PH31439A - Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol. - Google Patents

Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol.

Info

Publication number: PH31439A
Authority: PH; Philippines
Prior art keywords: cholecalciferol; ene; dihydroxy; stable; active metabolites
Prior art date: 1993-10-01

Application number

PH49098A

Other languages

English (en)

Inventor

Mclane John Arthur

Satyanarayama G Reddy

Milar R Uskokovic

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-01

Filing date

1994-09-30

Publication date

1998-11-03

1994-09-30 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1998-11-03 Publication of PH31439A publication Critical patent/PH31439A/en

Links

239000011647 vitamin D3 Substances 0.000 title abstract 6
229940021056 vitamin d3 Drugs 0.000 title abstract 6
239000002207 metabolite Substances 0.000 title 1
239000003795 chemical substances by application Substances 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
238000009877 rendering Methods 0.000 abstract 2
201000004681 Psoriasis Diseases 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000004069 differentiation Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
230000003463 hyperproliferative effect Effects 0.000 abstract 1
210000002510 keratinocyte Anatomy 0.000 abstract 1
210000003734 kidney Anatomy 0.000 abstract 1
208000032839 leukemia Diseases 0.000 abstract 1
230000001613 neoplastic effect Effects 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1
210000003491 skin Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Hematology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PH49098A 1993-10-01 1994-09-30 Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol. PH31439A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/131,264 US5401733A (en)	1993-10-01	1993-10-01	Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol

Publications (1)

Publication Number	Publication Date
PH31439A true PH31439A (en)	1998-11-03

Family

ID=22448675

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH49098A PH31439A (en)	1993-10-01	1994-09-30	Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol.

Country Status (15)

Country	Link
US (1)	US5401733A (da)
EP (1)	EP0646576B1 (da)
JP (1)	JP2677520B2 (da)
CN (1)	CN1041201C (da)
AT (1)	ATE162786T1 (da)
AU (1)	AU683917B2 (da)
CA (1)	CA2133144C (da)
DE (1)	DE69408244T2 (da)
DK (1)	DK0646576T3 (da)
ES (1)	ES2113020T3 (da)
GR (1)	GR3026154T3 (da)
NZ (1)	NZ264537A (da)
PH (1)	PH31439A (da)
RU (1)	RU2133738C1 (da)
ZA (1)	ZA947453B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9524812D0 (en) *	1995-12-05	1996-02-07	Leo Pharm Prod Ltd	Chemical compounds
GB9625271D0 (en) *	1996-12-04	1997-01-22	Leo Pharm Prod Ltd	Chemical compounds
KR20050123185A (ko) *	1996-12-20	2005-12-29	쥬가이 세이야쿠 가부시키가이샤	16-엔-비타민 ｄ 유도체
JPH10316652A (ja) *	1997-05-02	1998-12-02	Duphar Internatl Res Bv	１６−デヒドロビタミンｄ化合物の製造方法
CA2289209C (en)	1997-05-16	2006-07-25	Women & Infants Hospital	Cyclic ether vitamin d3 compounds, 1.alpha. (oh) 3-epi-vitamin d3 compounds and uses thereof
DE69834109T2 (de) *	1997-05-16	2007-04-19	Woman & Infants Hospital	3-epi-vitamin d2 verbindungen und ihre anwendungen
WO1999011272A1 (en) *	1997-09-02	1999-03-11	Johns Hopkins University School Of Medicine	Vitamin d3 analog loaded polymer formulations for cancer and neurodegenerative disorders
US6331642B1 (en) *	1999-07-12	2001-12-18	Hoffmann-La Roche Inc.	Vitamin D3 analogs
JP2004292314A (ja) *	2000-12-14	2004-10-21	Chugai Pharmaceut Co Ltd	ケラチノサイト増殖抑制剤

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4617297A (en) *	1982-02-12	1986-10-14	Hoffmann-La Roche Inc.	Method of treating disease states by the administration of 1α,25,26-trihydroxycholecalciferol
US4594432A (en) *	1983-01-28	1986-06-10	Hoffman-La Roche Inc.	Process for the synthesis of 1α,23(S),25-trihydroxycholecalciferol and 1α,23(R),25-trihydroxycholecalciferol
US4501738A (en) *	1983-06-30	1985-02-26	Kureha Kagaku Kogyo Kabushiki Kaisha	Pharmaceutical composition containing 24,25-dihydroxycholecalciferol as an active ingredient to treat pain, pyrexia or inflammatory diseases
US4495181A (en) *	1983-10-03	1985-01-22	The Regents Of The University Of California	1,25-Dihydroxy-24-oxo-vitamin D3 and 1,23,25-trihydroxy-24-oxo-vitamin D3
US4719205A (en) *	1984-01-30	1988-01-12	Wisconsin Alumini Research Foundation	Side-chain unsaturated 1-hydroxyvitamin D compounds
JPS6144860A (ja) *	1984-08-10	1986-03-04	Taisho Pharmaceut Co Ltd	１α．２５−ジヒドロキシ−２６．２７−ジメチルビタミンＤ↓３
JPS61129130A (ja) *	1984-11-27	1986-06-17	Kureha Chem Ind Co Ltd	抗尿毒症剤
US4612308A (en) *	1984-11-29	1986-09-16	Hoffmann-La Roche Inc.	25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
ATE45347T1 (de) *	1985-05-30	1989-08-15	Taisho Pharmaceutical Co Ltd	Vitamin d3-derivate.
WO1987003282A1 (fr) *	1985-11-21	1987-06-04	Taisho Pharmaceutical Co., Ltd.	Derive de la vitamine d3
JPS6391323A (ja) *	1986-10-03	1988-04-22	Kureha Chem Ind Co Ltd	抗尿路結石症剤
US5001118A (en) *	1986-12-29	1991-03-19	Kureha Kagaku Kogyo Kabushiki Kaisha	Method for preventing senescence and increasing bone mass
ZA8923B (en) *	1988-01-20	1989-09-27	Hoffmann La Roche	16-dehydro-vitamin d3-derivatives
US5087619A (en) *	1988-01-20	1992-02-11	Hoffman-La Roche Inc.	Vitamin D3 analogs
US4804502A (en) *	1988-01-20	1989-02-14	Hoffmann-La Roche Inc.	Vitamin D compounds
US5145846A (en) *	1988-01-20	1992-09-08	Hoffmann-La Roche Inc.	Vitamin D3 analogs
US4851401A (en) *	1988-07-14	1989-07-25	Wisconsin Alumni Research Foundation	Novel cyclopentano-vitamin D analogs
GB8915770D0 (en) *	1989-07-10	1989-08-31	Leo Pharm Prod Ltd	Chemical compounds
US5260290A (en) *	1990-02-14	1993-11-09	Wisconsin Alumni Research Foundation	Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
DE4011682A1 (de) *	1990-04-06	1991-10-10	Schering Ag	24-oxa-derivate in der vitamin d-reihe
US5200536A (en) *	1992-02-10	1993-04-06	Daikin Industries Ltd.	Fluorine-containing vitamin D3 analogues
US5194431A (en) *	1992-07-08	1993-03-16	Wisconsin Alumni Research Foundation	24-cyclopropane vitamin D derivatives

1993
- 1993-10-01 US US08/131,264 patent/US5401733A/en not_active Expired - Lifetime
1994
- 1994-09-17 AT AT94114668T patent/ATE162786T1/de not_active IP Right Cessation
- 1994-09-17 DE DE69408244T patent/DE69408244T2/de not_active Expired - Fee Related
- 1994-09-17 ES ES94114668T patent/ES2113020T3/es not_active Expired - Lifetime
- 1994-09-17 DK DK94114668T patent/DK0646576T3/da active
- 1994-09-17 EP EP94114668A patent/EP0646576B1/en not_active Expired - Lifetime
- 1994-09-23 ZA ZA947453A patent/ZA947453B/xx unknown
- 1994-09-26 NZ NZ264537A patent/NZ264537A/en unknown
- 1994-09-26 AU AU74225/94A patent/AU683917B2/en not_active Ceased
- 1994-09-27 RU RU94035663A patent/RU2133738C1/ru not_active IP Right Cessation
- 1994-09-27 JP JP6231094A patent/JP2677520B2/ja not_active Expired - Fee Related
- 1994-09-28 CN CN94116578A patent/CN1041201C/zh not_active Expired - Fee Related
- 1994-09-28 CA CA002133144A patent/CA2133144C/en not_active Expired - Fee Related
- 1994-09-30 PH PH49098A patent/PH31439A/en unknown
1998
- 1998-02-17 GR GR980400329T patent/GR3026154T3/el unknown

Also Published As

Publication number	Publication date
RU94035663A (ru)	1996-07-20
JP2677520B2 (ja)	1997-11-17
ES2113020T3 (es)	1998-04-16
DE69408244D1 (de)	1998-03-05
EP0646576A1 (en)	1995-04-05
NZ264537A (en)	1996-05-28
CN1106384A (zh)	1995-08-09
CN1041201C (zh)	1998-12-16
CA2133144C (en)	2005-05-24
CA2133144A1 (en)	1995-04-02
ATE162786T1 (de)	1998-02-15
DK0646576T3 (da)	1998-09-23
EP0646576B1 (en)	1998-01-28
JPH07179418A (ja)	1995-07-18
AU683917B2 (en)	1997-11-27
RU2133738C1 (ru)	1999-07-27
US5401733A (en)	1995-03-28
AU7422594A (en)	1995-04-13
GR3026154T3 (en)	1998-05-29
DE69408244T2 (de)	1998-08-27
ZA947453B (en)	1995-04-03

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DE122006000018I2 (de)	2008-05-08	19-Nor-Vitamin-D-Derivate.
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PH24969A (en)	1990-12-26	Insecticidal pyrazolines
PH31439A (en)	1998-11-03	Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol.
DE60018554D1 (de)	2005-04-14	Arzneimittel zur förderung der neuronalen zelldifferenzierung, die cyclische glycerophosphate und deren analoga enthalten
ZA955826B (en)	1996-02-21	Dinucleoside-5',5'pyrophosphates
BG101126A (en)	1997-09-30	The use of muramylpeptide compounds
BG103260A (en)	2000-01-31	The application of 1-hydroxy-2-pyridons for the treatment of seborrheic dermatitis
MY103593A (en)	1993-08-28	Bicyclic compounds, their use as pharmaceuticals, their preparation, and intermediates useful in their preparation
ES8302634A1 (es)	1982-08-16	Procedimiento de preparacion de derivados del acido metilen-2-succinamico
JPS5753475A (en)	1982-03-30	Novel thiazolyl-2-oxamic acid derivative, manufacture and medicine containing same
ZA873928B (en)	1988-02-24	Topical methotrexate preparation for the treatment of hyperproliferative epithelial disease
IL57609A (en)	1983-05-15	Pharmaceutical compositions for the treatment of sickle cell disease comprising p-nitrobenzyl esters or amides of aromatic or hydrophobic aminoacids
EP0551844A3 (da)	1996-05-22
HK64993A (en)	1993-07-16	Therapeutic agent for the treatment of disorders associated with cerebral ischemia
IE830308L (en)	1983-08-16	Selective herbicidals
IT1244459B (it)	1994-07-15	Composizione terapeutica per il trattamento di malattie della pelle quali vitiligine,acne,psoriasi,alopecia,ipotricosi
GR3024709T3 (en)	1997-12-31	Novel cytarabine derivatives, their production and use
RU95100512A (ru)	1997-11-10	Мазь для лечения кожных заболеваний