PL1932918T3 - Sposób otrzymywania kladrybiny - Google Patents

Sposób otrzymywania kladrybiny

Info

Publication number
PL1932918T3
PL1932918T3 PL06026046T PL06026046T PL1932918T3 PL 1932918 T3 PL1932918 T3 PL 1932918T3 PL 06026046 T PL06026046 T PL 06026046T PL 06026046 T PL06026046 T PL 06026046T PL 1932918 T3 PL1932918 T3 PL 1932918T3
Authority
PL
Poland
Prior art keywords
cladribine
reaction medium
production
reaction
phosphorylase
Prior art date
Application number
PL06026046T
Other languages
English (en)
Inventor
Gabriele Zuffi
Simone Monciardini
Original Assignee
Explora Laboratories Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Explora Laboratories Sa filed Critical Explora Laboratories Sa
Publication of PL1932918T3 publication Critical patent/PL1932918T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL06026046T 2006-12-15 2006-12-15 Sposób otrzymywania kladrybiny PL1932918T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06026046A EP1932918B1 (en) 2006-12-15 2006-12-15 Method for the production of cladribine

Publications (1)

Publication Number Publication Date
PL1932918T3 true PL1932918T3 (pl) 2010-03-31

Family

ID=38038673

Family Applications (1)

Application Number Title Priority Date Filing Date
PL06026046T PL1932918T3 (pl) 2006-12-15 2006-12-15 Sposób otrzymywania kladrybiny

Country Status (9)

Country Link
US (1) US8012717B2 (pl)
EP (1) EP1932918B1 (pl)
AT (1) ATE443151T1 (pl)
CA (1) CA2610862A1 (pl)
DE (1) DE602006009282D1 (pl)
ES (1) ES2335796T3 (pl)
PL (1) PL1932918T3 (pl)
PT (1) PT1932918E (pl)
SI (1) SI1932918T1 (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI399381B (zh) * 2009-08-18 2013-06-21 Scinopharm Taiwan Ltd 克拉屈濱（ｃｌａｄｒｉｂｉｎｅ）的製備方法
EP2993177A1 (en) 2014-09-05 2016-03-09 Technische Universität Berlin A chemo-enzymatic preparation method for purine nucleosides and their deaza- and aza- analogues
CN106929553B (zh) * 2015-12-31 2021-02-19 上海鑫欣生物科技有限公司 一种酶法合成阿糖腺苷的方法
EP3645635B1 (en) * 2017-06-30 2021-08-04 Dow Global Technologies LLC Coating for aldehyde remediation and method of making
DE102023123718A1 (de) 2023-09-04 2025-03-06 CHIRACON Pharma GmbH Verfahren zur Herstellung von Nukleosiden
CZ2024206A3 (cs) * 2024-05-20 2025-12-03 Vuab Pharma A.S. Způsob výroby kladribinu

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1269659A (en) 1984-08-06 1990-05-29 Brigham Young University Method for the production of 2'-deoxyadenosine compounds
US5208327A (en) 1991-12-18 1993-05-04 Ortho Pharmaceutical Corporation Intermediates useful in a synthesis of 2-chloro-2'-deoxyadenosine
US6252061B1 (en) 1998-03-23 2001-06-26 Reliable Biopharmaceutical, Inc. Process for the production of 2-halo-6-aminopurine derivatives
US20020052491A1 (en) 1999-04-28 2002-05-02 Szepsel Gerszberg Method for the production of 2-chloro-2' -deoxyadenosine (cladribine) and its 3,5-di-O-p-toluoyl derivative
BR0104461A (pt) 2000-02-10 2002-08-06 Mitsui Chemicals Inc Processo seletivo para produzir um anÈmero a partir de um derivado de sacarìdeo 1-fosforilado e processo para produzir um nucleosìdeo
US6884880B2 (en) 2002-08-21 2005-04-26 Ash Stevens, Inc. Process for the preparation of 9-β-anomeric nucleoside analogs
AU2003275267A1 (en) 2002-09-25 2004-04-19 Brigham Young University, Technology Transfer Office Method for the preparation of 2-halo-2'-deoxyadenosine compounds from 2'-deoxyguanosine
ES2292927T3 (es) * 2003-01-16 2008-03-16 Adorkem Technology Spa Biocatalizadores inmovilizados utilizables para la produccion de nucleosidos naturales y de analogos modificados a traves de reacciones enzimaticas de transglicosilacion.

Also Published As

Publication number Publication date
EP1932918B1 (en) 2009-09-16
ATE443151T1 (de) 2009-10-15
CA2610862A1 (en) 2008-06-15
ES2335796T3 (es) 2010-04-05
EP1932918A1 (en) 2008-06-18
DE602006009282D1 (de) 2009-10-29
US20100291632A1 (en) 2010-11-18
US8012717B2 (en) 2011-09-06
SI1932918T1 (sl) 2010-02-26
PT1932918E (pt) 2010-01-05

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