PL1789432T3 - Sole metanosulfonianowe 3-estrów abirateronu i odzyskiwanie soli 3-estrów abirateronu z roztworu w eterze metylowo-tert-butylowym - Google Patents
Sole metanosulfonianowe 3-estrów abirateronu i odzyskiwanie soli 3-estrów abirateronu z roztworu w eterze metylowo-tert-butylowymInfo
- Publication number
- PL1789432T3 PL1789432T3 PL05775781T PL05775781T PL1789432T3 PL 1789432 T3 PL1789432 T3 PL 1789432T3 PL 05775781 T PL05775781 T PL 05775781T PL 05775781 T PL05775781 T PL 05775781T PL 1789432 T3 PL1789432 T3 PL 1789432T3
- Authority
- PL
- Poland
- Prior art keywords
- abiraterone
- esters
- salts
- butyl ether
- methyl tert
- Prior art date
Links
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 title abstract 6
- 150000003839 salts Chemical class 0.000 title abstract 4
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 title abstract 3
- 238000011084 recovery Methods 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940098779 methanesulfonic acid Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60355904P | 2004-08-24 | 2004-08-24 | |
| GBGB0418900.7A GB0418900D0 (en) | 2004-08-24 | 2004-08-24 | Novel salt forms |
| EP05775781A EP1789432B1 (en) | 2004-08-24 | 2005-08-23 | Methanesulfonate salts of abiraterone-3-esters and recovery of salts of abiraterone-3-esters from solution in methyl tert-butyl ether |
| PCT/GB2005/003282 WO2006021776A1 (en) | 2004-08-24 | 2005-08-23 | Methanesulfonate salts of abiraterone-3-esters and recovery of salts of abirater one-3-esters from solution in methyl tert-butyl ether |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1789432T3 true PL1789432T3 (pl) | 2010-11-30 |
Family
ID=33104570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL05775781T PL1789432T3 (pl) | 2004-08-24 | 2005-08-23 | Sole metanosulfonianowe 3-estrów abirateronu i odzyskiwanie soli 3-estrów abirateronu z roztworu w eterze metylowo-tert-butylowym |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US7700766B2 (pl) |
| EP (1) | EP1789432B1 (pl) |
| JP (1) | JP5069561B2 (pl) |
| KR (2) | KR101245727B1 (pl) |
| CN (2) | CN102863498B (pl) |
| AT (1) | ATE472553T1 (pl) |
| AU (1) | AU2005276298C1 (pl) |
| BR (1) | BRPI0514543A (pl) |
| CA (1) | CA2576922C (pl) |
| CY (1) | CY1110800T1 (pl) |
| DE (1) | DE602005022083D1 (pl) |
| DK (1) | DK1789432T3 (pl) |
| ES (1) | ES2345345T3 (pl) |
| GB (1) | GB0418900D0 (pl) |
| MX (1) | MX2007002032A (pl) |
| NZ (1) | NZ553085A (pl) |
| PL (1) | PL1789432T3 (pl) |
| PT (1) | PT1789432E (pl) |
| SI (1) | SI1789432T1 (pl) |
| WO (1) | WO2006021776A1 (pl) |
| ZA (1) | ZA200701533B (pl) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8569275B2 (en) | 2002-08-28 | 2013-10-29 | Harbor Therapeutics, Inc. | Steroids having 7-oxgen and 17-heteroaryl substitution |
| ES2534587T3 (es) * | 2004-08-24 | 2015-04-24 | Btg International Limited | Composición para la preparación de 17-vinil-triflatos como intermedios |
| GB0418900D0 (en) * | 2004-08-24 | 2004-09-29 | Btg Int Ltd | Novel salt forms |
| PL2061561T3 (pl) * | 2006-08-25 | 2013-12-31 | Janssen Oncology Inc | Kompozycje do leczenia raka |
| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| MA33451B1 (fr) | 2009-06-26 | 2012-07-03 | Novartis Ag | Dérivés d'imidazolidin-2-one 1,3-disubstitués en tant qu'inhibiteurs de cyp 17 |
| JP2013537210A (ja) | 2010-09-16 | 2013-09-30 | ノバルティス アーゲー | １７α−ヒドロキシラーゼ／Ｃ１７，２０−リアーゼ阻害剤 |
| CN102558274B (zh) * | 2010-12-08 | 2014-10-15 | 深圳万乐药业有限公司 | 一种适合工业化生产醋酸阿比特龙的合成方法 |
| CN102030798B (zh) * | 2010-12-17 | 2012-10-17 | 深圳万乐药业有限公司 | 一种醋酸阿比特龙的纯化方法 |
| EA023064B1 (ru) | 2011-04-28 | 2016-04-29 | Новартис Аг | ИНГИБИТОРЫ 17α-ГИДРОКСИЛАЗЫ/C-ЛИАЗЫ |
| JP6091510B2 (ja) | 2011-10-10 | 2017-03-08 | ザック システム | １７−置換ステロイドの製造方法 |
| CN103172690B (zh) * | 2011-12-23 | 2016-08-24 | 重庆医药工业研究院有限责任公司 | 醋酸阿比特龙及其中间体的制备方法 |
| EP2607371A1 (en) | 2011-12-23 | 2013-06-26 | Crystal Pharma, S.A.U. | Processes for the preparation of abiraterone and related compouds |
| CN103193849B (zh) * | 2012-01-04 | 2016-05-04 | 连云港润众制药有限公司 | 一种高纯度醋酸阿比特龙的制备方法 |
| CN103254265B (zh) | 2012-02-21 | 2016-07-13 | 上海希迈医药科技有限公司 | 醋酸阿比特龙三氟乙酸盐及其制备方法和应用 |
| CN103360458B (zh) * | 2012-03-26 | 2015-05-20 | 信泰制药（苏州）有限公司 | 一种阿比特龙的合成方法 |
| CN102731605B (zh) * | 2012-06-19 | 2016-04-13 | 鲁南制药集团股份有限公司 | 一种醋酸阿比特龙的纯化方法 |
| CN103665084A (zh) * | 2012-09-04 | 2014-03-26 | 重庆安格龙翔医药科技有限公司 | 一种制备醋酸阿比特龙的方法 |
| CN102816200B (zh) * | 2012-09-05 | 2015-04-15 | 中山大学 | 一种醋酸阿比特龙的制备方法 |
| CN102816201A (zh) * | 2012-09-25 | 2012-12-12 | 成都伊诺达博医药科技有限公司 | 一种阿比特龙的纯化方法 |
| WO2014058785A1 (en) | 2012-10-10 | 2014-04-17 | Novartis Ag | Combination therapy |
| ITMI20121788A1 (it) | 2012-10-22 | 2014-04-23 | Olon Spa | Procedimento per la purificazione di abiraterone acetato |
| WO2014071984A1 (en) | 2012-11-09 | 2014-05-15 | Synthon Bv | Process for making abiraterone-3-acetate |
| EP2917226A1 (en) | 2012-11-09 | 2015-09-16 | Synthon BV | Process for making the 17-triflate intermediate of abiraterone-3-acetate |
| TWI570131B (zh) * | 2012-11-13 | 2017-02-11 | 賽克系統公司 | 製備１７－經取代類固醇之方法 |
| WO2014075978A1 (en) | 2012-11-16 | 2014-05-22 | Synthon B.V. | Process for the production of abiraterone-3-acetate involving an enol trliflation reaction in the presence of an alkoxy-pyridine compound |
| CN103059091B (zh) * | 2012-11-22 | 2017-04-19 | 常州靶点医药科技有限公司 | 一种避免重金属残留的醋酸阿比特龙的制备方法 |
| US9962452B2 (en) | 2013-02-04 | 2018-05-08 | Zhuhai Beihai Biotech Co., Ltd. | Soluble complexes of drug analogs and albumin |
| RS55673B1 (sr) | 2013-04-19 | 2017-06-30 | Zach System | Postupak za dobijanje čvrstog oblika abirateron acetata |
| CN103242410B (zh) * | 2013-05-09 | 2015-08-26 | 苏州明锐医药科技有限公司 | 醋酸阿比特龙的制备方法 |
| IN2013MU02133A (pl) * | 2013-06-24 | 2015-06-05 | Sun Pharmaceutical Ind Ltd | |
| ES2705579T3 (es) * | 2013-06-28 | 2019-03-26 | Scinopharm Taiwan Ltd | Procedimiento de preparación de abiraterona e intermedios de la misma |
| CZ306623B6 (cs) * | 2013-07-04 | 2017-04-05 | Zentiva, K.S. | Soli abirateronu acetátu |
| US10045998B2 (en) | 2013-12-12 | 2018-08-14 | Basf Se | Solid form of abiraterone acetate |
| US9556219B2 (en) | 2014-01-28 | 2017-01-31 | Olon S.P.A. | Procedure for the preparation of abiraterone acetate and intermediates thereof |
| CN103965282B (zh) | 2014-04-21 | 2016-01-20 | 武汉百科药物开发有限公司 | 一种醋酸阿比特龙的制备方法 |
| US9315541B2 (en) * | 2014-05-20 | 2016-04-19 | Olon S.P.A. | Process for the preparation of unsaturated trifluoromethanesulfonate steroid derivatives |
| CN105294806A (zh) * | 2014-06-13 | 2016-02-03 | 江苏希迪制药有限公司 | 一种制备醋酸阿比特龙中间体的方法 |
| US9937259B2 (en) | 2014-06-27 | 2018-04-10 | Zhuhai Beihai Biotech Co., Ltd. | Abiraterone derivatives and non-covalent complexes with albumin |
| WO2016065139A1 (en) | 2014-10-24 | 2016-04-28 | Fl Therapeutics Llc | 3-substituted piperidine-2, 6-diones and non-covalent complexes with albumin |
| CN104447934B (zh) * | 2014-12-08 | 2017-03-15 | 深圳科兴生物工程有限公司 | 一种醋酸阿比特龙的纯化方法 |
| US10722527B2 (en) | 2015-04-10 | 2020-07-28 | Capsugel Belgium Nv | Abiraterone acetate lipid formulations |
| CN119606965A (zh) | 2016-07-29 | 2025-03-14 | 詹森药业有限公司 | 治疗前列腺癌的方法 |
| CN109922809B (zh) | 2016-10-11 | 2021-08-13 | 珠海贝海生物技术有限公司 | 阿比特龙衍生物及其制剂 |
| CN108586561B (zh) * | 2018-04-03 | 2020-08-04 | 科兴生物制药股份有限公司 | 一种制备醋酸阿比特龙的方法 |
| JP7644713B2 (ja) | 2019-03-06 | 2025-03-12 | プロペラ セラピューティクス インコーポレイテッド | アビラテロンプロドラッグ |
| CN112812147A (zh) * | 2019-11-15 | 2021-05-18 | 江苏佳尔科药业集团股份有限公司 | 一种醋酸阿比特龙的合成方法及其中间体 |
| CA3207282A1 (en) | 2021-02-15 | 2022-08-18 | Matthew J. Sharp | Abiraterone prodrugs |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5604213A (en) * | 1992-03-31 | 1997-02-18 | British Technology Group Limited | 17-substituted steroids useful in cancer treatment |
| GB2265624B (en) | 1992-03-31 | 1995-04-19 | British Tech Group | 17-substituted steroids useful in cancer treatment |
| DK0721461T3 (da) * | 1993-09-30 | 1999-09-20 | Btg Int Ltd | Syntese af 17-(3-pyridyl)-steroider |
| GB0418900D0 (en) * | 2004-08-24 | 2004-09-29 | Btg Int Ltd | Novel salt forms |
-
2004
- 2004-08-24 GB GBGB0418900.7A patent/GB0418900D0/en not_active Ceased
-
2005
- 2005-08-23 AU AU2005276298A patent/AU2005276298C1/en not_active Expired
- 2005-08-23 CA CA2576922A patent/CA2576922C/en not_active Expired - Lifetime
- 2005-08-23 CN CN201210299567.4A patent/CN102863498B/zh not_active Expired - Lifetime
- 2005-08-23 DE DE602005022083T patent/DE602005022083D1/de not_active Expired - Lifetime
- 2005-08-23 CN CN2005800360449A patent/CN101044155B/zh not_active Expired - Lifetime
- 2005-08-23 US US11/660,869 patent/US7700766B2/en active Active
- 2005-08-23 AT AT05775781T patent/ATE472553T1/de active
- 2005-08-23 ES ES05775781T patent/ES2345345T3/es not_active Expired - Lifetime
- 2005-08-23 NZ NZ553085A patent/NZ553085A/en not_active IP Right Cessation
- 2005-08-23 ZA ZA200701533A patent/ZA200701533B/xx unknown
- 2005-08-23 EP EP05775781A patent/EP1789432B1/en not_active Expired - Lifetime
- 2005-08-23 JP JP2007528970A patent/JP5069561B2/ja not_active Expired - Lifetime
- 2005-08-23 KR KR1020077004205A patent/KR101245727B1/ko not_active Expired - Lifetime
- 2005-08-23 DK DK05775781.7T patent/DK1789432T3/da active
- 2005-08-23 BR BRPI0514543-0A patent/BRPI0514543A/pt not_active Application Discontinuation
- 2005-08-23 MX MX2007002032A patent/MX2007002032A/es active IP Right Grant
- 2005-08-23 PL PL05775781T patent/PL1789432T3/pl unknown
- 2005-08-23 KR KR1020127031465A patent/KR101358661B1/ko not_active Expired - Lifetime
- 2005-08-23 PT PT05775781T patent/PT1789432E/pt unknown
- 2005-08-23 WO PCT/GB2005/003282 patent/WO2006021776A1/en not_active Ceased
- 2005-08-23 SI SI200531092T patent/SI1789432T1/sl unknown
-
2010
- 2010-02-04 US US12/656,581 patent/US8076474B2/en not_active Expired - Lifetime
- 2010-09-27 CY CY20101100867T patent/CY1110800T1/el unknown
-
2011
- 2011-11-02 US US13/317,997 patent/US8338588B2/en not_active Expired - Lifetime
-
2012
- 2012-11-26 US US13/685,004 patent/US20130090468A1/en not_active Abandoned
-
2015
- 2015-07-23 US US14/807,086 patent/US20150329585A1/en not_active Abandoned
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