PL1608655T3 - Pochodne piroloimidazolowe, ich wytwarzanie, zawierające je kompozycje farmaceutyczne i ich zastosowanie jako środków o działaniu nootropowym - Google Patents

Pochodne piroloimidazolowe, ich wytwarzanie, zawierające je kompozycje farmaceutyczne i ich zastosowanie jako środków o działaniu nootropowym

Info

Publication number: PL1608655T3
Authority: PL; Poland
Prior art keywords: preparation; pharmaceutical compositions; compositions containing; nootropic agents; action
Prior art date: 2003-03-24

Application number

PL04741432T

Other languages

English (en)

Inventor

Carlo Farina

Stefania Gagliardi

Carlo Parini

Marisa Martinelli

Carla Ghelardini

Original Assignee

Neurotune Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-24

Filing date

2004-03-22

Publication date

2009-03-31

2004-03-22 Application filed by Neurotune Ag filed Critical Neurotune Ag

2009-03-31 Publication of PL1608655T3 publication Critical patent/PL1608655T3/pl

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
239000002664 nootropic agent Substances 0.000 title 1
MHOZZUICEDXVGD-UHFFFAOYSA-N pyrrolo[2,3-d]imidazole Chemical class C1=NC2=CC=NC2=N1 MHOZZUICEDXVGD-UHFFFAOYSA-N 0.000 title 1
230000000202 analgesic effect Effects 0.000 abstract 1
230000003070 anti-hyperalgesia Effects 0.000 abstract 1
125000002619 bicyclic group Chemical group 0.000 abstract 1
230000002490 cerebral effect Effects 0.000 abstract 1
230000007278 cognition impairment Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000001777 nootropic effect Effects 0.000 abstract 1
230000004936 stimulating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PL04741432T 2003-03-24 2004-03-22 Pochodne piroloimidazolowe, ich wytwarzanie, zawierające je kompozycje farmaceutyczne i ich zastosowanie jako środków o działaniu nootropowym PL1608655T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IT000573A ITMI20030573A1 (it)	2003-03-24	2003-03-24	Composti ad azione nootropica, loro preparazione,
PCT/EP2004/050339 WO2004085438A2 (en)	2003-03-24	2004-03-22	Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents
EP04741432A EP1608655B8 (en)	2003-03-24	2004-03-22	Pyrroloimidazole derivatives, their preparation, pharmaceutical compositions containing them, and their use as nootropic agents

Publications (1)

Publication Number	Publication Date
PL1608655T3 true PL1608655T3 (pl)	2009-03-31

Family

ID=33042696

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL378939A PL378939A1 (pl)	2003-03-24	2004-03-22	Związki z działaniem nootropowym, ich wytwarzanie, zawierające je kompozycje farmaceutyczne i ich zastosowanie
PL04741432T PL1608655T3 (pl)	2003-03-24	2004-03-22	Pochodne piroloimidazolowe, ich wytwarzanie, zawierające je kompozycje farmaceutyczne i ich zastosowanie jako środków o działaniu nootropowym

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PL378939A PL378939A1 (pl)	2003-03-24	2004-03-22	Związki z działaniem nootropowym, ich wytwarzanie, zawierające je kompozycje farmaceutyczne i ich zastosowanie

Country Status (23)

Country	Link
US (3)	US7544705B2 (pl)
EP (1)	EP1608655B8 (pl)
JP (1)	JP4920408B2 (pl)
CN (1)	CN100522963C (pl)
AT (1)	ATE401327T1 (pl)
AU (1)	AU2004224087B2 (pl)
BR (1)	BRPI0408601A (pl)
CA (1)	CA2520008C (pl)
CY (1)	CY1108401T1 (pl)
DE (1)	DE602004015089D1 (pl)
DK (1)	DK1608655T3 (pl)
EA (1)	EA009558B1 (pl)
ES (1)	ES2309534T3 (pl)
HR (1)	HRP20050833A2 (pl)
IT (1)	ITMI20030573A1 (pl)
NO (1)	NO20054898L (pl)
NZ (1)	NZ543154A (pl)
PL (2)	PL378939A1 (pl)
PT (1)	PT1608655E (pl)
RS (1)	RS20050725A (pl)
SI (1)	SI1608655T1 (pl)
WO (1)	WO2004085438A2 (pl)
ZA (1)	ZA200508578B (pl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ITMI20030573A1 (it) *	2003-03-24	2004-09-25	Nikem Research Srl	Composti ad azione nootropica, loro preparazione,
EP1925304A1 (en) *	2006-11-15	2008-05-28	Nikem Research S.R.L.	Pyrrolo[1,2-a]imidazoledione effective in the treatment of peripheral neurotoxicity induced by chemotherapeutic agents
AU2012201853B2 (en) *	2007-04-16	2013-06-27	Neurotune Ag	Use of dimiracetam in the treatment of chronic pain
ITMI20070770A1 (it) *	2007-04-16	2008-10-17	Brane Discovery S R L	Impiego di dimiracetam nel trattamento del dolore cronico
ES2865504T3 (es)	2008-10-16	2021-10-15	Univ Johns Hopkins	Procedimientos y composiciones para la mejora de la función cognitiva
US9125898B2 (en)	2008-11-14	2015-09-08	Neurotune Ag	Acetam derivatives for pain relief
AU2011215870B2 (en) *	2010-02-09	2016-01-28	The Johns Hopkins University	Methods and compositions for improving cognitive function
PT2598504E (pt) *	2010-07-26	2014-07-14	Neurotune Ag	Novo processo de fabrico de dimiracetam
US20140206667A1 (en)	2012-11-14	2014-07-24	Michela Gallagher	Methods and compositions for treating schizophrenia
JP6433482B2 (ja)	2013-03-15	2018-12-05	エージンバイオ，インコーポレイテッド	認知機能を改善するための方法および組成物
WO2014144663A1 (en)	2013-03-15	2014-09-18	The Johns Hopkins University	Methods and compositions for improving cognitive function
WO2016191288A1 (en)	2015-05-22	2016-12-01	Agenebio, Inc.	Extended release pharmaceutical compositions of levetiracetam
JOP20190251A1 (ar)	2017-05-31	2019-10-21	Metys Pharmaceuticals AG	تركيبات تآزرية تشتمل على (r)-ديميراسيتام (1) و(s)-ديميراسيتام (2) بنسبة غير راسيمية
CN113195494B (zh)	2018-12-04	2024-06-28	美蒂斯制药公司	包含非外消旋比例的R-2-（取代的磺酰基）-六氢-吡咯并[1,2-a]吡嗪-6（2H）-酮和S-2-（取代的磺酰基）-六氢-吡咯并[1,2- a]吡嗪-6（2H）-酮的协同组合物
BR112021010739A2 (pt)	2018-12-04	2021-08-24	Metys Pharmaceuticals AG	Composições sinérgicas compreendendo (r)-(2-(2-oxopirrolidina-1-il)butanamida e (s)-2-(2-oxopirrolidina-1-il)butanamida) em uma proporção não racêmica

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4582838A (en) *	1984-08-24	1986-04-15	Warner-Lambert Company	Derivatives of dihydro-1H-pyrrolo[1,2-c]imidazol-3,5-dione as cognition activators
IT1233860B (it) *	1988-02-08	1992-04-21	Isf Spa	Derivati del peridroazacicloalca (1,2-a) imidazolo ad attivita' nootropa
US5200406A (en) *	1988-02-08	1993-04-06	I.S.F. Societa Per Azioni	Pharmaceutically useful 2,5-dioxo-1H-octahydroimidazo[1,2-A]azepines
JP3400466B2 (ja) *	1991-10-28	2003-04-28	日本水産株式会社	高純度エイコサペンタエン酸またはそのエステルの製造方法
GB9123641D0 (en) *	1991-11-07	1992-01-02	Isf Spa	Process
ITMI20030573A1 (it) *	2003-03-24	2004-09-25	Nikem Research Srl	Composti ad azione nootropica, loro preparazione,
EP1925304A1 (en) *	2006-11-15	2008-05-28	Nikem Research S.R.L.	Pyrrolo[1,2-a]imidazoledione effective in the treatment of peripheral neurotoxicity induced by chemotherapeutic agents

2003
- 2003-03-24 IT IT000573A patent/ITMI20030573A1/it unknown
2004
- 2004-03-22 EP EP04741432A patent/EP1608655B8/en not_active Expired - Lifetime
- 2004-03-22 DE DE602004015089T patent/DE602004015089D1/de not_active Expired - Lifetime
- 2004-03-22 SI SI200430868T patent/SI1608655T1/sl unknown
- 2004-03-22 BR BRPI0408601-5A patent/BRPI0408601A/pt not_active Application Discontinuation
- 2004-03-22 WO PCT/EP2004/050339 patent/WO2004085438A2/en not_active Ceased
- 2004-03-22 NZ NZ543154A patent/NZ543154A/en unknown
- 2004-03-22 PL PL378939A patent/PL378939A1/pl unknown
- 2004-03-22 PT PT04741432T patent/PT1608655E/pt unknown
- 2004-03-22 ES ES04741432T patent/ES2309534T3/es not_active Expired - Lifetime
- 2004-03-22 HR HR20050833A patent/HRP20050833A2/hr not_active Application Discontinuation
- 2004-03-22 AT AT04741432T patent/ATE401327T1/de not_active IP Right Cessation
- 2004-03-22 EA EA200501501A patent/EA009558B1/ru not_active IP Right Cessation
- 2004-03-22 JP JP2006505479A patent/JP4920408B2/ja not_active Expired - Fee Related
- 2004-03-22 DK DK04741432T patent/DK1608655T3/da active
- 2004-03-22 PL PL04741432T patent/PL1608655T3/pl unknown
- 2004-03-22 RS YUP-2005/0725A patent/RS20050725A/sr unknown
- 2004-03-22 CA CA2520008A patent/CA2520008C/en not_active Expired - Fee Related
- 2004-03-22 CN CNB2004800055916A patent/CN100522963C/zh not_active Expired - Fee Related
- 2004-03-22 US US10/550,483 patent/US7544705B2/en not_active Expired - Fee Related
- 2004-03-22 AU AU2004224087A patent/AU2004224087B2/en not_active Ceased
2005
- 2005-10-21 ZA ZA200508578A patent/ZA200508578B/en unknown
- 2005-10-24 NO NO20054898A patent/NO20054898L/no not_active Application Discontinuation
2008
- 2008-10-08 CY CY20081101113T patent/CY1108401T1/el unknown
2009
- 2009-02-13 US US12/378,475 patent/US7732473B2/en not_active Expired - Fee Related
2010
- 2010-02-17 US US12/658,973 patent/US20100173945A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1608655B8 (en)	2008-10-15
EP1608655B1 (en)	2008-07-16
EA200501501A1 (ru)	2006-04-28
US7544705B2 (en)	2009-06-09
DK1608655T3 (da)	2008-11-03
ITMI20030573A1 (it)	2004-09-25
PT1608655E (pt)	2008-10-07
ZA200508578B (en)	2007-04-25
EP1608655A2 (en)	2005-12-28
NZ543154A (en)	2008-03-28
US20100173945A1 (en)	2010-07-08
CA2520008C (en)	2011-08-23
CN100522963C (zh)	2009-08-05
SI1608655T1 (sl)	2008-12-31
BRPI0408601A (pt)	2006-03-07
CA2520008A1 (en)	2004-10-07
CY1108401T1 (el)	2014-02-12
EA009558B1 (ru)	2008-02-28
AU2004224087A1 (en)	2004-10-07
WO2004085438A3 (en)	2004-11-25
US7732473B2 (en)	2010-06-08
US20070027137A1 (en)	2007-02-01
AU2004224087B2 (en)	2010-04-01
ES2309534T3 (es)	2008-12-16
RS20050725A (sr)	2007-11-15
WO2004085438A2 (en)	2004-10-07
CN1756757A (zh)	2006-04-05
JP4920408B2 (ja)	2012-04-18
DE602004015089D1 (de)	2008-08-28
JP2006523198A (ja)	2006-10-12
HK1083837A1 (en)	2006-07-14
HRP20050833A2 (en)	2006-02-28
NO20054898L (no)	2005-10-24
US20090163565A1 (en)	2009-06-25
ATE401327T1 (de)	2008-08-15
PL378939A1 (pl)	2006-06-12

Publication	Publication Date	Title
SI1608655T1 (sl)	2008-12-31	Derivati piroloimidazola, njihova priprava, farmacevtske sestave, ki jih vsebujejo, in njihova rabakot nutropiäśnih sredstev
EA200601212A1 (ru)	2006-10-27	Ингибиторы фосфодиэстеразы, получение и их терапевтическое применение
TNSN04113A1 (en)	2006-06-01	3-â-D-RIBOFURANOSYLTHIAZOLO[4,5-d]PYRIDIMINE NUCLEOSIDES AND USES THEREOF
MXPA05007462A (es)	2006-01-27	Derivados de pirrolopiridazina.
AU2004263179A8 (en)	2011-07-14	Heteroarylaminosulfonylphenyl derivatives for use as sodium or calcium channel blockers in the treatment of pain
ZA200706029B (en)	2008-12-31	Tricyclic &-opioid domulators
WO2005004802A3 (en)	2005-09-22	N-alkyl phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer's disease
MY140488A (en)	2009-12-31	Substituted oxazolidinones and their use in the field of blood coagulation
ATE442142T1 (de)	2009-09-15	Fredericamycin-derivate als arzneimittel zur tumorbehandlung
TW200716546A (en)	2007-05-01	Oxindole compounds and their uses as therapeutic agents
CA2473070A1 (en)	2003-07-31	Proline compounds as ns3-serine protease inhibitors for use in treatment of hepatites c virus infection
IL176110A0 (en)	2006-10-05	Azabicyclic heterocycles as cannabinoid receptor modulators
WO2005018545A3 (en)	2005-05-19	Macrocyclic beta-secretase inhibitors for the treatment of alzheimer's disease
TW200724543A (en)	2007-07-01	Heterocyclic compounds and their uses as therapeutic agents
WO2004110376A3 (en)	2005-02-24	Ccr-2 antagonists for treatment of neuropathic pain
UA86024C2 (ru)	2009-03-25	Трициклические дельта-опиоидные модуляторы
MXPA03008635A (es)	2004-02-23	Compuestos de dihidropirimidina ciano sustituidos y su uso para tratar enfermedades.
IL175819A0 (en)	2006-10-05	Tricyclic indole hydroxyethylamine derivatives and their use in the treatment of alzheimer's disease
TNSN06403A1 (en)	2008-02-22	3-B-D-RIBOFURANOSYLTHIAZOLO[4,5-d]PYRIDIMINE NUCLEOSIDES AND USES THEREOF
MX2008002234A (es)	2008-03-27	Inhibidores de sulfonamida n-biciclico puenteados de gamma secretasa.
MXPA06007007A (es)	2007-06-08	Derivados de prolina usados como ingredientes farmaceuticos activos para el tratamiento de tumores.
TW200621767A (en)	2006-07-01	Tricyclic δ-opioid modulators
WO2002076930A3 (en)	2003-01-16	Substituted diarylureas as stimulators for fas-mediated apoptosis
SG146685A1 (en)	2008-10-30	Dihydroporphine derivatives, processes for their preparation, and pharmaceutical compositions containing them
GB0522908D0 (en)	2005-12-21	Therapeutic agents