NO311939B1 - Nye 2-tiosubstituerte karbapenemer, anvendelse derav og farmasöytisk blanding - Google Patents

Nye 2-tiosubstituerte karbapenemer, anvendelse derav og farmasöytisk blanding Download PDF

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Publication number
NO311939B1
NO311939B1 NO19940928A NO940928A NO311939B1 NO 311939 B1 NO311939 B1 NO 311939B1 NO 19940928 A NO19940928 A NO 19940928A NO 940928 A NO940928 A NO 940928A NO 311939 B1 NO311939 B1 NO 311939B1
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NO
Norway
Prior art keywords
methyl
amino
oxo
thio
azabicyclo
Prior art date
Application number
NO19940928A
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English (en)
Norwegian (no)
Other versions
NO940928L (no
NO940928D0 (no
Inventor
Yang-I Lin
Panayota Bitha
Subas Sakya
Timothy W Strohmeyer
Karen Bush
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of NO940928D0 publication Critical patent/NO940928D0/no
Publication of NO940928L publication Critical patent/NO940928L/no
Publication of NO311939B1 publication Critical patent/NO311939B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65611—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO19940928A 1993-03-16 1994-03-15 Nye 2-tiosubstituerte karbapenemer, anvendelse derav og farmasöytisk blanding NO311939B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3368493A 1993-03-16 1993-03-16

Publications (3)

Publication Number Publication Date
NO940928D0 NO940928D0 (no) 1994-03-15
NO940928L NO940928L (no) 1994-09-19
NO311939B1 true NO311939B1 (no) 2002-02-18

Family

ID=21871845

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19940928A NO311939B1 (no) 1993-03-16 1994-03-15 Nye 2-tiosubstituerte karbapenemer, anvendelse derav og farmasöytisk blanding

Country Status (19)

Country Link
US (4) US5602118A (fr)
EP (1) EP0617036A3 (fr)
JP (1) JPH06321948A (fr)
KR (1) KR100353751B1 (fr)
CN (3) CN1482122A (fr)
AU (1) AU676877B2 (fr)
CA (1) CA2118961A1 (fr)
CZ (1) CZ290494B6 (fr)
FI (1) FI106718B (fr)
HU (2) HUT67741A (fr)
IL (1) IL108939A0 (fr)
NO (1) NO311939B1 (fr)
NZ (1) NZ260102A (fr)
PL (1) PL179558B1 (fr)
RU (1) RU2130457C1 (fr)
SG (2) SG91908A1 (fr)
SK (1) SK31694A3 (fr)
TW (1) TW474937B (fr)
ZA (1) ZA941828B (fr)

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DE69942571D1 (de) * 1998-04-23 2010-08-26 Dentsply Detrey Gmbh Lagerungsbeständige polymerisierbare Zusammensetzung
JP3531648B2 (ja) * 1998-08-04 2004-05-31 武田シェリング・プラウ アニマルヘルス株式会社 β−ラクタム抗生物質の安定化製剤
US6162924A (en) 1999-04-09 2000-12-19 Eastman Chemical Company Process for halohydrin preparation
AU2001247649A1 (en) * 2000-03-21 2001-10-30 Atherogenics, Inc N-substituted dithiocarbamates for the treatment of biological disorders
US6649756B2 (en) 2000-07-13 2003-11-18 Wyeth, Five Giralda Farms Process improvement in the preparation of (4r, 5s, 6s)-3-[[(2r,3r)-2-[[[(s)-2-amino-3-methyl-1-oxobutyl]amino]methyl]tetrahydro-3-furanyl]thio]-6-[(r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
US20020049315A1 (en) * 2000-09-06 2002-04-25 Williams John M. Crystalline forms of carbapenem intermediates
US6818787B2 (en) * 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en) * 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) * 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US20050152887A1 (en) * 2004-01-14 2005-07-14 Doctor's Signature Sales And Marketing International Corp. [Dba Life Force International Protonic formulation
KR100621782B1 (ko) * 2004-06-14 2006-09-19 한국과학기술연구원 1-베타메틸카바페넴 유도체 및 이의 제조방법
KR101713472B1 (ko) * 2005-09-22 2017-03-07 메이지 세이카 파루마 가부시키가이샤 메탈로-β-락타마제 저해제
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
CN101432289B (zh) * 2006-04-28 2013-07-10 株式会社钟化 碳青霉素烯抗生素中间体的改良结晶析出方法
EP2066649A1 (fr) * 2006-07-28 2009-06-10 KRKA, tovarna zdravil, d.d., Novo mesto Procédé de préparation de formes amorphes et cristallines de candésartan cilexétil par chromatographie sur colonne
US20110046101A1 (en) * 2008-03-17 2011-02-24 Dmitrienko Gary I Bate-lactamase inhibitors
US20110118462A1 (en) * 2009-11-18 2011-05-19 Guangzhou Baiyunshan Pharmaceutical Co., Ltd. Guangzhou Baiyunshan Pharmaceutical Factory N-heterocyclic substituent-containing antibiotic, preparation and use thereof
CA2929742C (fr) 2013-12-04 2022-09-20 Evotec International Gmbh Quinazolines substituees par une sulfoximine destinees a des compositions pharmaceutiques
DE102015011861B4 (de) 2015-09-10 2018-03-01 Rudolf Schindler Neue cyclische Carboxamide als NMDA NR2B Rezeptor Inhibitoren
WO2017158616A1 (fr) 2016-03-16 2017-09-21 Orchid Pharma Ltd. Composés de carbapénème

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Also Published As

Publication number Publication date
US5602118A (en) 1997-02-11
EP0617036A2 (fr) 1994-09-28
AU676877B2 (en) 1997-03-27
ZA941828B (en) 1994-10-18
HUT67741A (en) 1995-04-28
CN1223261A (zh) 1999-07-21
SG77541A1 (en) 2001-01-16
US5744465A (en) 1998-04-28
FI941215L (fi) 1994-09-17
US5750735A (en) 1998-05-12
TW474937B (en) 2002-02-01
KR100353751B1 (ko) 2003-02-25
CN1482122A (zh) 2004-03-17
NO940928L (no) 1994-09-19
US5623081A (en) 1997-04-22
EP0617036A3 (fr) 1998-01-14
SG91908A1 (en) 2002-10-15
PL179558B1 (pl) 2000-09-29
RU2130457C1 (ru) 1999-05-20
CN1136208C (zh) 2004-01-28
SK31694A3 (en) 1994-10-05
FI106718B (fi) 2001-03-30
CA2118961A1 (fr) 1994-09-17
KR940021555A (ko) 1994-10-19
CZ290494B6 (cs) 2002-08-14
CZ58694A3 (en) 1995-10-18
HU211883A9 (en) 1995-12-28
CN1104214A (zh) 1995-06-28
CN1041633C (zh) 1999-01-13
HU9400724D0 (en) 1994-06-28
IL108939A0 (en) 1994-06-24
JPH06321948A (ja) 1994-11-22
FI941215A0 (fi) 1994-03-15
NZ260102A (en) 1996-05-28
NO940928D0 (no) 1994-03-15
AU5783194A (en) 1994-09-22

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