BRPI0408956A - emprego de derivativos de carbamazepina para o tratamento de agitação em pacientes com demência - Google Patents
emprego de derivativos de carbamazepina para o tratamento de agitação em pacientes com demênciaInfo
- Publication number
- BRPI0408956A BRPI0408956A BRPI0408956-1A BRPI0408956A BRPI0408956A BR PI0408956 A BRPI0408956 A BR PI0408956A BR PI0408956 A BRPI0408956 A BR PI0408956A BR PI0408956 A BRPI0408956 A BR PI0408956A
- Authority
- BR
- Brazil
- Prior art keywords
- agitation
- treatment
- compound
- dementia
- patients
- Prior art date
Links
- 206010001497 Agitation Diseases 0.000 title abstract 3
- 238000013019 agitation Methods 0.000 title abstract 3
- 206010012289 Dementia Diseases 0.000 title abstract 2
- FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical class C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 2
- RXPRRQLKFXBCSJ-GIVPXCGWSA-N vincamine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C[C@](O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-GIVPXCGWSA-N 0.000 abstract 2
- QHZUABXEBRGBLP-LKWYKXIFSA-N (6aR,9R,10aR)-N-[(2R,4R,9aS,9bR)-4-benzyl-9b-hydroxy-3,5-dioxo-2-propan-2-yl-3a,4,7,8,9,9a-hexahydrofuro[3,2-g]indolizin-2-yl]-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide (6aR,9R,10aR)-N-[(2R,4R,9aS,9bR)-9b-hydroxy-3,5-dioxo-2,4-di(propan-2-yl)-3a,4,7,8,9,9a-hexahydrofuro[3,2-g]indolizin-2-yl]-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide (6aR,10aR)-N-[(2S,4S,9bS)-9b-hydroxy-4-(2-methylpropyl)-3,5-dioxo-2-propan-2-yl-3a,4,7,8,9,9a-hexahydrofuro[3,2-g]indolizin-2-yl]-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide methanesulfonic acid Chemical compound CS(O)(=O)=O.CS(O)(=O)=O.CS(O)(=O)=O.C1=CC([C@H]2C[C@H](CN(C)[C@@H]2C2)C(=O)N[C@]3(C(=O)C4[C@H](C(N5CCC[C@H]5[C@]4(O)O3)=O)C(C)C)C(C)C)=C3C2=CNC3=C1.C1=CC([C@H]2CC(CN(C)[C@@H]2C2)C(=O)N[C@@]3(C(=O)C4[C@@H](C(N5CCCC5[C@@]4(O)O3)=O)CC(C)C)C(C)C)=C3C2=CNC3=C1.C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](C(C21)=O)(NC(=O)[C@H]1CN(C)[C@H]2[C@@H](C=3C=CC=C4NC=C(C=34)C2)C1)C(C)C)C1=CC=CC=C1 QHZUABXEBRGBLP-LKWYKXIFSA-N 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 229940127291 Calcium channel antagonist Drugs 0.000 abstract 1
- YSEXMKHXIOCEJA-FVFQAYNVSA-N Nicergoline Chemical compound C([C@@H]1C[C@]2([C@H](N(C)C1)CC=1C3=C2C=CC=C3N(C)C=1)OC)OC(=O)C1=CN=CC(Br)=C1 YSEXMKHXIOCEJA-FVFQAYNVSA-N 0.000 abstract 1
- DDNCQMVWWZOMLN-IRLDBZIGSA-N Vinpocetine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C=C(C(=O)OCC)N5C2=C1 DDNCQMVWWZOMLN-IRLDBZIGSA-N 0.000 abstract 1
- 230000003542 behavioural effect Effects 0.000 abstract 1
- -1 calcium antagonists Substances 0.000 abstract 1
- 239000000544 cholinesterase inhibitor Substances 0.000 abstract 1
- RXPRRQLKFXBCSJ-UHFFFAOYSA-N dl-Vincamin Natural products C1=CC=C2C(CCN3CCC4)=C5C3C4(CC)CC(O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-UHFFFAOYSA-N 0.000 abstract 1
- 229960003642 nicergoline Drugs 0.000 abstract 1
- 230000001777 nootropic effect Effects 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000419 plant extract Substances 0.000 abstract 1
- SIXLXDIJGIWWFU-UHFFFAOYSA-N pyritinol Chemical compound OCC1=C(O)C(C)=NC=C1CSSCC1=CN=C(C)C(O)=C1CO SIXLXDIJGIWWFU-UHFFFAOYSA-N 0.000 abstract 1
- 229960004986 pyritinol Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229960002726 vincamine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"EMPREGO DE DERIVATIVOS DE CARBAMAZEPINA PARA O TRATAMENTO DE AGITAçãO EM PACIENTES COM DEMêNCIA". A presente invenção refere-se ao emprego de um composto de fórmula I em que (a) R~ 1~, e R~ 2~ juntos formam um grupo de óxi ou (b) R, é hidrogênio e R~ 2~ é hidróxi ou acetóxi, ou um sal farmaceuticamente aceitável do mesmo, para a fabricação de uma composição farmacêutica para o tratamento de agitação, em particular, agitação comportamental, especialmente em pacientes com demência; um método para o tratamento de agitação; composições farmacêuticas que compreendem um composto de fórmula I; uma combinação que compreende (a) um composto de fórmula I e (b) pelo menos um composto selecionado a partir do grupo consistindo em extratos de planta nootrópicos, antagonistas de cálcio, inibidores de colinesterase, dihidroergotoxina, nicergolina, piracetame, derivados de purina, piritinol, vincamina e vimpocetina; e um pacote comercial que inclui tal combinação.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45933803P | 2003-04-01 | 2003-04-01 | |
| PCT/EP2004/003418 WO2004087166A1 (en) | 2003-04-01 | 2004-03-31 | Use of carbamazepine derivatives for the treatment of agitation in dementia patients |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0408956A true BRPI0408956A (pt) | 2006-04-04 |
Family
ID=33131880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0408956-1A BRPI0408956A (pt) | 2003-04-01 | 2004-03-31 | emprego de derivativos de carbamazepina para o tratamento de agitação em pacientes com demência |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US20070066593A1 (pt) |
| EP (1) | EP1613328B8 (pt) |
| JP (1) | JP2006522050A (pt) |
| KR (1) | KR20050121236A (pt) |
| CN (1) | CN1767833A (pt) |
| AT (1) | ATE425756T1 (pt) |
| AU (1) | AU2004226805B2 (pt) |
| BR (1) | BRPI0408956A (pt) |
| CA (1) | CA2521371A1 (pt) |
| DE (1) | DE602004020060D1 (pt) |
| ES (1) | ES2323270T3 (pt) |
| HR (1) | HRP20050872A2 (pt) |
| IS (1) | IS8096A (pt) |
| MA (1) | MA27638A1 (pt) |
| MX (1) | MXPA05010608A (pt) |
| NO (1) | NO20054994L (pt) |
| NZ (1) | NZ542554A (pt) |
| PL (1) | PL1613328T3 (pt) |
| PT (1) | PT1613328E (pt) |
| RU (1) | RU2351338C2 (pt) |
| TN (1) | TNSN05247A1 (pt) |
| TW (1) | TW200501962A (pt) |
| WO (1) | WO2004087166A1 (pt) |
| ZA (1) | ZA200507439B (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200501962A (en) * | 2003-04-01 | 2005-01-16 | Novartis Ag | Use of carbamazepine derivatives for the treatment of agitation in dementia patients |
| GB0424563D0 (en) * | 2004-11-05 | 2004-12-08 | Novartis Ag | Organic compounds |
| US20060252745A1 (en) | 2005-05-06 | 2006-11-09 | Almeida Jose L D | Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use |
| GB0517740D0 (en) * | 2005-08-31 | 2005-10-12 | Novartis Ag | Organic compounds |
| GB0700773D0 (en) | 2007-01-15 | 2007-02-21 | Portela & Ca Sa | Drug therapies |
| WO2010019392A1 (en) * | 2008-08-13 | 2010-02-18 | Merck Sharp & Dohme Corp. | Purine derivatives for treatment of alzheimer's disease |
| CN102180965B (zh) * | 2011-03-02 | 2014-01-01 | 广州金域医学检验中心有限公司 | 卡马西平免疫原、抗卡马西平特异性抗体、检测试剂及检测试剂盒 |
| CN102183659B (zh) * | 2011-03-02 | 2014-07-02 | 广州金域医学检验中心有限公司 | 一种卡马西平检测方法 |
| RU2504367C1 (ru) * | 2012-06-05 | 2014-01-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Амурская государственная медицинская академия" Минздравсоцразвития Российской Федерации | Способ коррекции психического состояния пациентов и антиоксидантного статуса при органическом расстройстве личности |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH500196A (de) * | 1969-03-10 | 1970-12-15 | Ciba Geigy Ag | Verfahren zur Herstellung von neuen Azepinderivaten |
| US3637661A (en) * | 1970-03-04 | 1972-01-25 | Ciba Geigy Corp | 10-hydroxy-10 11-dihydro-dibenzazepine derivative |
| US5827819A (en) * | 1990-11-01 | 1998-10-27 | Oregon Health Sciences University | Covalent polar lipid conjugates with neurologically active compounds for targeting |
| JP3057471B2 (ja) * | 1993-06-07 | 2000-06-26 | 武田薬品工業株式会社 | アンジオテンシンｉｉ介在性諸疾患の予防または治療剤 |
| PT101732B (pt) * | 1995-06-30 | 1997-12-31 | Portela & Ca Sa | Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso |
| US5736647A (en) * | 1995-08-07 | 1998-04-07 | Oval Corporation | Vortex flow meter detector and vortex flow meter |
| AU6472799A (en) * | 1998-10-16 | 2000-05-08 | Janssen Pharmaceutica N.V. | Therapy for improving cognition |
| EP1246632A4 (en) * | 1999-12-30 | 2004-08-18 | Proteotech Inc | CATECHINE AND GREEN TEA EXTRACT FOR TREATING AMYLOIDOSES IN GENERAL OR. AT ALZHEIMER |
| GB0113663D0 (en) * | 2001-06-05 | 2001-07-25 | Novartis Ag | Use of organic compounds |
| TW200501962A (en) * | 2003-04-01 | 2005-01-16 | Novartis Ag | Use of carbamazepine derivatives for the treatment of agitation in dementia patients |
-
2004
- 2004-03-29 TW TW093108532A patent/TW200501962A/zh unknown
- 2004-03-31 ES ES04724599T patent/ES2323270T3/es not_active Expired - Lifetime
- 2004-03-31 KR KR1020057018720A patent/KR20050121236A/ko not_active Ceased
- 2004-03-31 BR BRPI0408956-1A patent/BRPI0408956A/pt not_active IP Right Cessation
- 2004-03-31 AT AT04724599T patent/ATE425756T1/de not_active IP Right Cessation
- 2004-03-31 CN CNA2004800084961A patent/CN1767833A/zh active Pending
- 2004-03-31 PT PT04724599T patent/PT1613328E/pt unknown
- 2004-03-31 RU RU2005133478/15A patent/RU2351338C2/ru not_active IP Right Cessation
- 2004-03-31 EP EP04724599A patent/EP1613328B8/en not_active Expired - Lifetime
- 2004-03-31 JP JP2006504935A patent/JP2006522050A/ja active Pending
- 2004-03-31 AU AU2004226805A patent/AU2004226805B2/en not_active Ceased
- 2004-03-31 PL PL04724599T patent/PL1613328T3/pl unknown
- 2004-03-31 MX MXPA05010608A patent/MXPA05010608A/es active IP Right Grant
- 2004-03-31 DE DE602004020060T patent/DE602004020060D1/de not_active Expired - Fee Related
- 2004-03-31 HR HR20050872A patent/HRP20050872A2/xx not_active Application Discontinuation
- 2004-03-31 US US10/550,380 patent/US20070066593A1/en not_active Abandoned
- 2004-03-31 WO PCT/EP2004/003418 patent/WO2004087166A1/en not_active Ceased
- 2004-03-31 NZ NZ542554A patent/NZ542554A/en unknown
- 2004-03-31 CA CA002521371A patent/CA2521371A1/en not_active Abandoned
-
2005
- 2005-09-15 ZA ZA200507439A patent/ZA200507439B/en unknown
- 2005-09-30 MA MA28522A patent/MA27638A1/fr unknown
- 2005-09-30 TN TNP2005000247A patent/TNSN05247A1/en unknown
- 2005-10-26 NO NO20054994A patent/NO20054994L/no not_active Application Discontinuation
- 2005-10-27 IS IS8096A patent/IS8096A/is unknown
-
2009
- 2009-04-07 US US12/419,651 patent/US20090192142A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20070066593A1 (en) | 2007-03-22 |
| CA2521371A1 (en) | 2004-10-14 |
| EP1613328B1 (en) | 2009-03-18 |
| IS8096A (is) | 2005-10-27 |
| JP2006522050A (ja) | 2006-09-28 |
| MXPA05010608A (es) | 2005-11-23 |
| TNSN05247A1 (en) | 2007-06-11 |
| ZA200507439B (en) | 2007-06-27 |
| TW200501962A (en) | 2005-01-16 |
| AU2004226805A1 (en) | 2004-10-14 |
| NZ542554A (en) | 2008-10-31 |
| US20090192142A1 (en) | 2009-07-30 |
| ES2323270T3 (es) | 2009-07-10 |
| ATE425756T1 (de) | 2009-04-15 |
| HK1090543A1 (en) | 2006-12-29 |
| RU2351338C2 (ru) | 2009-04-10 |
| DE602004020060D1 (de) | 2009-04-30 |
| PT1613328E (pt) | 2009-06-15 |
| CN1767833A (zh) | 2006-05-03 |
| PL1613328T3 (pl) | 2009-08-31 |
| HRP20050872A2 (en) | 2006-12-31 |
| EP1613328B8 (en) | 2009-06-10 |
| NO20054994L (no) | 2005-10-26 |
| MA27638A1 (fr) | 2005-11-01 |
| RU2005133478A (ru) | 2007-06-10 |
| EP1613328A1 (en) | 2006-01-11 |
| KR20050121236A (ko) | 2005-12-26 |
| WO2004087166A1 (en) | 2004-10-14 |
| AU2004226805B2 (en) | 2008-03-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 7A E 8A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012. |