PL1879580T3 - Pochodne 4-fenylo-5-okso-1,4,5,6,7,8-heksahydrochinoliny jako leki do leczenia niepłodności - Google Patents

Pochodne 4-fenylo-5-okso-1,4,5,6,7,8-heksahydrochinoliny jako leki do leczenia niepłodności

Info

Publication number
PL1879580T3
PL1879580T3 PL06754952T PL06754952T PL1879580T3 PL 1879580 T3 PL1879580 T3 PL 1879580T3 PL 06754952 T PL06754952 T PL 06754952T PL 06754952 T PL06754952 T PL 06754952T PL 1879580 T3 PL1879580 T3 PL 1879580T3
Authority
PL
Poland
Prior art keywords
infertility
medicaments
oxo
phenyl
treatment
Prior art date
Application number
PL06754952T
Other languages
English (en)
Inventor
Cornelis Marius Timmers
Willem Frederik Johan Karstens
Poveda Pedro Manuel Grima
Original Assignee
N V Organon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by N V Organon filed Critical N V Organon
Publication of PL1879580T3 publication Critical patent/PL1879580T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL06754952T 2005-05-04 2006-05-02 Pochodne 4-fenylo-5-okso-1,4,5,6,7,8-heksahydrochinoliny jako leki do leczenia niepłodności PL1879580T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05103738 2005-05-04
PCT/EP2006/061976 WO2006117370A1 (en) 2005-05-04 2006-05-02 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY
EP06754952A EP1879580B1 (en) 2005-05-04 2006-05-02 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives as medicaments for the treatment of infertility

Publications (1)

Publication Number Publication Date
PL1879580T3 true PL1879580T3 (pl) 2009-08-31

Family

ID=34939695

Family Applications (1)

Application Number Title Priority Date Filing Date
PL06754952T PL1879580T3 (pl) 2005-05-04 2006-05-02 Pochodne 4-fenylo-5-okso-1,4,5,6,7,8-heksahydrochinoliny jako leki do leczenia niepłodności

Country Status (28)

Country Link
US (1) US8034945B2 (pl)
EP (1) EP1879580B1 (pl)
JP (1) JP5129738B2 (pl)
KR (1) KR20080010427A (pl)
CN (1) CN101212972B (pl)
AR (1) AR056338A1 (pl)
AT (1) ATE424823T1 (pl)
AU (1) AU2006243190B2 (pl)
BR (1) BRPI0611118A2 (pl)
CA (1) CA2606682C (pl)
CY (1) CY1109076T1 (pl)
DE (1) DE602006005640D1 (pl)
DK (1) DK1879580T3 (pl)
ES (1) ES2322295T3 (pl)
HR (1) HRP20090189T1 (pl)
IL (1) IL186676A (pl)
MX (1) MX2007013742A (pl)
NO (1) NO20075567L (pl)
NZ (1) NZ562685A (pl)
PE (1) PE20061440A1 (pl)
PL (1) PL1879580T3 (pl)
PT (1) PT1879580E (pl)
RS (1) RS50968B (pl)
RU (1) RU2403243C2 (pl)
SI (1) SI1879580T1 (pl)
UA (1) UA92008C2 (pl)
WO (1) WO2006117370A1 (pl)
ZA (1) ZA200709094B (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA92007C2 (ru) * 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности
UA92009C2 (ru) * 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия
CN101171234B (zh) * 2005-05-04 2011-11-16 欧加农股份有限公司 二氢吡啶衍生物
TW200944523A (en) 2008-02-08 2009-11-01 Organon Nv (Dihydro)pyrrolo[2,1-a]isoquinolines
US8071587B2 (en) * 2009-05-27 2011-12-06 N. V. Organon (Dihydro)imidazoiso[5,1-A]quinolines
US8431564B2 (en) 2009-07-29 2013-04-30 Merck Sharp & Dohme B.V. Ring-annulated dihydropyrrolo[2,1-α]isoquinolines
TW201116531A (en) 2009-07-29 2011-05-16 Organon Nv Ring-annulated dihydropyrrolo[2,1-a]isoquinolines
TW201116515A (en) 2009-07-31 2011-05-16 Organon Nv Dihydrobenzoindazoles
ES2555260T3 (es) 2010-06-15 2015-12-30 Bayer Intellectual Property Gmbh Derivados de diamida de ácido antranílico
RU2648352C1 (ru) * 2017-07-18 2018-03-23 Федеральное государственное бюджетное образовательное учреждение высшего образования "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации Способ лечения первичного бесплодия, обусловленного тромбофилиями при проведении экстракорпорального оплодотворения

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1070162B (de) 1959-12-03 Farbwerke Hoechst Aktiengesellschaft vormals Meister Lucius &. Brüning, Frankfurt/M Verfahren zur Herstellung von 5 - Brom - 3 - nitro - 4 - hydroxybenzaldehyd bzw. 5 - Chlor - 3 - nitro - 4 - hydroxybenzaldehyd
GB9318935D0 (en) * 1992-10-20 1993-10-27 Zeneca Ltd Heterocyclic derivatives
US5455253A (en) * 1992-10-20 1995-10-03 Zeneca Limited Heterocyclic derivatives
GB9407432D0 (en) * 1994-04-14 1994-06-08 Zeneca Ltd Heterocyclic derivative
DE4430639A1 (de) * 1994-08-29 1996-03-07 Bayer Ag Verwendung von 5-substituierten Pyridin- und Hexahydrochinolin-3-carbonsäurederivaten
GB9515445D0 (en) * 1995-07-27 1995-09-27 Pharmacia Spa Dihydropyridine and pyridine derivatives and process for their preparation
CA2229201A1 (en) * 1995-10-19 1997-04-24 Satoshi Sasaki Quinoline derivatives, their production and use
US6593335B1 (en) 1997-12-18 2003-07-15 Abbott Laboratories Potassium channel openers
WO2000008015A2 (en) 1998-08-07 2000-02-17 Applied Research Systems Ars Holding N.V. Fsh mimetics for the treatment of infertility
WO2002009706A1 (en) 2000-07-27 2002-02-07 Smithkline Beecham Corporation Agonists of follicle stimulating hormone activity
CA2452606C (en) * 2001-07-02 2011-09-13 Akzo Nobel N.V. Tetrahydroquinoline derivatives
JP2003026630A (ja) 2001-07-13 2003-01-29 Taoka Chem Co Ltd カラーカプラー中間体用カルボン酸クロリド類の製造法
TWI322012B (en) 2002-12-20 2010-03-21 Organon Nv Tetrahydroquinoline derivatives
UA92007C2 (ru) * 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности
CN101171234B (zh) * 2005-05-04 2011-11-16 欧加农股份有限公司 二氢吡啶衍生物
UA92009C2 (ru) * 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия

Also Published As

Publication number Publication date
CA2606682C (en) 2013-10-29
SI1879580T1 (sl) 2009-06-30
RU2403243C2 (ru) 2010-11-10
RU2007144988A (ru) 2009-06-10
MX2007013742A (es) 2008-01-24
BRPI0611118A2 (pt) 2010-11-09
US8034945B2 (en) 2011-10-11
ZA200709094B (en) 2008-09-25
IL186676A0 (en) 2008-02-09
JP2008540378A (ja) 2008-11-20
EP1879580A1 (en) 2008-01-23
JP5129738B2 (ja) 2013-01-30
RS50968B (sr) 2010-10-31
US20080300270A1 (en) 2008-12-04
EP1879580B1 (en) 2009-03-11
PT1879580E (pt) 2009-05-27
WO2006117370A1 (en) 2006-11-09
PE20061440A1 (es) 2007-02-03
AR056338A1 (es) 2007-10-03
DE602006005640D1 (de) 2009-04-23
ES2322295T3 (es) 2009-06-18
KR20080010427A (ko) 2008-01-30
CN101212972A (zh) 2008-07-02
CA2606682A1 (en) 2006-11-09
AU2006243190B2 (en) 2011-04-07
CY1109076T1 (el) 2014-07-02
UA92008C2 (en) 2010-09-27
NZ562685A (en) 2010-10-29
NO20075567L (no) 2007-12-03
DK1879580T3 (da) 2009-05-18
IL186676A (en) 2011-08-31
ATE424823T1 (de) 2009-03-15
HRP20090189T1 (hr) 2009-05-31
AU2006243190A1 (en) 2006-11-09
CN101212972B (zh) 2011-06-08

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