ATE472553T1 - Methansulfonatsalze von abirateron-3-estern und wiederherstellung von salzen von abirateron-3- estern durch auflösung in methyl-tert-butyl-ether - Google Patents

Methansulfonatsalze von abirateron-3-estern und wiederherstellung von salzen von abirateron-3- estern durch auflösung in methyl-tert-butyl-ether

Info

Publication number: ATE472553T1
Authority: AT; Austria
Prior art keywords: esters; salts; butyl ether; tert; methyl
Prior art date: 2004-08-24

Application number

AT05775781T

Other languages

English (en)

Inventor

Neil John Hunt

Original Assignee

Btg Int Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-08-24

Filing date

2005-08-23

Publication date

2010-07-15

2005-08-23 Application filed by Btg Int Ltd filed Critical Btg Int Ltd

2010-07-15 Application granted granted Critical

2010-07-15 Publication of ATE472553T1 publication Critical patent/ATE472553T1/de

Links

BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 title abstract 6
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 title abstract 3
238000004090 dissolution Methods 0.000 title 1
238000011084 recovery Methods 0.000 title 1
150000003839 salts Chemical class 0.000 abstract 3
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229940098779 methanesulfonic acid Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Epoxy Compounds (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cephalosporin Compounds (AREA)

AT05775781T 2004-08-24 2005-08-23 Methansulfonatsalze von abirateron-3-estern und wiederherstellung von salzen von abirateron-3- estern durch auflösung in methyl-tert-butyl-ether ATE472553T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US60355904P	2004-08-24	2004-08-24
GBGB0418900.7A GB0418900D0 (en)	2004-08-24	2004-08-24	Novel salt forms
PCT/GB2005/003282 WO2006021776A1 (en)	2004-08-24	2005-08-23	Methanesulfonate salts of abiraterone-3-esters and recovery of salts of abirater one-3-esters from solution in methyl tert-butyl ether

Publications (1)

Publication Number	Publication Date
ATE472553T1 true ATE472553T1 (de)	2010-07-15

Family

ID=33104570

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05775781T ATE472553T1 (de)	2004-08-24	2005-08-23	Methansulfonatsalze von abirateron-3-estern und wiederherstellung von salzen von abirateron-3- estern durch auflösung in methyl-tert-butyl-ether

Country Status (21)

Country	Link
US (5)	US7700766B2 (de)
EP (1)	EP1789432B1 (de)
JP (1)	JP5069561B2 (de)
KR (2)	KR101358661B1 (de)
CN (2)	CN101044155B (de)
AT (1)	ATE472553T1 (de)
AU (1)	AU2005276298C1 (de)
BR (1)	BRPI0514543A (de)
CA (1)	CA2576922C (de)
CY (1)	CY1110800T1 (de)
DE (1)	DE602005022083D1 (de)
DK (1)	DK1789432T3 (de)
ES (1)	ES2345345T3 (de)
GB (1)	GB0418900D0 (de)
MX (1)	MX2007002032A (de)
NZ (1)	NZ553085A (de)
PL (1)	PL1789432T3 (de)
PT (1)	PT1789432E (de)
SI (1)	SI1789432T1 (de)
WO (1)	WO2006021776A1 (de)
ZA (1)	ZA200701533B (de)

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US20080051380A1 (en)	2006-08-25	2008-02-28	Auerbach Alan H	Methods and compositions for treating cancer
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WO2010149755A1 (en)	2009-06-26	2010-12-29	Novartis Ag	1, 3-disubstituted imidazolidin-2-one derivatives as inhibitors of cyp 17
JP2013537210A (ja)	2010-09-16	2013-09-30	ノバルティスアーゲー	１７α−ヒドロキシラーゼ／Ｃ１７，２０−リアーゼ阻害剤
CN102558274B (zh) *	2010-12-08	2014-10-15	深圳万乐药业有限公司	一种适合工业化生产醋酸阿比特龙的合成方法
CN102030798B (zh) *	2010-12-17	2012-10-17	深圳万乐药业有限公司	一种醋酸阿比特龙的纯化方法
US9029399B2 (en)	2011-04-28	2015-05-12	Novartis Ag	17α-hydroxylase/C17,20-lyase inhibitors
CN104066744B (zh)	2011-10-10	2017-03-22	扎克系统公司	用于制备17‑取代的甾体的方法
EP2607371A1 (de)	2011-12-23	2013-06-26	Crystal Pharma, S.A.U.	Verfahren zur Herstellung von Abirateron und verwandten Verbindungen
CN103172690B (zh) *	2011-12-23	2016-08-24	重庆医药工业研究院有限责任公司	醋酸阿比特龙及其中间体的制备方法
CN103193849B (zh) *	2012-01-04	2016-05-04	连云港润众制药有限公司	一种高纯度醋酸阿比特龙的制备方法
CN103254265B (zh) *	2012-02-21	2016-07-13	上海希迈医药科技有限公司	醋酸阿比特龙三氟乙酸盐及其制备方法和应用
CN103360458B (zh) *	2012-03-26	2015-05-20	信泰制药（苏州）有限公司	一种阿比特龙的合成方法
CN102731605B (zh) *	2012-06-19	2016-04-13	鲁南制药集团股份有限公司	一种醋酸阿比特龙的纯化方法
CN103665084A (zh) *	2012-09-04	2014-03-26	重庆安格龙翔医药科技有限公司	一种制备醋酸阿比特龙的方法
CN102816200B (zh) *	2012-09-05	2015-04-15	中山大学	一种醋酸阿比特龙的制备方法
CN102816201A (zh) *	2012-09-25	2012-12-12	成都伊诺达博医药科技有限公司	一种阿比特龙的纯化方法
WO2014058785A1 (en)	2012-10-10	2014-04-17	Novartis Ag	Combination therapy
ITMI20121788A1 (it)	2012-10-22	2014-04-23	Olon Spa	Procedimento per la purificazione di abiraterone acetato
WO2014071983A1 (en)	2012-11-09	2014-05-15	Synthon Bv	Process for making the 17-triflate intermediate of abiraterone-3-acetate
EP2917225A1 (de)	2012-11-09	2015-09-16	Synthon BV	Verfahren zur herstellung von abirateron-3-acetat
TWI570131B (zh) *	2012-11-13	2017-02-11	賽克系統公司	製備１７－經取代類固醇之方法
WO2014075978A1 (en)	2012-11-16	2014-05-22	Synthon B.V.	Process for the production of abiraterone-3-acetate involving an enol trliflation reaction in the presence of an alkoxy-pyridine compound
CN103059091B (zh) *	2012-11-22	2017-04-19	常州靶点医药科技有限公司	一种避免重金属残留的醋酸阿比特龙的制备方法
WO2014121033A1 (en)	2013-02-04	2014-08-07	Fl Therapeutics Llc	Soluble complexes of drug analogs and albumin
PL2792682T3 (pl)	2013-04-19	2017-04-28	Zach System	Sposób wytwarzania stałej postaci octanu abirateronu
CN103242410B (zh) *	2013-05-09	2015-08-26	苏州明锐医药科技有限公司	醋酸阿比特龙的制备方法
US20160176915A1 (en) *	2013-06-24	2016-06-23	Sun Pharmaceutical Industries Limited	Process for preparation of abiraterone acetate
CA2914305A1 (en) *	2013-06-28	2014-12-31	Scinopharm Taiwan, Ltd.	Process for the preparation of abiraterone and intermediates thereof
CZ306623B6 (cs) *	2013-07-04	2017-04-05	Zentiva, K.S.	Soli abirateronu acetátu
WO2015086596A1 (en)	2013-12-12	2015-06-18	Basf Se	Solid form of abiraterone acetate
WO2015114518A2 (en)	2014-01-28	2015-08-06	Olon S.P.A.	Procedure for the preparation of abiraterone acetate and intermediates thereof
CN103965282B (zh)	2014-04-21	2016-01-20	武汉百科药物开发有限公司	一种醋酸阿比特龙的制备方法
US9315541B2 (en) *	2014-05-20	2016-04-19	Olon S.P.A.	Process for the preparation of unsaturated trifluoromethanesulfonate steroid derivatives
CN105294806A (zh) *	2014-06-13	2016-02-03	江苏希迪制药有限公司	一种制备醋酸阿比特龙中间体的方法
US9937259B2 (en)	2014-06-27	2018-04-10	Zhuhai Beihai Biotech Co., Ltd.	Abiraterone derivatives and non-covalent complexes with albumin
WO2016065139A1 (en)	2014-10-24	2016-04-28	Fl Therapeutics Llc	3-substituted piperidine-2, 6-diones and non-covalent complexes with albumin
CN104447934B (zh) *	2014-12-08	2017-03-15	深圳科兴生物工程有限公司	一种醋酸阿比特龙的纯化方法
US10722527B2 (en)	2015-04-10	2020-07-28	Capsugel Belgium Nv	Abiraterone acetate lipid formulations
UA124972C2 (uk)	2016-07-29	2021-12-22	Янссен Фармацевтика Нв	Способи лікування раку передміхурової залози
US10717762B2 (en)	2016-10-11	2020-07-21	Zhuhai Beihai Biotech Co., Ltd.	Abiraterone derivative and formulations thereof
CN108586561B (zh) *	2018-04-03	2020-08-04	科兴生物制药股份有限公司	一种制备醋酸阿比特龙的方法
US10792292B2 (en)	2019-03-06	2020-10-06	Propella Therapeutics, Inc.	Abiraterone prodrugs
CN112812147A (zh) *	2019-11-15	2021-05-18	江苏佳尔科药业集团股份有限公司	一种醋酸阿比特龙的合成方法及其中间体
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CA2132449C (en) *	1992-03-31	2002-09-10	Susan E. Barrie	17 - substituted steroids useful in cancer treatment
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GB0418900D0 (en) *	2004-08-24	2004-09-29	Btg Int Ltd	Novel salt forms

2004
- 2004-08-24 GB GBGB0418900.7A patent/GB0418900D0/en not_active Ceased
2005
- 2005-08-23 KR KR1020127031465A patent/KR101358661B1/ko not_active Expired - Lifetime
- 2005-08-23 BR BRPI0514543-0A patent/BRPI0514543A/pt not_active Application Discontinuation
- 2005-08-23 SI SI200531092T patent/SI1789432T1/sl unknown
- 2005-08-23 JP JP2007528970A patent/JP5069561B2/ja not_active Expired - Lifetime
- 2005-08-23 DE DE602005022083T patent/DE602005022083D1/de not_active Expired - Lifetime
- 2005-08-23 CA CA2576922A patent/CA2576922C/en not_active Expired - Lifetime
- 2005-08-23 CN CN2005800360449A patent/CN101044155B/zh not_active Expired - Lifetime
- 2005-08-23 KR KR1020077004205A patent/KR101245727B1/ko not_active Expired - Lifetime
- 2005-08-23 DK DK05775781.7T patent/DK1789432T3/da active
- 2005-08-23 ZA ZA200701533A patent/ZA200701533B/xx unknown
- 2005-08-23 NZ NZ553085A patent/NZ553085A/en not_active IP Right Cessation
- 2005-08-23 PL PL05775781T patent/PL1789432T3/pl unknown
- 2005-08-23 ES ES05775781T patent/ES2345345T3/es not_active Expired - Lifetime
- 2005-08-23 AU AU2005276298A patent/AU2005276298C1/en not_active Expired
- 2005-08-23 AT AT05775781T patent/ATE472553T1/de active
- 2005-08-23 WO PCT/GB2005/003282 patent/WO2006021776A1/en not_active Ceased
- 2005-08-23 MX MX2007002032A patent/MX2007002032A/es active IP Right Grant
- 2005-08-23 EP EP05775781A patent/EP1789432B1/de not_active Expired - Lifetime
- 2005-08-23 CN CN201210299567.4A patent/CN102863498B/zh not_active Expired - Lifetime
- 2005-08-23 US US11/660,869 patent/US7700766B2/en active Active
- 2005-08-23 PT PT05775781T patent/PT1789432E/pt unknown
2010
- 2010-02-04 US US12/656,581 patent/US8076474B2/en not_active Expired - Lifetime
- 2010-09-27 CY CY20101100867T patent/CY1110800T1/el unknown
2011
- 2011-11-02 US US13/317,997 patent/US8338588B2/en not_active Expired - Lifetime
2012
- 2012-11-26 US US13/685,004 patent/US20130090468A1/en not_active Abandoned
2015
- 2015-07-23 US US14/807,086 patent/US20150329585A1/en not_active Abandoned

Also Published As

Publication number	Publication date
GB0418900D0 (en)	2004-09-29
CA2576922A1 (en)	2006-03-02
CN102863498A (zh)	2013-01-09
EP1789432B1 (de)	2010-06-30
EP1789432A1 (de)	2007-05-30
US20120053340A1 (en)	2012-03-01
AU2005276298A1 (en)	2006-03-02
US20130090468A1 (en)	2013-04-11
PT1789432E (pt)	2010-08-09
BRPI0514543A (pt)	2008-06-17
NZ553085A (en)	2010-08-27
DK1789432T3 (da)	2010-08-16
HK1180694A1 (en)	2013-10-25
DE602005022083D1 (de)	2010-08-12
CN101044155A (zh)	2007-09-26
ZA200701533B (en)	2008-08-27
AU2005276298C1 (en)	2012-02-02
US7700766B2 (en)	2010-04-20
HK1103091A1 (en)	2007-12-14
AU2005276298B2 (en)	2011-06-23
MX2007002032A (es)	2007-10-11
SI1789432T1 (sl)	2010-10-29
PL1789432T3 (pl)	2010-11-30
JP2008510780A (ja)	2008-04-10
CY1110800T1 (el)	2015-06-10
ES2345345T3 (es)	2010-09-21
CA2576922C (en)	2013-05-07
US8338588B2 (en)	2012-12-25
WO2006021776A1 (en)	2006-03-02
KR20120135931A (ko)	2012-12-17
KR101358661B1 (ko)	2014-02-07
KR20070049171A (ko)	2007-05-10
CN101044155B (zh)	2012-10-10
US20070249836A1 (en)	2007-10-25
KR101245727B1 (ko)	2013-03-25
JP5069561B2 (ja)	2012-11-07
US8076474B2 (en)	2011-12-13
US20100152437A1 (en)	2010-06-17
US20150329585A1 (en)	2015-11-19
CN102863498B (zh)	2015-04-08

Publication	Publication Date	Title
ATE472553T1 (de)	2010-07-15	Methansulfonatsalze von abirateron-3-estern und wiederherstellung von salzen von abirateron-3- estern durch auflösung in methyl-tert-butyl-ether
ES2531190T3 (es)	2015-03-11	Método para producir un compuesto de 4-oxoquinolina
EA200900676A1 (ru)	2010-02-26	Ингибиторы вируса гепатита с
NO20091871L (no)	2009-07-31	Hepatitt C virus inhibitorer
EA201200826A1 (ru)	2013-01-30	Инсектицидные соединения, основанные на производных изоксазолина
DK2057126T3 (da)	2011-02-28	Fremgangsmåde til fremstilling af 3-dihalomethyl-pyrazol-4-carboxylsyrederivater
EA200500239A1 (ru)	2005-12-29	Новый способ синтеза (1s)-4-,5-диметокси-1-(метиламинометил)-бензоциклобутана и его солей присоединения и применение при синтезе ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой
DK2203430T3 (da)	2011-09-26	N-phenyl-dioxo-hydropyrimidiner anvendelige som inhibitorer for hepatitis C virus (HCV)
EA200800670A1 (ru)	2009-12-30	Ингибиторы сериновых протеаз
DK1781683T3 (da)	2012-02-06	Fremgangsmåde til fremstilling af 17-vinyl-triflater som halvfabrikata
EA200970805A1 (ru)	2010-02-26	Ингибиторы серинпротеаз для лечения hcv инфекций
NO20091846L (no)	2009-06-08	Makrocykliske peptider som hepatitt C virus- inhibitorer
NZ594671A (en)	2013-05-31	Compositions and methods for inhibiting the agglomeration of hydrates in a process
EA201171329A1 (ru)	2012-05-30	Твердый препарат
BR112013032049A2 (pt)	2016-09-13	inibidores do vírus da hepatite c
EP2196460A4 (de)	2011-11-23	Sulfonsäuresalzverbindung eines 4-carbamoyl-5-hydroxyimidazolderivats
EA200900780A1 (ru)	2010-08-30	Аналоги эпотилона, модифицированные в положениях c12-c13, как противораковые лекарственные средства
UY29857A1 (es)	2007-05-31	Derivados de la 4-amino-quinazolina, su preparación y su aplicación en terapéutica.
DK1735309T3 (da)	2010-04-06	Forbedret fremgangsmåde til fremstilling af N-([1,2,4]triazolopyrimidin-2-yl)arylsulfonamider
EA201170273A1 (ru)	2011-08-30	Твердая фармацевтическая композиция
TW200504052A (en)	2005-02-01	Method for preparing acid addition salts of polyacidic basic compounds
NO20090332L (no)	2009-03-12	4-amino-3-arylamino-6-arylpyrazol[3,4-D]pyrimidinderivater, fremgangsmater for deres fremstilling og dere anvendelse som antivirale midler
AR079299A1 (es)	2012-01-18	Mejora de los procesos para la preparacion de granulos solubles de las sales de los acidos carboxilicos que contienen piridina
NZ587591A (en)	2012-10-26	Diarylthiazole derivatives such as tetomilast as mmp-2 and/or mmp-9 inhibitors
ECSP088170A (es)	2008-03-26	Derivados de 5-piridinil-1-azabiciclo[3.2.1]octano, su preparación y su aplicación en terapéutica