ATE472553T1 - Methansulfonatsalze von abirateron-3-estern und wiederherstellung von salzen von abirateron-3- estern durch auflösung in methyl-tert-butyl-ether - Google Patents

Methansulfonatsalze von abirateron-3-estern und wiederherstellung von salzen von abirateron-3- estern durch auflösung in methyl-tert-butyl-ether

Info

Publication number: ATE472553T1
Authority: AT; Austria
Prior art keywords: esters; salts; butyl ether; tert; methyl
Prior art date: 2004-08-24

Application number

AT05775781T

Other languages

English (en)

Inventor

Neil John Hunt

Original Assignee

Btg Int Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-08-24

Filing date

2005-08-23

Publication date

2010-07-15

2005-08-23 Application filed by Btg Int Ltd filed Critical Btg Int Ltd

2010-07-15 Application granted granted Critical

2010-07-15 Publication of ATE472553T1 publication Critical patent/ATE472553T1/de

Links

BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 title abstract 6
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 title abstract 3
238000004090 dissolution Methods 0.000 title 1
238000011084 recovery Methods 0.000 title 1
150000003839 salts Chemical class 0.000 abstract 3
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229940098779 methanesulfonic acid Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Epoxy Compounds (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cephalosporin Compounds (AREA)

AT05775781T 2004-08-24 2005-08-23 Methansulfonatsalze von abirateron-3-estern und wiederherstellung von salzen von abirateron-3- estern durch auflösung in methyl-tert-butyl-ether ATE472553T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US60355904P	2004-08-24	2004-08-24
GBGB0418900.7A GB0418900D0 (en)	2004-08-24	2004-08-24	Novel salt forms
PCT/GB2005/003282 WO2006021776A1 (en)	2004-08-24	2005-08-23	Methanesulfonate salts of abiraterone-3-esters and recovery of salts of abirater one-3-esters from solution in methyl tert-butyl ether

Publications (1)

Publication Number	Publication Date
ATE472553T1 true ATE472553T1 (de)	2010-07-15

Family

ID=33104570

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05775781T ATE472553T1 (de)	2004-08-24	2005-08-23	Methansulfonatsalze von abirateron-3-estern und wiederherstellung von salzen von abirateron-3- estern durch auflösung in methyl-tert-butyl-ether

Country Status (21)

Country	Link
US (5)	US7700766B2 (de)
EP (1)	EP1789432B1 (de)
JP (1)	JP5069561B2 (de)
KR (2)	KR101358661B1 (de)
CN (2)	CN101044155B (de)
AT (1)	ATE472553T1 (de)
AU (1)	AU2005276298C1 (de)
BR (1)	BRPI0514543A (de)
CA (1)	CA2576922C (de)
CY (1)	CY1110800T1 (de)
DE (1)	DE602005022083D1 (de)
DK (1)	DK1789432T3 (de)
ES (1)	ES2345345T3 (de)
GB (1)	GB0418900D0 (de)
MX (1)	MX2007002032A (de)
NZ (1)	NZ553085A (de)
PL (1)	PL1789432T3 (de)
PT (1)	PT1789432E (de)
SI (1)	SI1789432T1 (de)
WO (1)	WO2006021776A1 (de)
ZA (1)	ZA200701533B (de)

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US20080051380A1 (en)	2006-08-25	2008-02-28	Auerbach Alan H	Methods and compositions for treating cancer
HRP20130961T1 (hr) *	2006-08-25	2013-11-22	Janssen Oncology, Inc.	Kombinacije za tretman raka
PE20121048A1 (es)	2009-06-26	2012-08-25	Novartis Ag	Derivados de imidazolidin-2-ona 1,3-disustituida como inhibidores de cyp17
EP2627648A1 (de)	2010-09-16	2013-08-21	Novartis AG	17a-HYDROXYLASE-C17, 20-LYASE-INHIBITOREN
CN102558274B (zh) *	2010-12-08	2014-10-15	深圳万乐药业有限公司	一种适合工业化生产醋酸阿比特龙的合成方法
CN102030798B (zh) *	2010-12-17	2012-10-17	深圳万乐药业有限公司	一种醋酸阿比特龙的纯化方法
MX359399B (es)	2011-04-28	2018-09-27	Novartis Ag	Inhibidores de 17alfa-hidroxilasa/c17-20-liasa.
CN104066744B (zh)	2011-10-10	2017-03-22	扎克系统公司	用于制备17‑取代的甾体的方法
CN103172690B (zh) *	2011-12-23	2016-08-24	重庆医药工业研究院有限责任公司	醋酸阿比特龙及其中间体的制备方法
EP2607371A1 (de)	2011-12-23	2013-06-26	Crystal Pharma, S.A.U.	Verfahren zur Herstellung von Abirateron und verwandten Verbindungen
CN103193849B (zh) *	2012-01-04	2016-05-04	连云港润众制药有限公司	一种高纯度醋酸阿比特龙的制备方法
CN103254265B (zh)	2012-02-21	2016-07-13	上海希迈医药科技有限公司	醋酸阿比特龙三氟乙酸盐及其制备方法和应用
CN103360458B (zh) *	2012-03-26	2015-05-20	信泰制药（苏州）有限公司	一种阿比特龙的合成方法
CN102731605B (zh) *	2012-06-19	2016-04-13	鲁南制药集团股份有限公司	一种醋酸阿比特龙的纯化方法
CN103665084A (zh) *	2012-09-04	2014-03-26	重庆安格龙翔医药科技有限公司	一种制备醋酸阿比特龙的方法
CN102816200B (zh) *	2012-09-05	2015-04-15	中山大学	一种醋酸阿比特龙的制备方法
CN102816201A (zh) *	2012-09-25	2012-12-12	成都伊诺达博医药科技有限公司	一种阿比特龙的纯化方法
WO2014058785A1 (en)	2012-10-10	2014-04-17	Novartis Ag	Combination therapy
ITMI20121788A1 (it)	2012-10-22	2014-04-23	Olon Spa	Procedimento per la purificazione di abiraterone acetato
EP2917226A1 (de)	2012-11-09	2015-09-16	Synthon BV	Verfahren zur herstellung des 17-triflat-zwischenprodukts von abirateron-3-acetat
WO2014071984A1 (en)	2012-11-09	2014-05-15	Synthon Bv	Process for making abiraterone-3-acetate
TWI570131B (zh) *	2012-11-13	2017-02-11	賽克系統公司	製備１７－經取代類固醇之方法
WO2014075978A1 (en)	2012-11-16	2014-05-22	Synthon B.V.	Process for the production of abiraterone-3-acetate involving an enol trliflation reaction in the presence of an alkoxy-pyridine compound
CN103059091B (zh) *	2012-11-22	2017-04-19	常州靶点医药科技有限公司	一种避免重金属残留的醋酸阿比特龙的制备方法
WO2014121033A1 (en)	2013-02-04	2014-08-07	Fl Therapeutics Llc	Soluble complexes of drug analogs and albumin
PL2792682T3 (pl) *	2013-04-19	2017-04-28	Zach System	Sposób wytwarzania stałej postaci octanu abirateronu
CN103242410B (zh) *	2013-05-09	2015-08-26	苏州明锐医药科技有限公司	醋酸阿比特龙的制备方法
US20160176915A1 (en) *	2013-06-24	2016-06-23	Sun Pharmaceutical Industries Limited	Process for preparation of abiraterone acetate
CN105377871B (zh) *	2013-06-28	2017-06-06	台湾神隆股份有限公司	阿比特龙及其中间体的制备方法
CZ306623B6 (cs) *	2013-07-04	2017-04-05	Zentiva, K.S.	Soli abirateronu acetátu
EP3080141A1 (de)	2013-12-12	2016-10-19	Basf Se	Feste form von abirateronacetat
US9556219B2 (en)	2014-01-28	2017-01-31	Olon S.P.A.	Procedure for the preparation of abiraterone acetate and intermediates thereof
CN103965282B (zh) *	2014-04-21	2016-01-20	武汉百科药物开发有限公司	一种醋酸阿比特龙的制备方法
US9315541B2 (en) *	2014-05-20	2016-04-19	Olon S.P.A.	Process for the preparation of unsaturated trifluoromethanesulfonate steroid derivatives
CN105294806A (zh) *	2014-06-13	2016-02-03	江苏希迪制药有限公司	一种制备醋酸阿比特龙中间体的方法
US9937259B2 (en)	2014-06-27	2018-04-10	Zhuhai Beihai Biotech Co., Ltd.	Abiraterone derivatives and non-covalent complexes with albumin
WO2016065139A1 (en)	2014-10-24	2016-04-28	Fl Therapeutics Llc	3-substituted piperidine-2, 6-diones and non-covalent complexes with albumin
CN104447934B (zh) *	2014-12-08	2017-03-15	深圳科兴生物工程有限公司	一种醋酸阿比特龙的纯化方法
EP3824908A1 (de)	2015-04-10	2021-05-26	Capsugel Belgium NV	Abirateron-acetat-lipidformulierungen
WO2018023017A1 (en)	2016-07-29	2018-02-01	Janssen Pharmaceutica Nv	Methods of treating prostate cancer
US10717762B2 (en)	2016-10-11	2020-07-21	Zhuhai Beihai Biotech Co., Ltd.	Abiraterone derivative and formulations thereof
CN108586561B (zh) *	2018-04-03	2020-08-04	科兴生物制药股份有限公司	一种制备醋酸阿比特龙的方法
CN114026106B (zh) *	2019-03-06	2025-01-21	普洛拉治疗公司	阿比特龙前药
CN112812147A (zh) *	2019-11-15	2021-05-18	江苏佳尔科药业集团股份有限公司	一种醋酸阿比特龙的合成方法及其中间体
CN117120034A (zh)	2021-02-15	2023-11-24	普洛佩拉治疗公司	阿比特龙前药

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2004
- 2004-08-24 GB GBGB0418900.7A patent/GB0418900D0/en not_active Ceased
2005
- 2005-08-23 NZ NZ553085A patent/NZ553085A/en not_active IP Right Cessation
- 2005-08-23 SI SI200531092T patent/SI1789432T1/sl unknown
- 2005-08-23 ES ES05775781T patent/ES2345345T3/es not_active Expired - Lifetime
- 2005-08-23 BR BRPI0514543-0A patent/BRPI0514543A/pt not_active Application Discontinuation
- 2005-08-23 KR KR1020127031465A patent/KR101358661B1/ko not_active Expired - Lifetime
- 2005-08-23 ZA ZA200701533A patent/ZA200701533B/xx unknown
- 2005-08-23 CN CN2005800360449A patent/CN101044155B/zh not_active Expired - Lifetime
- 2005-08-23 AT AT05775781T patent/ATE472553T1/de active
- 2005-08-23 CA CA2576922A patent/CA2576922C/en not_active Expired - Lifetime
- 2005-08-23 PT PT05775781T patent/PT1789432E/pt unknown
- 2005-08-23 WO PCT/GB2005/003282 patent/WO2006021776A1/en not_active Ceased
- 2005-08-23 DK DK05775781.7T patent/DK1789432T3/da active
- 2005-08-23 EP EP05775781A patent/EP1789432B1/de not_active Expired - Lifetime
- 2005-08-23 PL PL05775781T patent/PL1789432T3/pl unknown
- 2005-08-23 CN CN201210299567.4A patent/CN102863498B/zh not_active Expired - Lifetime
- 2005-08-23 JP JP2007528970A patent/JP5069561B2/ja not_active Expired - Lifetime
- 2005-08-23 KR KR1020077004205A patent/KR101245727B1/ko not_active Expired - Lifetime
- 2005-08-23 AU AU2005276298A patent/AU2005276298C1/en not_active Expired
- 2005-08-23 MX MX2007002032A patent/MX2007002032A/es active IP Right Grant
- 2005-08-23 DE DE602005022083T patent/DE602005022083D1/de not_active Expired - Lifetime
- 2005-08-23 US US11/660,869 patent/US7700766B2/en active Active
2010
- 2010-02-04 US US12/656,581 patent/US8076474B2/en not_active Expired - Lifetime
- 2010-09-27 CY CY20101100867T patent/CY1110800T1/el unknown
2011
- 2011-11-02 US US13/317,997 patent/US8338588B2/en not_active Expired - Lifetime
2012
- 2012-11-26 US US13/685,004 patent/US20130090468A1/en not_active Abandoned
2015
- 2015-07-23 US US14/807,086 patent/US20150329585A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AU2005276298B2 (en)	2011-06-23
JP5069561B2 (ja)	2012-11-07
HK1103091A1 (en)	2007-12-14
US20070249836A1 (en)	2007-10-25
US20120053340A1 (en)	2012-03-01
US20130090468A1 (en)	2013-04-11
KR20120135931A (ko)	2012-12-17
AU2005276298C1 (en)	2012-02-02
MX2007002032A (es)	2007-10-11
US8076474B2 (en)	2011-12-13
GB0418900D0 (en)	2004-09-29
KR101245727B1 (ko)	2013-03-25
CN101044155A (zh)	2007-09-26
US8338588B2 (en)	2012-12-25
CY1110800T1 (el)	2015-06-10
CN102863498A (zh)	2013-01-09
BRPI0514543A (pt)	2008-06-17
CA2576922A1 (en)	2006-03-02
HK1180694A1 (en)	2013-10-25
KR101358661B1 (ko)	2014-02-07
ES2345345T3 (es)	2010-09-21
US7700766B2 (en)	2010-04-20
NZ553085A (en)	2010-08-27
KR20070049171A (ko)	2007-05-10
DK1789432T3 (da)	2010-08-16
EP1789432A1 (de)	2007-05-30
US20150329585A1 (en)	2015-11-19
AU2005276298A1 (en)	2006-03-02
PL1789432T3 (pl)	2010-11-30
JP2008510780A (ja)	2008-04-10
ZA200701533B (en)	2008-08-27
CN102863498B (zh)	2015-04-08
EP1789432B1 (de)	2010-06-30
CA2576922C (en)	2013-05-07
PT1789432E (pt)	2010-08-09
US20100152437A1 (en)	2010-06-17
DE602005022083D1 (de)	2010-08-12
SI1789432T1 (sl)	2010-10-29
WO2006021776A1 (en)	2006-03-02
CN101044155B (zh)	2012-10-10

Publication	Publication Date	Title
ZA200701533B (en)	2008-08-27	Methanesulfonate salts of abiraterone-3-esters and recovery of salts of abirater one-3-esters from solution in methyl tert-butyl ether
ES2531190T3 (es)	2015-03-11	Método para producir un compuesto de 4-oxoquinolina
EA200900676A1 (ru)	2010-02-26	Ингибиторы вируса гепатита с
DK2020996T3 (da)	2012-02-27	Fremgangsmåder og sammensætninger til behandling af hæmatologiske sygdomme
NO20091871L (no)	2009-07-31	Hepatitt C virus inhibitorer
EA200500239A1 (ru)	2005-12-29	Новый способ синтеза (1s)-4-,5-диметокси-1-(метиламинометил)-бензоциклобутана и его солей присоединения и применение при синтезе ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой
DK1781683T3 (da)	2012-02-06	Fremgangsmåde til fremstilling af 17-vinyl-triflater som halvfabrikata
MX2010002904A (es)	2010-06-02	N-fenil-dioxo-hidropirimidinas utiles como inhibidores de virus de hepatitis c (hcv).
NO20075616L (no)	2008-01-30	Tripeptider som hepatitt C virus inhibitorer
NZ594671A (en)	2013-05-31	Compositions and methods for inhibiting the agglomeration of hydrates in a process
AR062797A1 (es)	2008-12-03	Derivados de piperidina como inhibidores de renina, composiciones farmaceuticas.
EA201171329A1 (ru)	2012-05-30	Твердый препарат
BR112013032049A2 (pt)	2016-09-13	inibidores do vírus da hepatite c
EP2196460A4 (de)	2011-11-23	Sulfonsäuresalzverbindung eines 4-carbamoyl-5-hydroxyimidazolderivats
EA200900780A1 (ru)	2010-08-30	Аналоги эпотилона, модифицированные в положениях c12-c13, как противораковые лекарственные средства
UY29857A1 (es)	2007-05-31	Derivados de la 4-amino-quinazolina, su preparación y su aplicación en terapéutica.
DK1885187T3 (da)	2013-12-09	Fremgangsmåde til behandling af lægemiddelresistent cancer
AR073871A1 (es)	2010-12-09	Intermediario de fulvestran
NO20090332L (no)	2009-03-12	4-amino-3-arylamino-6-arylpyrazol[3,4-D]pyrimidinderivater, fremgangsmater for deres fremstilling og dere anvendelse som antivirale midler
AR079299A1 (es)	2012-01-18	Mejora de los procesos para la preparacion de granulos solubles de las sales de los acidos carboxilicos que contienen piridina
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ECSP088170A (es)	2008-03-26	Derivados de 5-piridinil-1-azabiciclo[3.2.1]octano, su preparación y su aplicación en terapéutica
CR10957A (es)	2009-09-01	Derivados de ciclohexil-amida del acido aril-carboxilico
CO5611198A2 (es)	2006-02-28	Proceso para preparar sales acidas de gemifloxacina
NO20064422L (no)	2006-09-29	Krystallinske former av 5,11-dihydro-11-etyl-5-metyl-8{2-{(1-oksido-4-kinolin 1)oksy}etyl}-6H-dipyrido[3,2-B:2',3'-E][1,4]diazepin--on