PL1613328T3 - Zastosowanie pochodnych karbamezepiny do leczenia stanów pobudzenia u pacjentów z otępieniem - Google Patents

Zastosowanie pochodnych karbamezepiny do leczenia stanów pobudzenia u pacjentów z otępieniem

Info

Publication number: PL1613328T3
Authority: PL; Poland
Prior art keywords: agitation; treatment; dementia patients; compound; formula
Prior art date: 2003-04-01

Application number

PL04724599T

Other languages

English (en)

Inventor

Joshua Shua-Haim

Ferenc Martenyi

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-01

Filing date

2004-03-31

Publication date

2009-08-31

2004-03-31 Application filed by Novartis Ag filed Critical Novartis Ag

2009-08-31 Publication of PL1613328T3 publication Critical patent/PL1613328T3/pl

Links

206010001497 Agitation Diseases 0.000 title abstract 3
238000013019 agitation Methods 0.000 title abstract 3
206010012289 Dementia Diseases 0.000 title abstract 2
FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical class C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 2
RXPRRQLKFXBCSJ-GIVPXCGWSA-N vincamine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C[C@](O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-GIVPXCGWSA-N 0.000 abstract 2
QHZUABXEBRGBLP-LKWYKXIFSA-N (6aR,9R,10aR)-N-[(2R,4R,9aS,9bR)-4-benzyl-9b-hydroxy-3,5-dioxo-2-propan-2-yl-3a,4,7,8,9,9a-hexahydrofuro[3,2-g]indolizin-2-yl]-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide (6aR,9R,10aR)-N-[(2R,4R,9aS,9bR)-9b-hydroxy-3,5-dioxo-2,4-di(propan-2-yl)-3a,4,7,8,9,9a-hexahydrofuro[3,2-g]indolizin-2-yl]-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide (6aR,10aR)-N-[(2S,4S,9bS)-9b-hydroxy-4-(2-methylpropyl)-3,5-dioxo-2-propan-2-yl-3a,4,7,8,9,9a-hexahydrofuro[3,2-g]indolizin-2-yl]-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide methanesulfonic acid Chemical compound CS(O)(=O)=O.CS(O)(=O)=O.CS(O)(=O)=O.C1=CC([C@H]2C[C@H](CN(C)[C@@H]2C2)C(=O)N[C@]3(C(=O)C4[C@H](C(N5CCC[C@H]5[C@]4(O)O3)=O)C(C)C)C(C)C)=C3C2=CNC3=C1.C1=CC([C@H]2CC(CN(C)[C@@H]2C2)C(=O)N[C@@]3(C(=O)C4[C@@H](C(N5CCCC5[C@@]4(O)O3)=O)CC(C)C)C(C)C)=C3C2=CNC3=C1.C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](C(C21)=O)(NC(=O)[C@H]1CN(C)[C@H]2[C@@H](C=3C=CC=C4NC=C(C=34)C2)C1)C(C)C)C1=CC=CC=C1 QHZUABXEBRGBLP-LKWYKXIFSA-N 0.000 abstract 1
208000024827 Alzheimer disease Diseases 0.000 abstract 1
229940127291 Calcium channel antagonist Drugs 0.000 abstract 1
YSEXMKHXIOCEJA-FVFQAYNVSA-N Nicergoline Chemical compound C([C@@H]1C[C@]2([C@H](N(C)C1)CC=1C3=C2C=CC=C3N(C)C=1)OC)OC(=O)C1=CN=CC(Br)=C1 YSEXMKHXIOCEJA-FVFQAYNVSA-N 0.000 abstract 1
DDNCQMVWWZOMLN-IRLDBZIGSA-N Vinpocetine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C=C(C(=O)OCC)N5C2=C1 DDNCQMVWWZOMLN-IRLDBZIGSA-N 0.000 abstract 1
230000003542 behavioural effect Effects 0.000 abstract 1
-1 calcium antagonists Substances 0.000 abstract 1
239000000544 cholinesterase inhibitor Substances 0.000 abstract 1
RXPRRQLKFXBCSJ-UHFFFAOYSA-N dl-Vincamin Natural products C1=CC=C2C(CCN3CCC4)=C5C3C4(CC)CC(O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-UHFFFAOYSA-N 0.000 abstract 1
229960003642 nicergoline Drugs 0.000 abstract 1
230000001777 nootropic effect Effects 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000419 plant extract Substances 0.000 abstract 1
SIXLXDIJGIWWFU-UHFFFAOYSA-N pyritinol Chemical compound OCC1=C(O)C(C)=NC=C1CSSCC1=CN=C(C)C(O)=C1CO SIXLXDIJGIWWFU-UHFFFAOYSA-N 0.000 abstract 1
229960004986 pyritinol Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229960002726 vincamine Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Psychology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Hydrogenated Pyridines (AREA)
Medicines Containing Plant Substances (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PL04724599T 2003-04-01 2004-03-31 Zastosowanie pochodnych karbamezepiny do leczenia stanów pobudzenia u pacjentów z otępieniem PL1613328T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US45933803P	2003-04-01	2003-04-01
EP04724599A EP1613328B8 (en)	2003-04-01	2004-03-31	Use of carbamazepine derivatives for the treatment of agitation in dementia patients
PCT/EP2004/003418 WO2004087166A1 (en)	2003-04-01	2004-03-31	Use of carbamazepine derivatives for the treatment of agitation in dementia patients

Publications (1)

Publication Number	Publication Date
PL1613328T3 true PL1613328T3 (pl)	2009-08-31

Family

ID=33131880

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL04724599T PL1613328T3 (pl)	2003-04-01	2004-03-31	Zastosowanie pochodnych karbamezepiny do leczenia stanów pobudzenia u pacjentów z otępieniem

Country Status (24)

Country	Link
US (2)	US20070066593A1 (pl)
EP (1)	EP1613328B8 (pl)
JP (1)	JP2006522050A (pl)
KR (1)	KR20050121236A (pl)
CN (1)	CN1767833A (pl)
AT (1)	ATE425756T1 (pl)
AU (1)	AU2004226805B2 (pl)
BR (1)	BRPI0408956A (pl)
CA (1)	CA2521371A1 (pl)
DE (1)	DE602004020060D1 (pl)
ES (1)	ES2323270T3 (pl)
HR (1)	HRP20050872A2 (pl)
IS (1)	IS8096A (pl)
MA (1)	MA27638A1 (pl)
MX (1)	MXPA05010608A (pl)
NO (1)	NO20054994L (pl)
NZ (1)	NZ542554A (pl)
PL (1)	PL1613328T3 (pl)
PT (1)	PT1613328E (pl)
RU (1)	RU2351338C2 (pl)
TN (1)	TNSN05247A1 (pl)
TW (1)	TW200501962A (pl)
WO (1)	WO2004087166A1 (pl)
ZA (1)	ZA200507439B (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200501962A (en) *	2003-04-01	2005-01-16	Novartis Ag	Use of carbamazepine derivatives for the treatment of agitation in dementia patients
GB0424563D0 (en) *	2004-11-05	2004-12-08	Novartis Ag	Organic compounds
US20060252745A1 (en)	2005-05-06	2006-11-09	Almeida Jose L D	Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use
GB0517740D0 (en) *	2005-08-31	2005-10-12	Novartis Ag	Organic compounds
GB0700773D0 (en)	2007-01-15	2007-02-21	Portela & Ca Sa	Drug therapies
US20110251172A1 (en) *	2008-08-13	2011-10-13	Rivkin Alexey A	Purine derivatives for treatment of alzheimer's disease
CN102183659B (zh) *	2011-03-02	2014-07-02	广州金域医学检验中心有限公司	一种卡马西平检测方法
CN102180965B (zh) *	2011-03-02	2014-01-01	广州金域医学检验中心有限公司	卡马西平免疫原、抗卡马西平特异性抗体、检测试剂及检测试剂盒
RU2504367C1 (ru) *	2012-06-05	2014-01-20	Государственное бюджетное образовательное учреждение высшего профессионального образования "Амурская государственная медицинская академия" Минздравсоцразвития Российской Федерации	Способ коррекции психического состояния пациентов и антиоксидантного статуса при органическом расстройстве личности

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH500196A (de) *	1969-03-10	1970-12-15	Ciba Geigy Ag	Verfahren zur Herstellung von neuen Azepinderivaten
US3637661A (en) *	1970-03-04	1972-01-25	Ciba Geigy Corp	10-hydroxy-10 11-dihydro-dibenzazepine derivative
US5827819A (en) *	1990-11-01	1998-10-27	Oregon Health Sciences University	Covalent polar lipid conjugates with neurologically active compounds for targeting
JP3057471B2 (ja) *	1993-06-07	2000-06-26	武田薬品工業株式会社	アンジオテンシンｉｉ介在性諸疾患の予防または治療剤
PT101732B (pt) *	1995-06-30	1997-12-31	Portela & Ca Sa	Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso
US5736647A (en) *	1995-08-07	1998-04-07	Oval Corporation	Vortex flow meter detector and vortex flow meter
IL142588A0 (en) *	1998-10-16	2002-03-10	Janssen Pharmaceutica Nv	Therapy for improving cognition
EP1246632A4 (en) *	1999-12-30	2004-08-18	Proteotech Inc	CATECHINE AND GREEN TEA EXTRACT FOR TREATING AMYLOIDOSES IN GENERAL OR. AT ALZHEIMER
GB0113663D0 (en) *	2001-06-05	2001-07-25	Novartis Ag	Use of organic compounds
TW200501962A (en) *	2003-04-01	2005-01-16	Novartis Ag	Use of carbamazepine derivatives for the treatment of agitation in dementia patients

2004
- 2004-03-29 TW TW093108532A patent/TW200501962A/zh unknown
- 2004-03-31 PL PL04724599T patent/PL1613328T3/pl unknown
- 2004-03-31 US US10/550,380 patent/US20070066593A1/en not_active Abandoned
- 2004-03-31 CN CNA2004800084961A patent/CN1767833A/zh active Pending
- 2004-03-31 RU RU2005133478/15A patent/RU2351338C2/ru not_active IP Right Cessation
- 2004-03-31 EP EP04724599A patent/EP1613328B8/en not_active Expired - Lifetime
- 2004-03-31 MX MXPA05010608A patent/MXPA05010608A/es active IP Right Grant
- 2004-03-31 WO PCT/EP2004/003418 patent/WO2004087166A1/en not_active Ceased
- 2004-03-31 AU AU2004226805A patent/AU2004226805B2/en not_active Ceased
- 2004-03-31 NZ NZ542554A patent/NZ542554A/en unknown
- 2004-03-31 KR KR1020057018720A patent/KR20050121236A/ko not_active Ceased
- 2004-03-31 BR BRPI0408956-1A patent/BRPI0408956A/pt not_active IP Right Cessation
- 2004-03-31 ES ES04724599T patent/ES2323270T3/es not_active Expired - Lifetime
- 2004-03-31 DE DE602004020060T patent/DE602004020060D1/de not_active Expired - Fee Related
- 2004-03-31 JP JP2006504935A patent/JP2006522050A/ja active Pending
- 2004-03-31 PT PT04724599T patent/PT1613328E/pt unknown
- 2004-03-31 AT AT04724599T patent/ATE425756T1/de not_active IP Right Cessation
- 2004-03-31 HR HR20050872A patent/HRP20050872A2/xx not_active Application Discontinuation
- 2004-03-31 CA CA002521371A patent/CA2521371A1/en not_active Abandoned
2005
- 2005-09-15 ZA ZA200507439A patent/ZA200507439B/en unknown
- 2005-09-30 MA MA28522A patent/MA27638A1/fr unknown
- 2005-09-30 TN TNP2005000247A patent/TNSN05247A1/en unknown
- 2005-10-26 NO NO20054994A patent/NO20054994L/no not_active Application Discontinuation
- 2005-10-27 IS IS8096A patent/IS8096A/is unknown
2009
- 2009-04-07 US US12/419,651 patent/US20090192142A1/en not_active Abandoned

Also Published As

Publication number	Publication date
NO20054994L (no)	2005-10-26
ATE425756T1 (de)	2009-04-15
NZ542554A (en)	2008-10-31
EP1613328B1 (en)	2009-03-18
IS8096A (is)	2005-10-27
EP1613328A1 (en)	2006-01-11
US20090192142A1 (en)	2009-07-30
EP1613328B8 (en)	2009-06-10
CN1767833A (zh)	2006-05-03
WO2004087166A1 (en)	2004-10-14
PT1613328E (pt)	2009-06-15
ZA200507439B (en)	2007-06-27
TW200501962A (en)	2005-01-16
KR20050121236A (ko)	2005-12-26
CA2521371A1 (en)	2004-10-14
AU2004226805B2 (en)	2008-03-06
US20070066593A1 (en)	2007-03-22
BRPI0408956A (pt)	2006-04-04
DE602004020060D1 (de)	2009-04-30
TNSN05247A1 (en)	2007-06-11
RU2351338C2 (ru)	2009-04-10
RU2005133478A (ru)	2007-06-10
MA27638A1 (fr)	2005-11-01
JP2006522050A (ja)	2006-09-28
HK1090543A1 (en)	2006-12-29
ES2323270T3 (es)	2009-07-10
HRP20050872A2 (en)	2006-12-31
MXPA05010608A (es)	2005-11-23
AU2004226805A1 (en)	2004-10-14

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WO2007143523A8 (en)	2008-01-31	Fused, tricyclic sulfonamide inhibitors of gamma secretase
TR200102782T2 (tr)	2002-04-22	Bisiklik heterosikleler, bu bileşikleri ihtiva eden farmasötik kompozisyonlar
WO2002085909A8 (en)	2004-04-29	9-deazaguanine derivatives as inhibitors of gsk-3
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NO20050851L (no)	2005-03-29	Kaspase-inhibitorer og anvendelser derav
SG147450A1 (en)	2008-11-28	Sustained release pharmaceutical compositions comprising aplindore and derivatives thereof
DE60312736D1 (de)	2007-05-03	1,2,4-triaminobenzolderivate zur behandlung von erkrankungen des zentralnervensystems
PL1682528T3 (pl)	2008-01-31	Pochodne benzo[b][1,4]dioksepiny
UA84896C2 (ru)	2008-12-10	Производные гидронопола как агонисты человеческих рецепторов orl1
MX2008001606A (es)	2008-04-14	Piperazinas substituidas como antagonistas de receptor de glutamato metabotropico.
NO20032261L (no)	2003-07-09	Medisinske preparater
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BR0210392A (pt)	2004-10-13	Composto, métodos de tratar um paciente que tenha ou de prevenir um paciente de contrair uma doença ou condição e de preparar um composto, e, uso de um composto
WO2006038006A3 (en)	2006-05-18	5-sulfonyl-1-piperidinyl substituted indole derivatives as 5-ht6 receptor antagonists for the treatment of cns disorders
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EP1613328B8 (en)	2009-06-10	Use of carbamazepine derivatives for the treatment of agitation in dementia patients
ZA961069B (en)	1996-08-12	Heterocyclic derivatives
EA200601687A1 (ru)	2007-04-27	Тетрагидроизохинолиновые и тетрагидробензазепиновые производные (варианты), фармацевтическая композиция и фармацевтический набор, лекарственное и эталонное средство для тест-систем на их основе, способ лечения и профилактики заболевания, при котором благоприятна понижающая регуляция или ингибирование экспрессии или функции рецептора igf-1
SE0002729D0 (sv)	2000-07-20	Novel compound form
DE69917005D1 (de)	2004-06-09	Substituierte pyrrolobenzimidazolderivate zur entzündungshemmung
TW200519102A (en)	2005-06-16	Hydronopol substituted benzimidazolone and quinazolinone derivatives as agonists on human ORL1 receptors