PL126652B1 - Method for producing new substituted pyrazole /1,5-a/ pyrimidines - Google Patents

Method for producing new substituted pyrazole /1,5-a/ pyrimidines Download PDF

Info

Publication number
PL126652B1
PL126652B1 PL1980225541A PL22554180A PL126652B1 PL 126652 B1 PL126652 B1 PL 126652B1 PL 1980225541 A PL1980225541 A PL 1980225541A PL 22554180 A PL22554180 A PL 22554180A PL 126652 B1 PL126652 B1 PL 126652B1
Authority
PL
Poland
Prior art keywords
pyridyl
pyrimidine
pyrazolo
formula
hours
Prior art date
Application number
PL1980225541A
Other languages
English (en)
Polish (pl)
Other versions
PL225541A1 (2
Original Assignee
American Cyanamid Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Company filed Critical American Cyanamid Company
Publication of PL225541A1 publication Critical patent/PL225541A1/xx
Publication of PL126652B1 publication Critical patent/PL126652B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL1980225541A 1979-07-09 1980-07-08 Method for producing new substituted pyrazole /1,5-a/ pyrimidines PL126652B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5594179A 1979-07-09 1979-07-09
US06/124,686 US4281000A (en) 1979-07-09 1980-02-26 Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents

Publications (2)

Publication Number Publication Date
PL225541A1 PL225541A1 (2) 1981-10-30
PL126652B1 true PL126652B1 (en) 1983-08-31

Family

ID=26734791

Family Applications (1)

Application Number Title Priority Date Filing Date
PL1980225541A PL126652B1 (en) 1979-07-09 1980-07-08 Method for producing new substituted pyrazole /1,5-a/ pyrimidines

Country Status (12)

Country Link
US (1) US4281000A (2)
EP (1) EP0025819B1 (2)
AR (1) AR227766A1 (2)
AU (1) AU536081B2 (2)
CA (1) CA1140125A (2)
DD (1) DD153840A5 (2)
DE (1) DE3065270D1 (2)
GR (1) GR70075B (2)
HU (1) HU182153B (2)
IL (1) IL60330A (2)
PL (1) PL126652B1 (2)
YU (1) YU172280A (2)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU557300B2 (en) * 1982-03-16 1986-12-18 Farmitalia Carlo Erba S.P.A. Substituted 1h-pyrazolo(1,5-alpha)pyrimidines and processes for their preparation
ZA831407B (en) * 1982-03-25 1983-11-30 Erba Farmitalia Substituted ethenyl derivatives of 1h-pyrazolo(1,5-a)pyrimidine and process for their preparation
US4444774A (en) * 1982-07-29 1984-04-24 American Cyanamid Company 7-Heteroaryl[1,2,4]triazolo[1,5-a]pyrimidines
NZ208554A (en) * 1983-06-23 1987-06-30 American Cyanamid Co (aryl and heteroaryl)-(7-(aryl and heteroaryl)-pyrazolo (1,5-a) pyrimidin-3-yl)-methanone derivatives and pharmaceutical compositions
US4654347A (en) * 1983-06-23 1987-03-31 American Cyanamid Company Aryl and heteroaryl[[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]methanones
US4626538A (en) * 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
NZ208555A (en) * 1983-06-23 1987-06-30 American Cyanamid Co (3-amino-1h-pyrazol-4-yl)-arylmethanone derivatives
US4521422A (en) * 1983-06-23 1985-06-04 American Cyanamid Company Aryl and heteroaryl[7-(aryl and heteroaryl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones
US4576943A (en) * 1984-10-09 1986-03-18 American Cyanamid Company Pyrazolo[1,5-a]pyrimidines
GB8610531D0 (en) * 1986-04-30 1986-06-04 Fbc Ltd Herbicides
EP0264773A1 (en) * 1986-10-16 1988-04-27 American Cyanamid Company 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidines
US5013737A (en) * 1988-02-22 1991-05-07 American Cyanamid Company 2,4,8-Trisubstituted-3H,6H-1,4,5A,8A-tetraazaacenaphtylene-3,5-(4H)-diones and 2,4-8-trisubstituted-4,5-dihydro-5-thioxo-3H,6H-1,4,5A,8A-tetrazaacenaphthylen-3-ones
US5059709A (en) * 1990-11-13 1991-10-22 American Cyanamid Company Process for the synthesis of α-[(dialkylamino)substituted-methylene]-β-oxo-(substituted)propanentriles
DE4333705C2 (de) * 1993-10-02 2003-10-30 Guenter Ege Arylmethylsubstituierte Pyrazolo-azine, insbesondere 3-Arylmethylpyrazolo[1,5-a]pyrimidine und Verfahren zur Herstellung von 8-Arylmethyl-pyrazolo[5,1-c][1,2,4]triazinen
US5538977A (en) * 1995-03-17 1996-07-23 American Cyanamid Company 3-Substituted-7-[3-(imidazol-1-yl)phenyl]-pyrazolo[1,5-a]pyrimidines
US5714607A (en) * 1995-12-01 1998-02-03 American Cyanamid Company Process improvement in the synthesis of N- 3-(3-cyano-pyrazolo 1,5-a!pyrimidin-7-yl)phenyl!-N-ethylacetamide
WO2000059908A2 (en) * 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolopyrimidines as crf antagonists
RU2183610C1 (ru) * 2000-11-15 2002-06-20 Институт молекулярной генетики РАН Высокомеченный тритием n-[3-(3-цианопиразоло[1,5-а]пиримидин-7-ил)фенил]-n-этилацетамид
GB0202873D0 (en) * 2002-02-07 2002-03-27 Novartis Ag Organic compounds
TW200719895A (en) * 2005-05-26 2007-06-01 Wyeth Corp Method for the treatment of noise phobia in companion animals
US20100029657A1 (en) * 2008-02-29 2010-02-04 Wyeth Bridged, Bicyclic Heterocyclic or Spiro Bicyclic Heterocyclic Derivatives of Pyrazolo[1, 5-A]Pyrimidines, Methods for Preparation and Uses Thereof
WO2013035102A1 (en) 2011-09-05 2013-03-14 Natco Pharma Limited Processes for the preparation of imatinib base and intermediates thereof
US11167081B2 (en) 2016-06-16 2021-11-09 Smiths Medical Asd, Inc. Assemblies and methods for infusion pump system administration sets
CN117659025A (zh) * 2017-10-30 2024-03-08 科罗拉多州立大学董事会法人团体 Toll样受体8（tlr8）特异性拮抗剂及其制备方法和用途
US12479816B2 (en) 2019-02-08 2025-11-25 University of Pittsburgh—of the Commonwealth System of Higher Education 20-HETE formation inhibitors
UY39482A (es) 2020-10-23 2022-05-31 Ildong Pharmaceutical Co Ltd Compuestos moduladores del cftr, composiciones y usos de estos
CN112745300A (zh) * 2021-01-21 2021-05-04 杭州浙中医药科技有限公司 一种制备n-(5-羧基-2-甲基苯基)-4-(3-吡啶)-2-嘧啶胺的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3157655A (en) * 1962-05-18 1964-11-17 Shionogi & Co Pyrazolopyrimidine derivative
BE786611A (fr) * 1971-08-16 1973-01-22 Int Chem & Nuclear Corp Nouveaux inhibiteurs de xanthine-oxydase et leur procede de preparatio
US3907799A (en) * 1971-08-16 1975-09-23 Icn Pharmaceuticals Xanthine oxidase inhibitors
US3925385A (en) * 1972-04-20 1975-12-09 Icn Pharmaceuticals 6-Carbethoxy-3,7-disubstitutedpyrazolo{8 1,5a{9 pyrimidines
BE792533A (fr) * 1971-12-09 1973-06-08 Int Chem & Nuclear Corp Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation
US4093617A (en) * 1974-11-12 1978-06-06 Icn Pharmaceuticals, Inc. 3,5,7-Trisubstituted pyrazolo[1,5-a]pyrimidines
US4178449A (en) * 1978-04-17 1979-12-11 American Cyanamid Company Pyrazolo[1,5-a]pyrimidines and imidazo-[1,5-a]pyrimidines

Also Published As

Publication number Publication date
YU172280A (en) 1983-02-28
US4281000A (en) 1981-07-28
EP0025819A1 (en) 1981-04-01
IL60330A0 (en) 1980-09-16
EP0025819B1 (en) 1983-10-12
HU182153B (en) 1983-12-28
DE3065270D1 (en) 1983-11-17
GR70075B (2) 1982-07-27
DD153840A5 (de) 1982-02-03
AU536081B2 (en) 1984-04-19
AR227766A1 (es) 1982-12-15
IL60330A (en) 1984-05-31
CA1140125A (en) 1983-01-25
AU5951780A (en) 1981-01-15
PL225541A1 (2) 1981-10-30

Similar Documents

Publication Publication Date Title
PL126652B1 (en) Method for producing new substituted pyrazole /1,5-a/ pyrimidines
US4062848A (en) Tetracyclic compounds
DE69930120T2 (de) Annellierte azepinone als inhibitoren cyclin-abhängiger kinasen
EP0029103B1 (en) 6- and 8-heteroaryl-1,2,4-triazolo(4,3-b)pyridazines
PT92919B (pt) Processo para a preparacao de agentes ansioliticos bis-azabiciclicos
EP0115469B1 (de) Heterocyclisch ankondensierte Pyrazolo(3,4-d)pyridin-3-one
CA1288097C (en) 2-substituted-e-fused-¬1,2,4|triazolo-¬1,5- c|pyrimidines pharmaceutical compositions and uses thereof
US20090227565A1 (en) Biphenyl Vasopressin Agonists
DE2609486C2 (2)
EP1329454A1 (en) Thienopyrimidine compounds and their salts and process for preparation of both
US3957783A (en) Thieno[2,3-d]pyrimidine derivatives
WO2000041695A1 (de) Verwendung von pyrimidinderivaten zur prophylaxe und therapie der zerebralen ischämie
KR900001886B1 (ko) 아릴 및 헤테로 아릴[7-(아릴 및 헤테로 아릴)-피라졸로[1,5-a]피리미딘-3-일]메탄온류 및 그의 제법
DE69230125T2 (de) Tricyclische triazolderivate, ihre herstellung und ihre verwendung
DK145577B (da) Analogifremgangsmaade til fremstilling af s-triazolo(4,3-a)-(1,4)-benzodiazepiner eller 5n-oxyder eller syreadditionssalte deraf
NL8601146A (nl) Antipsychotische pyridinylpiperazinederivaten, werkwijzen ter bereiding daarvan en farmaceutische preparaten, die zulke verbindingen bevatten.
SK124695A3 (en) Disubstituted polycyclic compounds and their derivatives alone and for treatment, and pharmaceutical compositions on their base
EP0888356B1 (de) Kondensierte 2,3-benzodiazepin derivate und deren verwendung als ampa-rezeptoren-hemmer
Francis et al. Anxiolytic properties of certain annelated [1, 2, 4] triazolo [1, 5-c] pyrimidin-5 (6H)-ones
NO163056B (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrazolo (3,4-d) - pyridin-3-on-derivater.
JP2002105082A (ja) 縮合チエノピリミジン化合物、その塩及び製造法
AU625779B2 (en) Imidazodiazepine derivatives
JPS62135475A (ja) ２−置換−ｅ−融合−〔１，２，４〕トリアゾロ−〔１，５−Ｃ〕ピリミジン
Khedkar et al. Synthesis, characterization and antihyperlipidemic activity of novel condensed pyarazolo [3, 4-d] pyrimidine derivatives
AT395155B (de) Verfahren zur herstellung von neuen imidazo(1,5-a)(1,4)diazepinverbindungen