PL1740197T3 - Endopeptydaza prolilowa (PEP) i endoproteaza glutaminowa w leczeniu celiakii - Google Patents

Endopeptydaza prolilowa (PEP) i endoproteaza glutaminowa w leczeniu celiakii

Info

Publication number
PL1740197T3
PL1740197T3 PL05714080T PL05714080T PL1740197T3 PL 1740197 T3 PL1740197 T3 PL 1740197T3 PL 05714080 T PL05714080 T PL 05714080T PL 05714080 T PL05714080 T PL 05714080T PL 1740197 T3 PL1740197 T3 PL 1740197T3
Authority
PL
Poland
Prior art keywords
endopeptidease
prolyl
pep
treatment
celiac sprue
Prior art date
Application number
PL05714080T
Other languages
English (en)
Inventor
Lu Shan
Michael Bethune
Chaitan Khosla
Jonathan Gass
Original Assignee
Alvine Pharmaceuticals Inc
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alvine Pharmaceuticals Inc, Univ Leland Stanford Junior filed Critical Alvine Pharmaceuticals Inc
Publication of PL1740197T3 publication Critical patent/PL1740197T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4813—Exopeptidases (3.4.11. to 3.4.19)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/06—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • Microbiology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PL05714080T 2004-04-26 2005-02-23 Endopeptydaza prolilowa (PEP) i endoproteaza glutaminowa w leczeniu celiakii PL1740197T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US56566804P 2004-04-26 2004-04-26
US10/969,314 US7320788B2 (en) 2002-02-14 2004-10-19 Enzyme treatment of foodstuffs for Celiac Sprue
EP05714080.8A EP1740197B1 (en) 2004-04-26 2005-02-23 Prolyl endopeptidease (PEP) and glutamine endoprotease for the treatment of Celiac Sprue
PCT/US2005/006129 WO2005107786A1 (en) 2004-04-26 2005-02-23 Therapeutic enzyme formulations and uses thereof

Publications (1)

Publication Number Publication Date
PL1740197T3 true PL1740197T3 (pl) 2014-03-31

Family

ID=35320040

Family Applications (1)

Application Number Title Priority Date Filing Date
PL05714080T PL1740197T3 (pl) 2004-04-26 2005-02-23 Endopeptydaza prolilowa (PEP) i endoproteaza glutaminowa w leczeniu celiakii

Country Status (11)

Country Link
US (1) US7320788B2 (pl)
EP (1) EP1740197B1 (pl)
JP (3) JP2007534752A (pl)
AU (1) AU2005239985B2 (pl)
CA (1) CA2563505C (pl)
DK (1) DK1740197T3 (pl)
ES (1) ES2437569T3 (pl)
NO (1) NO340598B1 (pl)
PL (1) PL1740197T3 (pl)
PT (1) PT1740197E (pl)
WO (1) WO2005107786A1 (pl)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE505201T1 (de) * 2002-02-14 2011-04-15 Univ Leland Stanford Junior Enzymbehandlung von nahrungsmitteln für zöliakie- sprue
US8143210B2 (en) * 2002-02-14 2012-03-27 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for celiac sprue
US7265093B2 (en) * 2002-05-14 2007-09-04 The Board Of Trustees Of The Leland Stanford Junior University Drug therapy for Celiac Sprue
US7462688B2 (en) * 2002-05-14 2008-12-09 The Board Of Trustees Of The Leland Stanford Junior University Peptides for diagnostic and therapeutic methods for celiac sprue
US7605150B2 (en) * 2002-05-14 2009-10-20 The Board Of Trustees Of The Leland Stanford Junior University Drug therapy for Celiac Sprue
GB0212885D0 (en) * 2002-06-05 2002-07-17 Isis Innovation Therapeutic epitopes and uses thereof
CA2502700C (en) * 2002-11-20 2017-01-17 Chaitan Khosla Diagnostic method for celiac sprue
US7579313B2 (en) * 2003-11-18 2009-08-25 The Board Of Trustees Of The Leland Stanford Junior University Transglutaminase inhibitors and methods of use thereof
US10105437B2 (en) 2004-04-28 2018-10-23 Btg International Limited Epitopes related to coeliac disease
CN104056251B (zh) 2004-04-28 2019-09-17 英国技术集团国际有限公司 与腹部疾病有关的表位
IL161886A0 (en) * 2004-05-09 2005-11-20 Technion Res & Dev Foundation Development of inducers of udp-n-acetyl-alphad-galactosamine: polypeptide n-acetylgalactosami-nyltransferase 3(ppgantase
WO2006097949A1 (en) * 2005-03-16 2006-09-21 Actial Farmacêutica, Lda. Mixture of at least 6 species of lactic acid bacteria and/or bifidobacteria in the manufacture of sourdough
ES2441969T3 (es) * 2005-10-11 2014-02-07 Mofin S.R.L. Productos lácteos con veteado azul "libres de gluten" destinados a personas afectadas por enfermedad celiaca
EP1949093A2 (en) * 2005-10-11 2008-07-30 Alvine Pharmaceuticals, Inc. Compositions and methods for enhanced gastrointestinal stability of oligopeptides and polypeptides
WO2008115428A2 (en) * 2007-03-16 2008-09-25 The Board Of Trustees Of The Leland Stanford Junior University A scaleable manufacturing process for cysteine endoprotease b, isoform 2
MX2009009780A (es) * 2007-03-16 2010-05-20 Univ Leland Stanford Junior Terapia de enzima de combinacion para la digestion de gluten dietetico.
US20100322912A1 (en) * 2007-12-10 2010-12-23 Chaitan Khosla Combination Enzyme Therapy for Gastric Digestion of Dietary Gluten in Celiac Sprue Patients
ES2343499B1 (es) 2007-12-24 2011-06-10 Consejo Superior De Investigaciones Cientificas Microorganismos para mejorar el estado de salud de individuos con desordenes relacionados con la ingesta de gluten.
CA2733514C (en) 2008-08-21 2017-10-24 Alvine Pharmaceuticals, Inc. Formulation for oral administration of proteins
JP2012505211A (ja) * 2008-10-10 2012-03-01 アルヴィン ファーマシューティカルズ インコーポレーティッド チモーゲンの迅速な活性化を促進する剤形
JP5851243B2 (ja) 2008-11-30 2016-02-03 イミューサンティー インコーポレーテッドＩｍｍｕｓａｎＴ，Ｉｎｃ． セリアック病の処置のための組成物および方法
CN102365112A (zh) * 2009-01-15 2012-02-29 澳大利亚格伦塔根有限公司 治疗谷蛋白不耐受的组合物及其应用
DE102009045268A1 (de) 2009-10-01 2011-04-07 Charité - Universitätsmedizin Berlin Neue Marker für die Diagnose von Zöliakie
WO2011044365A1 (en) 2009-10-07 2011-04-14 Trustees Of Boston University Rothia species glutamine endopeptidases and use thereof
CN102858795A (zh) 2010-02-02 2013-01-02 天野酶制品美国有限公司 蛋白酶针对谷蛋白不耐受的用途
EP2545160B1 (en) * 2010-03-12 2018-07-18 Compagnie Gervais Danone Lactic acid bacteria for coeliac disease
WO2012006384A2 (en) 2010-07-07 2012-01-12 Trustees Of Boston University Rothia species gluten-degrading enzymes and uses thereof
RU2017137415A (ru) * 2011-01-20 2019-02-11 Иммьюносайнсиз Лаб, Инк. Способы и устройство для обнаружения глютеновой чувствительности и ее дифференцирования с целиакией
WO2012135646A2 (en) * 2011-03-30 2012-10-04 Alvine Pharmaceuticals, Inc. Proteases for degrading gluten
EP2736525A1 (en) 2011-07-25 2014-06-04 Alvine Pharmaceuticals, Inc. Methods and pharmaceutical compositions for treating celiac disease and gluten intolerance
SI2718434T1 (en) 2011-08-10 2018-06-29 University Of Washington Through Its Center For Commercialization Compositions and methods for treating celiac sprue disease
WO2013047082A1 (ja) * 2011-09-29 2013-04-04 天野エンザイム株式会社 外因性オピオイドペプチド分解酵素剤
EA028228B1 (ru) * 2011-12-06 2017-10-31 Фондацьоне Иституто Инсубрико Ди Ричерка Пер Ла Вита Гидролизующая глютеновые олигопептиды эндопептидазная композиция, способ ее получения и применение
US20150197738A1 (en) * 2012-07-09 2015-07-16 Alvine Pharmaceuticals, Inc. Acid Stable Prolyl Endopeptidases for Degrading Gluten
ITRM20120468A1 (it) * 2012-10-02 2014-04-03 Uni Degli Studi Di Foggia Metodo per la detossificazione delle proteine del glutine dalla granella dei cereali
US9005610B2 (en) * 2012-11-21 2015-04-14 Nepetx, Llc Treatment of gluten intolerance and related conditions
EP2948170B1 (en) 2013-01-23 2020-08-19 Alvine Pharmaceuticals, Inc. Pharmaceutical compositions for treating celiac disease and gluten intolerance
CN119424620A (zh) 2013-08-14 2025-02-14 华盛顿大学商业中心 用于治疗口炎性腹泻的组合物和方法
EP3043812A1 (en) 2013-09-10 2016-07-20 Immusant Inc. Dosage of a gluten peptide composition
EP2883458A1 (en) 2013-12-11 2015-06-17 DSM IP Assets B.V. Medicament and method for treating innate immune response diseases
PT3139961T (pt) * 2014-05-07 2018-07-13 Nemysis Ltd Hidrogéis de derivados metacrílicos de ácido hialurónico para terapia enzimática oral na doença celíaca
DK3220946T3 (da) * 2014-06-16 2021-08-02 Codexis Inc Sammensætninger og fremgangsmåder til dæmpning og forebyggelse af tarminflammation på grund af tilstedeværelsen af peptidiske fødevareantigener i tarmen
AU2015323979A1 (en) 2014-09-29 2017-05-18 Immusant, Inc. Use of HLA genetic status to assess or select treatment of celiac disease
FR3034307B1 (fr) 2015-04-03 2021-10-22 Univ Grenoble 1 Reacteur intestinal implantable
EA037603B1 (ru) 2015-06-08 2021-04-20 Юниверсити Оф Вашингтон Композиции и способы для лечения целиакии спру
US10857214B2 (en) 2015-12-16 2020-12-08 Codexis, Inc. Compositions and methods for treating gluten intolerance and disorders arising therefrom
WO2018098082A1 (en) 2016-11-23 2018-05-31 Immunogenics, Llc Latiglutenase (alv003) for use in the treatment of symptomatic celiac disease, gluten intolerance or gluten sensitivity
WO2020087017A1 (en) * 2018-10-26 2020-04-30 The Regents Of The University Of California Use of proteolytic enzymes to enhance protein bioavailability
KR102184812B1 (ko) * 2018-12-13 2020-11-30 대한민국 새찰쌀보리 추출물을 포함하는 골다공증 예방 또는 치료용 조성물
EA202192668A1 (ru) * 2019-04-02 2022-02-07 Сами-Сабинса Груп Лимитед Способ и композиция для терапевтического лечения непереносимости глютена
IT201900012942A1 (it) 2019-07-25 2021-01-25 Nemysis Ltd Metodo per la produzione di una composizione enzimatica comprendente una endopeptidasi ricombinante
AU2020318422B2 (en) 2019-07-25 2026-03-19 Nemysis Limited Method for the production of an enzymatic composition comprising a recombinant endopeptidase
CA3250056A1 (en) 2022-01-26 2023-08-03 Digestiva, Inc. METHODS AND COMPOSITIONS FOR BLOOD GLUCOSE STABILIZATION
CN116004751B (zh) * 2022-12-13 2026-02-10 江南大学 一种利用生姜提取液和谷朊粉制备功能性肽的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4203967A (en) * 1977-01-13 1980-05-20 Hoffmann-La Roche Inc. Diagnostic test for malabsorption
WO1994026774A1 (en) 1993-05-19 1994-11-24 Cytel Corporation Novel treatments for allergic diseases
US6197356B1 (en) * 1993-08-03 2001-03-06 Immunopath Profile, Inc. Process for preparing hypoallergenic foods
US5834428A (en) * 1995-04-14 1998-11-10 1149336 Ontario Inc. Glucagon-like peptide-2 and its therapeutic use
US7048906B2 (en) * 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
DE19630557C2 (de) * 1996-07-18 1998-07-02 Schuppan Detlef Priv Doz Dr Dr Verfahren zum Nachweis von Antikörpern aus Körperflüssigkeiten durch eine Immunreaktion mit Gewebe-Transglutaminase (tTG) sowie die Verwendung von tTG in Diagnose und Therapie
EP0905518A1 (en) 1997-09-23 1999-03-31 Academisch Ziekenhuis Leiden Peptides specific for gluten-sensitive T-cells and use thereof
IL136727A0 (en) * 1997-12-31 2001-06-14 Pfizer Prod Inc Aryl fused azapolycyclic compounds
GB9923306D0 (en) 1999-10-01 1999-12-08 Isis Innovation Diagnostic and therapeutic epitope, and transgenic plant
US6667160B2 (en) * 2000-03-15 2003-12-23 Kenneth D. Fine Method for diagnosing immunologic food sensitivity
KR20030085112A (ko) * 2000-12-07 2003-11-03 디에스엠 아이피 어셋츠 비.브이. 카르복시 말단 프롤린 잔기를 갖는 펩티드가 풍부한단백질 가수분해물
ATE505201T1 (de) 2002-02-14 2011-04-15 Univ Leland Stanford Junior Enzymbehandlung von nahrungsmitteln für zöliakie- sprue

Also Published As

Publication number Publication date
EP1740197A1 (en) 2007-01-10
JP2007534752A (ja) 2007-11-29
ES2437569T3 (es) 2014-01-13
AU2005239985A1 (en) 2005-11-17
DK1740197T3 (da) 2013-11-11
CA2563505C (en) 2020-09-08
CA2563505A1 (en) 2005-11-17
EP1740197B1 (en) 2013-10-16
JP2012092125A (ja) 2012-05-17
NO340598B1 (no) 2017-05-15
AU2005239985B2 (en) 2010-08-12
NO20065195L (no) 2007-01-18
US20050249719A1 (en) 2005-11-10
PT1740197E (pt) 2013-12-02
EP1740197A4 (en) 2009-09-16
US7320788B2 (en) 2008-01-22
JP2015063554A (ja) 2015-04-09
WO2005107786A1 (en) 2005-11-17

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