PL1799662T3 - Sposoby syntezy chemicznej i oczyszczania związków diaminofenotiazynowych, w tym chlorku metylotioniny (MTC) - Google Patents

Sposoby syntezy chemicznej i oczyszczania związków diaminofenotiazynowych, w tym chlorku metylotioniny (MTC)

Info

Publication number: PL1799662T3
Authority: PL; Poland
Prior art keywords: mtc; purification; methods; chemical synthesis; compounds including
Prior art date: 2004-09-23

Application number

PL05783989T

Other languages

English (en)

Inventor

John Mervyn David Storey

James Peter Sinclair

Colin Marshall

Han Wan Tan

Claude Michel Wischik

Original Assignee

Wista Lab Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-09-23

Filing date

2005-09-21

Publication date

2013-09-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35241172&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL1799662(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-09-23 Priority claimed from GBGB0421234.6A external-priority patent/GB0421234D0/en

2005-02-17 Priority claimed from GB0503343A external-priority patent/GB0503343D0/en

2005-09-21 Application filed by Wista Lab Ltd filed Critical Wista Lab Ltd

2013-09-30 Publication of PL1799662T3 publication Critical patent/PL1799662T3/pl

Links

KPYHKEZPEDJERZ-UHFFFAOYSA-N 10h-phenothiazine-1,2-diamine Chemical class C1=CC=C2NC3=C(N)C(N)=CC=C3SC2=C1 KPYHKEZPEDJERZ-UHFFFAOYSA-N 0.000 title 1
RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 title 1
238000000034 method Methods 0.000 title 1
229960000907 methylthioninium chloride Drugs 0.000 title 1
238000000746 purification Methods 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B19/00—Oxazine dyes
- C09B19/02—Bisoxazines prepared from aminoquinones
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Oncology (AREA)
Virology (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Immunology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Physics & Mathematics (AREA)
Tropical Medicine & Parasitology (AREA)
Biotechnology (AREA)
General Physics & Mathematics (AREA)
Cell Biology (AREA)
Microbiology (AREA)
Optics & Photonics (AREA)
Food Science & Technology (AREA)
Biodiversity & Conservation Biology (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
Dermatology (AREA)
Pathology (AREA)
Hospice & Palliative Care (AREA)

PL05783989T 2004-09-23 2005-09-21 Sposoby syntezy chemicznej i oczyszczania związków diaminofenotiazynowych, w tym chlorku metylotioniny (MTC) PL1799662T3 (pl)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
GBGB0421234.6A GB0421234D0 (en)	2004-09-23	2004-09-23	Methods of chemical synthesis
GB0503343A GB0503343D0 (en)	2005-02-17	2005-02-17	Methods of chemical synthesis
GB2005003441		2005-09-07
PCT/GB2005/003634 WO2006032879A2 (en)	2004-09-23	2005-09-21	Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (mtc)
EP05783989.6A EP1799662B1 (en)	2004-09-23	2005-09-21	Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (mtc)

Publications (1)

Publication Number	Publication Date
PL1799662T3 true PL1799662T3 (pl)	2013-09-30

Family

ID=35241172

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL05783989T PL1799662T3 (pl)	2004-09-23	2005-09-21	Sposoby syntezy chemicznej i oczyszczania związków diaminofenotiazynowych, w tym chlorku metylotioniny (MTC)
PL10010049T PL2322517T3 (pl)	2004-09-23	2005-09-21	Sposoby syntezy chemicznej i oczyszczania związków diaminofenotiazyniowych, w tym chlorku metylotioniny (MTC)

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PL10010049T PL2322517T3 (pl)	2004-09-23	2005-09-21	Sposoby syntezy chemicznej i oczyszczania związków diaminofenotiazyniowych, w tym chlorku metylotioniny (MTC)

Country Status (15)

Country	Link
US (5)	US9242946B2 (pl)
EP (3)	EP2322517B1 (pl)
JP (1)	JP2012184244A (pl)
CN (1)	CN103012315A (pl)
AU (1)	AU2005286235C1 (pl)
CA (1)	CA2579169C (pl)
DK (2)	DK1799662T3 (pl)
ES (2)	ES2736160T3 (pl)
HR (1)	HRP20191100T1 (pl)
HU (1)	HUE044355T2 (pl)
PL (2)	PL1799662T3 (pl)
PT (2)	PT2322517T (pl)
SI (2)	SI2322517T1 (pl)
TR (1)	TR201910292T4 (pl)
WO (1)	WO2006032879A2 (pl)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9506197D0 (en)	1995-03-27	1995-05-17	Hoffmann La Roche	Inhibition of tau-tau association.
GB0100119D0 (en)	2001-01-03	2001-02-14	Univ Aberdeen	Materials and methods relating to protein aggregation in neurodegenerative disease
GB0101049D0 (en)	2001-01-15	2001-02-28	Univ Aberdeen	Materials and methods relating to protein aggregation in neurodegenerative disease
GB0106953D0 (en)	2001-03-20	2001-05-09	Univ Aberdeen	Neufofibrillary labels
GB0117326D0 (en)	2001-07-16	2001-09-05	Univ Aberdeen	Napthoquinone-type inhibitors of protein aggregation
CN101084204B (zh)	2004-09-23	2012-12-05	卫思道制药有限公司	包括亚甲蓝(mtc)在内的二氨基吩噻嗪鎓化合物的化学合成和纯化方法
SI2322517T1 (sl) *	2004-09-23	2019-06-28	Wista Laboratories Ltd.	Postopki za kemijsko sintezo in čiščenje diaminofenotiazinijevih spojin, vključno metiltioninijevega klorida (MTC)
WO2006127482A1 (en) *	2005-05-20	2006-11-30	Bioenvision, Inc.	Methylene blue therapy of viral disease
ES2349322T7 (es)	2006-03-29	2019-10-17	Wista Lab Ltd	Sales de 3,7-diamino-10H-fenotiazina y su utilización
SI2004155T1 (en)	2006-03-29	2018-05-31	Wista Laboratories Ltd.	Inhibitors of protein aggregation
WO2007110630A1 (en)	2006-03-29	2007-10-04	Wista Laboratories Ltd.	Thioninium compounds and their use
AU2013200264B2 (en) *	2006-07-11	2014-11-13	TauRx Therapeutics Management Ltd	Methods of synthesis and/or purification of diaminophenothiazinium compounds
MY148145A (en)	2006-07-11	2013-03-15	Wista Lab Ltd	Methods of synthesis and/or purification of diaminophenothiazinium compounds
FR2903696B1 (fr)	2006-07-12	2011-02-11	Provence Technologies	Procede de purification de composes diaminophenothiazium
CN100436431C (zh) *	2006-12-15	2008-11-26	贵州同济堂制药有限公司	药用亚甲蓝的合成方法
US8227459B2 (en)	2007-04-03	2012-07-24	Prosetta Antiviral Inc.	Diamino-phenothiazinyl derivatives as antiviral treatments
AU2008265045B2 (en) *	2007-06-19	2014-02-27	Taurx Therapeutics Management Ltd.	Phenothiazine compounds for treating Mild Cognitive Impairment
CN103319434A (zh) *	2007-09-10	2013-09-25	中国医学科学院药物研究所	3-氨基-7-二烷基胺基取代吩噻嗪类化合物的制备方法
SI2430007T1 (sl)	2009-05-12	2014-05-30	Wista Laboratories Ltd.	Postopki kemijske sinteze diaminofenotiazinijevih spojin, ki vključujejo uporabo persulfatnih oksidantov
JP5918136B2 (ja) *	2009-09-24	2016-05-18	ウィスタラボラトリーズリミテッド	プロセス
MX355627B (es)	2009-09-24	2018-04-25	Wista Lab Ltd	Clorhidratos de metiltioninio (azul de metileno) cristalinos.
JP5868955B2 (ja)	2010-04-30	2016-02-24	プロセッタアンチバイラルインコーポレイテッド	抗ウイルス化合物
JP6093707B2 (ja)	2010-11-30	2017-03-08	ウィスタラボラトリーズリミテッド	化合物製剤
JP5898701B2 (ja)	2011-02-11	2016-04-13	ウィスタラボラトリーズリミテッド	フェノチアジンジアミニウム塩およびそれらの使用
WO2012125983A1 (en)	2011-03-17	2012-09-20	Prosetta Antiviral Inc.	Antiviral treatments
EP2699241B1 (en)	2011-04-20	2016-07-27	Prosetta Antiviral Inc.	Antiviral compounds
US20120301904A1 (en)	2011-04-26	2012-11-29	Prosetta Antiviral, Inc	Multiprotein assemblies
JP5924187B2 (ja)	2012-08-23	2016-05-25	スズキ株式会社	車載用バッテリパックの冷却装置
AU2013341383B2 (en)	2012-11-12	2017-08-24	The Roger B. And Ann K. Mcnamee Trust U/T/A/D	Systems and methods for communicating a live event to users using the internet
US10160735B2 (en)	2013-08-15	2018-12-25	Eupharma Pty Ltd	Process for the purification of diaminophenothiazinium compounds
CN105612148B (zh)	2013-08-15	2018-09-14	益友制药私人有限公司	用于纯化二氨基吩噻嗪化合物的方法
GB201317702D0 (en) *	2013-10-07	2013-11-20	Wista Lab Ltd	Methods of chemical synthesis of diaminophenothiazinium compounds including methylthioninium chloride (MTC)
CN103923037B (zh) *	2014-04-24	2015-06-03	山东理工大学	一种利用磷酸钙降低亚甲基蓝溶液中铜离子的方法
CN104586853A (zh) *	2014-12-31	2015-05-06	武汉联程生物科技有限公司	一种用于治疗外伤性颅脑创伤的药物组合物及其制备方法
CN105130926B (zh) *	2015-07-31	2018-02-13	江苏恒润制药有限公司	一种亚甲基蓝的制备方法
EP3397623A1 (en)	2015-12-28	2018-11-07	John V. Frangioni	Method of preparing diaminophenothiazinium
ITUA20163526A1 (it)	2016-05-17	2017-11-17	Icrom Spa	Procedimento per la preparazione di composti diamminofenotiazinici ad elevato grado di purezza
JP7073330B2 (ja)	2016-07-25	2022-05-23	ウィスタラボラトリーズリミテッド	ジアミノフェノチアジンの投与及び投与量
GB201614834D0 (en)	2016-09-01	2016-10-19	Wista Lab Ltd	Treatment of dementia
GB201621817D0 (en)	2016-12-21	2017-02-01	Wista Lab Ltd	Methods of chemical synthesis
FR3063495B1 (fr)	2017-03-02	2019-04-05	Provepharm Life Solutions	Procede de preparation de l’iodure de 3,7-bis(dimethylamino)phenothiazine-5-ylium
CN108658895B (zh) *	2018-04-24	2020-06-19	上海沃凯生物技术有限公司	一种亚甲蓝的提纯方法
FI4385512T3 (fi)	2018-07-26	2026-01-12	Taurx Therapeutics Man Ltd	Diaminofenotiatsiinien optimoitu annostus populaatioille
EP3982974A4 (en) *	2019-06-12	2023-06-21	Achal Narendrakumar Agrawal	NOVEL IMPROVED PROCESS FOR THE SYNTHESIS OF DIAMINOPHENOTHIAZINE COMPOUNDS
US12215234B2 (en)	2019-09-21	2025-02-04	RK Pharma Solutions LLC	Process for the purification of methylene blue
WO2021171235A1 (en)	2020-02-28	2021-09-02	Dishman Carbogen Amcis Ltd	A process for the preparation of methylene blue
AU2023279800A1 (en)	2022-05-31	2024-12-19	TauRx Therapeutics Management Ltd	Treatment of neurodegenerative disorders utilising methylthioninium (mt)-containing compounds
CN114989113A (zh) *	2022-06-01	2022-09-02	山东科源制药股份有限公司	一种药用亚甲基蓝的精制方法
EP4590306A1 (en)	2022-09-21	2025-07-30	Yin Sze Loh	Oral formulation of diaminophenothiazines and methods of making and using the same in the treatment and/or prevention of diseases
EP4342451A1 (en)	2022-09-22	2024-03-27	Galenicum Health SLU	Pharmaceutical compositions and manufacturing methods thereof
US20240115579A1 (en)	2022-09-22	2024-04-11	Galenicum Health S.L.U.	Pharmaceutical compositions and manufacturing methods thereof

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1886C (de) *	1877-12-15	1877-12-15	Basf Ag	Verfahren zur darstellung blauer farbstoffe aus dimethylanilin und anderen tertiaeren aromatischen monaminen
DE103147C (de)	1898-06-07	1899-04-05	Cohn Georg	Verfahren zur darstellung von acetylleukomethylenblau und -äthylenblau.
DE113721C (de)	1899-06-01	1900-09-28		Verfahren zur Darstellung von Acidylderivaten der Leukothioninfarbstoffe
US3641016A (en) *	1968-02-16	1972-02-08	Egyt Gyogyszervegyeszeti Gyar	Thionine derivatives
DE2515966C3 (de)	1975-04-11	1979-11-22	Boehringer Mannheim Gmbh, 6800 Mannheim	Vorgefärbte Objektträger für die Blutunte rsuchung
US4003892A (en)	1975-04-17	1977-01-18	Serva-Entwicklungslabor V. Grothe & Co.	Method of separating thionine and its N-methyl derivatives from each other
US4212971A (en)	1979-03-08	1980-07-15	American Cyanamid Company	Process for preparing methylene blue
US5091385A (en) *	1988-09-30	1992-02-25	Baylor Research Institute	Pre-activated therapeutic agents derived from photoactive compounds
CA2055463C (en) *	1989-05-11	1997-09-30	Raymond F. Schinazi	Antiviral therapy using thiazine and xanthene dyes
US5344928A (en) *	1991-04-26	1994-09-06	Takeda Chemical Industries, Ltd.	Phenothiazine derivatives, their production and use
US6238931B1 (en)	1993-09-24	2001-05-29	Biosite Diagnostics, Inc.	Fluorescence energy transfer in particles
GB9506197D0 (en)	1995-03-27	1995-05-17	Hoffmann La Roche	Inhibition of tau-tau association.
WO1998031219A1 (en)	1997-01-21	1998-07-23	The American National Red Cross	Intracellular and extracellular decontamination of whole blood and blood components by amphiphilic phenothiazin-5-ium dyes plus light
JP2000344685A (ja)	1999-03-26	2000-12-12	Bf Kenkyusho:Kk	アズールａ類似化合物によるアミロイドが蓄積する疾患の画像診断プローブおよびそれを含む画像診断用組成物
IT1307270B1 (it)	1999-10-12	2001-10-30	Dideco Spa	Procedimento e dispositivo per la determinazione della concentrazionedi eparina in un campione di fluido.
CA2401624C (en)	2000-02-26	2011-08-16	Merrill A. Biel	Photodynamic cellular and acellular organism eradication utilizing a photosensitive material and surfactant
FR2810318B1 (fr)	2000-06-15	2005-09-23	Laurent Galey	Derives de diamano-phenothiazine
GB0101049D0 (en)	2001-01-15	2001-02-28	Univ Aberdeen	Materials and methods relating to protein aggregation in neurodegenerative disease
GB2373787A (en)	2001-03-08	2002-10-02	Univ Central Lancashire	Phenothiazinium derivatives and their use to reduce pathogenic contaminants
GB0106953D0 (en)	2001-03-20	2001-05-09	Univ Aberdeen	Neufofibrillary labels
GB0113121D0 (en)	2001-05-30	2001-07-18	Univ Leeds	Biologically active photosensitisers
EP1687286A1 (en)	2003-11-28	2006-08-09	Photopharmica Limited	Developments in biologically active methylene blue derivatives (2)
CN101084204B (zh) *	2004-09-23	2012-12-05	卫思道制药有限公司	包括亚甲蓝(mtc)在内的二氨基吩噻嗪鎓化合物的化学合成和纯化方法
SI2322517T1 (sl) *	2004-09-23	2019-06-28	Wista Laboratories Ltd.	Postopki za kemijsko sintezo in čiščenje diaminofenotiazinijevih spojin, vključno metiltioninijevega klorida (MTC)
MY148145A (en)	2006-07-11	2013-03-15	Wista Lab Ltd	Methods of synthesis and/or purification of diaminophenothiazinium compounds
JP5570510B2 (ja)	2009-07-21	2014-08-13	株式会社トクヤマ	クロメン化合物

2005
- 2005-09-21 SI SI200532253T patent/SI2322517T1/sl unknown
- 2005-09-21 EP EP10010049.4A patent/EP2322517B1/en not_active Expired - Lifetime
- 2005-09-21 HU HUE10010049 patent/HUE044355T2/hu unknown
- 2005-09-21 DK DK05783989.6T patent/DK1799662T3/da active
- 2005-09-21 PT PT10010049T patent/PT2322517T/pt unknown
- 2005-09-21 PL PL05783989T patent/PL1799662T3/pl unknown
- 2005-09-21 PT PT57839896T patent/PT1799662E/pt unknown
- 2005-09-21 CA CA2579169A patent/CA2579169C/en not_active Expired - Lifetime
- 2005-09-21 EP EP05783989.6A patent/EP1799662B1/en not_active Expired - Lifetime
- 2005-09-21 SI SI200531740T patent/SI1799662T1/sl unknown
- 2005-09-21 WO PCT/GB2005/003634 patent/WO2006032879A2/en not_active Ceased
- 2005-09-21 AU AU2005286235A patent/AU2005286235C1/en not_active Expired
- 2005-09-21 ES ES10010049T patent/ES2736160T3/es not_active Expired - Lifetime
- 2005-09-21 DK DK10010049.4T patent/DK2322517T3/da active
- 2005-09-21 ES ES05783989T patent/ES2409683T3/es not_active Expired - Lifetime
- 2005-09-21 EP EP19168452.1A patent/EP3564223A1/en active Pending
- 2005-09-21 CN CN2012103966522A patent/CN103012315A/zh active Pending
- 2005-09-21 TR TR2019/10292T patent/TR201910292T4/tr unknown
- 2005-09-21 PL PL10010049T patent/PL2322517T3/pl unknown
2010
- 2010-09-03 US US12/875,465 patent/US9242946B2/en active Active
2012
- 2012-05-08 JP JP2012106551A patent/JP2012184244A/ja active Pending
2016
- 2016-01-19 US US15/000,723 patent/US9555043B2/en not_active Expired - Lifetime
2017
- 2017-01-30 US US15/419,763 patent/US9801890B2/en not_active Expired - Lifetime
- 2017-09-28 US US15/718,662 patent/US10537578B2/en not_active Expired - Lifetime
2019
- 2019-06-18 HR HRP20191100TT patent/HRP20191100T1/hr unknown
- 2019-11-27 US US16/697,907 patent/US11116772B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ES2736160T3 (es)	2019-12-26
US20200268767A1 (en)	2020-08-27
AU2005286235A1 (en)	2006-03-30
CA2579169C (en)	2018-03-06
ES2409683T3 (es)	2013-06-27
HK1100001A1 (en)	2007-08-31
SI2322517T1 (sl)	2019-06-28
AU2005286235C1 (en)	2013-08-22
EP3564223A1 (en)	2019-11-06
US9555043B2 (en)	2017-01-31
DK1799662T3 (da)	2013-07-15
EP1799662B1 (en)	2013-04-17
AU2005286235B2 (en)	2012-08-23
EP1799662A2 (en)	2007-06-27
JP2012184244A (ja)	2012-09-27
HUE044355T2 (hu)	2019-10-28
WO2006032879A2 (en)	2006-03-30
US10537578B2 (en)	2020-01-21
US20160129009A1 (en)	2016-05-12
US20180078562A1 (en)	2018-03-22
US9801890B2 (en)	2017-10-31
PL2322517T3 (pl)	2019-09-30
WO2006032879A3 (en)	2006-07-13
PT2322517T (pt)	2019-07-30
SI1799662T1 (sl)	2013-08-30
EP2322517B1 (en)	2019-04-24
PT1799662E (pt)	2013-07-09
EP2322517A8 (en)	2011-07-13
CA2579169A1 (en)	2006-03-30
HRP20191100T1 (hr)	2019-09-20
CN103012315A (zh)	2013-04-03
US20110021510A1 (en)	2011-01-27
EP2322517A1 (en)	2011-05-18
US11116772B2 (en)	2021-09-14
TR201910292T4 (tr)	2019-08-21
DK2322517T3 (da)	2019-06-11
US9242946B2 (en)	2016-01-26
US20170209456A1 (en)	2017-07-27

Publication	Publication Date	Title
HUE044355T2 (hu)	2019-10-28	Eljárások diaminofenotiazínium vegyületek, többek között metiltionínium-klorid (MTC) kémiai szintézisére és tisztítására
PL2457905T3 (pl)	2017-02-28	Sposoby syntezy i/lub oczyszczania związków diaminofenotiazyniowych
EP1611440A4 (en)	2008-10-29	PHOTOELECTROCHEMICAL DETERMINATION OF OXYGEN CHEMICAL DEMAND
AU2003260291A8 (en)	2004-04-30	Proximity-aided synthesis of templated molecules
AP2006003756A0 (en)	2006-10-31	Anti-parasitic compounds and methods of their use
GB0305150D0 (en)	2003-04-09	Use of therapeutic compounds
GB0304433D0 (en)	2003-04-02	Improvements relating to chemical libraries
GB2395203B (en)	2005-05-18	Purification of metals from mixtures thereof
EP1767565A4 (en)	2010-02-03	PROCESS FOR CLEANING OLIGOANILINES AND OLIGOANILINES
EP1812451A4 (en)	2009-10-21	COMPOUNDS AND METHODS OF USE THEREOF
ZA200509966B (en)	2006-11-29	The treatment of water containing dissolved gases
EP1583729A4 (en)	2006-07-05	PROCESS FOR PURIFYING REDUCED COENZYME Q
EP1697008A4 (en)	2008-05-07	TREATMENT OF HYDROLYSATES CHEMICAL AGENTS
GB0304555D0 (en)	2003-04-02	Compounds and methods of manufacture
GB0421234D0 (en)	2004-10-27	Methods of chemical synthesis
ZA200600494B (en)	2009-09-30	Reduction of the concentration of undesired compounds
IL160322A0 (en)	2004-07-25	Purification process of tamsulosin
ZA200401867B (en)	2004-09-08	Purification of chemical compounds.
GB0300793D0 (en)	2003-02-12	Treatment of chemical waste
GB0418125D0 (en)	2004-09-15	Treatment of effluent gases
GB0323814D0 (en)	2003-11-12	Purification of biological macromolecules
GB0503239D0 (en)	2005-03-23	Treatment of effluent gases
GB0328318D0 (en)	2004-01-07	Synthesis of spongosine
GB0319466D0 (en)	2003-09-17	Synthesis of nanostructures
GB0305278D0 (en)	2003-04-09	Chemical compounds and processes