DK1608655T3 - Pyrroloimidazolderivater, fremstillingen deraf, farmaceutiske præparater indeholdende disse og anvendelse deraf som nootrope midler - Google Patents

Pyrroloimidazolderivater, fremstillingen deraf, farmaceutiske præparater indeholdende disse og anvendelse deraf som nootrope midler

Info

Publication number: DK1608655T3
Authority: DK; Denmark
Prior art keywords: preparation; pharmaceutical compositions; compositions containing; nootropic agents; action
Prior art date: 2003-03-24

Application number

DK04741432T

Other languages

Danish (da)

English (en)

Inventor

Carlo Farina

Stefania Gagliardi

Carlo Parini

Marisa Martinelli

Carla Ghelardini

Dipartimento Di O

Original Assignee

Brane Discovery S R L

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-24

Filing date

2004-03-22

Publication date

2008-11-03

2004-03-22 Application filed by Brane Discovery S R L filed Critical Brane Discovery S R L

2008-11-03 Application granted granted Critical

2008-11-03 Publication of DK1608655T3 publication Critical patent/DK1608655T3/da

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
239000002664 nootropic agent Substances 0.000 title 1
MHOZZUICEDXVGD-UHFFFAOYSA-N pyrrolo[2,3-d]imidazole Chemical class C1=NC2=CC=NC2=N1 MHOZZUICEDXVGD-UHFFFAOYSA-N 0.000 title 1
230000000202 analgesic effect Effects 0.000 abstract 1
230000003070 anti-hyperalgesia Effects 0.000 abstract 1
125000002619 bicyclic group Chemical group 0.000 abstract 1
230000002490 cerebral effect Effects 0.000 abstract 1
230000007278 cognition impairment Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000001777 nootropic effect Effects 0.000 abstract 1
230000004936 stimulating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK04741432T 2003-03-24 2004-03-22 Pyrroloimidazolderivater, fremstillingen deraf, farmaceutiske præparater indeholdende disse og anvendelse deraf som nootrope midler DK1608655T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT000573A ITMI20030573A1 (it)	2003-03-24	2003-03-24	Composti ad azione nootropica, loro preparazione,
PCT/EP2004/050339 WO2004085438A2 (en)	2003-03-24	2004-03-22	Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents

Publications (1)

Publication Number	Publication Date
DK1608655T3 true DK1608655T3 (da)	2008-11-03

Family

ID=33042696

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04741432T DK1608655T3 (da)	2003-03-24	2004-03-22	Pyrroloimidazolderivater, fremstillingen deraf, farmaceutiske præparater indeholdende disse og anvendelse deraf som nootrope midler

Country Status (23)

Country	Link
US (3)	US7544705B2 (pl)
EP (1)	EP1608655B8 (pl)
JP (1)	JP4920408B2 (pl)
CN (1)	CN100522963C (pl)
AT (1)	ATE401327T1 (pl)
AU (1)	AU2004224087B2 (pl)
BR (1)	BRPI0408601A (pl)
CA (1)	CA2520008C (pl)
CY (1)	CY1108401T1 (pl)
DE (1)	DE602004015089D1 (pl)
DK (1)	DK1608655T3 (pl)
EA (1)	EA009558B1 (pl)
ES (1)	ES2309534T3 (pl)
HR (1)	HRP20050833A2 (pl)
IT (1)	ITMI20030573A1 (pl)
NO (1)	NO20054898L (pl)
NZ (1)	NZ543154A (pl)
PL (2)	PL378939A1 (pl)
PT (1)	PT1608655E (pl)
RS (1)	RS20050725A (pl)
SI (1)	SI1608655T1 (pl)
WO (1)	WO2004085438A2 (pl)
ZA (1)	ZA200508578B (pl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ITMI20030573A1 (it) *	2003-03-24	2004-09-25	Nikem Research Srl	Composti ad azione nootropica, loro preparazione,
EP1925304A1 (en) *	2006-11-15	2008-05-28	Nikem Research S.R.L.	Pyrrolo[1,2-a]imidazoledione effective in the treatment of peripheral neurotoxicity induced by chemotherapeutic agents
ITMI20070770A1 (it) *	2007-04-16	2008-10-17	Brane Discovery S R L	Impiego di dimiracetam nel trattamento del dolore cronico
AU2012201853B2 (en) *	2007-04-16	2013-06-27	Neurotune Ag	Use of dimiracetam in the treatment of chronic pain
EP2346500B1 (en)	2008-10-16	2017-05-17	The Johns Hopkins University	Methods and compositions for improving cognitive function
US9125898B2 (en)	2008-11-14	2015-09-08	Neurotune Ag	Acetam derivatives for pain relief
EP2533645B1 (en) *	2010-02-09	2016-07-27	The Johns Hopkins University	Methods and compositions for improving cognitive function
PL2598504T3 (pl) *	2010-07-26	2014-10-31	Neurotune Ag	Sposób otrzymywania dimiracetamu
US10154988B2 (en)	2012-11-14	2018-12-18	The Johns Hopkins University	Methods and compositions for treating schizophrenia
US10806717B2 (en)	2013-03-15	2020-10-20	The Johns Hopkins University	Methods and compositions for improving cognitive function
CA2904767C (en)	2013-03-15	2022-06-21	Agenebio, Inc.	Methods and compositions for improving cognitive function
EA034167B8 (ru)	2015-05-22	2021-04-27	Эйджинбайо, Инк.	Фармацевтические композиции леветирацетама пролонгированного высвобождения
JOP20190251A1 (ar)	2017-05-31	2019-10-21	Metys Pharmaceuticals AG	تركيبات تآزرية تشتمل على (r)-ديميراسيتام (1) و(s)-ديميراسيتام (2) بنسبة غير راسيمية
EA202191486A1 (ru)	2018-12-04	2021-09-14	Метис Фармасьютиклз Аг	СИНЕРГЕТИЧЕСКИЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ R-2-(ЗАМЕЩЕННЫЙ СУЛЬФОНИЛ)ГЕКСАГИДРОПИРРОЛО[1,2-а]ПИРАЗИН-6(2H)ОНЫ И S-2-(ЗАМЕЩЕННЫЙ СУЛЬФОНИЛ)ГЕКСАГИДРОПИРРОЛО[1,2-а]ПИРАЗИН-6(2H)ОНЫ В НЕРАЦЕМИЧЕСКОМ СООТНОШЕНИИ
JP2022510363A (ja)	2018-12-04	2022-01-26	メティスファーマシューティカルズアクチェンゲゼルシャフト	（ｒ）－２－（２－オキソピロリジン－１－イル）ブタンアミドと（ｓ）－２－（２－オキソピロリジン－１－イル）ブタンアミドを非ラセミ比で含む相乗的組成物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4582838A (en)	1984-08-24	1986-04-15	Warner-Lambert Company	Derivatives of dihydro-1H-pyrrolo[1,2-c]imidazol-3,5-dione as cognition activators
IT1233860B (it) *	1988-02-08	1992-04-21	Isf Spa	Derivati del peridroazacicloalca (1,2-a) imidazolo ad attivita' nootropa
US5200406A (en) *	1988-02-08	1993-04-06	I.S.F. Societa Per Azioni	Pharmaceutically useful 2,5-dioxo-1H-octahydroimidazo[1,2-A]azepines
JP3400466B2 (ja) *	1991-10-28	2003-04-28	日本水産株式会社	高純度エイコサペンタエン酸またはそのエステルの製造方法
GB9123641D0 (en)	1991-11-07	1992-01-02	Isf Spa	Process
ITMI20030573A1 (it) *	2003-03-24	2004-09-25	Nikem Research Srl	Composti ad azione nootropica, loro preparazione,
EP1925304A1 (en) *	2006-11-15	2008-05-28	Nikem Research S.R.L.	Pyrrolo[1,2-a]imidazoledione effective in the treatment of peripheral neurotoxicity induced by chemotherapeutic agents

2003
- 2003-03-24 IT IT000573A patent/ITMI20030573A1/it unknown
2004
- 2004-03-22 PL PL378939A patent/PL378939A1/pl unknown
- 2004-03-22 SI SI200430868T patent/SI1608655T1/sl unknown
- 2004-03-22 PL PL04741432T patent/PL1608655T3/pl unknown
- 2004-03-22 NZ NZ543154A patent/NZ543154A/en unknown
- 2004-03-22 AU AU2004224087A patent/AU2004224087B2/en not_active Ceased
- 2004-03-22 PT PT04741432T patent/PT1608655E/pt unknown
- 2004-03-22 ES ES04741432T patent/ES2309534T3/es not_active Expired - Lifetime
- 2004-03-22 BR BRPI0408601-5A patent/BRPI0408601A/pt not_active Application Discontinuation
- 2004-03-22 RS YUP-2005/0725A patent/RS20050725A/sr unknown
- 2004-03-22 AT AT04741432T patent/ATE401327T1/de not_active IP Right Cessation
- 2004-03-22 JP JP2006505479A patent/JP4920408B2/ja not_active Expired - Fee Related
- 2004-03-22 EP EP04741432A patent/EP1608655B8/en not_active Expired - Lifetime
- 2004-03-22 DK DK04741432T patent/DK1608655T3/da active
- 2004-03-22 HR HR20050833A patent/HRP20050833A2/hr not_active Application Discontinuation
- 2004-03-22 US US10/550,483 patent/US7544705B2/en not_active Expired - Fee Related
- 2004-03-22 CN CNB2004800055916A patent/CN100522963C/zh not_active Expired - Fee Related
- 2004-03-22 DE DE602004015089T patent/DE602004015089D1/de not_active Expired - Lifetime
- 2004-03-22 CA CA2520008A patent/CA2520008C/en not_active Expired - Fee Related
- 2004-03-22 WO PCT/EP2004/050339 patent/WO2004085438A2/en not_active Ceased
- 2004-03-22 EA EA200501501A patent/EA009558B1/ru not_active IP Right Cessation
2005
- 2005-10-21 ZA ZA200508578A patent/ZA200508578B/en unknown
- 2005-10-24 NO NO20054898A patent/NO20054898L/no not_active Application Discontinuation
2008
- 2008-10-08 CY CY20081101113T patent/CY1108401T1/el unknown
2009
- 2009-02-13 US US12/378,475 patent/US7732473B2/en not_active Expired - Fee Related
2010
- 2010-02-17 US US12/658,973 patent/US20100173945A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CN1756757A (zh)	2006-04-05
WO2004085438A2 (en)	2004-10-07
PL378939A1 (pl)	2006-06-12
WO2004085438A3 (en)	2004-11-25
AU2004224087B2 (en)	2010-04-01
ES2309534T3 (es)	2008-12-16
NO20054898L (no)	2005-10-24
JP2006523198A (ja)	2006-10-12
EA200501501A1 (ru)	2006-04-28
DE602004015089D1 (de)	2008-08-28
US7732473B2 (en)	2010-06-08
JP4920408B2 (ja)	2012-04-18
NZ543154A (en)	2008-03-28
ZA200508578B (en)	2007-04-25
EP1608655A2 (en)	2005-12-28
US20070027137A1 (en)	2007-02-01
ITMI20030573A1 (it)	2004-09-25
US20090163565A1 (en)	2009-06-25
HK1083837A1 (en)	2006-07-14
EP1608655B1 (en)	2008-07-16
CA2520008A1 (en)	2004-10-07
RS20050725A (sr)	2007-11-15
US7544705B2 (en)	2009-06-09
US20100173945A1 (en)	2010-07-08
PT1608655E (pt)	2008-10-07
CN100522963C (zh)	2009-08-05
HRP20050833A2 (en)	2006-02-28
CY1108401T1 (el)	2014-02-12
AU2004224087A1 (en)	2004-10-07
BRPI0408601A (pt)	2006-03-07
CA2520008C (en)	2011-08-23
ATE401327T1 (de)	2008-08-15
EA009558B1 (ru)	2008-02-28
SI1608655T1 (sl)	2008-12-31
PL1608655T3 (pl)	2009-03-31
EP1608655B8 (en)	2008-10-15

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BRPI0410727A (pt)	2006-06-20	composto, composição farmacêutica, e, uso de um composto
TW200611702A (en)	2006-04-16	Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
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