PL1859330T3 - Urządzenia i sposoby manipulacji kropelkami na płytkach obwodów drukowanych - Google Patents
Urządzenia i sposoby manipulacji kropelkami na płytkach obwodów drukowanychInfo
- Publication number
- PL1859330T3 PL1859330T3 PL06734056T PL06734056T PL1859330T3 PL 1859330 T3 PL1859330 T3 PL 1859330T3 PL 06734056 T PL06734056 T PL 06734056T PL 06734056 T PL06734056 T PL 06734056T PL 1859330 T3 PL1859330 T3 PL 1859330T3
- Authority
- PL
- Poland
- Prior art keywords
- methods
- devices
- printed circuit
- circuit boards
- handling drops
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44769—Continuous electrophoresis, i.e. the sample being continuously introduced, e.g. free flow electrophoresis [FFE]
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
- G05D19/00—Control of mechanical oscillations, e.g. of amplitude, of frequency, of phase
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
- B01F33/3021—Micromixers the materials to be mixed flowing in the form of droplets the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/3031—Micromixers using electro-hydrodynamic [EHD] or electro-kinetic [EKI] phenomena to mix or move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
- B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B3/00—Devices comprising flexible or deformable elements, e.g. comprising elastic tongues or membranes
- B81B3/0018—Structures acting upon the moving or flexible element for transforming energy into mechanical movement or vice versa, i.e. actuators, sensors, generators
- B81B3/0021—Transducers for transforming electrical into mechanical energy or vice versa
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
- B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
- B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
- B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
- B81C1/00119—Arrangement of basic structures like cavities or channels, e.g. suitable for microfluidic systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6846—Common amplification features
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44791—Microapparatus
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
- G05D7/00—Control of flow
- G05D7/06—Control of flow characterised by the use of electric means
- G05D7/0617—Control of flow characterised by the use of electric means specially adapted for fluid materials
- G05D7/0629—Control of flow characterised by the use of electric means specially adapted for fluid materials characterised by the type of regulator means
- G05D7/0694—Control of flow characterised by the use of electric means specially adapted for fluid materials characterised by the type of regulator means by action on throttling means or flow sources of very small size, e.g. microfluidics
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10P—GENERIC PROCESSES OR APPARATUS FOR THE MANUFACTURE OR TREATMENT OF DEVICES COVERED BY CLASS H10
- H10P72/00—Handling or holding of wafers, substrates or devices during manufacture or treatment thereof
- H10P72/04—Apparatus for manufacture or treatment
- H10P72/0448—Apparatus for applying a liquid, a resin, an ink or the like
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/12—Specific details about manufacturing devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0663—Whole sensors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0819—Microarrays; Biochips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/089—Virtual walls for guiding liquids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
- B01L2400/0424—Dielectrophoretic forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B2201/00—Specific applications of microelectromechanical systems
- B81B2201/05—Microfluidics
- B81B2201/058—Microfluidics not provided for in B81B2201/051 - B81B2201/054
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Clinical Laboratory Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Manufacturing & Machinery (AREA)
- Pathology (AREA)
- Electrochemistry (AREA)
- Automation & Control Theory (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Computer Hardware Design (AREA)
- Fluid Mechanics (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Micromachines (AREA)
- Printing Elements For Providing Electric Connections Between Printed Circuits (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64805105P | 2005-01-28 | 2005-01-28 | |
| PCT/US2006/003230 WO2006081558A2 (en) | 2005-01-28 | 2006-01-30 | Apparatuses and methods for manipulating droplets on a printed circuit board |
| EP06734056A EP1859330B1 (en) | 2005-01-28 | 2006-01-30 | Apparatuses and methods for manipulating droplets on a printed circuit board |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1859330T3 true PL1859330T3 (pl) | 2013-01-31 |
Family
ID=36741149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06734056T PL1859330T3 (pl) | 2005-01-28 | 2006-01-30 | Urządzenia i sposoby manipulacji kropelkami na płytkach obwodów drukowanych |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | US8349276B2 (pl) |
| EP (1) | EP1859330B1 (pl) |
| JP (2) | JP5897780B2 (pl) |
| KR (1) | KR101198038B1 (pl) |
| CN (1) | CN101146595B (pl) |
| AU (1) | AU2006207933B2 (pl) |
| BR (1) | BRPI0607213B1 (pl) |
| CA (1) | CA2594483C (pl) |
| DK (1) | DK1859330T3 (pl) |
| ES (1) | ES2390800T3 (pl) |
| PL (1) | PL1859330T3 (pl) |
| WO (1) | WO2006081558A2 (pl) |
Families Citing this family (285)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10162188A1 (de) * | 2001-12-17 | 2003-06-18 | Sunyx Surface Nanotechnologies | Hydrophobe Oberfläche mit einer Vielzahl von Elektroden |
| US6911132B2 (en) | 2002-09-24 | 2005-06-28 | Duke University | Apparatus for manipulating droplets by electrowetting-based techniques |
| US7329545B2 (en) * | 2002-09-24 | 2008-02-12 | Duke University | Methods for sampling a liquid flow |
| DK1859330T3 (da) * | 2005-01-28 | 2012-10-15 | Univ Duke | Apparater og fremgangsmåder til håndtering af små dråber på et trykt kredsløbskort |
| CN101287845B (zh) | 2005-05-11 | 2012-07-18 | 先进液体逻辑公司 | 用于在多个温度下进行生化或化学反应的方法和设备 |
| JP4923494B2 (ja) * | 2005-09-22 | 2012-04-25 | 富士通株式会社 | 多層回路基板設計支援方法、プログラム、装置及び多層回路基板 |
| FR2890875B1 (fr) * | 2005-09-22 | 2008-02-22 | Commissariat Energie Atomique | Fabrication d'un systeme diphasique liquide/liquide ou gaz en micro-fluidique |
| GB0601703D0 (en) * | 2006-01-27 | 2006-03-08 | Intellitect Water Ltd | Improvement To The Design And Construction Of Electrochemical Sensors |
| US20140193807A1 (en) | 2006-04-18 | 2014-07-10 | Advanced Liquid Logic, Inc. | Bead manipulation techniques |
| US9476856B2 (en) | 2006-04-13 | 2016-10-25 | Advanced Liquid Logic, Inc. | Droplet-based affinity assays |
| US8980198B2 (en) * | 2006-04-18 | 2015-03-17 | Advanced Liquid Logic, Inc. | Filler fluids for droplet operations |
| US8637324B2 (en) | 2006-04-18 | 2014-01-28 | Advanced Liquid Logic, Inc. | Bead incubation and washing on a droplet actuator |
| US8658111B2 (en) * | 2006-04-18 | 2014-02-25 | Advanced Liquid Logic, Inc. | Droplet actuators, modified fluids and methods |
| US7439014B2 (en) * | 2006-04-18 | 2008-10-21 | Advanced Liquid Logic, Inc. | Droplet-based surface modification and washing |
| WO2007123908A2 (en) * | 2006-04-18 | 2007-11-01 | Advanced Liquid Logic, Inc. | Droplet-based multiwell operations |
| US8809068B2 (en) | 2006-04-18 | 2014-08-19 | Advanced Liquid Logic, Inc. | Manipulation of beads in droplets and methods for manipulating droplets |
| US10078078B2 (en) | 2006-04-18 | 2018-09-18 | Advanced Liquid Logic, Inc. | Bead incubation and washing on a droplet actuator |
| US8716015B2 (en) * | 2006-04-18 | 2014-05-06 | Advanced Liquid Logic, Inc. | Manipulation of cells on a droplet actuator |
| US8389297B2 (en) | 2006-04-18 | 2013-03-05 | Duke University | Droplet-based affinity assay device and system |
| WO2009140671A2 (en) | 2008-05-16 | 2009-11-19 | Advanced Liquid Logic, Inc. | Droplet actuator devices and methods for manipulating beads |
| US7901947B2 (en) * | 2006-04-18 | 2011-03-08 | Advanced Liquid Logic, Inc. | Droplet-based particle sorting |
| WO2009111769A2 (en) | 2008-03-07 | 2009-09-11 | Advanced Liquid Logic, Inc. | Reagent and sample preparation and loading on a fluidic device |
| TWI327361B (en) * | 2006-07-28 | 2010-07-11 | Unimicron Technology Corp | Circuit board structure having passive component and stack structure thereof |
| US8173071B2 (en) | 2006-08-29 | 2012-05-08 | International Business Machines Corporation | Micro-fluidic test apparatus and method |
| WO2008055256A2 (en) * | 2006-11-02 | 2008-05-08 | The Regents Of The University Of California | Method and apparatus for real-time feedback control of electrical manipulation of droplets on chip |
| US20090002796A1 (en) * | 2006-11-28 | 2009-01-01 | Mansell, Justin D. | Electrostatic snap-down prevention for membrane deformable mirrors |
| GB2445738A (en) * | 2007-01-16 | 2008-07-23 | Lab901 Ltd | Microfluidic device |
| WO2008091848A2 (en) * | 2007-01-22 | 2008-07-31 | Advanced Liquid Logic, Inc. | Surface assisted fluid loading and droplet dispensing |
| ES2423930T3 (es) | 2007-02-09 | 2013-09-25 | Advanced Liquid Logic, Inc. | Dispositivos actuadores de gotitas y métodos que emplean perlas magnéticas |
| WO2008101194A2 (en) | 2007-02-15 | 2008-08-21 | Advanced Liquid Logic, Inc. | Capacitance detection in a droplet actuator |
| WO2008101348A1 (en) * | 2007-02-21 | 2008-08-28 | The Royal Institution For The Advancement Of Learning/Mcgill University | System and method for surface plasmon resonance based detection of molecules |
| EP2121329B1 (en) * | 2007-03-01 | 2014-05-14 | Advanced Liquid Logic, Inc. | Droplet actuator structures |
| CA2716603A1 (en) * | 2007-03-05 | 2009-09-12 | Advanced Liquid Logic, Inc. | Hydrogen peroxide droplet-based assays |
| US8202686B2 (en) | 2007-03-22 | 2012-06-19 | Advanced Liquid Logic, Inc. | Enzyme assays for a droplet actuator |
| WO2011084703A2 (en) | 2009-12-21 | 2011-07-14 | Advanced Liquid Logic, Inc. | Enzyme assays on a droplet actuator |
| EP2837692A1 (en) | 2007-03-22 | 2015-02-18 | Advanced Liquid Logic, Inc. | Enzymatic assays for a droplet actuator |
| WO2010009463A2 (en) * | 2008-07-18 | 2010-01-21 | Advanced Liquid Logic, Inc. | Droplet operations device |
| CA2719549A1 (en) * | 2007-04-10 | 2008-10-16 | Advanced Liquid Logic, Inc. | Droplet dispensing device and methods |
| US8951732B2 (en) | 2007-06-22 | 2015-02-10 | Advanced Liquid Logic, Inc. | Droplet-based nucleic acid amplification in a temperature gradient |
| US8268246B2 (en) | 2007-08-09 | 2012-09-18 | Advanced Liquid Logic Inc | PCB droplet actuator fabrication |
| AU2008293652B2 (en) * | 2007-08-24 | 2013-02-21 | Advanced Liquid Logic, Inc. | Bead manipulations on a droplet actuator |
| WO2009032863A2 (en) | 2007-09-04 | 2009-03-12 | Advanced Liquid Logic, Inc. | Droplet actuator with improved top substrate |
| WO2009052095A1 (en) * | 2007-10-17 | 2009-04-23 | Advanced Liquid Logic, Inc. | Reagent storage and reconstitution for a droplet actuator |
| US20100236928A1 (en) * | 2007-10-17 | 2010-09-23 | Advanced Liquid Logic, Inc. | Multiplexed Detection Schemes for a Droplet Actuator |
| WO2009052354A2 (en) * | 2007-10-17 | 2009-04-23 | Advanced Liquid Logic, Inc. | Droplet actuator structures |
| US20100236929A1 (en) * | 2007-10-18 | 2010-09-23 | Advanced Liquid Logic, Inc. | Droplet Actuators, Systems and Methods |
| US20090127113A1 (en) * | 2007-11-15 | 2009-05-21 | Chien-Hsing Chen | Microfluidic detector and manufacturing method |
| WO2009076414A2 (en) | 2007-12-10 | 2009-06-18 | Advanced Liquid Logic, Inc. | Droplet actuator configurations and methods |
| GB0724736D0 (en) | 2007-12-19 | 2008-01-30 | Oxford Nanolabs Ltd | Formation of layers of amphiphilic molecules |
| AU2008345138B2 (en) * | 2007-12-23 | 2014-05-29 | Advanced Liquid Logic, Inc. | Droplet actuator configurations and methods of conducting droplet operations |
| US20090159709A1 (en) * | 2007-12-24 | 2009-06-25 | Dynamics Inc. | Advanced dynamic credit cards |
| EP2250483A4 (en) * | 2008-03-04 | 2011-09-28 | Waters Technologies Corp | Interfacing with a digital microfluidic device |
| US9206794B2 (en) * | 2008-04-28 | 2015-12-08 | Nxp, B.V. | Microfluidic pump with metal electrode having variable oxidation state |
| WO2009137415A2 (en) | 2008-05-03 | 2009-11-12 | Advanced Liquid Logic, Inc. | Reagent and sample preparation, loading, and storage |
| US20110097763A1 (en) * | 2008-05-13 | 2011-04-28 | Advanced Liquid Logic, Inc. | Thermal Cycling Method |
| US7943862B2 (en) * | 2008-08-20 | 2011-05-17 | Electro Scientific Industries, Inc. | Method and apparatus for optically transparent via filling |
| WO2010028288A2 (en) | 2008-09-05 | 2010-03-11 | Aueon, Inc. | Methods for stratifying and annotating cancer drug treatment options |
| CH700127A1 (de) | 2008-12-17 | 2010-06-30 | Tecan Trading Ag | System und Vorrichtung zur Aufarbeitung biologischer Proben und zur Manipulation von Flüssigkeiten mit biologischen Proben. |
| US8877512B2 (en) * | 2009-01-23 | 2014-11-04 | Advanced Liquid Logic, Inc. | Bubble formation techniques using physical or chemical features to retain a gas bubble within a droplet actuator |
| US9404152B2 (en) | 2009-01-26 | 2016-08-02 | Canon U.S. Life Sciences, Inc. | Microfluidic flow monitoring |
| US10066977B2 (en) | 2009-01-26 | 2018-09-04 | Canon U.S. Life Sciences, Inc. | Microfluidic flow monitoring |
| US8264249B2 (en) * | 2009-08-02 | 2012-09-11 | Chunghwa Precision Test Tech. Co., Ltd. | Vertical probe card |
| US8926065B2 (en) | 2009-08-14 | 2015-01-06 | Advanced Liquid Logic, Inc. | Droplet actuator devices and methods |
| FR2950133B1 (fr) * | 2009-09-14 | 2011-12-09 | Commissariat Energie Atomique | Dispositif d'echange thermique a efficacite amelioree |
| US8846414B2 (en) | 2009-09-29 | 2014-09-30 | Advanced Liquid Logic, Inc. | Detection of cardiac markers on a droplet actuator |
| US9091649B2 (en) | 2009-11-06 | 2015-07-28 | Advanced Liquid Logic, Inc. | Integrated droplet actuator for gel; electrophoresis and molecular analysis |
| TWI399488B (zh) * | 2009-12-31 | 2013-06-21 | Nat Univ Chung Cheng | 微流體驅動裝置 |
| US8734628B2 (en) * | 2010-03-10 | 2014-05-27 | Empire Technology Development, Llc | Microfluidic channel device with array of drive electrodes |
| EP2553473A4 (en) * | 2010-03-30 | 2016-08-10 | Advanced Liquid Logic Inc | DROPLET OPERATION PLATFORM |
| WO2011127099A1 (en) | 2010-04-05 | 2011-10-13 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| WO2011137533A1 (en) | 2010-05-05 | 2011-11-10 | The Governing Council Of The University Of Toronto | Method of processing dried samples using digital microfluidic device |
| CN102237481B (zh) * | 2010-05-07 | 2013-01-16 | 佛山市国星光电股份有限公司 | 一种表面贴装型功率led支架制造方法及其产品 |
| US9011662B2 (en) | 2010-06-30 | 2015-04-21 | Advanced Liquid Logic, Inc. | Droplet actuator assemblies and methods of making same |
| EP2619329B1 (en) | 2010-09-24 | 2019-05-22 | The Board of Trustees of The Leland Stanford Junior University | Direct capture, amplification and sequencing of target dna using immobilized primers |
| WO2012092259A1 (en) | 2010-12-27 | 2012-07-05 | Ibis Biosciences, Inc. | Quantitating high titer samples by digital pcr |
| WO2012102701A1 (en) * | 2011-01-25 | 2012-08-02 | Hewlett-Packard Development Company, L.P. | Capacitive fluid level sensing |
| CN102671722B (zh) * | 2011-02-17 | 2015-03-11 | 王崇智 | 基于微电极阵列结构的现场可编程芯片实验室 |
| CN102671723B (zh) * | 2011-02-17 | 2015-03-11 | 王崇智 | 介质上电润湿微电极阵列结构上的液滴处理方法 |
| US20120231464A1 (en) * | 2011-03-10 | 2012-09-13 | Instrument Technology Research Center, National Applied Research Laboratories | Heatable Droplet Device |
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| EP2711079B1 (en) | 2011-05-09 | 2018-12-19 | Advanced Liquid Logic, Inc. | Microfluidic Feedback Using Impedance Detection |
| WO2012154794A2 (en) | 2011-05-10 | 2012-11-15 | Advanced Liquid Logic, Inc. | Enzyme concentration and assays |
| CA2840949A1 (en) | 2011-07-06 | 2013-01-10 | Advanced Liquid Logic Inc | Reagent storage on a droplet actuator |
| US8901043B2 (en) | 2011-07-06 | 2014-12-02 | Advanced Liquid Logic, Inc. | Systems for and methods of hybrid pyrosequencing |
| US9513253B2 (en) | 2011-07-11 | 2016-12-06 | Advanced Liquid Logic, Inc. | Droplet actuators and techniques for droplet-based enzymatic assays |
| US9857332B2 (en) * | 2011-07-22 | 2018-01-02 | Tecan Trading Ag | System for manipulating samples in liquid droplets |
| US8470153B2 (en) | 2011-07-22 | 2013-06-25 | Tecan Trading Ag | Cartridge and system for manipulating samples in liquid droplets |
| US9435765B2 (en) | 2011-07-22 | 2016-09-06 | Tecan Trading Ag | Cartridge and system for manipulating samples in liquid droplets |
| WO2013016413A2 (en) | 2011-07-25 | 2013-01-31 | Advanced Liquid Logic Inc | Droplet actuator apparatus and system |
| US8980075B2 (en) | 2011-07-29 | 2015-03-17 | The Texas A & M University System | Digital microfluidic platform for actuating and heating individual liquid droplets |
| US8637242B2 (en) | 2011-11-07 | 2014-01-28 | Illumina, Inc. | Integrated sequencing apparatuses and methods of use |
| US10731199B2 (en) | 2011-11-21 | 2020-08-04 | Advanced Liquid Logic, Inc. | Glucose-6-phosphate dehydrogenase assays |
| US9377439B2 (en) | 2011-11-25 | 2016-06-28 | Tecan Trading Ag | Disposable cartridge for microfluidics system |
| US10724988B2 (en) | 2011-11-25 | 2020-07-28 | Tecan Trading Ag | Digital microfluidics system with swappable PCB's |
| US8808519B2 (en) * | 2011-12-14 | 2014-08-19 | Hamilton Sundstrand Space Systems International | Microfluidic device |
| WO2013101741A1 (en) | 2011-12-30 | 2013-07-04 | Abbott Molecular, Inc. | Channels with cross-sectional thermal gradients |
| GB201202519D0 (en) | 2012-02-13 | 2012-03-28 | Oxford Nanopore Tech Ltd | Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules |
| US8992183B2 (en) * | 2012-02-17 | 2015-03-31 | Cornell University | System and methods for moving objects individually and in parallel |
| JP6102916B2 (ja) * | 2012-03-30 | 2017-03-29 | 日本電気株式会社 | リチウムイオン二次電池 |
| US9223317B2 (en) | 2012-06-14 | 2015-12-29 | Advanced Liquid Logic, Inc. | Droplet actuators that include molecular barrier coatings |
| WO2014004908A1 (en) | 2012-06-27 | 2014-01-03 | Advanced Liquid Logic Inc. | Techniques and droplet actuator designs for reducing bubble formation |
| US8764958B2 (en) * | 2012-08-24 | 2014-07-01 | Gary Chorng-Jyh Wang | High-voltage microfluidic droplets actuation by low-voltage fabrication technologies |
| EP2703817A1 (en) * | 2012-09-03 | 2014-03-05 | Celoxio AB | On chip control of fluids using electrodes |
| WO2014062551A1 (en) | 2012-10-15 | 2014-04-24 | Advanced Liquid Logic, Inc. | Digital microfluidics cartridge and system for operating a flow cell |
| EP4592400A3 (en) | 2012-10-17 | 2025-10-29 | 10x Genomics Sweden AB | Methods and product for optimising localised or spatial detection of gene expression in a tissue sample |
| US20140322706A1 (en) | 2012-10-24 | 2014-10-30 | Jon Faiz Kayyem | Integrated multipelx target analysis |
| AU2013334189B2 (en) | 2012-10-24 | 2018-08-02 | Genmark Diagnostics, Inc. | Integrated multiplex target analysis |
| GB201313121D0 (en) | 2013-07-23 | 2013-09-04 | Oxford Nanopore Tech Ltd | Array of volumes of polar medium |
| US9090459B2 (en) * | 2012-11-30 | 2015-07-28 | Harris Corporation | Control circuitry routing configuration for MEMS devices |
| CN104994955B (zh) | 2013-01-09 | 2017-09-26 | 泰肯贸易股份公司 | 用于操纵液滴中的样品的系统 |
| US9630176B2 (en) | 2013-01-09 | 2017-04-25 | Tecan Trading Ag | Microfluidics systems with waste hollow |
| WO2014108184A1 (en) | 2013-01-09 | 2014-07-17 | Tecan Trading Ag | Cartridge and system for manipulating samples in liquid droplets |
| US9805407B2 (en) | 2013-01-25 | 2017-10-31 | Illumina, Inc. | Methods and systems for using a cloud computing environment to configure and sell a biological sample preparation cartridge and share related data |
| CN105008052B (zh) * | 2013-03-04 | 2018-09-14 | 泰肯贸易股份公司 | 数字微流体系统中液滴大小的操纵 |
| CA2903295A1 (en) * | 2013-03-05 | 2014-09-12 | Micromass Uk Limited | Charging plate for enhancing multiply charged ions by laser desorption |
| US9048222B2 (en) | 2013-03-06 | 2015-06-02 | Taiwan Semiconductor Manufacturing Company, Ltd. | Method of fabricating interconnect structure for package-on-package devices |
| JP6351702B2 (ja) | 2013-03-15 | 2018-07-04 | ジェンマーク ダイアグノスティクス， インコーポレイテッド | 変形可能流体容器を操作するためのシステム、方法、および装置 |
| US9113829B2 (en) | 2013-03-27 | 2015-08-25 | Google Inc. | Systems and methods for encapsulating electronics in a mountable device |
| CN104321141B (zh) * | 2013-05-23 | 2017-09-22 | 泰肯贸易股份公司 | 具有可调换的pcb的数字微流体系统 |
| CA2916662C (en) | 2013-06-25 | 2022-03-08 | Prognosys Biosciences, Inc. | Methods and systems for determining spatial patterns of biological targets in a sample |
| CN103412024B (zh) * | 2013-07-05 | 2016-01-20 | 复旦大学 | 一种集成电化学传感芯片 |
| EP3024582A4 (en) * | 2013-07-22 | 2017-03-08 | President and Fellows of Harvard College | Microfluidic cartridge assembly |
| CN111957453B (zh) | 2013-08-13 | 2022-08-19 | 先进流体逻辑公司 | 使用作为流体输入的接通致动器储液器来提高液滴计量的准确度和精度的方法 |
| KR20160081896A (ko) | 2013-08-30 | 2016-07-08 | 일루미나, 인코포레이티드 | 친수성 또는 다양한-친수성 표면 상에서의 액적의 조작 |
| JP6606070B2 (ja) * | 2013-10-23 | 2019-11-13 | ザ ガバニング カウンシル オブ ザ ユニバーシティ オブ トロント | プリントデジタルマイクロ流体装置、その使用方法および製造方法 |
| USD881409S1 (en) | 2013-10-24 | 2020-04-14 | Genmark Diagnostics, Inc. | Biochip cartridge |
| US9498778B2 (en) | 2014-11-11 | 2016-11-22 | Genmark Diagnostics, Inc. | Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system |
| US20150140671A1 (en) * | 2013-11-18 | 2015-05-21 | Johnson Electric S.A. | Method and system for assembling a microfluidic sensor |
| US9691693B2 (en) * | 2013-12-04 | 2017-06-27 | Invensas Corporation | Carrier-less silicon interposer using photo patterned polymer as substrate |
| US9583420B2 (en) | 2015-01-23 | 2017-02-28 | Taiwan Semiconductor Manufacturing Company, Ltd. | Semiconductor device and method of manufactures |
| WO2015125158A2 (en) * | 2014-02-21 | 2015-08-27 | Shilps Sciences Private Limited | A micro-droplet array for multiple screening of a sample |
| JP2015169432A (ja) * | 2014-03-04 | 2015-09-28 | ソニー株式会社 | 電気的測定用カートリッジ、並びに電気的測定装置及び電気的測定方法 |
| US9281297B2 (en) | 2014-03-07 | 2016-03-08 | Taiwan Semiconductor Manufacturing Company, Ltd. | Solution for reducing poor contact in info packages |
| CA3060708A1 (en) | 2014-04-29 | 2015-11-05 | Illumina, Inc | Multiplexed single cell gene expression analysis using template switch and tagmentation |
| US9449947B2 (en) | 2014-07-01 | 2016-09-20 | Taiwan Semiconductor Manufacturing Company, Ltd. | Semiconductor package for thermal dissipation |
| KR101527768B1 (ko) * | 2014-09-10 | 2015-06-12 | 주식회사 엑세스바이오코리아 | 미세유체 칩 및 진단기기 |
| CN106999850B (zh) | 2014-10-09 | 2020-04-07 | 亿明达股份有限公司 | 用于分离不混溶的液体以有效地隔离至少一种液体的方法和装置 |
| EP4578539A3 (en) | 2014-11-11 | 2025-10-01 | Roche Diagnostics GmbH | Instrument and cartridge for performing assays in a closed sample preparation and reaction system |
| US10005080B2 (en) | 2014-11-11 | 2018-06-26 | Genmark Diagnostics, Inc. | Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation |
| US9598722B2 (en) | 2014-11-11 | 2017-03-21 | Genmark Diagnostics, Inc. | Cartridge for performing assays in a closed sample preparation and reaction system |
| DK3229958T3 (da) | 2014-12-08 | 2020-11-30 | Berkeley Lights Inc | Mikrofluidanordning, der omfatter laterale/vertikale transistorstrukturer, samt fremgangsmåde til fremstilling og anvendelse heraf |
| TWI700125B (zh) | 2014-12-10 | 2020-08-01 | 美商柏克萊燈光有限公司 | 用於操作電氣動力裝置之系統 |
| ES2898103T3 (es) | 2014-12-31 | 2022-03-03 | Visby Medical Inc | Dispositivos para pruebas de diagnóstico molecular |
| GB2533953A (en) * | 2015-01-08 | 2016-07-13 | Sharp Kk | Active matrix device and method of driving |
| CN107406890B (zh) | 2015-02-10 | 2023-07-18 | 亿明达股份有限公司 | 用于分析细胞组分的方法和组合物 |
| US10576471B2 (en) | 2015-03-20 | 2020-03-03 | Illumina, Inc. | Fluidics cartridge for use in the vertical or substantially vertical position |
| EP3901282B1 (en) | 2015-04-10 | 2023-06-28 | Spatial Transcriptomics AB | Spatially distinguished, multiplex nucleic acid analysis of biological specimens |
| US9841402B2 (en) | 2015-04-15 | 2017-12-12 | Sharp Life Science (Eu) Limited | Multifunction electrode with combined heating and EWOD drive functionality |
| SG11201708429WA (en) | 2015-04-22 | 2017-11-29 | Berkeley Lights Inc | Microfluidic cell culture |
| RU2724998C2 (ru) | 2015-05-11 | 2020-06-29 | Иллюмина, Инк. | Платформа для обнаружения и анализа терапевтических агентов |
| US10464067B2 (en) | 2015-06-05 | 2019-11-05 | Miroculus Inc. | Air-matrix digital microfluidics apparatuses and methods for limiting evaporation and surface fouling |
| WO2016197106A1 (en) | 2015-06-05 | 2016-12-08 | Miroculus Inc. | Evaporation management in digital microfluidic devices |
| WO2016209734A1 (en) | 2015-06-22 | 2016-12-29 | Fluxergy, Llc | Device for analyzing a fluid sample and use of test card with same |
| WO2016209735A1 (en) | 2015-06-22 | 2016-12-29 | Fluxergy, Llc | Camera imaging system for a fluid sample assay and method of using same |
| US10214772B2 (en) | 2015-06-22 | 2019-02-26 | Fluxergy, Llc | Test card for assay and method of manufacturing same |
| WO2017007757A1 (en) | 2015-07-06 | 2017-01-12 | Illumina, Inc. | Balanced ac modulation for driving droplet operations electrodes |
| US20170013715A1 (en) * | 2015-07-10 | 2017-01-12 | Rohde & Schwarz Gmbh & Co. Kg | Printed circuit board and corresponding method for producing a printed circuit board |
| US10955411B2 (en) | 2015-08-04 | 2021-03-23 | Psomagen, Inc. | Manipulation of sample droplets with an electrode system |
| DK3334839T3 (da) | 2015-08-14 | 2021-04-26 | Illumina Inc | Systemer og fremgangsmåder under anvendelse af magnetisk reagerende sensorer til bestemmelse af en genetisk egenskab |
| EP4086357A1 (en) | 2015-08-28 | 2022-11-09 | Illumina, Inc. | Nucleic acid sequence analysis from single cells |
| HK1253910A1 (zh) | 2015-09-02 | 2019-07-05 | 伊卢米纳剑桥有限公司 | 改善流控系统中的液滴操作的系统和方法 |
| WO2017070363A1 (en) | 2015-10-22 | 2017-04-27 | Illumina, Inc. | Filler fluid for fluidic devices |
| US10799865B2 (en) | 2015-10-27 | 2020-10-13 | Berkeley Lights, Inc. | Microfluidic apparatus having an optimized electrowetting surface and related systems and methods |
| US10675627B2 (en) * | 2015-11-17 | 2020-06-09 | The Regents Of The University Of California | Ferromagnet infused microstructure array |
| US11203016B2 (en) * | 2015-12-01 | 2021-12-21 | Illumina, Inc. | Digital microfluidic system for single-cell isolation and characterization of analytes |
| WO2017095845A1 (en) | 2015-12-01 | 2017-06-08 | Illumina, Inc. | Liquid storage and delivery mechanisms and methods |
| EP3405428B1 (en) | 2016-01-20 | 2021-05-19 | The Regents of the University of California | Methods and devices for fluid manipulation by electrodewetting |
| WO2017165535A1 (en) * | 2016-03-24 | 2017-09-28 | Kansas State University Research Foundation | Integrated dielectric elastomeric actuators |
| EP3440220B1 (en) | 2016-04-07 | 2020-03-25 | Illumina, Inc. | Methods and systems for construction of normalized nucleic acid libraries |
| US10987674B2 (en) | 2016-04-22 | 2021-04-27 | Visby Medical, Inc. | Printed circuit board heater for an amplification module |
| WO2017197040A1 (en) | 2016-05-11 | 2017-11-16 | Click Diagnostics, Inc. | Devices and methods for nucleic acid extraction |
| CN115678773A (zh) | 2016-05-26 | 2023-02-03 | 伯克利之光生命科技公司 | 共价修饰的表面、试剂盒及制备方法和用途 |
| CN109414663B (zh) * | 2016-06-29 | 2022-05-17 | 数字生物系统公司 | 在数字微流体装置中创建高分辨率温度谱线 |
| GB201611770D0 (en) | 2016-07-06 | 2016-08-17 | Oxford Nanopore Tech | Microfluidic device |
| JP2020501107A (ja) | 2016-08-22 | 2020-01-16 | ミロキュラス インコーポレイテッド | デジタルマイクロ流体デバイスにおける並行小滴制御のためのフィードバックシステム |
| US11300578B2 (en) | 2016-09-19 | 2022-04-12 | Roche Molecular Systems, Inc. | Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system |
| WO2018093779A2 (en) * | 2016-11-18 | 2018-05-24 | Digital Biosystems | Digital microfluidic devices |
| AU2017368267B2 (en) | 2016-12-01 | 2022-12-15 | Berkeley Lights, Inc. | Apparatuses, systems and methods for imaging micro-objects |
| WO2018126082A1 (en) | 2016-12-28 | 2018-07-05 | Miroculis Inc. | Digital microfluidic devices and methods |
| US11623219B2 (en) | 2017-04-04 | 2023-04-11 | Miroculus Inc. | Digital microfluidics apparatuses and methods for manipulating and processing encapsulated droplets |
| EP3582892A4 (en) | 2017-04-21 | 2020-03-04 | Hewlett-Packard Development Company, L.P. | COPLANAR MICROFLUIDIC MANIPULATION |
| EP3582894A4 (en) | 2017-04-21 | 2020-03-04 | Hewlett-Packard Development Company, L.P. | MICROFLUIDIC CHIP |
| EP3583416B1 (en) | 2017-04-21 | 2024-05-29 | Hewlett-Packard Development Company, L.P. | Chip to chip fluidic interconnect |
| EP3582971A4 (en) * | 2017-04-21 | 2020-05-13 | Hewlett-Packard Development Company, L.P. | DROPLET HANDLING BY ELECTROWETTING FORCE |
| US11364496B2 (en) | 2017-04-21 | 2022-06-21 | Hewlett-Packard Development Company, L.P. | Coplanar fluidic interconnect |
| CN107118955B (zh) * | 2017-05-12 | 2020-03-10 | 京东方科技集团股份有限公司 | 基因测序芯片及基因测序方法 |
| CA3067105C (en) | 2017-06-21 | 2025-05-27 | Lightcast Discovery Ltd | MICROFLUID ANALYSIS DEVICE |
| EP4450162A3 (en) | 2017-06-21 | 2025-01-08 | Lightcast Discovery Ltd | Microdroplet manipulation device |
| GB2566002B (en) * | 2017-06-22 | 2019-10-23 | Sphere Fluidics Ltd | Droplet dispensing systems |
| US10926256B2 (en) * | 2017-07-12 | 2021-02-23 | Sharp Life Science (Eu) Limited | Housing for simple assembly of an EWOD device |
| US10772215B2 (en) | 2017-07-14 | 2020-09-08 | International Business Machines Corporation | Conductive polymers within drilled holes of printed circuit boards |
| WO2019023133A1 (en) | 2017-07-24 | 2019-01-31 | Miroculus Inc. | DIGITAL MICROFLUIDIC SYSTEMS AND METHODS WITH INTEGRATED PLASMA COLLECTION DEVICE |
| WO2019023646A2 (en) * | 2017-07-27 | 2019-01-31 | Maxim Integrated Products, Inc. | ANALYTE SENSOR HOUSING AND METHOD FOR ANALYZING FLUID SAMPLES |
| CN109420532B (zh) * | 2017-09-01 | 2020-11-10 | 京东方科技集团股份有限公司 | 数字微流控基板及其制作方法、数字微流控芯片及方法 |
| JP7341124B2 (ja) | 2017-09-01 | 2023-09-08 | ミロキュラス インコーポレイテッド | デジタルマイクロ流体デバイスおよびその使用方法 |
| US11185862B2 (en) | 2017-10-31 | 2021-11-30 | National Technology & Engineering Solutions Of Sandia, Llc | Digital microfluidic systems with electrode bus and methods for droplet manipulation |
| KR20200079264A (ko) | 2017-11-09 | 2020-07-02 | 비스비 메디컬, 인코포레이티드 | 표적 바이러스 검출을 위한 휴대용 분자 진단 디바이스 및 방법 |
| US11383236B2 (en) | 2017-11-10 | 2022-07-12 | Christopher Walker | Polymerase chain reaction using a microfluidic chip fabricated with printed circuit board techniques |
| US10396053B2 (en) | 2017-11-17 | 2019-08-27 | General Electric Company | Semiconductor logic device and system and method of embedded packaging of same |
| US10566301B2 (en) * | 2017-11-17 | 2020-02-18 | General Electric Company | Semiconductor logic device and system and method of embedded packaging of same |
| GB2568895B (en) | 2017-11-29 | 2021-10-27 | Oxford Nanopore Tech Ltd | Microfluidic device |
| GB2569630B (en) * | 2017-12-21 | 2022-10-12 | Sharp Life Science Eu Ltd | Droplet Interfaces in Electro-wetting Devices |
| ES2937927T3 (es) | 2018-01-29 | 2023-04-03 | St Jude Childrens Res Hospital Inc | Método para la amplificación de ácidos nucleicos |
| US10879195B2 (en) * | 2018-02-15 | 2020-12-29 | Micron Technology, Inc. | Method for substrate moisture NCF voiding elimination |
| GB201802819D0 (en) * | 2018-02-21 | 2018-04-04 | Univ Oxford Innovation Ltd | Methods and apparatus for manufacturing a microfluidic arrangement, and a microfluidic arrangement |
| US20190262829A1 (en) | 2018-02-28 | 2019-08-29 | Volta Labs, Inc. | Directing Motion of Droplets Using Differential Wetting |
| US20190329258A1 (en) * | 2018-04-25 | 2019-10-31 | Tecan Trading Ag | Cartridge and electrowetting sample processing system with delivery zone |
| WO2019226919A1 (en) | 2018-05-23 | 2019-11-28 | Miroculus Inc. | Control of evaporation in digital microfluidics |
| GB2574048B (en) * | 2018-05-24 | 2021-06-16 | Oxford Nanopore Tech Ltd | Nanopore sensor component with electrostatic discharge protection |
| US10926523B2 (en) | 2018-06-19 | 2021-02-23 | Sensel, Inc. | Performance enhancement of sensors through surface processing |
| AU2019337088A1 (en) | 2018-09-03 | 2021-05-06 | Visby Medical, Inc. | Devices and methods for antibiotic susceptibility testing |
| US10999925B2 (en) * | 2018-09-19 | 2021-05-04 | Ii-Vi Delaware, Inc. | Stretchable conductor circuit |
| CN109092380A (zh) * | 2018-09-19 | 2018-12-28 | 深圳先进技术研究院 | 数字微流控系统及液滴驱动方法 |
| US10913067B2 (en) * | 2018-10-01 | 2021-02-09 | Sharp Life Science (Eu) Limited | Barrier droplet configurations against migration between droplets on AM-EWOD devices |
| JP2022504466A (ja) | 2018-10-08 | 2022-01-13 | バイオエレクトロニカ コーポレイション | 試料を光学的に処理するためのシステムおよび方法 |
| PL3639925T3 (pl) * | 2018-10-18 | 2020-12-14 | Lightcast Discovery Ltd | Generator kropelek i sposób ich wytwarzania |
| US11865543B2 (en) | 2018-11-09 | 2024-01-09 | Mgi Tech Co., Ltd. | Multilayer electrical connection for digital microfluidics on substrates |
| SG11202104544WA (en) | 2018-11-19 | 2021-06-29 | Berkeley Lights Inc | Microfluidic device with programmable switching elements |
| US20220018799A1 (en) * | 2018-11-19 | 2022-01-20 | Zio Health Ltd. | System and methods for measuring analyte concentration |
| US12385929B2 (en) | 2018-12-02 | 2025-08-12 | Polymer Technology Systems, Inc. | Systems and methods for a combined strip detection and heating system in an electrochemical test strip |
| CN113167760B (zh) | 2018-12-02 | 2023-11-03 | 聚合物技术系统公司 | 用于电化学测试条带中的电子门特征的系统和方法 |
| CN113543883A (zh) | 2019-01-31 | 2021-10-22 | 米罗库鲁斯公司 | 非结垢组合物以及用于操控和处理包封的微滴的方法 |
| WO2020167574A1 (en) | 2019-02-14 | 2020-08-20 | Omniome, Inc. | Mitigating adverse impacts of detection systems on nucleic acids and other biological analytes |
| WO2020176816A1 (en) | 2019-02-28 | 2020-09-03 | Miroculus Inc. | Digital microfluidics devices and methods of using them |
| JP7492200B2 (ja) | 2019-03-12 | 2024-05-29 | オックスフォード ナノポール テクノロジーズ ピーエルシー | ナノ細孔センシングデバイスと操作方法およびその成形方法 |
| CN119158636A (zh) | 2019-04-08 | 2024-12-20 | 米罗库鲁斯公司 | 多盒式数字微流控装置和使用方法 |
| CN111857191A (zh) * | 2019-04-25 | 2020-10-30 | 北大方正集团有限公司 | 电路板制造过程中药水控制方法、装置、设备及存储介质 |
| CN113767470A (zh) * | 2019-05-07 | 2021-12-07 | 阿尔法装配解决方案公司 | 即烧结型银膜 |
| CN113993624B (zh) * | 2019-06-21 | 2024-02-09 | 亚德诺半导体国际无限责任公司 | 热平台和制造热平台的方法 |
| US11224877B2 (en) | 2019-07-23 | 2022-01-18 | a.u. Vista Inc. | Systems and methods for analyzing droplets |
| WO2021016614A1 (en) | 2019-07-25 | 2021-01-28 | Miroculus Inc. | Digital microfluidics devices and methods of use thereof |
| MX2022001324A (es) | 2019-07-31 | 2022-05-19 | Bioskryb Genomics Inc | Análisis de células individuales. |
| CN110528039B (zh) * | 2019-07-31 | 2020-11-17 | 浙江大学 | 基于微弱离子电流检测监控的微纳结构局域电沉积装置 |
| CN110665556A (zh) * | 2019-09-30 | 2020-01-10 | 浙江大学 | 基于疏水薄膜可复用单层数字微流控芯片及快速制备方法 |
| CN110653011A (zh) * | 2019-09-30 | 2020-01-07 | 浙江大学 | 基于疏水薄膜可复用双层数字微流控芯片及快速制备方法 |
| CN110882729A (zh) * | 2019-09-30 | 2020-03-17 | 浙江大学 | 基于聚合物复合膜快速制备单层dmf芯片及制备方法 |
| US12157124B2 (en) | 2019-11-06 | 2024-12-03 | 10X Genomics, Inc. | Imaging system hardware |
| EP4061530B1 (en) | 2019-11-20 | 2025-12-10 | Nuclera Ltd | Spatially variable hydrophobic layers for digital microfluidics |
| US11352675B2 (en) | 2020-01-03 | 2022-06-07 | Visby Medical, Inc. | Devices and methods for antibiotic susceptability testing |
| WO2021146573A1 (en) | 2020-01-17 | 2021-07-22 | E Ink Corporation | Spatially variable dielectric layers for digital microfluidics |
| US12405264B2 (en) | 2020-01-17 | 2025-09-02 | 10X Genomics, Inc. | Electrophoretic system and method for analyte capture |
| WO2021154627A1 (en) | 2020-01-27 | 2021-08-05 | E Ink Corporation | Method for degassing liquid droplets by electrowetting actuation at higher temperatures |
| US12110541B2 (en) | 2020-02-03 | 2024-10-08 | 10X Genomics, Inc. | Methods for preparing high-resolution spatial arrays |
| WO2021168131A1 (en) | 2020-02-18 | 2021-08-26 | Nuclear Nucleics Ltd. | Adaptive gate driving for high frequency ac driving of ewod arrays |
| TWI795730B (zh) | 2020-02-19 | 2023-03-11 | 英商核酸有限公司 | 用於介電濕潤陣列之高頻交流電驅動的鎖存電晶體驅動 |
| US12542990B2 (en) * | 2020-03-30 | 2026-02-03 | Boe Technology Group Co., Ltd. | Acoustic transducer and manufacturing method thereof |
| WO2021222061A1 (en) | 2020-04-27 | 2021-11-04 | Nuclera Nucleics Ltd. | Segmented top plate for variable driving and short protection for digital microfluidics |
| US12416603B2 (en) | 2020-05-19 | 2025-09-16 | 10X Genomics, Inc. | Electrophoresis cassettes and instrumentation |
| EP3912722A1 (en) * | 2020-05-21 | 2021-11-24 | Biothink Technologies S.L. | Laboratory integrated on a chip and manufacturing procedure |
| EP4414459B1 (en) | 2020-05-22 | 2025-09-03 | 10X Genomics, Inc. | Simultaneous spatio-temporal measurement of gene expression and cellular activity |
| US12031177B1 (en) | 2020-06-04 | 2024-07-09 | 10X Genomics, Inc. | Methods of enhancing spatial resolution of transcripts |
| WO2021252747A1 (en) | 2020-06-10 | 2021-12-16 | 1Ox Genomics, Inc. | Fluid delivery methods |
| WO2021252923A1 (en) | 2020-06-12 | 2021-12-16 | Genmark Diagnostics, Inc. | Systems and methods for assessing bays on diagnostic devices |
| US12508586B2 (en) | 2020-06-30 | 2025-12-30 | Plexium, Inc. | Uniform fluid flow with constant resistance and velocity |
| JP7690501B2 (ja) | 2020-06-30 | 2025-06-10 | プレクシアム・インコーポレイテッド | 流体デバイスおよび方法 |
| CN113213420A (zh) * | 2020-07-15 | 2021-08-06 | 江苏力博医药生物技术股份有限公司 | 一种微阵列结构图案化的装置 |
| EP4675256A3 (en) | 2020-07-17 | 2026-01-28 | Oxford Nanopore Technologies PLC | Nanopore sensing device |
| WO2022051840A1 (en) * | 2020-09-08 | 2022-03-17 | Nicoya Lifesciences, Inc. | Pipette dispenser system and method |
| WO2022061150A2 (en) | 2020-09-18 | 2022-03-24 | 10X Geonomics, Inc. | Sample handling apparatus and image registration methods |
| WO2022074399A1 (en) | 2020-10-08 | 2022-04-14 | Nuclera Nucleics Ltd | Electrowetting system and method for reagent-specific driving ewod arrays in microfluidic systems |
| CN116635153A (zh) | 2020-11-04 | 2023-08-22 | 核蛋白有限公司 | 用于数字微流体设备的电介质层 |
| CN112717851A (zh) * | 2020-12-24 | 2021-04-30 | 苏州大学 | 一种光驱动液态金属微液滴的装置及方法 |
| EP4186593A4 (en) * | 2020-12-25 | 2023-12-27 | BOE Technology Group Co., Ltd. | SUBSTRATE FOR DROPLETS AND PRODUCTION METHOD THEREOF AND MICROFLUIDIC DEVICE |
| EP4421491A3 (en) | 2021-02-19 | 2024-11-27 | 10X Genomics, Inc. | Method of using a modular assay support device |
| KR102423154B1 (ko) | 2021-04-13 | 2022-07-20 | 주식회사 시큐어메드 | 전도성 플라스틱을 이용한 진단 장치 및 그 장치의 제조 방법 |
| SE2150773A1 (en) * | 2021-06-16 | 2022-12-17 | Water Stuff & Sun Gmbh | Micro-electro-mechanical system fluid control |
| US12553805B2 (en) | 2021-08-02 | 2026-02-17 | 10X Genomics, Inc. | Methods of preserving a biological sample |
| CN113710037B (zh) * | 2021-09-16 | 2022-10-18 | 维沃移动通信有限公司 | 盖板组件和电子设备 |
| USD1064308S1 (en) | 2021-09-17 | 2025-02-25 | 10X Genomics, Inc. | Sample handling device |
| CN113858540B (zh) * | 2021-10-08 | 2023-07-28 | 佛山华智新材料有限公司 | 微流控芯片及其制造方法 |
| CA3237966A1 (en) * | 2021-11-12 | 2023-05-19 | The Governing Council Of The University Of Toronto | Microfluidics devices and methods |
| CN114203592B (zh) * | 2021-11-29 | 2025-05-27 | 北京芯可鉴科技有限公司 | 芯片局部涂覆装置 |
| WO2023122033A1 (en) | 2021-12-20 | 2023-06-29 | 10X Genomics, Inc. | Self-test for pathology/histology slide imaging device |
| CN116408154A (zh) * | 2021-12-29 | 2023-07-11 | 群创光电股份有限公司 | 电子装置 |
| US11857961B2 (en) | 2022-01-12 | 2024-01-02 | Miroculus Inc. | Sequencing by synthesis using mechanical compression |
| CN115121305A (zh) * | 2022-07-13 | 2022-09-30 | 北京理工大学 | 一种新型数字微流控芯片及其制备方法 |
| KR102815113B1 (ko) * | 2022-07-15 | 2025-05-30 | 주식회사 시큐어메드 | 전도성 폴리머를 이용한 진단 장치 및 그것의 전극 구조 |
| KR102815115B1 (ko) * | 2022-07-15 | 2025-05-30 | 주식회사 시큐어메드 | 전도성 폴리머를 이용한 진단 장치 및 그것의 제조 방법 |
| KR20240031829A (ko) | 2022-09-01 | 2024-03-08 | 주식회사 시큐어메드 | 액적 액추에이터 및 그것의 액적 조작 방법 |
| US20240382965A1 (en) * | 2023-05-19 | 2024-11-21 | Cytesi, Inc | Electrowetting-on-dielectric (ewod) device |
| EP4724205A2 (en) * | 2023-06-06 | 2026-04-15 | University of Utah Research Foundation | Microfluidic integrated cmos based impedance array biosensor |
| US20250060333A1 (en) | 2023-08-16 | 2025-02-20 | E Ink Corporation | Devices, methods, and systems for visualizing electrowetting pathing using electrophoretic materials |
| US20260025915A1 (en) * | 2024-07-18 | 2026-01-22 | Artisan Insight, Inc. | Programmable circuit board and method of use |
Family Cites Families (440)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3687834A (en) | 1970-04-06 | 1972-08-29 | James T Candor | Method and apparatus for removing particles from fluid containing the same |
| JPS4917079B1 (pl) | 1970-12-21 | 1974-04-26 | ||
| US3746911A (en) | 1971-04-13 | 1973-07-17 | Westinghouse Electric Corp | Electrostatically deflectable light valves for projection displays |
| BE790280A (fr) | 1971-11-19 | 1973-04-19 | Technicon Instr | Analyse photometrique d'une goutellette d'un echantillon liquide |
| US3795605A (en) | 1972-06-16 | 1974-03-05 | J Candor | Method and apparatus for removing and/or separating particles from fluid containing the same |
| US4057482A (en) | 1972-06-16 | 1977-11-08 | Candor James T | Apparatus for removing liquid from liquid bearing material |
| US3930982A (en) | 1973-04-06 | 1976-01-06 | The Carborundum Company | Ferroelectric apparatus for dielectrophoresis particle extraction |
| US3872480A (en) | 1974-03-14 | 1975-03-18 | Rca Corp | Method of electrostatic recording on electrically insulating films by non-wetting electrically conductive liquids |
| US3934180A (en) | 1974-08-12 | 1976-01-20 | Rca Corporation | Method of reproducing an electrostatic charge pattern in intensified form |
| US4127460A (en) | 1976-10-27 | 1978-11-28 | Desoto, Inc. | Radiation-curing aqueous coatings providing a nonadherent surface |
| US4244693A (en) | 1977-02-28 | 1981-01-13 | The United States Of America As Represented By The United States Department Of Energy | Method and composition for testing for the presence of an alkali metal |
| US4257774A (en) | 1979-07-16 | 1981-03-24 | Meloy Laboratories, Inc. | Intercalation inhibition assay for compounds that interact with DNA or RNA |
| US4430645A (en) | 1981-04-07 | 1984-02-07 | Sensormatic Electronics Corporation | Surveillance system employing a dual function floor mat radiator |
| US4418346A (en) | 1981-05-20 | 1983-11-29 | Batchelder J Samuel | Method and apparatus for providing a dielectrophoretic display of visual information |
| US4390403A (en) | 1981-07-24 | 1983-06-28 | Batchelder J Samuel | Method and apparatus for dielectrophoretic manipulation of chemical species |
| US4467325A (en) | 1981-11-02 | 1984-08-21 | Sperry Corporation | Electro-optically addressed flat panel display |
| FR2524658A1 (fr) | 1982-03-30 | 1983-10-07 | Socapex | Commutateur optique et matrice de commutation comprenant de tels commutateurs |
| WO1984001174A1 (en) | 1982-09-20 | 1984-03-29 | Harvard College | Identification of microorganisms |
| FR2543320B1 (fr) | 1983-03-23 | 1986-01-31 | Thomson Csf | Dispositif indicateur a commande electrique de deplacement d'un fluide |
| FR2548431B1 (fr) | 1983-06-30 | 1985-10-25 | Thomson Csf | Dispositif a commande electrique de deplacement de fluide |
| FR2548795B1 (fr) | 1983-07-04 | 1986-11-21 | Thomson Csf | Dispositif de commutation optique a deplacement de fluide et dispositif de composition d'une ligne de points |
| FR2553907B1 (fr) | 1983-10-21 | 1985-12-13 | Thomson Csf | Modulateur optique |
| US5038852A (en) | 1986-02-25 | 1991-08-13 | Cetus Corporation | Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps |
| US4863849A (en) | 1985-07-18 | 1989-09-05 | New York Medical College | Automatable process for sequencing nucleotide |
| US4824776A (en) | 1985-07-25 | 1989-04-25 | Molecular Biosystems, Inc. | Method for increasing the sensitivity of nucleic acid hybridization assays |
| US4742345A (en) | 1985-11-19 | 1988-05-03 | Copytele, Inc. | Electrophoretic display panel apparatus and methods therefor |
| JP3293820B2 (ja) | 1985-12-13 | 2002-06-17 | エンゾ− バイオケム インコ−ポレイテツド | 標的ポリヌクレオチドにハイブリツド形成するための新規な一工程方法とポリヌクレオチド化合物 |
| AU622104B2 (en) | 1987-03-11 | 1992-04-02 | Sangtec Molecular Diagnostics Ab | Method of assaying of nucleic acids, a reagent combination and kit therefore |
| CA1317535C (en) | 1987-06-30 | 1993-05-11 | Nanibhushan Dattagupta | Assay of sequences using amplified genes |
| WO1989001050A1 (en) | 1987-07-31 | 1989-02-09 | The Board Of Trustees Of The Leland Stanford Junior University | Selective amplification of target polynucleotide sequences |
| US6013531A (en) | 1987-10-26 | 2000-01-11 | Dade International Inc. | Method to use fluorescent magnetic polymer particles as markers in an immunoassay |
| AU2735988A (en) | 1987-12-21 | 1989-07-13 | Amoco Corporation | Target and background capture methods with amplification for affinity assays |
| DE3808942A1 (de) | 1988-03-17 | 1989-09-28 | Bio Med Gmbh Ges Fuer Biotechn | Inkubator, insbes. fuer die polymerase-ketten-methode |
| US4911782A (en) | 1988-03-28 | 1990-03-27 | Cyto-Fluidics, Inc. | Method for forming a miniaturized biological assembly |
| US5225332A (en) | 1988-04-22 | 1993-07-06 | Massachusetts Institute Of Technology | Process for manipulation of non-aqueous surrounded microdroplets |
| US4908112A (en) | 1988-06-16 | 1990-03-13 | E. I. Du Pont De Nemours & Co. | Silicon semiconductor wafer for analyzing micronic biological samples |
| JPH0288615A (ja) * | 1988-09-27 | 1990-03-28 | Mitsubishi Rayon Co Ltd | 難燃性液状感光性樹脂組成物 |
| WO1990015881A1 (fr) | 1989-06-12 | 1990-12-27 | Cis Bio International | Procede de detection de sequences specifiques d'acides nucleiques et ses applications |
| GB8917963D0 (en) | 1989-08-05 | 1989-09-20 | Scras | Apparatus for repeated automatic execution of a thermal cycle for treatment of biological samples |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5001594A (en) | 1989-09-06 | 1991-03-19 | Mcnc | Electrostatic handling device |
| US5266498A (en) | 1989-10-27 | 1993-11-30 | Abbott Laboratories | Ligand binding assay for an analyte using surface-enhanced scattering (SERS) signal |
| GB8926269D0 (en) | 1989-11-21 | 1990-01-10 | Dynal As | Plasmid |
| DE3939964A1 (de) | 1989-12-02 | 1991-06-06 | Bayer Ag | Hitzehaertbare beschichtungszusammensetzungen |
| US5795457A (en) | 1990-01-30 | 1998-08-18 | British Technology Group Ltd. | Manipulation of solid, semi-solid or liquid materials |
| US5750015A (en) | 1990-02-28 | 1998-05-12 | Soane Biosciences | Method and device for moving molecules by the application of a plurality of electrical fields |
| GB2245708A (en) | 1990-06-29 | 1992-01-08 | Philips Electronic Associated | Touch sensor array systems |
| SE467309B (sv) | 1990-10-22 | 1992-06-29 | Berol Nobel Ab | Hydrofiliserad fast yta, foerfarande foer dess framstaellning samt medel daerfoer |
| US5181016A (en) | 1991-01-15 | 1993-01-19 | The United States Of America As Represented By The United States Department Of Energy | Micro-valve pump light valve display |
| DE59108006D1 (de) | 1991-01-28 | 1996-08-22 | Ciba Geigy Ag | Vorrichtung zur Vorbereitung von Proben insbesondere für Analysezwecke |
| US5994056A (en) | 1991-05-02 | 1999-11-30 | Roche Molecular Systems, Inc. | Homogeneous methods for nucleic acid amplification and detection |
| DE4127405C2 (de) | 1991-08-19 | 1996-02-29 | Fraunhofer Ges Forschung | Verfahren zur Trennung von Gemischen mikroskopisch kleiner, in einer Flüssigkeit oder einem Gel suspendierter dielektrischer Teilchen und Vorrichtung zur Durchführung des Verfahrens |
| US5849486A (en) | 1993-11-01 | 1998-12-15 | Nanogen, Inc. | Methods for hybridization analysis utilizing electrically controlled hybridization |
| US5605662A (en) | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
| US6017696A (en) | 1993-11-01 | 2000-01-25 | Nanogen, Inc. | Methods for electronic stringency control for molecular biological analysis and diagnostics |
| US5632957A (en) | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
| DE4137261C2 (de) | 1991-11-13 | 1995-06-29 | Meinhard Prof Dr Knoll | Miniaturisiertes Sensorelement zur Bestimmung von Stoffkonzentrationen in Flüssigkeiten und Verfahren zu seiner Herstellung |
| DE59108591D1 (de) | 1991-12-06 | 1997-04-10 | Ciba Geigy Ag | Elektrophoretische Trennvorrichtung und elektrophoretisches Trennverfahren |
| DE4234086A1 (de) | 1992-02-05 | 1993-08-12 | Diagen Inst Molekularbio | Verfahren zur bestimmung von in vitro amplifizierten nukleinsaeuresequenzen |
| GB2264783A (en) | 1992-02-24 | 1993-09-08 | Gen Electric Co Plc | Electrophoretic analysis method utilising wave effect |
| US5498392A (en) | 1992-05-01 | 1996-03-12 | Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification device and method |
| DE69324067T2 (de) | 1992-06-08 | 1999-07-15 | Synaptics Inc | Objekt-Positionsdetektor |
| WO1994008759A1 (en) | 1992-10-16 | 1994-04-28 | Thomas Jefferson University | Method and apparatus for robotically performing sanger dideoxynucleotide dna sequencing reactions |
| US5472881A (en) | 1992-11-12 | 1995-12-05 | University Of Utah Research Foundation | Thiol labeling of DNA for attachment to gold surfaces |
| US6152181A (en) | 1992-11-16 | 2000-11-28 | The United States Of America As Represented By The Secretary Of The Air Force | Microdevices based on surface tension and wettability that function as sensors, actuators, and other devices |
| GB9306729D0 (en) | 1993-03-31 | 1993-05-26 | British Tech Group | Improvements in separators |
| GB9311241D0 (en) | 1993-06-01 | 1993-07-21 | Celsis Ltd | Reagents for use in bioluminescence |
| DE69429038T2 (de) | 1993-07-28 | 2002-03-21 | Pe Corporation (Ny), Norwalk | Vorrichtung und Verfahren zur Nukleinsäurevervielfältigung |
| US6099803A (en) | 1994-07-07 | 2000-08-08 | Nanogen, Inc. | Advanced active electronic devices for molecular biological analysis and diagnostics |
| US6225059B1 (en) | 1993-11-01 | 2001-05-01 | Nanogen, Inc. | Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics |
| US6068818A (en) | 1993-11-01 | 2000-05-30 | Nanogen, Inc. | Multicomponent devices for molecular biological analysis and diagnostics |
| US5486337A (en) | 1994-02-18 | 1996-01-23 | General Atomics | Device for electrostatic manipulation of droplets |
| EP0746408B1 (de) | 1994-02-24 | 1998-09-23 | Fraunhofer-Gesellschaft Zur Förderung Der Angewandten Forschung E.V. | Formen von mikropartikeln in elektrischen feldkaefigen |
| US5635671A (en) | 1994-03-16 | 1997-06-03 | Amkor Electronics, Inc. | Mold runner removal from a substrate-based packaged electronic device |
| DE4412286A1 (de) | 1994-04-09 | 1995-10-12 | Boehringer Mannheim Gmbh | System zur kontaminationsfreien Bearbeitung von Reaktionsabläufen |
| DE4418513A1 (de) | 1994-05-27 | 1995-11-30 | Bayer Ag | Immuntest zum Nachweis hochmolekularer Antigene |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| US5472577A (en) | 1994-06-30 | 1995-12-05 | Iowa State University Research Foundation | Fluid pumping system based on electrochemically-induced surface tension changes |
| US6071394A (en) | 1996-09-06 | 2000-06-06 | Nanogen, Inc. | Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis |
| US6379897B1 (en) | 2000-11-09 | 2002-04-30 | Nanogen, Inc. | Methods for gene expression monitoring on electronic microarrays |
| US6001229A (en) | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
| US6613560B1 (en) | 1994-10-19 | 2003-09-02 | Agilent Technologies, Inc. | PCR microreactor for amplifying DNA using microquantities of sample fluid |
| US5571410A (en) | 1994-10-19 | 1996-11-05 | Hewlett Packard Company | Fully integrated miniaturized planar liquid sample handling and analysis device |
| US5603351A (en) | 1995-06-07 | 1997-02-18 | David Sarnoff Research Center, Inc. | Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device |
| DE69533554T2 (de) | 1994-11-10 | 2005-01-27 | Orchid Biosciences, Inc. | Flüssigkeitsverteilungssystem |
| US5632876A (en) | 1995-06-06 | 1997-05-27 | David Sarnoff Research Center, Inc. | Apparatus and methods for controlling fluid flow in microchannels |
| JP3487524B2 (ja) | 1994-12-20 | 2004-01-19 | 株式会社ルネサステクノロジ | 半導体装置及びその製造方法 |
| US6673533B1 (en) | 1995-03-10 | 2004-01-06 | Meso Scale Technologies, Llc. | Multi-array multi-specific electrochemiluminescence testing |
| US6319668B1 (en) | 1995-04-25 | 2001-11-20 | Discovery Partners International | Method for tagging and screening molecules |
| CA2176053C (en) | 1995-05-09 | 1999-10-05 | Yoshihiro Kinoshita | Method and apparatus for agglutination immunoassay |
| EP0830595A1 (en) | 1995-06-08 | 1998-03-25 | Visible Genetics Inc. | Microelectrophoresis chip for moving and separating nucleic acids and other charged molecules |
| US6124851A (en) | 1995-07-20 | 2000-09-26 | E Ink Corporation | Electronic book with multiple page displays |
| US6057149A (en) | 1995-09-15 | 2000-05-02 | The University Of Michigan | Microscale devices and reactions in microscale devices |
| US6130098A (en) | 1995-09-15 | 2000-10-10 | The Regents Of The University Of Michigan | Moving microdroplets |
| US5851769A (en) | 1995-09-27 | 1998-12-22 | The Regents Of The University Of California | Quantitative DNA fiber mapping |
| DE19544127C1 (de) | 1995-11-27 | 1997-03-20 | Gimsa Jan Dr | Verfahren und Vorrichtung zur Erzeugung von Resonanzerscheinungen in Partikelsuspensionen und ihre Verwendung |
| US5956005A (en) | 1995-12-29 | 1999-09-21 | Xerox Corporation | Electrocapillary display sheet which utilizes an applied electric field to move a liquid inside the display sheet |
| US5993630A (en) | 1996-01-31 | 1999-11-30 | Board Of Regents The University Of Texas System | Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation |
| US5888370A (en) | 1996-02-23 | 1999-03-30 | Board Of Regents, The University Of Texas System | Method and apparatus for fractionation using generalized dielectrophoresis and field flow fractionation |
| US5945281A (en) | 1996-02-02 | 1999-08-31 | Becton, Dickinson And Company | Method and apparatus for determining an analyte from a sample fluid |
| US6355198B1 (en) | 1996-03-15 | 2002-03-12 | President And Fellows Of Harvard College | Method of forming articles including waveguides via capillary micromolding and microtransfer molding |
| US7244622B2 (en) | 1996-04-03 | 2007-07-17 | Applera Corporation | Device and method for multiple analyte detection |
| US5885470A (en) | 1997-04-14 | 1999-03-23 | Caliper Technologies Corporation | Controlled fluid transport in microfabricated polymeric substrates |
| US5731792A (en) | 1996-05-06 | 1998-03-24 | Xerox Corporation | Electrocapillary color display sheet |
| US5757345A (en) | 1996-05-06 | 1998-05-26 | Xerox Corportion | Electrocapillary color display sheet |
| US6022463A (en) * | 1996-05-16 | 2000-02-08 | Sendx Medical, Inc. | Sensors with subminiature through holes |
| US5808593A (en) | 1996-06-03 | 1998-09-15 | Xerox Corporation | Electrocapillary color display sheet |
| US6136212A (en) | 1996-08-12 | 2000-10-24 | The Regents Of The University Of Michigan | Polymer-based micromachining for microfluidic devices |
| CA2266930C (en) | 1996-09-24 | 2007-11-27 | Case Western Reserve University | Device for optical and electrochemical measurements in microliter size samples |
| GB9620209D0 (en) | 1996-09-27 | 1996-11-13 | Cemu Bioteknik Ab | Method of sequencing DNA |
| CA2276251A1 (en) | 1996-11-20 | 1998-05-28 | The Regents Of The University Of Michigan | Microfabricated isothermal nucleic acid amplification devices and methods |
| GB9626815D0 (en) | 1996-12-23 | 1997-02-12 | Cemu Bioteknik Ab | Method of sequencing DNA |
| EP1030733A4 (en) | 1997-02-05 | 2000-08-30 | California Inst Of Techn | Microfluidic sub-millisecond mixers |
| US6235471B1 (en) | 1997-04-04 | 2001-05-22 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
| US6143496A (en) | 1997-04-17 | 2000-11-07 | Cytonix Corporation | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly |
| DE19717085C2 (de) | 1997-04-23 | 1999-06-17 | Bruker Daltonik Gmbh | Verfahren und Geräte für extrem schnelle DNA-Vervielfachung durch Polymerase-Kettenreaktionen (PCR) |
| WO1998049548A1 (en) | 1997-04-25 | 1998-11-05 | Caliper Technologies Corporation | Microfluidic devices incorporating improved channel geometries |
| US5980719A (en) | 1997-05-13 | 1999-11-09 | Sarnoff Corporation | Electrohydrodynamic receptor |
| US6106685A (en) | 1997-05-13 | 2000-08-22 | Sarnoff Corporation | Electrode combinations for pumping fluids |
| US6154226A (en) | 1997-05-13 | 2000-11-28 | Sarnoff Corporation | Parallel print array |
| US6109717A (en) | 1997-05-13 | 2000-08-29 | Sarnoff Corporation | Multi-element fluid delivery apparatus and methods |
| US5998224A (en) | 1997-05-16 | 1999-12-07 | Abbott Laboratories | Magnetically assisted binding assays utilizing a magnetically responsive reagent |
| FR2764385B1 (fr) | 1997-06-06 | 1999-07-16 | Commissariat Energie Atomique | Microsysteme d'analyse de liquides a cuvette integree |
| TW410534B (en) | 1997-07-16 | 2000-11-01 | Matsushita Electric Industrial Co Ltd | Wiring board and production process for the same |
| US6375871B1 (en) | 1998-06-18 | 2002-04-23 | 3M Innovative Properties Company | Methods of manufacturing microfluidic articles |
| US5876675A (en) | 1997-08-05 | 1999-03-02 | Caliper Technologies Corp. | Microfluidic devices and systems |
| US20020001544A1 (en) | 1997-08-28 | 2002-01-03 | Robert Hess | System and method for high throughput processing of droplets |
| US5989402A (en) | 1997-08-29 | 1999-11-23 | Caliper Technologies Corp. | Controller/detector interfaces for microfluidic systems |
| AU744879B2 (en) | 1997-09-19 | 2002-03-07 | Aclara Biosciences, Inc. | Apparatus and method for transferring liquids |
| US7214298B2 (en) | 1997-09-23 | 2007-05-08 | California Institute Of Technology | Microfabricated cell sorter |
| US6231177B1 (en) | 1997-09-29 | 2001-05-15 | Sarnoff Corporation | Final print medium having target regions corresponding to the nozzle of print array |
| US5958694A (en) | 1997-10-16 | 1999-09-28 | Caliper Technologies Corp. | Apparatus and methods for sequencing nucleic acids in microfluidic systems |
| US5929960A (en) | 1997-10-17 | 1999-07-27 | Kent State University | Method for forming liquid crystal display cell walls using a patterned electric field |
| US5992820A (en) | 1997-11-19 | 1999-11-30 | Sarnoff Corporation | Flow control in microfluidics devices by controlled bubble formation |
| DE19822123C2 (de) | 1997-11-21 | 2003-02-06 | Meinhard Knoll | Verfahren und Vorrichtung zum Nachweis von Analyten |
| US5911533A (en) | 1997-11-24 | 1999-06-15 | Eastman Kodak Company | Microfluidic writing pen |
| US6174675B1 (en) | 1997-11-25 | 2001-01-16 | Caliper Technologies Corp. | Electrical current for controlling fluid parameters in microchannels |
| US5948227A (en) | 1997-12-17 | 1999-09-07 | Caliper Technologies Corp. | Methods and systems for performing electrophoretic molecular separations |
| US6063339A (en) | 1998-01-09 | 2000-05-16 | Cartesian Technologies, Inc. | Method and apparatus for high-speed dot array dispensing |
| ATE477850T1 (de) | 1998-01-12 | 2010-09-15 | Massachusetts Inst Technology | Vorrichtung zur mikrotestdurchführung |
| US6167910B1 (en) | 1998-01-20 | 2001-01-02 | Caliper Technologies Corp. | Multi-layer microfluidic devices |
| EP1054735B1 (de) | 1998-02-11 | 2003-05-28 | Institut Für Physikalische Hochtechnologie E.V. | Miniaturisierter temperaturzonen flussreaktor |
| US6251343B1 (en) | 1998-02-24 | 2001-06-26 | Caliper Technologies Corp. | Microfluidic devices and systems incorporating cover layers |
| US6211477B1 (en) | 1998-02-26 | 2001-04-03 | Becton Dickinson And Company | Electrostatic deceleration system for flow cytometer |
| US6318970B1 (en) | 1998-03-12 | 2001-11-20 | Micralyne Inc. | Fluidic devices |
| FI980874A7 (fi) | 1998-04-20 | 1999-10-21 | Wallac Oy | Menetelmä ja laite pienten nestemäärien kemiallisen analyysin suorittamiseksi |
| US6123798A (en) | 1998-05-06 | 2000-09-26 | Caliper Technologies Corp. | Methods of fabricating polymeric structures incorporating microscale fluidic elements |
| WO1999056862A1 (en) | 1998-05-07 | 1999-11-11 | Purdue Research Foundation | An in situ micromachined mixer for microfluidic analytical systems |
| AU785167B2 (en) | 1998-05-29 | 2006-10-12 | Industrial Research Limited | Method and apparatus for concentrating and/or positioning particles or cells |
| US6274089B1 (en) | 1998-06-08 | 2001-08-14 | Caliper Technologies Corp. | Microfluidic devices, systems and methods for performing integrated reactions and separations |
| US6251595B1 (en) | 1998-06-18 | 2001-06-26 | Agilent Technologies, Inc. | Methods and devices for carrying out chemical reactions |
| US6226082B1 (en) | 1998-06-25 | 2001-05-01 | Amira Medical | Method and apparatus for the quantitative analysis of a liquid sample with surface enhanced spectroscopy |
| JP4315491B2 (ja) * | 1998-08-18 | 2009-08-19 | ジャパンゴアテックス株式会社 | 半導体装置及びその製造方法 |
| US6169394B1 (en) | 1998-09-18 | 2001-01-02 | University Of The Utah Research Foundation | Electrical detector for micro-analysis systems |
| US6136171A (en) | 1998-09-18 | 2000-10-24 | The University Of Utah Research Foundation | Micromachined electrical field-flow fractionation system |
| US6482306B1 (en) | 1998-09-22 | 2002-11-19 | University Of Washington | Meso- and microfluidic continuous flow and stopped flow electroösmotic mixer |
| US6086243A (en) | 1998-10-01 | 2000-07-11 | Sandia Corporation | Electrokinetic micro-fluid mixer |
| US6086740A (en) | 1998-10-29 | 2000-07-11 | Caliper Technologies Corp. | Multiplexed microfluidic devices and systems |
| US20030012699A1 (en) | 1998-11-18 | 2003-01-16 | Thomas Moore | Simultaneous handling of magnetic beads in a two-dimensional arrangement |
| US6062261A (en) | 1998-12-16 | 2000-05-16 | Lockheed Martin Energy Research Corporation | MicrofluIdic circuit designs for performing electrokinetic manipulations that reduce the number of voltage sources and fluid reservoirs |
| GB9901475D0 (en) | 1999-01-22 | 1999-03-17 | Pyrosequencing Ab | A method of DNA sequencing |
| US6565727B1 (en) | 1999-01-25 | 2003-05-20 | Nanolytics, Inc. | Actuators for microfluidics without moving parts |
| US6294063B1 (en) | 1999-02-12 | 2001-09-25 | Board Of Regents, The University Of Texas System | Method and apparatus for programmable fluidic processing |
| ATE556149T1 (de) | 1999-02-23 | 2012-05-15 | Caliper Life Sciences Inc | Manipulation von mikropartikeln in mikrofluidischen systemen |
| US7167156B1 (en) | 1999-02-26 | 2007-01-23 | Micron Technology, Inc. | Electrowetting display |
| US6225061B1 (en) | 1999-03-10 | 2001-05-01 | Sequenom, Inc. | Systems and methods for performing reactions in an unsealed environment |
| US6148508A (en) | 1999-03-12 | 2000-11-21 | Caliper Technologies Corp. | Method of making a capillary for electrokinetic transport of materials |
| CN1181337C (zh) | 2000-08-08 | 2004-12-22 | 清华大学 | 微流体系统中实体分子的操纵方法及相关试剂盒 |
| DE60036746T2 (de) | 1999-03-25 | 2008-07-24 | Tosoh Corp., Shinnanyo | Analysator |
| US6352838B1 (en) | 1999-04-07 | 2002-03-05 | The Regents Of The Universtiy Of California | Microfluidic DNA sample preparation method and device |
| US6326173B1 (en) | 1999-04-12 | 2001-12-04 | Nanogen/Becton Dickinson Partnership | Electronically mediated nucleic acid amplification in NASBA |
| US20040053290A1 (en) | 2000-01-11 | 2004-03-18 | Terbrueggen Robert Henry | Devices and methods for biochip multiplexing |
| IT1309430B1 (it) | 1999-05-18 | 2002-01-23 | Guerrieri Roberto | Metodo ed apparato per la manipolazione di particelle per mezzo delladielettroforesi |
| FR2794039B1 (fr) | 1999-05-27 | 2002-05-03 | Osmooze Sa | Dispositif de formation, de deplacement et de diffusion de petites quantites calibrees de liquides |
| AU779220B2 (en) | 1999-07-26 | 2005-01-13 | Clinical Micro Sensors, Inc. | Sequence determination of nucleic acids using electronic detection |
| US6977145B2 (en) | 1999-07-28 | 2005-12-20 | Serono Genetics Institute S.A. | Method for carrying out a biochemical protocol in continuous flow in a microreactor |
| KR20020021810A (ko) | 1999-08-11 | 2002-03-22 | 야마모토 카즈모토 | 분석용 카트리지 및 송액 제어 장치 |
| DE19938002A1 (de) | 1999-08-11 | 2001-02-15 | Studiengesellschaft Kohle Mbh | Beschichtung mit quervernetzten hydrophilen Polymeren |
| US6495104B1 (en) | 1999-08-19 | 2002-12-17 | Caliper Technologies Corp. | Indicator components for microfluidic systems |
| US20030027204A1 (en) | 1999-09-03 | 2003-02-06 | Yokogawa Electric Corporation, A Japan Corporation | Method and apparatus for producing biochips |
| US20040209376A1 (en) | 1999-10-01 | 2004-10-21 | Surromed, Inc. | Assemblies of differentiable segmented particles |
| EP1099484B1 (en) | 1999-11-11 | 2006-06-07 | The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | A dispensing method and assembly for liquid droplets |
| US6432290B1 (en) | 1999-11-26 | 2002-08-13 | The Governors Of The University Of Alberta | Apparatus and method for trapping bead based reagents within microfluidic analysis systems |
| WO2001040786A1 (en) | 1999-12-01 | 2001-06-07 | The Regents Of The University Of California | Electric-field-assisted fluidic assembly of inorganic and organic materials, molecules and like small things including living cells |
| SE9904802D0 (sv) | 1999-12-23 | 1999-12-23 | Amersham Pharm Biotech Ab | Microfluidic surfaces |
| JP2002162652A (ja) | 2000-01-31 | 2002-06-07 | Fujitsu Ltd | シート状表示装置、樹脂球状体、及びマイクロカプセル |
| WO2001061054A2 (en) | 2000-02-18 | 2001-08-23 | Board Of Trustees Of The Leland Stanford Junior University | Apparatus and methods for parallel processing of micro-volume liquid reactions |
| US6924792B1 (en) | 2000-03-10 | 2005-08-02 | Richard V. Jessop | Electrowetting and electrostatic screen display systems, colour displays and transmission means |
| JP3442338B2 (ja) | 2000-03-17 | 2003-09-02 | 株式会社日立製作所 | Ｄｎａ分析装置、ｄｎａ塩基配列決定装置、ｄｎａ塩基配列決定方法、および反応モジュール |
| US6442413B1 (en) | 2000-05-15 | 2002-08-27 | James H. Silver | Implantable sensor |
| US6520197B2 (en) | 2000-06-02 | 2003-02-18 | The Regents Of The University Of California | Continuous laminar fluid mixing in micro-electromechanical systems |
| US7351376B1 (en) | 2000-06-05 | 2008-04-01 | California Institute Of Technology | Integrated active flux microfluidic devices and methods |
| US6790330B2 (en) | 2000-06-14 | 2004-09-14 | Board Of Regents, The University Of Texas System | Systems and methods for cell subpopulation analysis |
| WO2001096024A2 (en) | 2000-06-14 | 2001-12-20 | Board Of Regents, The University Of Texas System | Apparatus and method for fluid injection |
| JP2004503775A (ja) | 2000-06-14 | 2004-02-05 | ボード・オブ・リージェンツ，ザ・ユニヴァーシティ・オヴ・テキサス・システム | 検体混合物の組み合わせた磁気泳動および誘電泳動の操作のための方法および装置 |
| US6602400B1 (en) | 2000-06-15 | 2003-08-05 | Motorola, Inc. | Method for enhanced bio-conjugation events |
| AU2001280796A1 (en) | 2000-07-25 | 2002-02-05 | The Regents Of The University Of California | Electrowetting-driven micropumping |
| CA2314398A1 (en) | 2000-08-10 | 2002-02-10 | Edward Shipwash | Microarrays and microsystems for amino acid analysis and protein sequencing |
| US6773566B2 (en) | 2000-08-31 | 2004-08-10 | Nanolytics, Inc. | Electrostatic actuators for microfluidics and methods for using same |
| WO2002023163A1 (en) | 2000-09-15 | 2002-03-21 | California Institute Of Technology | Microfabricated crossflow devices and methods |
| EP1336181A2 (en) | 2000-11-09 | 2003-08-20 | Koninklijke Philips Electronics N.V. | Multi-fluid elements device with controllable fluid level by means of matrix addressing |
| US6409698B1 (en) | 2000-11-27 | 2002-06-25 | John N. Robinson | Perforate electrodiffusion pump |
| US6453928B1 (en) | 2001-01-08 | 2002-09-24 | Nanolab Ltd. | Apparatus, and method for propelling fluids |
| US6685812B2 (en) | 2001-01-09 | 2004-02-03 | The Regents Of The University Of California | Movement of particles using sequentially activated dielectrophoretic particle trapping |
| US6897848B2 (en) | 2001-01-11 | 2005-05-24 | Xerox Corporation | Rotating element sheet material and stylus with gradient field addressing |
| US7070681B2 (en) | 2001-01-24 | 2006-07-04 | The Board Of Trustees Of The Leland Stanford Junior University | Electrokinetic instability micromixer |
| WO2002060754A1 (en) | 2001-01-29 | 2002-08-08 | Caliper Technologies Corp. | Non-mechanical valves for fluidic systems |
| JP2002232135A (ja) | 2001-01-30 | 2002-08-16 | Matsushita Electric Ind Co Ltd | 積層用両面回路基板とその製造方法及びそれを用いた多層プリント配線板 |
| US6621012B2 (en) | 2001-02-01 | 2003-09-16 | International Business Machines Corporation | Insertion of electrical component within a via of a printed circuit board |
| US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
| KR100398309B1 (ko) | 2001-02-20 | 2003-09-19 | 한국과학기술원 | 연속 전기습윤에 의해 유도된 운동하는 액체 방울에 의해구동되는 마이크로펌프 |
| US7078168B2 (en) | 2001-02-27 | 2006-07-18 | Biotage Ab | Method for determining allele frequencies |
| WO2002068821A2 (en) | 2001-02-28 | 2002-09-06 | Lightwave Microsystems Corporation | Microfluidic control using dieletric pumping |
| US7016560B2 (en) | 2001-02-28 | 2006-03-21 | Lightwave Microsystems Corporation | Microfluidic control for waveguide optical switches, variable attenuators, and other optical devices |
| US6586233B2 (en) | 2001-03-09 | 2003-07-01 | The Regents Of The University Of California | Convectively driven PCR thermal-cycling |
| US7010391B2 (en) | 2001-03-28 | 2006-03-07 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
| EP1384022A4 (en) | 2001-04-06 | 2004-08-04 | California Inst Of Techn | NUCLEIC ACID AMPLIFICATION USING MICROFLUID DEVICES |
| ITTO20010411A1 (it) | 2001-05-02 | 2002-11-02 | Silicon Biosystems S R L | Metodo e dispositivo per l'esecuzione di test e saggi ad alta processivita' ed alto valore biologico su cellule e/o composti. |
| US6491803B1 (en) | 2001-05-18 | 2002-12-10 | Apex Biotechnology Corporation | Test strip and biosensor incorporating with nanometer metal particles |
| US6665127B2 (en) | 2002-04-30 | 2003-12-16 | Lucent Technologies Inc. | Method and apparatus for aligning a photo-tunable microlens |
| US6965480B2 (en) | 2001-06-19 | 2005-11-15 | Lucent Technologies Inc. | Method and apparatus for calibrating a tunable microlens |
| US6538823B2 (en) | 2001-06-19 | 2003-03-25 | Lucent Technologies Inc. | Tunable liquid microlens |
| US7419574B2 (en) | 2001-06-20 | 2008-09-02 | Cummings Eric B | Dielectrophoresis device and method having non-uniform arrays for manipulating particles |
| US7211442B2 (en) | 2001-06-20 | 2007-05-01 | Cytonome, Inc. | Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system |
| US7179423B2 (en) | 2001-06-20 | 2007-02-20 | Cytonome, Inc. | Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system |
| US7014747B2 (en) | 2001-06-20 | 2006-03-21 | Sandia Corporation | Dielectrophoretic systems without embedded electrodes |
| US6844028B2 (en) | 2001-06-26 | 2005-01-18 | Accelr8 Technology Corporation | Functional surface coating |
| US6835293B2 (en) | 2001-07-09 | 2004-12-28 | Greiner Bio-One Gmbh | Analysis system |
| US6734436B2 (en) | 2001-08-07 | 2004-05-11 | Sri International | Optical microfluidic devices and methods |
| US6995024B2 (en) | 2001-08-27 | 2006-02-07 | Sri International | Method and apparatus for electrostatic dispensing of microdroplets |
| US6545815B2 (en) | 2001-09-13 | 2003-04-08 | Lucent Technologies Inc. | Tunable liquid microlens with lubrication assisted electrowetting |
| US7094379B2 (en) | 2001-10-24 | 2006-08-22 | Commissariat A L'energie Atomique | Device for parallel and synchronous injection for sequential injection of different reagents |
| US7338760B2 (en) | 2001-10-26 | 2008-03-04 | Ntu Ventures Private Limited | Sample preparation integrated chip |
| US6600888B2 (en) | 2001-11-02 | 2003-07-29 | Xerox Corporation | Liquid charging method and apparatus |
| US20030175947A1 (en) | 2001-11-05 | 2003-09-18 | Liu Robin Hui | Enhanced mixing in microfluidic devices |
| US7163612B2 (en) | 2001-11-26 | 2007-01-16 | Keck Graduate Institute | Method, apparatus and article for microfluidic control via electrowetting, for chemical, biochemical and biological assays and the like |
| US20040231987A1 (en) | 2001-11-26 | 2004-11-25 | Keck Graduate Institute | Method, apparatus and article for microfluidic control via electrowetting, for chemical, biochemical and biological assays and the like |
| GB0129068D0 (en) | 2001-12-05 | 2002-01-23 | Koninl Philips Electronics Nv | Display device |
| CN100350607C (zh) | 2001-12-07 | 2007-11-21 | 富士通株式会社 | 半导体器件及其制造方法 |
| DE10162188A1 (de) | 2001-12-17 | 2003-06-18 | Sunyx Surface Nanotechnologies | Hydrophobe Oberfläche mit einer Vielzahl von Elektroden |
| US20030119057A1 (en) | 2001-12-20 | 2003-06-26 | Board Of Regents | Forming and modifying dielectrically-engineered microparticles |
| US6866762B2 (en) | 2001-12-20 | 2005-03-15 | Board Of Regents, University Of Texas System | Dielectric gate and methods for fluid injection and control |
| JP2003194845A (ja) * | 2001-12-25 | 2003-07-09 | Matsushita Electric Works Ltd | 半導体加速度センサ |
| CA2472649A1 (en) | 2002-01-08 | 2003-07-17 | Japan Science And Technology Agency | Pcr and hybridization methods utilizing electrostatic transportation and devices therefor |
| US6887362B2 (en) | 2002-02-06 | 2005-05-03 | Nanogen, Inc. | Dielectrophoretic separation and immunoassay methods on active electronic matrix devices |
| AU2003201481A1 (en) | 2002-02-14 | 2003-09-04 | Koninklijke Philips Electronics N.V. | Variable focus lens |
| US6936196B2 (en) | 2002-03-12 | 2005-08-30 | Lucent Technologies Inc. | Solidifiable tunable liquid microlens |
| US7223371B2 (en) | 2002-03-14 | 2007-05-29 | Micronics, Inc. | Microfluidic channel network device |
| CA2480170A1 (en) | 2002-03-29 | 2003-10-09 | The University Of Utah Research Foundation | Hybrid phosphoinositide phospholipids: compositions and uses |
| US7147763B2 (en) | 2002-04-01 | 2006-12-12 | Palo Alto Research Center Incorporated | Apparatus and method for using electrostatic force to cause fluid movement |
| EP2283917B1 (en) | 2002-05-09 | 2021-12-15 | The University of Chicago | Device for pressure-driven plug transport and reaction |
| EP1509943A2 (en) * | 2002-05-31 | 2005-03-02 | Thermo Finnigan LLC | Mass spectrometer with improved mass accuracy |
| US6958132B2 (en) | 2002-05-31 | 2005-10-25 | The Regents Of The University Of California | Systems and methods for optical actuation of microfluidics based on opto-electrowetting |
| FR2841063B1 (fr) | 2002-06-18 | 2004-09-17 | Commissariat Energie Atomique | Dispositif de deplacement de petits volumes de liquide le long d'un micro-catenaire par des forces electrostatiques |
| JP2006507921A (ja) | 2002-06-28 | 2006-03-09 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 流体分散のための方法および装置 |
| FR2842747B1 (fr) | 2002-07-23 | 2004-10-15 | Commissariat Energie Atomique | Procede et dispositif pour le criblage de molecules dans des cellules |
| FR2843048B1 (fr) | 2002-08-01 | 2004-09-24 | Commissariat Energie Atomique | Dispositif d'injection et de melange de micro-gouttes liquides. |
| US20040091392A1 (en) | 2002-08-09 | 2004-05-13 | Mcbride Sterling Eduard | Method and apparatus for employing a tunable microfluidic device for optical switching, filtering and assaying of biological samples |
| GB0219872D0 (en) * | 2002-08-27 | 2002-10-02 | Univ Belfast | Charged particle manipulation |
| US6829415B2 (en) | 2002-08-30 | 2004-12-07 | Lucent Technologies Inc. | Optical waveguide devices with electro-wetting actuation |
| AU2003263436A1 (en) | 2002-09-19 | 2004-04-08 | Koninklijke Philips Electronics N.V. | Electrowetting optical switch |
| US7329545B2 (en) | 2002-09-24 | 2008-02-12 | Duke University | Methods for sampling a liquid flow |
| US6989234B2 (en) | 2002-09-24 | 2006-01-24 | Duke University | Method and apparatus for non-contact electrostatic actuation of droplets |
| US6911132B2 (en) | 2002-09-24 | 2005-06-28 | Duke University | Apparatus for manipulating droplets by electrowetting-based techniques |
| US20040055871A1 (en) | 2002-09-25 | 2004-03-25 | The Regents Of The University Of California | Use of ion beams for protecting substrates from particulate defect contamination in ultra-low-defect coating processes |
| JP2004163394A (ja) | 2002-09-26 | 2004-06-10 | Seiko Epson Corp | 液滴吐出ヘッド及びその製造方法、マイクロアレイ製造装置並びにマイクロアレイの製造方法 |
| EP1585583B1 (en) | 2002-10-23 | 2010-04-07 | The Trustees of Princeton University | Method for continuous particle separation using obstacle arrays asymmetrically aligned to fields |
| US7217542B2 (en) | 2002-10-31 | 2007-05-15 | Hewlett-Packard Development Company, L.P. | Microfluidic system for analyzing nucleic acids |
| JP4429585B2 (ja) * | 2002-11-08 | 2010-03-10 | 富士通株式会社 | 選択的絶縁方法及び貫通ビアを備えた実装基板 |
| FR2846957B1 (fr) | 2002-11-13 | 2005-09-30 | Commissariat Energie Atomique | Micro-systeme a remplissage de micro-billes et procede d'obtention |
| US20050038329A1 (en) | 2002-11-20 | 2005-02-17 | Morris Carol Ann | Methods and kits for assays of rapid screening of diabetes |
| JP2004207518A (ja) * | 2002-12-25 | 2004-07-22 | Nokia Corp | 多層プリント回路基板、受動素子アレイ、多層プリント回路基板の製造方法および受動素子アレイの製造方法 |
| US7547380B2 (en) * | 2003-01-13 | 2009-06-16 | North Carolina State University | Droplet transportation devices and methods having a fluid surface |
| US7604718B2 (en) | 2003-02-19 | 2009-10-20 | Bioarray Solutions Ltd. | Dynamically configurable electrode formed of pixels |
| GB0304033D0 (en) | 2003-02-21 | 2003-03-26 | Imp College Innovations Ltd | Apparatus |
| US7041481B2 (en) | 2003-03-14 | 2006-05-09 | The Regents Of The University Of California | Chemical amplification based on fluid partitioning |
| JP2004275921A (ja) | 2003-03-17 | 2004-10-07 | Seiko Epson Corp | 液滴吐出装置及び方法、液滴吐出ヘッド装置、並びにデバイス製造方法及びデバイス |
| JP2004327482A (ja) * | 2003-04-21 | 2004-11-18 | Fujikura Ltd | 多層配線板、多層基板用基材およびその製造方法 |
| JP2004322019A (ja) | 2003-04-28 | 2004-11-18 | Seiko Epson Corp | 液滴吐出装置及び方法 |
| JP4404672B2 (ja) | 2003-05-28 | 2010-01-27 | セイコーエプソン株式会社 | 液滴吐出ヘッド、液滴吐出ヘッドの製造方法、マイクロアレイ製造装置、及びマイクロアレイの製造方法 |
| JP2005019686A (ja) * | 2003-06-26 | 2005-01-20 | Kyocera Corp | コンデンサ素子内蔵多層配線基板 |
| WO2005005961A1 (ja) * | 2003-07-09 | 2005-01-20 | Olympus Corporation | 液体搬送処理デバイス及び液体搬送処理方法 |
| TWI230760B (en) | 2003-07-29 | 2005-04-11 | Univ Tsinghua | Electrowetting electrode design with electromagnetic field for actuation of the magnetic-beads biochemical detection system |
| US7767435B2 (en) | 2003-08-25 | 2010-08-03 | University Of Washington | Method and device for biochemical detection and analysis of subcellular compartments from a single cell |
| CA2479452C (en) | 2003-08-30 | 2008-11-04 | F.Hoffmann-La Roche Ag | Method and device for determining analytes in a liquid |
| WO2005039499A2 (en) | 2003-10-24 | 2005-05-06 | Adhesives Research, Inc. | Rapidly disintegrating film |
| JP2005139011A (ja) | 2003-11-04 | 2005-06-02 | Nof Corp | 火薬原料及びその製造方法 |
| JP4773360B2 (ja) | 2003-11-17 | 2011-09-14 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 流体を操作するためのシステム |
| KR100647282B1 (ko) | 2003-12-24 | 2006-11-17 | 삼성전자주식회사 | ＤＮＡ 마이크로어레이 스폿팅(Ｓｐｏｔｉｎｇ) 장치 및이를 이용한 스폿팅 방법 |
| EP1704402B1 (en) | 2004-01-14 | 2016-05-11 | Luminex Corporation | Methods and systems for dynamic range expansion |
| US20080226500A1 (en) | 2004-01-15 | 2008-09-18 | Mitsuhiro Shikida | Chemical Analytic Apparatus and Chemical Analytic Method |
| US7927797B2 (en) | 2004-01-28 | 2011-04-19 | 454 Life Sciences Corporation | Nucleic acid amplification with continuous flow emulsion |
| FR2866493B1 (fr) | 2004-02-16 | 2010-08-20 | Commissariat Energie Atomique | Dispositif de controle du deplacement d'une goutte entre deux ou plusieurs substrats solides |
| US7495031B2 (en) | 2004-02-24 | 2009-02-24 | Kao Corporation | Process for producing an emulsion |
| KR100552706B1 (ko) | 2004-03-12 | 2006-02-20 | 삼성전자주식회사 | 핵산 증폭 방법 및 장치 |
| US7048889B2 (en) | 2004-03-23 | 2006-05-23 | Lucent Technologies Inc. | Dynamically controllable biological/chemical detectors having nanostructured surfaces |
| US20050226991A1 (en) | 2004-04-07 | 2005-10-13 | Hossainy Syed F | Methods for modifying balloon of a catheter assembly |
| KR100583231B1 (ko) | 2004-04-13 | 2006-05-26 | 한국과학기술연구원 | 물방울형 세포 부유액을 이용한 세포 분리 장치 |
| JP2007536634A (ja) | 2004-05-04 | 2007-12-13 | フィッシャー−ローズマウント・システムズ・インコーポレーテッド | プロセス制御システムのためのサービス指向型アーキテクチャ |
| WO2006085905A1 (en) | 2004-05-28 | 2006-08-17 | Board Of Regents, The University Of Texas System | Programmable fluidic processors |
| US7799553B2 (en) | 2004-06-01 | 2010-09-21 | The Regents Of The University Of California | Microfabricated integrated DNA analysis system |
| FR2871076A1 (fr) | 2004-06-04 | 2005-12-09 | Univ Lille Sciences Tech | Dispositif pour desorption par rayonnement laser incorporant une manipulation de l'echantillon liquide sous forme de gouttes individuelles permettant leur traitement chimique et biochimique |
| US7121998B1 (en) | 2004-06-08 | 2006-10-17 | Eurica Califorrniaa | Vented microcradle for prenidial incubator |
| FR2872438B1 (fr) | 2004-07-01 | 2006-09-15 | Commissariat Energie Atomique | Dispositif de deplacement et de traitement de volumes de liquide |
| US7693666B2 (en) | 2004-07-07 | 2010-04-06 | Rensselaer Polytechnic Institute | Method, system, and program product for controlling chemical reactions in a digital microfluidic system |
| FR2872715B1 (fr) | 2004-07-08 | 2006-11-17 | Commissariat Energie Atomique | Microreacteur goutte |
| FR2872809B1 (fr) | 2004-07-09 | 2006-09-15 | Commissariat Energie Atomique | Methode d'adressage d'electrodes |
| US7267752B2 (en) | 2004-07-28 | 2007-09-11 | University Of Rochester | Rapid flow fractionation of particles combining liquid and particulate dielectrophoresis |
| JP2006058031A (ja) | 2004-08-17 | 2006-03-02 | Hitachi High-Technologies Corp | 化学分析装置 |
| ATE485888T1 (de) | 2004-08-26 | 2010-11-15 | Life Technologies Corp | Elektrobenetzende abgabevorrichtungen und dazugehörige verfahren |
| JP4047314B2 (ja) | 2004-09-07 | 2008-02-13 | 株式会社東芝 | 微細流路構造体 |
| EP1802395B1 (en) | 2004-09-09 | 2020-01-22 | Institut Curie | Microfluidic device using a collinear electric field |
| JP4185904B2 (ja) | 2004-10-27 | 2008-11-26 | 株式会社日立ハイテクノロジーズ | 液体搬送基板、分析システム、分析方法 |
| US7347533B2 (en) | 2004-12-20 | 2008-03-25 | Palo Alto Research Center Incorporated | Low cost piezo printhead based on microfluidics in printed circuit board and screen-printed piezoelectrics |
| FR2879946B1 (fr) | 2004-12-23 | 2007-02-09 | Commissariat Energie Atomique | Dispositif de dispense de gouttes |
| US7458661B2 (en) | 2005-01-25 | 2008-12-02 | The Regents Of The University Of California | Method and apparatus for promoting the complete transfer of liquid drops from a nozzle |
| DK1859330T3 (da) | 2005-01-28 | 2012-10-15 | Univ Duke | Apparater og fremgangsmåder til håndtering af små dråber på et trykt kredsløbskort |
| US7454988B2 (en) | 2005-02-10 | 2008-11-25 | Applera Corporation | Method for fluid sampling using electrically controlled droplets |
| JP4813544B2 (ja) | 2005-03-07 | 2011-11-09 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Ｘ線装置の天井支持システム |
| US20060210443A1 (en) | 2005-03-14 | 2006-09-21 | Stearns Richard G | Avoidance of bouncing and splashing in droplet-based fluid transport |
| FR2884437B1 (fr) | 2005-04-19 | 2007-07-20 | Commissariat Energie Atomique | Dispositif et procede microfluidique de transfert de matiere entre deux phases immiscibles. |
| US7053323B1 (en) * | 2005-05-04 | 2006-05-30 | Agilent Technologies, Inc. | Liquid metal switch employing an electrically isolated control element |
| CN101287845B (zh) | 2005-05-11 | 2012-07-18 | 先进液体逻辑公司 | 用于在多个温度下进行生化或化学反应的方法和设备 |
| JP4547301B2 (ja) | 2005-05-13 | 2010-09-22 | 株式会社日立ハイテクノロジーズ | 液体搬送デバイス及び分析システム |
| JP2006317364A (ja) | 2005-05-16 | 2006-11-24 | Hitachi High-Technologies Corp | 分注装置 |
| CN101237934B (zh) | 2005-05-21 | 2012-12-19 | 先进液体逻辑公司 | 用亲水性聚合物助剂减弱生物分子的吸附 |
| JP4500733B2 (ja) | 2005-05-30 | 2010-07-14 | 株式会社日立ハイテクノロジーズ | 化学分析装置 |
| JP2006329904A (ja) | 2005-05-30 | 2006-12-07 | Hitachi High-Technologies Corp | 液体搬送デバイス及び分析システム |
| JP4969060B2 (ja) | 2005-06-08 | 2012-07-04 | 株式会社日立ハイテクノロジーズ | 自動分析装置 |
| WO2006138543A1 (en) | 2005-06-16 | 2006-12-28 | Core-Microsolutions, Inc. | Biosensor detection by means of droplet driving, agitation, and evaporation |
| FR2887305B1 (fr) | 2005-06-17 | 2011-05-27 | Commissariat Energie Atomique | Dispositif de pompage par electromouillage et application aux mesures d'activite electrique |
| JP4855467B2 (ja) | 2005-07-01 | 2012-01-18 | コミサリア ア レネルジー アトミック エ オ ゼネルジー アルテルナティブ | 濡れヒステリシスが低い疎水性表面被覆、その堆積方法、微細要素および使用 |
| ITBO20050481A1 (it) | 2005-07-19 | 2007-01-20 | Silicon Biosystems S R L | Metodo ed apparato per la manipolazione e/o l'individuazione di particelle |
| FR2888912B1 (fr) | 2005-07-25 | 2007-08-24 | Commissariat Energie Atomique | Procede de commande d'une communication entre deux zones par electromouillage, dispositif comportant des zones isolables les unes des autres et procede de realisation d'un tel dispositif |
| US20070023292A1 (en) | 2005-07-26 | 2007-02-01 | The Regents Of The University Of California | Small object moving on printed circuit board |
| FR2889515B1 (fr) | 2005-08-02 | 2007-11-02 | Commissariat Energie Atomique | Dispositif de controle du deplacement d'un volume liquide entre deux ou plusieurs substrats solides et procede de deplacement |
| US20090145576A1 (en) | 2005-08-11 | 2009-06-11 | Eksigent Technologies, Llc | Microfluid based apparatus and method for thermal regulation and noise reduction |
| WO2007021864A2 (en) | 2005-08-11 | 2007-02-22 | Eksigent Technologies, Llc | Methods and apparatuses for generating a seal between a conduit and a reservoir well |
| US20090145485A1 (en) | 2005-08-11 | 2009-06-11 | Eksigent Technologies, Llc | Microfluidic methods and apparatuses for fluid mixing and valving |
| WO2007024798A2 (en) | 2005-08-22 | 2007-03-01 | Applera Corporation | Apparatus, system, and method using immiscible-fluid-discrete-volumes |
| US7556776B2 (en) | 2005-09-08 | 2009-07-07 | President And Fellows Of Harvard College | Microfluidic manipulation of fluids and reactions |
| EP4071458B1 (en) | 2005-09-21 | 2025-11-05 | Luminex Corporation | Methods and systems for image data processing |
| FR2890875B1 (fr) | 2005-09-22 | 2008-02-22 | Commissariat Energie Atomique | Fabrication d'un systeme diphasique liquide/liquide ou gaz en micro-fluidique |
| US20070075922A1 (en) | 2005-09-28 | 2007-04-05 | Jessop Richard V | Electronic display systems |
| US7344679B2 (en) | 2005-10-14 | 2008-03-18 | International Business Machines Corporation | Method and apparatus for point of care osmolarity testing |
| WO2007048111A2 (en) | 2005-10-22 | 2007-04-26 | Core-Microsolutions, Inc. | Droplet extraction from a liquid column for on-chip microfluidics |
| ITBO20050646A1 (it) | 2005-10-26 | 2007-04-27 | Silicon Biosystem S R L | Metodo ed apparato per la caratterizzazione ed il conteggio di particelle |
| JP2007147321A (ja) | 2005-11-24 | 2007-06-14 | Toshiba Corp | 液量検知構造 |
| TWI303312B (en) | 2005-12-21 | 2008-11-21 | Ind Tech Res Inst | Matrix electrodes controlling device and digital fluid detection platform thereof |
| CA3179247A1 (en) | 2005-12-21 | 2007-07-05 | Meso Scale Technologies, Llc | Assay modules having assay reagents and methods of making and using same |
| WO2007081385A2 (en) | 2006-01-11 | 2007-07-19 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
| US8124033B2 (en) | 2006-02-17 | 2012-02-28 | Agency, Science, Technology and Research | Apparatus for regulating the temperature of a biological and/or chemical sample and method of using the same |
| US20070207513A1 (en) | 2006-03-03 | 2007-09-06 | Luminex Corporation | Methods, Products, and Kits for Identifying an Analyte in a Sample |
| US8613889B2 (en) | 2006-04-13 | 2013-12-24 | Advanced Liquid Logic, Inc. | Droplet-based washing |
| WO2010006166A2 (en) | 2008-07-09 | 2010-01-14 | Advanced Liquid Logic, Inc. | Bead manipulation techniques |
| US8637317B2 (en) | 2006-04-18 | 2014-01-28 | Advanced Liquid Logic, Inc. | Method of washing beads |
| US8492168B2 (en) | 2006-04-18 | 2013-07-23 | Advanced Liquid Logic Inc. | Droplet-based affinity assays |
| WO2007123908A2 (en) | 2006-04-18 | 2007-11-01 | Advanced Liquid Logic, Inc. | Droplet-based multiwell operations |
| US8637324B2 (en) | 2006-04-18 | 2014-01-28 | Advanced Liquid Logic, Inc. | Bead incubation and washing on a droplet actuator |
| US7815871B2 (en) | 2006-04-18 | 2010-10-19 | Advanced Liquid Logic, Inc. | Droplet microactuator system |
| ATE542921T1 (de) | 2006-04-18 | 2012-02-15 | Advanced Liquid Logic Inc | Pyrosequenzierung auf tröpfchenbasis |
| US7763471B2 (en) | 2006-04-18 | 2010-07-27 | Advanced Liquid Logic, Inc. | Method of electrowetting droplet operations for protein crystallization |
| WO2010027894A2 (en) | 2008-08-27 | 2010-03-11 | Advanced Liquid Logic, Inc. | Droplet actuators, modified fluids and methods |
| US8470606B2 (en) | 2006-04-18 | 2013-06-25 | Duke University | Manipulation of beads in droplets and methods for splitting droplets |
| US7439014B2 (en) | 2006-04-18 | 2008-10-21 | Advanced Liquid Logic, Inc. | Droplet-based surface modification and washing |
| US8716015B2 (en) | 2006-04-18 | 2014-05-06 | Advanced Liquid Logic, Inc. | Manipulation of cells on a droplet actuator |
| WO2009140671A2 (en) | 2008-05-16 | 2009-11-19 | Advanced Liquid Logic, Inc. | Droplet actuator devices and methods for manipulating beads |
| US7816121B2 (en) | 2006-04-18 | 2010-10-19 | Advanced Liquid Logic, Inc. | Droplet actuation system and method |
| US7901947B2 (en) | 2006-04-18 | 2011-03-08 | Advanced Liquid Logic, Inc. | Droplet-based particle sorting |
| US8809068B2 (en) | 2006-04-18 | 2014-08-19 | Advanced Liquid Logic, Inc. | Manipulation of beads in droplets and methods for manipulating droplets |
| US8980198B2 (en) | 2006-04-18 | 2015-03-17 | Advanced Liquid Logic, Inc. | Filler fluids for droplet operations |
| US8685754B2 (en) | 2006-04-18 | 2014-04-01 | Advanced Liquid Logic, Inc. | Droplet actuator devices and methods for immunoassays and washing |
| WO2010042637A2 (en) | 2008-10-07 | 2010-04-15 | Advanced Liquid Logic, Inc. | Bead incubation and washing on a droplet actuator |
| US8658111B2 (en) | 2006-04-18 | 2014-02-25 | Advanced Liquid Logic, Inc. | Droplet actuators, modified fluids and methods |
| WO2009140373A2 (en) | 2008-05-13 | 2009-11-19 | Advanced Liquid Logic, Inc. | Droplet actuator devices, systems, and methods |
| US8389297B2 (en) | 2006-04-18 | 2013-03-05 | Duke University | Droplet-based affinity assay device and system |
| WO2009026339A2 (en) | 2007-08-20 | 2009-02-26 | Advanced Liquid Logic, Inc. | Modular droplet actuator drive |
| US7939021B2 (en) | 2007-05-09 | 2011-05-10 | Advanced Liquid Logic, Inc. | Droplet actuator analyzer with cartridge |
| US7822510B2 (en) | 2006-05-09 | 2010-10-26 | Advanced Liquid Logic, Inc. | Systems, methods, and products for graphically illustrating and controlling a droplet actuator |
| US8041463B2 (en) | 2006-05-09 | 2011-10-18 | Advanced Liquid Logic, Inc. | Modular droplet actuator drive |
| JP5266208B2 (ja) | 2006-05-09 | 2013-08-21 | アドヴァンスト リキッド ロジック インコーポレイテッド | 液滴処置システム |
| WO2009111769A2 (en) | 2008-03-07 | 2009-09-11 | Advanced Liquid Logic, Inc. | Reagent and sample preparation and loading on a fluidic device |
| EP2530167A1 (en) | 2006-05-11 | 2012-12-05 | Raindance Technologies, Inc. | Microfluidic Devices |
| JP2008008283A (ja) | 2006-05-30 | 2008-01-17 | Denso Corp | ベーン式の可変バルブタイミング調整機構の制御装置 |
| WO2007146025A2 (en) | 2006-06-06 | 2007-12-21 | University Of Virginia Patent Foundation | Capillary force actuator device and related method of applications |
| US7629124B2 (en) | 2006-06-30 | 2009-12-08 | Canon U.S. Life Sciences, Inc. | Real-time PCR in micro-channels |
| JP4881950B2 (ja) | 2006-07-10 | 2012-02-22 | 株式会社日立ハイテクノロジーズ | 液体搬送デバイス |
| EP1905513A1 (en) | 2006-09-13 | 2008-04-02 | Institut Curie | Methods and devices for sampling fluids |
| JP4901410B2 (ja) | 2006-10-10 | 2012-03-21 | シャープ株式会社 | バックライト装置及び映像表示装置 |
| WO2008055256A2 (en) | 2006-11-02 | 2008-05-08 | The Regents Of The University Of California | Method and apparatus for real-time feedback control of electrical manipulation of droplets on chip |
| FR2909293B1 (fr) | 2006-12-05 | 2011-04-22 | Commissariat Energie Atomique | Micro-dispositif de traitement d'echantillons liquides |
| CN102851369B (zh) | 2006-12-13 | 2015-01-21 | 卢米耐克斯公司 | 用于实时pcr多重分析的系统和方法 |
| US8338166B2 (en) | 2007-01-04 | 2012-12-25 | Lawrence Livermore National Security, Llc | Sorting, amplification, detection, and identification of nucleic acid subsequences in a complex mixture |
| WO2008091848A2 (en) | 2007-01-22 | 2008-07-31 | Advanced Liquid Logic, Inc. | Surface assisted fluid loading and droplet dispensing |
| ES2423930T3 (es) | 2007-02-09 | 2013-09-25 | Advanced Liquid Logic, Inc. | Dispositivos actuadores de gotitas y métodos que emplean perlas magnéticas |
| WO2008101194A2 (en) | 2007-02-15 | 2008-08-21 | Advanced Liquid Logic, Inc. | Capacitance detection in a droplet actuator |
| EP2121329B1 (en) | 2007-03-01 | 2014-05-14 | Advanced Liquid Logic, Inc. | Droplet actuator structures |
| CA2716603A1 (en) | 2007-03-05 | 2009-09-12 | Advanced Liquid Logic, Inc. | Hydrogen peroxide droplet-based assays |
| AU2008225060B2 (en) | 2007-03-13 | 2013-04-04 | Advanced Liquid Logic, Inc. | Droplet actuator devices, configurations, and methods for improving absorbance detection |
| US8093062B2 (en) | 2007-03-22 | 2012-01-10 | Theodore Winger | Enzymatic assays using umbelliferone substrates with cyclodextrins in droplets in oil |
| WO2008116221A1 (en) | 2007-03-22 | 2008-09-25 | Advanced Liquid Logic, Inc. | Bead sorting on a droplet actuator |
| EP2837692A1 (en) | 2007-03-22 | 2015-02-18 | Advanced Liquid Logic, Inc. | Enzymatic assays for a droplet actuator |
| US8202686B2 (en) | 2007-03-22 | 2012-06-19 | Advanced Liquid Logic, Inc. | Enzyme assays for a droplet actuator |
| US8317990B2 (en) | 2007-03-23 | 2012-11-27 | Advanced Liquid Logic Inc. | Droplet actuator loading and target concentration |
| WO2010009463A2 (en) | 2008-07-18 | 2010-01-21 | Advanced Liquid Logic, Inc. | Droplet operations device |
| CA2719549A1 (en) | 2007-04-10 | 2008-10-16 | Advanced Liquid Logic, Inc. | Droplet dispensing device and methods |
| US20100130369A1 (en) | 2007-04-23 | 2010-05-27 | Advanced Liquid Logic, Inc. | Bead-Based Multiplexed Analytical Methods and Instrumentation |
| WO2009011952A1 (en) | 2007-04-23 | 2009-01-22 | Advanced Liquid Logic, Inc. | Device and method for sample collection and concentration |
| US20100087012A1 (en) | 2007-04-23 | 2010-04-08 | Advanced Liquid Logic, Inc. | Sample Collector and Processor |
| US20080283414A1 (en) | 2007-05-17 | 2008-11-20 | Monroe Charles W | Electrowetting devices |
| CN101679078B (zh) | 2007-05-24 | 2013-04-03 | 数字化生物系统 | 基于电湿润的数字微流体 |
| US8951732B2 (en) | 2007-06-22 | 2015-02-10 | Advanced Liquid Logic, Inc. | Droplet-based nucleic acid amplification in a temperature gradient |
| US8926811B2 (en) | 2007-06-27 | 2015-01-06 | Digital Biosystems | Digital microfluidics based apparatus for heat-exchanging chemical processes |
| US20100120130A1 (en) | 2007-08-08 | 2010-05-13 | Advanced Liquid Logic, Inc. | Droplet Actuator with Droplet Retention Structures |
| WO2009021173A1 (en) | 2007-08-08 | 2009-02-12 | Advanced Liquid Logic, Inc. | Use of additives for enhancing droplet operations |
| US8268246B2 (en) | 2007-08-09 | 2012-09-18 | Advanced Liquid Logic Inc | PCB droplet actuator fabrication |
| AU2008293652B2 (en) | 2007-08-24 | 2013-02-21 | Advanced Liquid Logic, Inc. | Bead manipulations on a droplet actuator |
| WO2009032863A2 (en) | 2007-09-04 | 2009-03-12 | Advanced Liquid Logic, Inc. | Droplet actuator with improved top substrate |
| TWI375023B (en) | 2007-10-05 | 2012-10-21 | Univ Nat Taiwan | A cellular microarray and its microfabrication method |
| WO2009052354A2 (en) | 2007-10-17 | 2009-04-23 | Advanced Liquid Logic, Inc. | Droplet actuator structures |
| EP2212683A4 (en) | 2007-10-17 | 2011-08-31 | Advanced Liquid Logic Inc | MANIPULATION OF BEADS INTO DROPLETS |
| US20100236928A1 (en) | 2007-10-17 | 2010-09-23 | Advanced Liquid Logic, Inc. | Multiplexed Detection Schemes for a Droplet Actuator |
| WO2009052095A1 (en) | 2007-10-17 | 2009-04-23 | Advanced Liquid Logic, Inc. | Reagent storage and reconstitution for a droplet actuator |
| US20100236929A1 (en) | 2007-10-18 | 2010-09-23 | Advanced Liquid Logic, Inc. | Droplet Actuators, Systems and Methods |
| US7621059B2 (en) | 2007-10-18 | 2009-11-24 | Oceaneering International, Inc. | Underwater sediment evacuation system |
| WO2009076414A2 (en) | 2007-12-10 | 2009-06-18 | Advanced Liquid Logic, Inc. | Droplet actuator configurations and methods |
| AU2008345138B2 (en) | 2007-12-23 | 2014-05-29 | Advanced Liquid Logic, Inc. | Droplet actuator configurations and methods of conducting droplet operations |
| WO2009135205A2 (en) | 2008-05-02 | 2009-11-05 | Advanced Liquid Logic, Inc. | Droplet actuator techniques using coagulatable samples |
| WO2009137415A2 (en) | 2008-05-03 | 2009-11-12 | Advanced Liquid Logic, Inc. | Reagent and sample preparation, loading, and storage |
| US20110097763A1 (en) | 2008-05-13 | 2011-04-28 | Advanced Liquid Logic, Inc. | Thermal Cycling Method |
| US8093064B2 (en) | 2008-05-15 | 2012-01-10 | The Regents Of The University Of California | Method for using magnetic particles in droplet microfluidics |
| FR2933713B1 (fr) | 2008-07-11 | 2011-03-25 | Commissariat Energie Atomique | Procede et dispositif de manipulation et d'observation de gouttes de liquide |
| EP2331251A4 (en) | 2008-08-13 | 2017-03-08 | Advanced Liquid Logic, Inc. | Methods, systems, and products for conducting droplet operations |
| US20110311980A1 (en) | 2008-12-15 | 2011-12-22 | Advanced Liquid Logic, Inc. | Nucleic Acid Amplification and Sequencing on a Droplet Actuator |
| US8877512B2 (en) | 2009-01-23 | 2014-11-04 | Advanced Liquid Logic, Inc. | Bubble formation techniques using physical or chemical features to retain a gas bubble within a droplet actuator |
| WO2011002957A2 (en) | 2009-07-01 | 2011-01-06 | Advanced Liquid Logic, Inc. | Droplet actuator devices and methods |
| US20130288254A1 (en) | 2009-08-13 | 2013-10-31 | Advanced Liquid Logic, Inc. | Droplet Actuator and Droplet-Based Techniques |
| US8926065B2 (en) | 2009-08-14 | 2015-01-06 | Advanced Liquid Logic, Inc. | Droplet actuator devices and methods |
| TWI372137B (en) | 2009-09-04 | 2012-09-11 | Univ Nat Chiao Tung | Dielectrophoresis-based microfluidic system |
| US8846414B2 (en) | 2009-09-29 | 2014-09-30 | Advanced Liquid Logic, Inc. | Detection of cardiac markers on a droplet actuator |
-
2006
- 2006-01-30 DK DK06734056.2T patent/DK1859330T3/da active
- 2006-01-30 BR BRPI0607213A patent/BRPI0607213B1/pt not_active IP Right Cessation
- 2006-01-30 KR KR1020077019597A patent/KR101198038B1/ko not_active Expired - Fee Related
- 2006-01-30 WO PCT/US2006/003230 patent/WO2006081558A2/en not_active Ceased
- 2006-01-30 US US11/343,284 patent/US8349276B2/en not_active Expired - Fee Related
- 2006-01-30 JP JP2007553327A patent/JP5897780B2/ja not_active Expired - Fee Related
- 2006-01-30 CN CN2006800032222A patent/CN101146595B/zh not_active Expired - Fee Related
- 2006-01-30 CA CA2594483A patent/CA2594483C/en not_active Expired - Fee Related
- 2006-01-30 AU AU2006207933A patent/AU2006207933B2/en not_active Ceased
- 2006-01-30 PL PL06734056T patent/PL1859330T3/pl unknown
- 2006-01-30 ES ES06734056T patent/ES2390800T3/es not_active Expired - Lifetime
- 2006-01-30 EP EP06734056A patent/EP1859330B1/en not_active Expired - Lifetime
-
2007
- 2007-05-24 US US11/753,318 patent/US8048628B2/en not_active Expired - Fee Related
-
2009
- 2009-10-09 US US12/576,794 patent/US8388909B2/en not_active Expired - Fee Related
-
2013
- 2013-01-09 US US13/737,433 patent/US8906627B2/en not_active Expired - Fee Related
-
2014
- 2014-04-10 JP JP2014081244A patent/JP5964881B2/ja not_active Expired - Fee Related
- 2014-11-11 US US14/538,322 patent/US9110017B2/en not_active Expired - Fee Related
-
2015
- 2015-08-04 US US14/817,834 patent/US9638662B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL1859330T3 (pl) | Urządzenia i sposoby manipulacji kropelkami na płytkach obwodów drukowanych | |
| FI20050646L (fi) | Piirilevyrakenne ja menetelmä piirilevyrakenteen valmistamiseksi | |
| EP1887845A4 (en) | CIRCUIT BOARD | |
| EP1887846A4 (en) | CIRCUIT BOARD | |
| DE602006017908D1 (de) | Leiterplatte | |
| FI20050645L (fi) | Menetelmä piirilevyrakenteen valmistamiseksi ja piirilevyrakenne | |
| PL2130417T3 (pl) | Płytki obwodów drukowanych | |
| DK2036062T3 (da) | Elektronisk informationstavle | |
| EP2071907A4 (en) | FLEX RIGID PCB AND METHOD FOR PRODUCING THE FLEX RIGID PCB | |
| TWI348563B (en) | Embedded waveguide printed circuit board structure and method for forming an embedded waveguide | |
| EP1713314A4 (en) | MULTILAYER CONDUCTOR PLATE | |
| EP1713313A4 (en) | MULTILAYER CONDUCTOR PLATE | |
| GB2429847B (en) | Printed circuit board and manuafacturing method thereof | |
| DE602007000582D1 (de) | Leiterplatte | |
| EP1863326A4 (en) | CIRCUIT BOARD | |
| DE602005024783D1 (de) | Verbinder für Leiterplatte | |
| DE602008001212D1 (de) | Elektronische Vorrichtung und flexible Schaltplatte | |
| EP2007176A4 (en) | CIRCUIT BOARD AND CONNECTING SUBSTRATE | |
| EP1850647A4 (en) | MULTILAYER CONDUCTOR PLATE | |
| EP1931186A4 (en) | MULTILAYER PRINTED CIRCUIT BOARD AND ELECTRONIC DEVICE | |
| DE602006000514D1 (de) | Leiterplatte und Herstellungsverfahren dafür | |
| DE602006019994D1 (de) | Leiterplatte | |
| EP2091307A4 (en) | PCB CONNECTING STRUCTURE AND PCB | |
| TWI373293B (en) | Printed circuit board and fabrication method thereof | |
| DE602006021249D1 (de) | Oberflächenmontierbare elektronische Schaltungseinheit |