PL1711465T3 - Związki hydroizoindolinowe jako antagoniści receptora tachykininy - Google Patents

Związki hydroizoindolinowe jako antagoniści receptora tachykininy

Info

Publication number: PL1711465T3
Authority: PL; Poland
Prior art keywords: receptor antagonists; tachykinin receptor; hydroisoindoline; hydroisoindoline tachykinin; antagonists
Prior art date: 2004-01-27

Application number

PL05726323T

Other languages

English (en)

Inventor

Jaime Lynn Bunda

Robert J Devita

Jinlong Jiang

Sander G Mills

Original Assignee

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-01-27

Filing date

2005-01-26

Publication date

2008-05-30

2005-01-26 Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme

2008-05-30 Publication of PL1711465T3 publication Critical patent/PL1711465T3/pl

Links

239000002462 tachykinin receptor antagonist Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PL05726323T 2004-01-27 2005-01-26 Związki hydroizoindolinowe jako antagoniści receptora tachykininy PL1711465T3 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US53991304P	2004-01-27	2004-01-27
US56122704P	2004-04-09	2004-04-09
PCT/US2005/002149 WO2005073191A1 (en)	2004-01-27	2005-01-26	Hydroisoindoline tachykinin receptor antagonists
EP05726323A EP1711465B1 (en)	2004-01-27	2005-01-26	Hydroisoindoline tachykinin receptor antagonists

Publications (1)

Publication Number	Publication Date
PL1711465T3 true PL1711465T3 (pl)	2008-05-30

Family

ID=34830494

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL05726323T PL1711465T3 (pl)	2004-01-27	2005-01-26	Związki hydroizoindolinowe jako antagoniści receptora tachykininy

Country Status (30)

Country	Link
US (3)	US7645790B2 (pl)
EP (1)	EP1711465B1 (pl)
JP (1)	JP3987100B2 (pl)
KR (1)	KR20060127927A (pl)
AR (1)	AR047439A1 (pl)
AT (1)	ATE382034T1 (pl)
AU (1)	AU2005207934B2 (pl)
BR (1)	BRPI0507050A (pl)
CA (1)	CA2554550C (pl)
CO (1)	CO5700771A2 (pl)
CR (1)	CR8522A (pl)
CY (1)	CY1107167T1 (pl)
DE (1)	DE602005004011T2 (pl)
DK (1)	DK1711465T3 (pl)
EA (1)	EA010598B1 (pl)
EC (1)	ECSP066716A (pl)
ES (1)	ES2297687T3 (pl)
GE (1)	GEP20094691B (pl)
HR (1)	HRP20080100T3 (pl)
IL (1)	IL176879A0 (pl)
MA (1)	MA28359A1 (pl)
NI (1)	NI200600164A (pl)
NO (1)	NO339041B1 (pl)
NZ (1)	NZ548415A (pl)
PE (1)	PE20050687A1 (pl)
PL (1)	PL1711465T3 (pl)
PT (1)	PT1711465E (pl)
TW (1)	TWI341198B (pl)
UA (1)	UA84192C2 (pl)
WO (1)	WO2005073191A1 (pl)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR047439A1 (es)	2004-01-27	2006-01-18	Merck & Co Inc	Antagonistas del receptor hidroisoindolina taquiquinina
US7652058B2 (en)	2004-12-14	2010-01-26	Merck Sharp & Dohme Corp.	Octahydropyrano[3,4-C]pyrrole tachykinin receptor antagonists
CA2611550A1 (en) *	2005-06-27	2007-01-04	Merck & Co., Inc.	Hydroisoindoline tachykinin receptor antagonists
WO2007008564A1 (en)	2005-07-11	2007-01-18	Merck & Co., Inc.	Process for making hydroisoindoline tachykinin receptor antagonists
ATE511842T1 (de)	2005-10-04	2011-06-15	Merck Sharp & Dohme	Kombinationstherapie zur behandlung von erhöhter miktionsfrequenz, akutem harndrang und inkontinenz
WO2007075528A2 (en) *	2005-12-22	2007-07-05	Merck & Co., Inc.	Octahydropyrano[3,4-c]pyrrole tachykinin receptor antagonists
EP1978965A2 (en) *	2006-01-24	2008-10-15	Merck & Co., Inc.	Hexahydro-3h-pyrrolizin-3-ones useful as tachykinin receptor antagonists
US20100209496A1 (en) *	2006-09-06	2010-08-19	Eleni Dokou	Liquid and semi-solid pharmaceutical formulations for oral administration of a substituted amide
US20090270477A1 (en) *	2006-11-02	2009-10-29	Kuethe Jeffrey T	Polymorphs of a hydroisoindoline tachykinin receptor antagonist
AU2008233232A1 (en) *	2007-03-29	2008-10-09	Merck Sharp & Dohme Corp.	Combination therapy for the treatment-of lower urinary tract symptoms
US8124633B2 (en)	2007-04-10	2012-02-28	Merck Sharp & Dohme Corp.	Hydroxymethyl ether hydroisoindoline tachykinin receptor antagonists
WO2011137054A1 (en)	2010-04-30	2011-11-03	Merck Sharp & Dohme Corp.	Novel beta 3 adrenergic receptor agonists
US8627816B2 (en)	2011-02-28	2014-01-14	Intelliject, Inc.	Medicament delivery device for administration of opioid antagonists including formulations for naloxone
WO2013004766A1 (en)	2011-07-04	2013-01-10	Ferrari Giulio	Nk-1 receptor antagonists for treating corneal neovascularisation
CA2915474A1 (en) *	2013-06-24	2014-12-31	Tigercat Pharma, Inc.	Use of nk-1 receptor antagonist serlopitant in pruritus
US9198898B2 (en)	2013-06-24	2015-12-01	Tigercat Pharma, Inc.	Use of NK-1 receptor antagonists in pruritus
US8906951B1 (en)	2013-06-24	2014-12-09	Tigercat Pharma, Inc.	Use of NK-1 receptor antagonists in pruritus
IL312486B2 (en)	2017-04-10	2025-05-01	Chase Therapeutics Corp	NK1 antagonist combination and method for treating synucleinopathies
CA3104811C (en)	2017-06-30	2024-05-28	Chase Therapeutics Corporation	Composition comprising pramipexole and nk1-antagonists for treating depression
US20210015834A1 (en)	2018-02-26	2021-01-21	Ospedale San Raffaele S.R.L.	Nk-1 antagonists for use in the treatment of ocular pain
WO2021180885A1 (en)	2020-03-11	2021-09-16	Ospedale San Raffaele S.R.L.	Treatment of stem cell deficiency
CA3173697A1 (en)	2020-04-03	2021-10-07	Mike TROWER	An nk-1 receptor antagonist for treating a disease selecting from sepsis, septic shock, acute respiratory distress syndrome (ards) or multiple organ dysfunction syndrome (mods)
CA3177477A1 (en)	2020-06-02	2021-12-09	Nerre Therapeutics Limited	Neurokinin (nk)-1 receptor antagonists for use in the treatment of pulmonary fibrosis conditions promoted by mechanical injury to the lungs

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5650142A (en) *	1995-09-27	1997-07-22	Church & Dwight Co., Inc.	Bicarbonate-containing deodorant cosmetic stick compositions
AU722883B2 (en) *	1995-10-18	2000-08-10	Merck & Co., Inc.	Cyclopentyl tachykinin receptor antagonists
AU2004277932B2 (en)	2003-09-30	2009-07-16	Merck & Co., Inc.	Phenyl pyrrolidine ether tachykinin receptor antagonists
AR047439A1 (es)	2004-01-27	2006-01-18	Merck & Co Inc	Antagonistas del receptor hidroisoindolina taquiquinina

2005
- 2005-01-20 AR ARP050100203A patent/AR047439A1/es active IP Right Grant
- 2005-01-20 TW TW094101721A patent/TWI341198B/zh not_active IP Right Cessation
- 2005-01-24 PE PE2005000090A patent/PE20050687A1/es not_active Application Discontinuation
- 2005-01-26 DK DK05726323T patent/DK1711465T3/da active
- 2005-01-26 EP EP05726323A patent/EP1711465B1/en not_active Expired - Lifetime
- 2005-01-26 EA EA200601378A patent/EA010598B1/ru not_active IP Right Cessation
- 2005-01-26 GE GEAP20059594A patent/GEP20094691B/en unknown
- 2005-01-26 HR HR20080100T patent/HRP20080100T3/xx unknown
- 2005-01-26 UA UAA200609315A patent/UA84192C2/ru unknown
- 2005-01-26 DE DE602005004011T patent/DE602005004011T2/de not_active Expired - Lifetime
- 2005-01-26 PT PT05726323T patent/PT1711465E/pt unknown
- 2005-01-26 US US10/586,727 patent/US7645790B2/en active Active
- 2005-01-26 AT AT05726323T patent/ATE382034T1/de active
- 2005-01-26 WO PCT/US2005/002149 patent/WO2005073191A1/en not_active Ceased
- 2005-01-26 BR BRPI0507050-3A patent/BRPI0507050A/pt not_active IP Right Cessation
- 2005-01-26 ES ES05726323T patent/ES2297687T3/es not_active Expired - Lifetime
- 2005-01-26 AU AU2005207934A patent/AU2005207934B2/en not_active Ceased
- 2005-01-26 NZ NZ548415A patent/NZ548415A/en not_active IP Right Cessation
- 2005-01-26 PL PL05726323T patent/PL1711465T3/pl unknown
- 2005-01-26 JP JP2006551356A patent/JP3987100B2/ja not_active Expired - Fee Related
- 2005-01-26 CA CA2554550A patent/CA2554550C/en not_active Expired - Fee Related
- 2005-01-26 KR KR1020067015184A patent/KR20060127927A/ko not_active Ceased
- 2005-01-26 US US11/043,213 patent/US7217731B2/en not_active Expired - Lifetime
2006
- 2006-07-16 IL IL176879A patent/IL176879A0/en unknown
- 2006-07-19 CR CR8522A patent/CR8522A/es not_active Application Discontinuation
- 2006-07-21 EC EC2006006716A patent/ECSP066716A/es unknown
- 2006-07-26 NI NI200600164A patent/NI200600164A/es unknown
- 2006-07-27 CO CO06073837A patent/CO5700771A2/es active IP Right Grant
- 2006-08-11 MA MA29265A patent/MA28359A1/fr unknown
- 2006-08-25 NO NO20063810A patent/NO339041B1/no not_active IP Right Cessation
2007
- 2007-03-06 US US11/714,352 patent/US7345083B2/en not_active Expired - Lifetime
2008
- 2008-01-31 CY CY20081100113T patent/CY1107167T1/el unknown

Also Published As

Publication number	Publication date
WO2005073191A1 (en)	2005-08-11
KR20060127927A (ko)	2006-12-13
CR8522A (es)	2007-06-06
CY1107167T1 (el)	2012-10-24
PE20050687A1 (es)	2005-09-27
CA2554550A1 (en)	2005-08-11
AU2005207934A1 (en)	2005-08-11
IL176879A0 (en)	2006-10-31
NI200600164A (es)	2007-05-29
CO5700771A2 (es)	2006-11-30
AU2005207934B2 (en)	2010-11-25
BRPI0507050A (pt)	2007-06-12
NZ548415A (en)	2009-11-27
EA010598B1 (ru)	2008-10-30
GEP20094691B (en)	2009-05-25
CA2554550C (en)	2011-05-03
ECSP066716A (es)	2006-10-31
TW200534850A (en)	2005-11-01
NO20063810L (no)	2006-10-26
PT1711465E (pt)	2008-02-25
JP3987100B2 (ja)	2007-10-03
US20050165083A1 (en)	2005-07-28
DE602005004011D1 (de)	2008-02-07
DE602005004011T2 (de)	2008-12-11
EP1711465B1 (en)	2007-12-26
ES2297687T3 (es)	2008-05-01
US7645790B2 (en)	2010-01-12
ATE382034T1 (de)	2008-01-15
JP2007519728A (ja)	2007-07-19
MA28359A1 (fr)	2006-12-01
HK1100937A1 (zh)	2007-10-05
HRP20080100T3 (en)	2008-04-30
TWI341198B (en)	2011-05-01
AR047439A1 (es)	2006-01-18
US20080280966A1 (en)	2008-11-13
US20070161695A1 (en)	2007-07-12
DK1711465T3 (da)	2008-03-31
EP1711465A1 (en)	2006-10-18
US7217731B2 (en)	2007-05-15
NO339041B1 (no)	2016-11-07
UA84192C2 (en)	2008-09-25
US7345083B2 (en)	2008-03-18
EA200601378A1 (ru)	2007-02-27

Publication	Publication Date	Title
TWI346553B (en)	2011-08-11	Chemokine receptor antagonists
TWI341198B (en)	2011-05-01	Hydroisoindoline tachykinin receptor antagonists
ZA200702790B (en)	2008-09-25	Thrombin receptor antagonists
IL174538A0 (en)	2006-08-01	Thrombin receptor antagonists
PT1638969E (pt)	2009-01-16	Antagonistas do receptor de cgrp
ZA200708067B (en)	2008-11-26	Spirocyclic thrombin receptor antagonists
IL190686A0 (en)	2008-11-03	Il-21 receptor antagonists
IL237513A0 (en)	2015-04-30	Piperazindiones as oxytocin receptor antagonists
EP1814550A4 (en)	2009-10-21	ANTAGONISTS OF N-SULFONYLPIPERIDINE CANNABINOID RECEPTOR 1
TWI348467B (en)	2011-09-11	Nk1 antagonists
IL172822A0 (en)	2006-06-11	Muscarnic acetylcholine receptor antagonists
EP1812008A4 (en)	2008-10-29	ANTAGONISTS OF THE IL-8 RECEPTOR
EP1874302A4 (en)	2009-12-16	ANTAGONISTS OF ANGIOTENSIN II RECEPTORS
EP1819342A4 (en)	2008-12-17	QUINOLINE tachykinin ANTAGONISTS
IL178622A0 (en)	2007-02-11	Piperazinylpiperidine derivatives as chemokine receptor antagonists
SG131946A1 (en)	2007-05-28	Ccr3 receptor antagonists
ZA200605574B (en)	2007-12-27	Hydroisoindoline tachykinin receptor antagonists
IL180107A0 (en)	2007-05-15	Lactam tachykinin receptor antagonists
AP2008004537A0 (en)	2008-08-31	Muscarinic receptor antagonists
GB0414798D0 (en)	2004-08-04	Receptor
GB0302094D0 (en)	2003-02-26	EP4 receptor antagonists
GB0525029D0 (en)	2006-01-18	Receptor Antagonist
SI1711465T1 (sl)	2008-04-30	Antagonisti hidroizoindolin tahikininskega receptorja
ZA200806223B (en)	2009-07-29	Muscarinic receptor antagonists
GB0413872D0 (en)	2004-07-21	Receptor