PL129707B1 - Process for preparing novel n-substituted derivatives of aziridine-2-carboxylic acid - Google Patents

Process for preparing novel n-substituted derivatives of aziridine-2-carboxylic acid Download PDF

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Publication number
PL129707B1
PL129707B1 PL1980222088A PL22208880A PL129707B1 PL 129707 B1 PL129707 B1 PL 129707B1 PL 1980222088 A PL1980222088 A PL 1980222088A PL 22208880 A PL22208880 A PL 22208880A PL 129707 B1 PL129707 B1 PL 129707B1
Authority
PL
Poland
Prior art keywords
cyano
carboxylic acid
group
aziridine
ethanol
Prior art date
Application number
PL1980222088A
Other languages
English (en)
Polish (pl)
Other versions
PL222088A1 (2
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of PL222088A1 publication Critical patent/PL222088A1/xx
Publication of PL129707B1 publication Critical patent/PL129707B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/22—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
PL1980222088A 1979-02-21 1980-02-18 Process for preparing novel n-substituted derivatives of aziridine-2-carboxylic acid PL129707B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792906603 DE2906603A1 (de) 1979-02-21 1979-02-21 N-substituierte aziridin-2-carbonsaeurederivate, verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
PL222088A1 PL222088A1 (2) 1980-12-01
PL129707B1 true PL129707B1 (en) 1984-06-30

Family

ID=6063481

Family Applications (1)

Application Number Title Priority Date Filing Date
PL1980222088A PL129707B1 (en) 1979-02-21 1980-02-18 Process for preparing novel n-substituted derivatives of aziridine-2-carboxylic acid

Country Status (19)

Country Link
US (2) US4397848A (2)
EP (1) EP0014976B1 (2)
JP (1) JPS55113760A (2)
AR (1) AR223863A1 (2)
AT (1) ATE818T1 (2)
AU (1) AU529982B2 (2)
CA (1) CA1148962A (2)
CS (1) CS208798B2 (2)
DD (1) DD148772A5 (2)
DE (2) DE2906603A1 (2)
ES (1) ES488656A1 (2)
FI (1) FI70702C (2)
HU (1) HU182801B (2)
IE (1) IE49267B1 (2)
IL (1) IL59425A (2)
PL (1) PL129707B1 (2)
PT (1) PT70847A (2)
SU (1) SU1181541A3 (2)
ZA (1) ZA80902B (2)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925835A (en) * 1986-05-01 1990-05-15 Sloan-Kettering Institute For Cancer Research Aziridinyl putrescine containing compositions and their uses in treating prostate cancer
JPH07301287A (ja) * 1995-03-23 1995-11-14 Sumitomo Heavy Ind Ltd 制御装置に用いられる内接噛合遊星歯車機構
EP1027041B1 (en) 1997-06-27 2003-10-22 Amplimed, Inc. Novel cyanoaziridines for treating cancer
CA2431947A1 (en) * 2000-11-21 2002-05-30 Gabriel Lopez-Berestein Composition comprising an imexon or derivatives thereof and lipids
US20030129222A1 (en) * 2000-11-21 2003-07-10 Gabriel Lopez-Berestein Liposomal imexon
US7011846B2 (en) * 2001-12-21 2006-03-14 Shire Laboratories, Inc. Oral capsule formulation with increased physical stability
US20040005339A1 (en) * 2002-06-28 2004-01-08 Shojaei Amir H. Formulations of fenofibrate and/or fenofibrate derivatives with improved oral bioavailability
MXPA05007485A (es) 2003-01-14 2006-01-30 Arena Pharm Inc Derivados de arilo y heteroarilo 1,2,3-trisubstituidos como moduladores del metabolismo y la profilaxis y tratamiento de trastornos relacionados con ello tales como diabetes e hiperglicemia.
ES2316964T3 (es) * 2003-02-24 2009-04-16 Arena Pharmaceuticals, Inc. Fenil-y piridilpipereidinia-derivados como moduladores del metabolismo de la glucosa.
AR045047A1 (es) 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
EA011671B1 (ru) * 2004-06-04 2009-04-28 Арена Фармасьютикалз, Инк. Замещенные производные арила и гетероарила в качестве модуляторов метаболизма и для профилактики и лечения связанных с ним расстройств
MY148521A (en) * 2005-01-10 2013-04-30 Arena Pharm Inc Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
DOP2006000010A (es) 2005-01-10 2006-07-31 Arena Pharm Inc Procedimiento para preparar eteres aromáticos
BRPI0616245A2 (pt) * 2005-09-16 2011-06-14 Arena Pharm Inc modulador de metabolismo, seus usos, composiÇço farmaceutica compreendendo o mesmo, bem como mÉtodo para produÇço da referida composiÇço
TW200811147A (en) * 2006-07-06 2008-03-01 Arena Pharm Inc Modulators of metabolism and the treatment of disorders related thereto
TW200811140A (en) * 2006-07-06 2008-03-01 Arena Pharm Inc Modulators of metabolism and the treatment of disorders related thereto
SG10201906876PA (en) 2010-01-27 2019-09-27 Arena Pharm Inc Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
PH12013500547A1 (en) 2010-09-22 2013-06-10 Arena Pharm Inc Modulators of the gpr119 receptor and the treatment of disorders related thereto
MX386419B (es) 2015-01-06 2025-03-18 Arena Pharm Inc Metodos de condiciones de tratamiento relacionadas con el receptor s1p1.
EP3939965A1 (en) 2015-06-22 2022-01-19 Arena Pharmaceuticals, Inc. Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid for use in sipi receptor-associated disorders
MA47504A (fr) 2017-02-16 2019-12-25 Arena Pharm Inc Composés et méthodes de traitement de l'angiocholite biliaire primitive
ES2987794T3 (es) 2018-06-06 2024-11-18 Arena Pharm Inc Procedimientos de tratamiento de afecciones relacionadas con el receptor S1P1
CN113816887A (zh) * 2021-08-31 2021-12-21 华中科技大学 一种氮杂环丙烷类化合物及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2644820A1 (de) * 1976-10-05 1978-04-06 Boehringer Mannheim Gmbh Cancerostatisch und immunstimulierend wirkende 1-(n-acyl-carbamoyl)-2-cyanaziridine sowie verfahren zur herstellung derselben
DE2731264A1 (de) 1977-07-11 1979-02-01 Boehringer Mannheim Gmbh Neue 1-acyl-2-cyanaziridine, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische zubereitungen

Also Published As

Publication number Publication date
JPS55113760A (en) 1980-09-02
FI70702B (fi) 1986-06-26
ATE818T1 (de) 1982-04-15
HU182801B (en) 1984-03-28
US4517183A (en) 1985-05-14
PL222088A1 (2) 1980-12-01
CA1148962A (en) 1983-06-28
CS208798B2 (en) 1981-09-15
AU529982B2 (en) 1983-06-30
FI70702C (fi) 1986-10-06
IE49267B1 (en) 1985-09-04
EP0014976A1 (de) 1980-09-03
JPH0150700B2 (2) 1989-10-31
DD148772A5 (de) 1981-06-10
PT70847A (de) 1980-03-01
ES488656A1 (es) 1980-09-16
DE3060268D1 (en) 1982-05-19
SU1181541A3 (ru) 1985-09-23
AR223863A1 (es) 1981-09-30
ZA80902B (en) 1981-03-25
IL59425A0 (en) 1980-05-30
IE800327L (en) 1980-08-21
DE2906603A1 (de) 1980-09-04
FI800510A7 (fi) 1980-08-22
US4397848A (en) 1983-08-09
AU5564980A (en) 1980-08-28
IL59425A (en) 1984-05-31
EP0014976B1 (de) 1982-04-07

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