PL1789432T3 - Sole metanosulfonianowe 3-estrów abirateronu i odzyskiwanie soli 3-estrów abirateronu z roztworu w eterze metylowo-tert-butylowym - Google Patents

Sole metanosulfonianowe 3-estrów abirateronu i odzyskiwanie soli 3-estrów abirateronu z roztworu w eterze metylowo-tert-butylowym

Info

Publication number
PL1789432T3
PL1789432T3 PL05775781T PL05775781T PL1789432T3 PL 1789432 T3 PL1789432 T3 PL 1789432T3 PL 05775781 T PL05775781 T PL 05775781T PL 05775781 T PL05775781 T PL 05775781T PL 1789432 T3 PL1789432 T3 PL 1789432T3
Authority
PL
Poland
Prior art keywords
abiraterone
esters
salts
butyl ether
methyl tert
Prior art date
Application number
PL05775781T
Other languages
English (en)
Inventor
Neil John Safc Pharma Hunt
Original Assignee
Btg Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Btg Int Ltd filed Critical Btg Int Ltd
Publication of PL1789432T3 publication Critical patent/PL1789432T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
PL05775781T 2004-08-24 2005-08-23 Sole metanosulfonianowe 3-estrów abirateronu i odzyskiwanie soli 3-estrów abirateronu z roztworu w eterze metylowo-tert-butylowym PL1789432T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US60355904P 2004-08-24 2004-08-24
GBGB0418900.7A GB0418900D0 (en) 2004-08-24 2004-08-24 Novel salt forms
EP05775781A EP1789432B1 (en) 2004-08-24 2005-08-23 Methanesulfonate salts of abiraterone-3-esters and recovery of salts of abiraterone-3-esters from solution in methyl tert-butyl ether
PCT/GB2005/003282 WO2006021776A1 (en) 2004-08-24 2005-08-23 Methanesulfonate salts of abiraterone-3-esters and recovery of salts of abirater one-3-esters from solution in methyl tert-butyl ether

Publications (1)

Publication Number Publication Date
PL1789432T3 true PL1789432T3 (pl) 2010-11-30

Family

ID=33104570

Family Applications (1)

Application Number Title Priority Date Filing Date
PL05775781T PL1789432T3 (pl) 2004-08-24 2005-08-23 Sole metanosulfonianowe 3-estrów abirateronu i odzyskiwanie soli 3-estrów abirateronu z roztworu w eterze metylowo-tert-butylowym

Country Status (21)

Country Link
US (5) US7700766B2 (pl)
EP (1) EP1789432B1 (pl)
JP (1) JP5069561B2 (pl)
KR (2) KR101245727B1 (pl)
CN (2) CN101044155B (pl)
AT (1) ATE472553T1 (pl)
AU (1) AU2005276298C1 (pl)
BR (1) BRPI0514543A (pl)
CA (1) CA2576922C (pl)
CY (1) CY1110800T1 (pl)
DE (1) DE602005022083D1 (pl)
DK (1) DK1789432T3 (pl)
ES (1) ES2345345T3 (pl)
GB (1) GB0418900D0 (pl)
MX (1) MX2007002032A (pl)
NZ (1) NZ553085A (pl)
PL (1) PL1789432T3 (pl)
PT (1) PT1789432E (pl)
SI (1) SI1789432T1 (pl)
WO (1) WO2006021776A1 (pl)
ZA (1) ZA200701533B (pl)

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GB0418900D0 (en) * 2004-08-24 2004-09-29 Btg Int Ltd Novel salt forms
SI1781683T1 (sl) * 2004-08-24 2012-06-29 Btg Int Ltd Postopek za pripravo 17-vinil-triflatov kot intermediatov
EP3804730A1 (en) * 2006-08-25 2021-04-14 Janssen Oncology, Inc. Compositions for treating cancer
US20080051380A1 (en) 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
UY32730A (es) 2009-06-26 2011-01-31 Novartis Ag Inhibidores de cyp17
US8946260B2 (en) 2010-09-16 2015-02-03 Novartis Ag 17α-hydroxylase/C17,20-lyase inhibitors
CN102558274B (zh) * 2010-12-08 2014-10-15 深圳万乐药业有限公司 一种适合工业化生产醋酸阿比特龙的合成方法
CN102030798B (zh) * 2010-12-17 2012-10-17 深圳万乐药业有限公司 一种醋酸阿比特龙的纯化方法
AU2012249421B9 (en) 2011-04-28 2015-10-22 Novartis Ag 17alpha-hydroxylase/C17,20-lyase inhibitors
RS55223B1 (sr) 2011-10-10 2017-02-28 Zach System Postupak za dobijanje 17-supstituisanih steroida
EP2607371A1 (en) 2011-12-23 2013-06-26 Crystal Pharma, S.A.U. Processes for the preparation of abiraterone and related compouds
CN103172690B (zh) * 2011-12-23 2016-08-24 重庆医药工业研究院有限责任公司 醋酸阿比特龙及其中间体的制备方法
CN103193849B (zh) * 2012-01-04 2016-05-04 连云港润众制药有限公司 一种高纯度醋酸阿比特龙的制备方法
CN103254265B (zh) 2012-02-21 2016-07-13 上海希迈医药科技有限公司 醋酸阿比特龙三氟乙酸盐及其制备方法和应用
CN103360458B (zh) * 2012-03-26 2015-05-20 信泰制药（苏州）有限公司 一种阿比特龙的合成方法
CN102731605B (zh) * 2012-06-19 2016-04-13 鲁南制药集团股份有限公司 一种醋酸阿比特龙的纯化方法
CN103665084A (zh) * 2012-09-04 2014-03-26 重庆安格龙翔医药科技有限公司 一种制备醋酸阿比特龙的方法
CN102816200B (zh) * 2012-09-05 2015-04-15 中山大学 一种醋酸阿比特龙的制备方法
CN102816201A (zh) * 2012-09-25 2012-12-12 成都伊诺达博医药科技有限公司 一种阿比特龙的纯化方法
WO2014058785A1 (en) 2012-10-10 2014-04-17 Novartis Ag Combination therapy
ITMI20121788A1 (it) 2012-10-22 2014-04-23 Olon Spa Procedimento per la purificazione di abiraterone acetato
EP2917226A1 (en) 2012-11-09 2015-09-16 Synthon BV Process for making the 17-triflate intermediate of abiraterone-3-acetate
EP2917225A1 (en) 2012-11-09 2015-09-16 Synthon BV Process for making abiraterone-3-acetate
TWI570131B (zh) * 2012-11-13 2017-02-11 賽克系統公司 製備１７－經取代類固醇之方法
WO2014075978A1 (en) 2012-11-16 2014-05-22 Synthon B.V. Process for the production of abiraterone-3-acetate involving an enol trliflation reaction in the presence of an alkoxy-pyridine compound
CN103059091B (zh) * 2012-11-22 2017-04-19 常州靶点医药科技有限公司 一种避免重金属残留的醋酸阿比特龙的制备方法
US9962452B2 (en) 2013-02-04 2018-05-08 Zhuhai Beihai Biotech Co., Ltd. Soluble complexes of drug analogs and albumin
EP2792682B1 (en) 2013-04-19 2016-11-09 Zach System Process for producing a solid form of abiraterone acetate
CN103242410B (zh) * 2013-05-09 2015-08-26 苏州明锐医药科技有限公司 醋酸阿比特龙的制备方法
EP3013844A4 (en) * 2013-06-24 2017-03-01 Sun Pharmaceutical Industries LTD Process for preparation of abiraterone acetate
AU2014300639B2 (en) * 2013-06-28 2018-03-01 Scinopharm Taiwan, Ltd. Process for the preparation of abiraterone and intermediates thereof
CZ306623B6 (cs) 2013-07-04 2017-04-05 Zentiva, K.S. Soli abirateronu acetátu
US10045998B2 (en) 2013-12-12 2018-08-14 Basf Se Solid form of abiraterone acetate
ES2741505T3 (es) 2014-01-28 2020-02-11 Olon Spa Procedimiento para la preparación de acetato de abiraterona y sus productos intermedios
CN103965282B (zh) * 2014-04-21 2016-01-20 武汉百科药物开发有限公司 一种醋酸阿比特龙的制备方法
US9315541B2 (en) * 2014-05-20 2016-04-19 Olon S.P.A. Process for the preparation of unsaturated trifluoromethanesulfonate steroid derivatives
CN105294806A (zh) * 2014-06-13 2016-02-03 江苏希迪制药有限公司 一种制备醋酸阿比特龙中间体的方法
US9937259B2 (en) 2014-06-27 2018-04-10 Zhuhai Beihai Biotech Co., Ltd. Abiraterone derivatives and non-covalent complexes with albumin
WO2016065139A1 (en) 2014-10-24 2016-04-28 Fl Therapeutics Llc 3-substituted piperidine-2, 6-diones and non-covalent complexes with albumin
CN104447934B (zh) * 2014-12-08 2017-03-15 深圳科兴生物工程有限公司 一种醋酸阿比特龙的纯化方法
ES2863500T3 (es) 2015-04-10 2021-10-11 Capsugel Belgium Nv Formulaciones lipídicas de acetato de abiraterona
BR112019001398A2 (pt) 2016-07-29 2019-05-07 Janssen Pharmaceutica Nv métodos para tratamento de câncer de próstata
WO2018071544A1 (en) 2016-10-11 2018-04-19 Zhuhai Beihai Biotech Co., Ltd. Abiraterone derivative and formulations thereof
CN108586561B (zh) * 2018-04-03 2020-08-04 科兴生物制药股份有限公司 一种制备醋酸阿比特龙的方法
JP7644713B2 (ja) * 2019-03-06 2025-03-12 プロペラ セラピューティクス インコーポレイテッド アビラテロンプロドラッグ
CN112812147A (zh) * 2019-11-15 2021-05-18 江苏佳尔科药业集团股份有限公司 一种醋酸阿比特龙的合成方法及其中间体
CN117120034A (zh) 2021-02-15 2023-11-24 普洛佩拉治疗公司 阿比特龙前药

Family Cites Families (4)

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GB2265624B (en) * 1992-03-31 1995-04-19 British Tech Group 17-substituted steroids useful in cancer treatment
US5604213A (en) * 1992-03-31 1997-02-18 British Technology Group Limited 17-substituted steroids useful in cancer treatment
EP0721461B1 (en) * 1993-09-30 1999-02-03 Btg International Limited Synthesis of 17-(3-pyridyl) steroids
GB0418900D0 (en) * 2004-08-24 2004-09-29 Btg Int Ltd Novel salt forms

Also Published As

Publication number Publication date
EP1789432A1 (en) 2007-05-30
US8076474B2 (en) 2011-12-13
JP5069561B2 (ja) 2012-11-07
CA2576922C (en) 2013-05-07
EP1789432B1 (en) 2010-06-30
US7700766B2 (en) 2010-04-20
ZA200701533B (en) 2008-08-27
CY1110800T1 (el) 2015-06-10
US8338588B2 (en) 2012-12-25
CN101044155B (zh) 2012-10-10
SI1789432T1 (sl) 2010-10-29
KR101245727B1 (ko) 2013-03-25
WO2006021776A1 (en) 2006-03-02
US20100152437A1 (en) 2010-06-17
US20130090468A1 (en) 2013-04-11
JP2008510780A (ja) 2008-04-10
AU2005276298A1 (en) 2006-03-02
US20150329585A1 (en) 2015-11-19
BRPI0514543A (pt) 2008-06-17
ES2345345T3 (es) 2010-09-21
CN102863498B (zh) 2015-04-08
GB0418900D0 (en) 2004-09-29
KR20070049171A (ko) 2007-05-10
ATE472553T1 (de) 2010-07-15
KR101358661B1 (ko) 2014-02-07
US20070249836A1 (en) 2007-10-25
CN102863498A (zh) 2013-01-09
KR20120135931A (ko) 2012-12-17
MX2007002032A (es) 2007-10-11
CN101044155A (zh) 2007-09-26
AU2005276298B2 (en) 2011-06-23
DK1789432T3 (da) 2010-08-16
US20120053340A1 (en) 2012-03-01
PT1789432E (pt) 2010-08-09
NZ553085A (en) 2010-08-27
DE602005022083D1 (de) 2010-08-12
HK1180694A1 (en) 2013-10-25
CA2576922A1 (en) 2006-03-02
AU2005276298C1 (en) 2012-02-02
HK1103091A1 (en) 2007-12-14

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