PL179558B1 - oraz kompozycja farmaceutyczna zawierajaca te zwiazki PL PL PL PL PL PL - Google Patents

oraz kompozycja farmaceutyczna zawierajaca te zwiazki PL PL PL PL PL PL

Info

Publication number
PL179558B1
PL179558B1 PL94302626A PL30262694A PL179558B1 PL 179558 B1 PL179558 B1 PL 179558B1 PL 94302626 A PL94302626 A PL 94302626A PL 30262694 A PL30262694 A PL 30262694A PL 179558 B1 PL179558 B1 PL 179558B1
Authority
PL
Poland
Prior art keywords
amino
methyl
formula
thio
oxo
Prior art date
Application number
PL94302626A
Other languages
English (en)
Polish (pl)
Inventor
Yang-I Lin
Panayota Bitha
Subas Sakya
Timothy W Strohmeyer
Karen Bush
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of PL179558B1 publication Critical patent/PL179558B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65611—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL94302626A 1993-03-16 1994-03-15 oraz kompozycja farmaceutyczna zawierajaca te zwiazki PL PL PL PL PL PL PL179558B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3368493A 1993-03-16 1993-03-16

Publications (1)

Publication Number Publication Date
PL179558B1 true PL179558B1 (pl) 2000-09-29

Family

ID=21871845

Family Applications (1)

Application Number Title Priority Date Filing Date
PL94302626A PL179558B1 (pl) 1993-03-16 1994-03-15 oraz kompozycja farmaceutyczna zawierajaca te zwiazki PL PL PL PL PL PL

Country Status (19)

Country Link
US (4) US5602118A (fr)
EP (1) EP0617036A3 (fr)
JP (1) JPH06321948A (fr)
KR (1) KR100353751B1 (fr)
CN (3) CN1041633C (fr)
AU (1) AU676877B2 (fr)
CA (1) CA2118961A1 (fr)
CZ (1) CZ290494B6 (fr)
FI (1) FI106718B (fr)
HU (2) HUT67741A (fr)
IL (1) IL108939A0 (fr)
NO (1) NO311939B1 (fr)
NZ (1) NZ260102A (fr)
PL (1) PL179558B1 (fr)
RU (1) RU2130457C1 (fr)
SG (2) SG77541A1 (fr)
SK (1) SK31694A3 (fr)
TW (1) TW474937B (fr)
ZA (1) ZA941828B (fr)

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DE69942571D1 (de) * 1998-04-23 2010-08-26 Dentsply Detrey Gmbh Lagerungsbeständige polymerisierbare Zusammensetzung
EP1101497B1 (fr) * 1998-08-04 2008-02-20 Takeda Schering-Plough Animal Health K.K. Preparations huileuses stabilisees comprenant de la tobicillin (antibiotique beta-lactame )
US6162924A (en) * 1999-04-09 2000-12-19 Eastman Chemical Company Process for halohydrin preparation
US6747061B2 (en) * 2000-03-21 2004-06-08 Atherogenics, Inc. N-substituted dithiocarbamates for the treatment of biological disorders
US6649756B2 (en) * 2000-07-13 2003-11-18 Wyeth, Five Giralda Farms Process improvement in the preparation of (4r, 5s, 6s)-3-[[(2r,3r)-2-[[[(s)-2-amino-3-methyl-1-oxobutyl]amino]methyl]tetrahydro-3-furanyl]thio]-6-[(r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
US20020049315A1 (en) * 2000-09-06 2002-04-25 Williams John M. Crystalline forms of carbapenem intermediates
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) * 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) * 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en) * 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US20050152887A1 (en) * 2004-01-14 2005-07-14 Doctor's Signature Sales And Marketing International Corp. [Dba Life Force International Protonic formulation
KR100621782B1 (ko) * 2004-06-14 2006-09-19 한국과학기술연구원 1-베타메틸카바페넴 유도체 및 이의 제조방법
EP1941873A4 (fr) * 2005-09-22 2012-09-26 Meiji Seika Kaisha Inhibiteur de la métallo-pénicillinase
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
US8093378B2 (en) * 2006-04-28 2012-01-10 Kaneka Corporation Crystallization method for intermediates of carbapenem antibiotics
EP2049510A1 (fr) * 2006-07-28 2009-04-22 Krka Tovarna Zdravil, D.D., Novo Mesto Procédé de préparation de la forme i du candésartan cilexétil
WO2009114921A1 (fr) * 2008-03-17 2009-09-24 Dmitrienko Gary I INHIBITEURS DE β-LACTAMASES DE CLASSE B ET DE CLASSE D
US20110118462A1 (en) * 2009-11-18 2011-05-19 Guangzhou Baiyunshan Pharmaceutical Co., Ltd. Guangzhou Baiyunshan Pharmaceutical Factory N-heterocyclic substituent-containing antibiotic, preparation and use thereof
US10093660B2 (en) 2013-12-04 2018-10-09 Evotec Internatonal Gmbh Sulfoximine substituted quinazolines for pharmaceutical compositions
DE102015011861B4 (de) 2015-09-10 2018-03-01 Rudolf Schindler Neue cyclische Carboxamide als NMDA NR2B Rezeptor Inhibitoren
WO2017158616A1 (fr) 2016-03-16 2017-09-21 Orchid Pharma Ltd. Composés de carbapénème

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US2656362A (en) * 1951-07-05 1953-10-20 Allied Lab Inc Preparation of 2-halogenated tetrahydrothiophene 1, 1-dioxides
GB1441177A (en) * 1973-12-13 1976-06-30 Beheer Bv Pfw Sulphur-containing flavouring agents
CS176325B1 (fr) * 1975-01-31 1977-06-30
US4347368A (en) * 1977-10-19 1982-08-31 Merck & Co., Inc. 3-Substituted-6-substituted-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
IE51861B1 (en) * 1978-10-24 1987-04-15 Merck & Co Inc 6-,1-and 2-substituted-1-carbapen-2-em-3-carboxylic acids,processes for the preparation of such compounds and pharmaceutical compositions comprising such compounds
US4232036A (en) * 1978-10-24 1980-11-04 Merck & Co., Inc. 6-, 1- and 2-Substituted-1-carbadethiapen-2-em-3-carboxylic acids
US4260627A (en) * 1978-10-24 1981-04-07 Merck & Co., Inc. 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids
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Also Published As

Publication number Publication date
FI941215A0 (fi) 1994-03-15
CN1223261A (zh) 1999-07-21
JPH06321948A (ja) 1994-11-22
CZ290494B6 (cs) 2002-08-14
IL108939A0 (en) 1994-06-24
CZ58694A3 (en) 1995-10-18
AU5783194A (en) 1994-09-22
US5744465A (en) 1998-04-28
AU676877B2 (en) 1997-03-27
NO311939B1 (no) 2002-02-18
HUT67741A (en) 1995-04-28
RU2130457C1 (ru) 1999-05-20
FI941215L (fi) 1994-09-17
HU211883A9 (en) 1995-12-28
ZA941828B (en) 1994-10-18
EP0617036A3 (fr) 1998-01-14
EP0617036A2 (fr) 1994-09-28
NO940928L (no) 1994-09-19
KR940021555A (ko) 1994-10-19
SK31694A3 (en) 1994-10-05
US5602118A (en) 1997-02-11
CN1136208C (zh) 2004-01-28
NZ260102A (en) 1996-05-28
US5750735A (en) 1998-05-12
FI106718B (fi) 2001-03-30
KR100353751B1 (ko) 2003-02-25
CN1104214A (zh) 1995-06-28
CN1041633C (zh) 1999-01-13
SG91908A1 (en) 2002-10-15
TW474937B (en) 2002-02-01
CA2118961A1 (fr) 1994-09-17
US5623081A (en) 1997-04-22
SG77541A1 (en) 2001-01-16
HU9400724D0 (en) 1994-06-28
NO940928D0 (no) 1994-03-15
CN1482122A (zh) 2004-03-17

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