yeni ikame edilmi� pirazol t�revleri.
MX9704030A (es)	1998-02-28	1,1-dioxidos de 2-heterocicliloxi y tiometil-1,2,5-tiadiazolidin-3-ona y composiciones y metodo de uso de los mismos.
DE69120287D1 (en)	1996-07-18	Aminosulfonylharnstoff-acat-inhibitoren
IL125282A (en)	2003-06-24	Substituted imidazole compounds, process for their preparation, pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating cytokine mediated diseases
ATE255589T1 (de)	2003-12-15	Kristallin form i von clarithromycin
SE9704546D0 (sv)	1997-12-05	Novel compounds
DE69326776D1 (de)	1999-11-18	Verwendung von n-arylmethylen ethylendiamintriacetate, n-arylmethylen iminodiacetat oder n,n'-diarylmethylen ethylendiamindiacetat gegen oxidativen stress
FR2712812B1 (fr)	1996-02-09	Composition pour la production de produits thérapeutiques in vivo.
DK0725779T3 (da)	2001-10-29	Hidtil ukendte (R)-5-Carbamoyl-8-fluor-3-N,N-disubstitueret-amino-3,4-dihydro-2H-1-benzopyraner
EE200000318A (et)	2001-08-15	Uudsed ühendid
SE9702001D0 (sv)	1997-05-28	Novel compounds
DE69905170D1 (en)	2003-03-06	Thiazolopyrimidinderivate
BG103399A (en)	2000-01-31	New heterocycle-substituted benzamides and their application for the treatment of diseases
AU5186799A (en)	2000-02-07	Peptides of il-2 and derivatives thereof and their use as therapeutic agents
HRP20020330B1 (de)	2013-01-31
NO972391L (no)	1997-05-26	2-substituerte 1,2,5-tiadiazolidin-3-on 1,1-dioksider og preparater og metoder for anvendelse derav
YU13301A (sh)	2005-06-10	Muskarinski agonisti i antagonisti
SE9802937D0 (sv)	1998-09-01	Novel compounds
MX9403088A (es)	1997-02-28	Composiciones farmaceuticas que contienen deriva- dos de indol y metodos de uso.
AU8332791A (en)	1992-03-02	Oral pharmaceutical compositions containing melatonin
AU6415994A (en)	1994-10-24	Substituted caprolactams and derivatives thereof useful for treatment of hiv disease
RU94041028A (ru)	1996-09-20	Применение производных мелатонина для лечения десинхронизационных нарушений, фармацевтическая композиция
IL106237A0 (en)	1993-11-15	Piperidyl amides,sulfonamides and sulfoxamides as inhibitors of cholesterol biosynthesis
DK0720597T3 (da)	1998-10-07	Triarylethylenderivater til terapeutisk anvendelse