PH31610A - Taxol derivatives. - Google Patents

Taxol derivatives.

Info

Publication number
PH31610A
PH31610A PH46060A PH46060A PH31610A PH 31610 A PH31610 A PH 31610A PH 46060 A PH46060 A PH 46060A PH 46060 A PH46060 A PH 46060A PH 31610 A PH31610 A PH 31610A
Authority
PH
Philippines
Prior art keywords
taxol derivatives
taxol
derivatives
compounds
chain
Prior art date
Application number
PH46060A
Other languages
English (en)
Inventor
Geewananda P Gunawardana
Larry L Klein
James B Mcalpine
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of PH31610A publication Critical patent/PH31610A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
PH46060A 1992-04-17 1993-04-16 Taxol derivatives. PH31610A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87050992A 1992-04-17 1992-04-17
US91472092A 1992-07-16 1992-07-16

Publications (1)

Publication Number Publication Date
PH31610A true PH31610A (en) 1998-11-03

Family

ID=27128160

Family Applications (1)

Application Number Title Priority Date Filing Date
PH46060A PH31610A (en) 1992-04-17 1993-04-16 Taxol derivatives.

Country Status (15)

Country Link
US (3) US5352806A (fr)
EP (1) EP0639186B1 (fr)
JP (1) JPH07505887A (fr)
KR (1) KR100263496B1 (fr)
AT (1) ATE181551T1 (fr)
AU (1) AU672006B2 (fr)
CA (1) CA2130578A1 (fr)
DE (1) DE69325454T2 (fr)
DK (1) DK0639186T3 (fr)
ES (1) ES2134847T3 (fr)
GR (1) GR3031126T3 (fr)
IL (3) IL105421A (fr)
MX (1) MX9302214A (fr)
PH (1) PH31610A (fr)
WO (1) WO1993021173A1 (fr)

Families Citing this family (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411947A (en) * 1989-06-28 1995-05-02 Vestar, Inc. Method of converting a drug to an orally available form by covalently bonding a lipid to the drug
US5475120A (en) * 1990-11-02 1995-12-12 University Of Florida Method for the isolation and purification of taxol and its natural analogues
US5698582A (en) * 1991-07-08 1997-12-16 Rhone-Poulenc Rorer S.A. Compositions containing taxane derivatives
US5990325A (en) * 1993-03-05 1999-11-23 Florida State University Process for the preparation of 9-desoxotaxol, 9-desoxobaccatin III and analogs thereof
US6011056A (en) * 1991-09-23 2000-01-04 Florida State University C9 taxane derivatives and pharmaceutical compositions containing them
US5998656A (en) 1991-09-23 1999-12-07 Florida State University C10 tricyclic taxanes
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US6018073A (en) * 1991-09-23 2000-01-25 Florida State University Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US6495704B1 (en) 1991-09-23 2002-12-17 Florida State University 9-desoxotaxanes and process for the preparation of 9-desoxotaxanes
US5714513A (en) * 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5399726A (en) * 1993-01-29 1995-03-21 Florida State University Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
US5710287A (en) * 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US5440056A (en) * 1992-04-17 1995-08-08 Abbott Laboratories 9-deoxotaxane compounds
GB9213077D0 (en) * 1992-06-19 1992-08-05 Erba Carlo Spa Polymerbound taxol derivatives
FR2702212B1 (fr) * 1993-03-02 1995-04-07 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US6710191B2 (en) 1993-03-05 2004-03-23 Florida State University 9β-hydroxytetracyclic taxanes
US6066747A (en) * 1993-03-05 2000-05-23 Florida State University Process for the preparation of 9-desoxotaxanes
US5703247A (en) * 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
DK0690867T3 (da) * 1993-03-22 2003-06-10 Univ Florida State Taxaner med furyl- eller thienylsubstitueret sidekæde
US5468769A (en) * 1993-07-15 1995-11-21 Abbott Laboratories Paclitaxel derivatives
US6005120A (en) 1993-07-20 1999-12-21 Florida State University Tricyclic and tetracyclic taxanes
FR2711370B1 (fr) * 1993-10-18 1996-01-05 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5965566A (en) * 1993-10-20 1999-10-12 Enzon, Inc. High molecular weight polymer-based prodrugs
US5824701A (en) * 1993-10-20 1998-10-20 Enzon, Inc. Taxane-based prodrugs
FR2712289B1 (fr) * 1993-11-08 1996-01-05 Rhone Poulenc Rorer Sa Nouveaux dérivés de taxicine, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
FR2721928A1 (fr) * 1994-07-04 1996-01-05 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US5763477A (en) * 1994-07-22 1998-06-09 Dr. Reddy's Research Foundation Taxane derivatives from 14-β-hydroxy-10 deacetylbaccatin III
FR2723094A1 (fr) * 1994-07-26 1996-02-02 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
CA2162759A1 (fr) * 1994-11-17 1996-05-18 Kenji Tsujihara Derives de la baccatine et methodes de preparation
BR9608040B1 (pt) 1995-04-28 2010-02-23 composto taxàide pentacÍclico.
US5760251A (en) * 1995-08-11 1998-06-02 Sepracor, Inc. Taxol process and compounds
FR2742751B1 (fr) * 1995-12-22 1998-01-30 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US5688977A (en) * 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
US5635531A (en) * 1996-07-08 1997-06-03 Bristol-Myers Squibb Company 3'-aminocarbonyloxy paclitaxels
US5773464A (en) * 1996-09-30 1998-06-30 Bristol-Myers Squibb Company C-10 epoxy taxanes
CA2188190A1 (fr) * 1996-10-18 1998-04-18 Sarala Balachandran La semi-synthese d'une composition bacatin iii protegee
WO1998017656A1 (fr) 1996-10-24 1998-04-30 Institute Armand-Frappier Famille de taxanes canadensol, preparation semi-synthetique et usage therapeutique de ces derniers
US5977386A (en) * 1996-12-24 1999-11-02 Bristol-Myers Squibb Company 6-thio-substituted paclitaxels
US5739359A (en) * 1997-01-24 1998-04-14 Virginia Tech Intellectual Properties, Inc. Methods for preparing 1-deoxy paclitaxels
US5902822A (en) * 1997-02-28 1999-05-11 Bristol-Myers Squibb Company 7-methylthiooxomethyl and 7-methylthiodioxomethyl paclitaxels
US5912264A (en) * 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
US6017935A (en) * 1997-04-24 2000-01-25 Bristol-Myers Squibb Company 7-sulfur substituted paclitaxels
CA2204197A1 (fr) * 1997-05-01 1998-11-01 Jian Liu Methode pour convertir la 9-dihydro-13-acetylbaccatine iii en taxol et en ses derives
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
US6111144A (en) 1997-08-21 2000-08-29 Florida State University Method for the synthesis of a taxane intermediate
US6150537A (en) * 1997-12-12 2000-11-21 Emory University Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents
US6136988A (en) 1998-04-10 2000-10-24 Hauser, Inc. 7-hexanoyltaxol and methods for preparing the same
US6175023B1 (en) 2000-01-31 2001-01-16 Jian Liu Synthesis of water soluble 9-dihydro-paclitaxel derivatives from 9-dihydro-13-acetylbaccatin III
CO5280224A1 (es) * 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
US6452024B1 (en) 2000-02-22 2002-09-17 Chaichem Pharmaceuticals International Process for extraction and purification of paclitaxel from natural sources
US20010041803A1 (en) * 2000-03-21 2001-11-15 Kasitu Gertrude C. Conversion of 9-dihydro-13-acetylbaccatin III to baccatin III and 10-deacetyl baccatin III
CZ2003837A3 (cs) * 2000-09-22 2004-12-15 Bristol-Myers Squibb Company Způsob pro snížení toxicity při kombinovaných chemoterapiích
AU2002228772B2 (en) 2000-11-02 2005-12-08 Sloan Kettering Institute For Cancer Research Methods for enhancing the efficacy of cytotoxic agents through the use of HSP90 inhibitors
WO2002038556A2 (fr) 2000-11-08 2002-05-16 Actipharm, Inc. Procede de production en serie de gmp paclitaxel et taxanes apparentes
AUPR298901A0 (en) * 2001-02-07 2001-03-08 McComb Foundation, Inc., The Cell suspension preparation technique and device
US20040132991A1 (en) * 2002-10-09 2004-07-08 Phytogen Life Sciences Inc. Novel taxanes and methods related to use and preparation thereof
US7407675B2 (en) 2002-12-27 2008-08-05 The Trustees Of Columbia University In The City Of New York Anti-neoplastic compositions comprising extracts of black cohosh
US20090264377A1 (en) * 2002-12-27 2009-10-22 Linda Saxe Einbond Anti-neoplastic compositions comprising extracts of black cohosh
US20090186837A1 (en) * 2002-12-27 2009-07-23 The Trustees Of Columbia University In The City Of New York Anti-neoplastic compositions comprising extracts of black cohosh
US6759539B1 (en) 2003-02-27 2004-07-06 Chaichem Pharmaceuticals International Process for isolation and purification of paclitaxel from natural sources
US8088737B2 (en) 2003-04-04 2012-01-03 Incyte Corporation Compositions, methods and kits relating to Her-2 cleavage
EP1785416A3 (fr) 2003-09-25 2007-05-30 Tapestry Pharmaceuticals, Inc. Analogues de 9, 10-alpha, alpha-OH-Taxane et méthodes pour leur production
EP1810968A3 (fr) * 2003-09-25 2007-08-08 Tapestry Pharmaceuticals, Inc. Analogues de taxane 9, 10-a, a-OH et leur procédé de production
US7202370B2 (en) 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
EP1737444A4 (fr) 2004-03-05 2008-05-21 Univ Florida State Res Found Taxanes a substitution de c7 lactyloxy-
US7838694B2 (en) * 2004-04-23 2010-11-23 Chatham Biotec, Limited Semi-synthesis and isolation of taxane intermediates from a mixture of taxanes
US7893283B2 (en) * 2004-06-04 2011-02-22 Chatham Biotec, Limited Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
US20050288520A1 (en) 2004-06-25 2005-12-29 Phytogen Life Sciences Inc. One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
US20050288521A1 (en) * 2004-06-29 2005-12-29 Phytogen Life Sciences Inc. Semi-synthetic conversion of paclitaxel to docetaxel
EP2336140B1 (fr) 2004-10-25 2016-01-27 Dekk-Tec, Inc. Sels d'yperite d'isophosphoramide et analogues de ceux-ci utilises en tant qu'agents anti-tumoraux
USH2260H1 (en) 2005-02-17 2011-07-05 Angiotech International Ag Stents combined with paclitaxel derivatives
WO2007075870A2 (fr) * 2005-12-21 2007-07-05 Tapestry Pharmaceuticals, Inc. Procedes pour derives de taxane et intermediaires utiles correspondants
MX2008008120A (es) * 2005-12-21 2008-09-24 Tapestry Pharmaceuticals Inc Nuevos compuestos y metodos para formar taxanos y uso de los mismos.
US20090306400A1 (en) * 2006-03-27 2009-12-10 Henri John T Convergent process for the synthesis of taxane derivatives.
PL217731B1 (pl) 2006-06-01 2014-08-29 Tomasz Byrski Sposób wykrywania genetycznie uwarunkowanej obniżonej odpowiedzi na chemioterapię cytostatykiem taksanowym, zastosowanie mutacji założycielskiej oraz zestawu do wykrywania takiej odpowiedzi
US7847111B2 (en) * 2006-06-19 2010-12-07 Canada Inc. Semi-synthetic route for the preparation of paclitaxel, docetaxel, and 10-deacetylbaccatin III from 9-dihydro-13-acetylbaccatin III
US11786504B2 (en) 2006-09-28 2023-10-17 Tapestry Pharmaceuticals, Inc. Taxane analogs for the treatment of brain cancer
US11873308B2 (en) 2006-11-06 2024-01-16 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
WO2008121476A1 (fr) 2007-03-28 2008-10-09 Tapestry Pharmaceuticals, Inc. Analogues de taxane biologiquement actifs, et procédés de traitement par administration orale
CN101611007A (zh) 2006-12-20 2009-12-23 先灵公司 新颖的jnk抑制剂
EP2118079A1 (fr) 2007-02-07 2009-11-18 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Composés macrocycliques de synthèse
US20080207743A1 (en) * 2007-02-28 2008-08-28 Rodger Lamb Biologically Active Taxane Analogs and Methods of Treatment
WO2008109360A1 (fr) 2007-02-28 2008-09-12 Tapestry Pharmaceuticals, Inc Analogues de taxane pour le traitement du cancer du cerveau
MX2009010820A (es) 2007-04-06 2010-03-18 Ziopharm Oncology Inc Sales de mostaza isofosforamida y analogos de la misma.
NZ601139A (en) 2008-07-31 2014-02-28 Ziopharm Oncology Inc Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof
AU2010218109B2 (en) 2009-02-24 2015-04-09 Dekk-Tec, Inc. Complexes of 4-hydroperoxy ifosfamide as anti-tumor agents
WO2010138686A1 (fr) 2009-05-29 2010-12-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Agents s'opposant au gène mdr1
JP2013506669A (ja) 2009-09-30 2013-02-28 メルク・シャープ・アンド・ドーム・コーポレーション Ｅｒｋ阻害剤である新規化合物
EP2501431B1 (fr) 2009-11-19 2020-01-08 Wellinq Medical B.V. Cathéter médical à ballonet extensible, libérant une composition et de profil étroit
AU2011224241B2 (en) 2010-03-10 2014-05-08 Sri International The use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas
WO2012033601A1 (fr) 2010-08-20 2012-03-15 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Thiosemicarbazones à activité anti-mdr1
EP2608672B1 (fr) 2010-08-23 2020-12-16 Syntrix Biosystems, Inc. Aminopyridinecarboxamides et aminopyrimidinecarboxamides utilisables en tant que modulateurs des récepteurs cxcr2
SG194128A1 (en) * 2011-04-07 2013-11-29 Arbor Therapeutics Llc Taxane and abeo-taxane analogs
CA2841120C (fr) 2011-07-11 2020-10-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Conjugues anticorps-fluorophore photosensibilisants
WO2013177418A1 (fr) 2012-05-25 2013-11-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Procédés de régulation de troubles et maladies associés à une activité de récepteur cannabinoïde
AU2013205148B2 (en) 2013-03-14 2014-10-30 AVITA Medical Americas, LLC Systems and methods for tissue processing and preparation of cell suspension therefrom
JP2016528217A (ja) * 2013-07-26 2016-09-15 スレッショルド ファーマシューティカルズ，インコーポレイテッド 低酸素活性化プロドラッグおよびタキサンの組合せを用いた膵臓癌の治療
US10561676B2 (en) 2013-08-02 2020-02-18 Syntrix Biosystems Inc. Method for treating cancer using dual antagonists of CXCR1 and CXCR2
AU2013395662B2 (en) 2013-08-02 2019-03-14 Syntrix Biosystems, Inc. 2- (5- (N- (4 -fluorophenyl) carbamoyl) pyrimidin- 2 - ylsulfanylmethyl) -4- (trifluoromet hoxy) phenyl) boronic acid
US10046002B2 (en) 2013-08-02 2018-08-14 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists
US8969365B2 (en) 2013-08-02 2015-03-03 Syntrix Biosystems, Inc. Thiopyrimidinecarboxamides as CXCR1/2 modulators
CN105813654B (zh) 2013-10-11 2019-05-31 美国政府(由卫生和人类服务部的部长所代表) Tem8抗体及其用途
US10830678B2 (en) 2014-08-08 2020-11-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv Photo-controlled removal of targets in vitro and in vivo
EP3703723A4 (fr) 2017-10-31 2021-12-15 KaliVir Immunotherapeutics, Inc. Vecteur de plateforme oncolytique pour administration systémique
WO2019099615A1 (fr) 2017-11-17 2019-05-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Utilisation de copeptine pour moduler la réponse immunitaire et l'hématopoïèse et stimuler la croissance osseuse
JP2021521135A (ja) 2018-04-10 2021-08-26 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ がん細胞を標的とする近赤外光線免疫療法および宿主免疫活性化の組合せ
WO2021003297A1 (fr) 2019-07-02 2021-01-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps monoclonaux se liant à egfrviii et leurs utilisations
CA3151228A1 (fr) 2019-09-19 2021-03-25 Leap Therapeutics, Inc. Utilisation d'inhibiteurs de dkk-1 pour le traitement du cancer
EP4061419A1 (fr) 2019-11-22 2022-09-28 Leap Therapeutics, Inc. Méthodes de traitement du cancer à l'aide d'inhibiteurs de dkk-1
WO2021154705A1 (fr) 2020-01-27 2021-08-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Oligonucléotides antisens rab13 et net1 pour traiter le cancer métastatique
TW202227621A (zh) 2020-11-19 2022-07-16 美商凱立凡爾免疫治療股份有限公司 重塑腫瘤微環境的溶瘤免疫療法
US20240101685A1 (en) 2021-01-29 2024-03-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Near infrared photoimmunotherapy (nir-pit) combination therapy to treat cancer
BR112023022681A2 (pt) 2021-04-30 2024-01-23 Kalivir Immunotherapeutics Inc Vírus oncolíticos para expressão modificada de mhc
EP4547274A1 (fr) 2022-06-30 2025-05-07 The United States of America, as represented by the Secretary, Department of Health and Human Services Anticorps spécifiques de cd25 et leurs utilisations
US12570949B2 (en) 2022-12-27 2026-03-10 AVITA Medical Americas, LLC Systems and devices for wound therapy and related methods of use
DE202023002794U1 (de) 2022-12-27 2024-07-15 AVITA Medical Americas, LLC Kassette zur Herstellung einer regenerativen epidermalen Suspension
WO2025014896A1 (fr) 2023-07-07 2025-01-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps 40h3 humanisé
USD1112812S1 (en) 2023-12-22 2026-02-10 AVITA Medical Americas, LLC Tissue processing cartridge

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US4876399A (en) * 1987-11-02 1989-10-24 Research Corporation Technologies, Inc. Taxols, their preparation and intermediates thereof
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
CA2023645C (fr) * 1989-08-23 2002-03-26 Jean-Noel Denis Procede pour la preparation enantioselective de derives de la phenylisoserine
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
FR2658513B1 (fr) * 1990-02-21 1994-02-04 Rhone Poulenc Sante Procede de preparation de l'acide cis-beta-phenylglycidique-(2r,3r).
FR2658510B1 (fr) * 1990-02-21 1992-04-30 Rhone Poulenc Sante Nouveau derive de la beta-phenylisoserine, sa preparation et son emploi.
US5200534A (en) * 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
FR2711370B1 (fr) * 1993-10-18 1996-01-05 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
ATE181551T1 (de) 1999-07-15
IL105421A0 (en) 1993-08-18
GR3031126T3 (en) 1999-12-31
IL105421A (en) 1999-09-22
DE69325454T2 (de) 2000-01-20
ES2134847T3 (es) 1999-10-16
AU4286393A (en) 1993-11-18
EP0639186B1 (fr) 1999-06-23
DE69325454D1 (de) 1999-07-29
IL126339A (en) 2001-03-19
AU672006B2 (en) 1996-09-19
KR950700894A (ko) 1995-02-20
JPH07505887A (ja) 1995-06-29
DK0639186T3 (da) 1999-12-13
MX9302214A (es) 1993-10-01
EP0639186A4 (fr) 1995-01-10
CA2130578A1 (fr) 1993-10-28
US5352806A (en) 1994-10-04
KR100263496B1 (ko) 2002-01-09
EP0639186A1 (fr) 1995-02-22
US5594157A (en) 1997-01-14
US5530020A (en) 1996-06-25
WO1993021173A1 (fr) 1993-10-28
IL126339A0 (en) 1999-05-09

Similar Documents

Publication Publication Date Title
IL126339A (en) Taxol derivatives
IL124537A0 (en) Naphthyl-substituted benzimidazole derivatives and pharmaceutical compositions containing the same
PL295030A1 (en) Method of obtaining substituted derivatives of 2-cyclohexan-1-yl amine
AU6613896A (en) Chemical compounds
ZA909903B (en) New compounds
MX9708696A (es) Cefalosporinas antibacterianas.
HU9401584D0 (en) Preparation of substituted piperidines
AU7498494A (en) New bis-naphthalimides for the treatment of cancer
TW252979B (fr)
MY115533A (en) Benzothiophenes, formulation containing same and methods
PL309402A1 (en) Novel steroides
GR1002598B (el) Παραγωγα επι-επιβατιδινης.
GR3023757T3 (en) Cyclic benzylamino, benzylamido and benzylimido derivatives as antipsychotic agents.
ZA9419B (en) Preparation process for sulphurated derivatives of imidazole and the new intermediates obtained.
TW224461B (fr)
IL114646A0 (en) Method of inhibiting leukotriene biosynthesis
ES2101635A1 (es) Nuevo compuesto derivado del cromeno