PL1948606T3 - 3,5-dwupodstawione fenylopiperydyny jako modulatory neurotransmisji dopaminy - Google Patents

3,5-dwupodstawione fenylopiperydyny jako modulatory neurotransmisji dopaminy

Info

Publication number: PL1948606T3
Authority: PL; Poland
Prior art keywords: piperidines; modulators; disubstituted phenyl; dopamine neurotransmission; neurotransmission
Prior art date: 2005-10-13

Application number

PL06806224T

Other languages

English (en)

Inventor

Clas Sonesson

Original Assignee

Nsab Filial Af Neurosearch Sweden Ab Sverige

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-10-13

Filing date

2006-10-12

Publication date

2011-08-31

2006-10-12 Application filed by Nsab Filial Af Neurosearch Sweden Ab Sverige filed Critical Nsab Filial Af Neurosearch Sweden Ab Sverige

2011-08-31 Publication of PL1948606T3 publication Critical patent/PL1948606T3/pl

Links

VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title 2
-1 3, 5-disubstituted phenyl-piperidines Chemical class 0.000 title 1
229960003638 dopamine Drugs 0.000 title 1
230000005062 synaptic transmission Effects 0.000 title 1
LLSKXGRDUPMXLC-UHFFFAOYSA-N 1-phenylpiperidine Chemical class C1CCCCN1C1=CC=CC=C1 LLSKXGRDUPMXLC-UHFFFAOYSA-N 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/24—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by sulfur atoms to which a second hetero atom is attached
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Psychology (AREA)
Anesthesiology (AREA)
Addiction (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)

PL06806224T 2005-10-13 2006-10-12 3,5-dwupodstawione fenylopiperydyny jako modulatory neurotransmisji dopaminy PL1948606T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
SE0502254A SE529246C2 (sv)	2005-10-13	2005-10-13	Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission
PCT/EP2006/009866 WO2007042295A1 (en)	2005-10-13	2006-10-12	3, 5-disubstituted phenyl-piperidines as mdulators of dopamine? neurotransmission
EP06806224A EP1948606B1 (en)	2005-10-13	2006-10-12	3, 5-disubstituted phenyl-piperidines as modulators of dopamine neurotransmission

Publications (1)

Publication Number	Publication Date
PL1948606T3 true PL1948606T3 (pl)	2011-08-31

Family

ID=37467527

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL06806224T PL1948606T3 (pl)	2005-10-13	2006-10-12	3,5-dwupodstawione fenylopiperydyny jako modulatory neurotransmisji dopaminy

Country Status (23)

Country	Link
US (1)	US8501777B2 (pl)
EP (1)	EP1948606B1 (pl)
JP (1)	JP4857346B2 (pl)
KR (1)	KR20080046720A (pl)
CN (1)	CN101273014B (pl)
AT (1)	ATE494277T1 (pl)
AU (1)	AU2006301432B2 (pl)
BR (1)	BRPI0617355A2 (pl)
CA (1)	CA2625663A1 (pl)
DE (1)	DE602006019470D1 (pl)
DK (1)	DK1948606T3 (pl)
ES (1)	ES2358537T3 (pl)
HR (1)	HRP20110196T1 (pl)
IL (1)	IL189298A0 (pl)
MY (1)	MY143241A (pl)
NO (1)	NO20082174L (pl)
NZ (1)	NZ566015A (pl)
PL (1)	PL1948606T3 (pl)
RU (1)	RU2418787C2 (pl)
SE (1)	SE529246C2 (pl)
UA (1)	UA93380C2 (pl)
WO (1)	WO2007042295A1 (pl)
ZA (1)	ZA200802238B (pl)

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SE9904723D0 (sv)	1999-12-22	1999-12-22	Carlsson A Research Ab	New modulators of dopamine neurotransmission II
US7851629B2 (en)	2004-06-08	2010-12-14	Nsab, Filial Af Neurosearch Sweden Ab, Sverige	Disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission
SE0401465D0 (sv)	2004-06-08	2004-06-08	Carlsson A Research Ab	New substituted piperdines as modulators of dopamine neurotransmission
KR101245075B1 (ko) *	2004-06-08	2013-03-18	엔에스아베 필리알 아프 뉴로서치 스웨덴 아베 스베리게	도파민 신경전달의 모듈레이터로서 신 2기치환된페닐피페리딘/피페라진
WO2006040155A1 (en)	2004-10-13	2006-04-20	Neurosearch Sweden Ab	Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-n-propyl-piperidine
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AU2009242095A1 (en) *	2008-04-29	2009-11-05	Nsab, Filial Af Neurosearch Sweden Ab, Sverige	Modulators of dopamine neurotransmission
EP2271635A1 (en) *	2008-04-29	2011-01-12	NSAB, Filial af NeuroSearch Sweden AB, Sverige	Modulators of dopamine neurotransmission
KR20100135325A (ko) *	2008-04-29	2010-12-24	엔에스아베 필리알 아프 뉴로서치 스웨덴 아베 스베리게	도파민 신경전달의 조절제
WO2011107583A1 (en)	2010-03-04	2011-09-09	Nsab, Filial Af Neurosearch Sweden Ab, Sverige	Substituted 4-phenyl-n-alkyl-piperidines for preventing onset or slowing progression of neurodegenerative disorders
EP2611759A1 (en)	2010-09-03	2013-07-10	Ivax International Gmbh	Deuterated analogs of pridopidine useful as dopaminergic stabilizers
CA2847736A1 (en)	2011-09-07	2013-03-14	IVAX International GmbH	A new polymorphic form of pridopidine hydrochloride
TWI579272B (zh)	2011-12-08	2017-04-21	梯瓦製藥國際有限責任公司	普多比啶（ｐｒｉｄｏｐｉｄｉｎｅ）之氫溴酸鹽
JP6177875B2 (ja)	2012-04-04	2017-08-09	テバ・ファーマシューティカルズ・インターナショナル・ゲーエムベーハーＴｅｖａＰｈａｒｍａｃｅｕｔｉｃａｌｓＩｎｔｅｒｎａｔｉｏｎａｌＧｍｂＨ	併用療法のための医薬組成物
TW201613859A (en) *	2014-06-30	2016-04-16	Teva Pharma	Analogs of PRIDOPIDINE, their preparation and use
MX2019002190A (es)	2016-08-24	2019-09-11	Prilenia Therapeutics Dev Ltd	Uso de pridopidina para tratar distonías.
EP3678664A1 (en) *	2017-09-08	2020-07-15	Prilenia Neurotherapeutics Ltd.	Pridopidine for treating drug induced dyskinesias

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SE9904724D0 (sv)	1999-12-22	1999-12-22	Carlsson A Research Ab	New modulators of dopamine neurotransmission I
SE9904723D0 (sv) *	1999-12-22	1999-12-22	Carlsson A Research Ab	New modulators of dopamine neurotransmission II
AU2001280599A1 (en)	2000-07-15	2002-01-30	Smith Kline Beecham Corporation	Compounds and methods
CA2432985A1 (en)	2001-01-23	2002-08-01	Vincent Mancuso	Piperazine- and piperidine-derivatives as melanocortin receptor agonists
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EP2204363A1 (en)	2004-06-08	2010-07-07	NSAB, Filial af NeuroSearch Sweden AB, Sverige	New disubstituted phenylpiperidines/piperazines as modulators of dopamine neurotransmission
SE0401465D0 (sv)	2004-06-08	2004-06-08	Carlsson A Research Ab	New substituted piperdines as modulators of dopamine neurotransmission
KR101245075B1 (ko) *	2004-06-08	2013-03-18	엔에스아베 필리알 아프 뉴로서치 스웨덴 아베 스베리게	도파민 신경전달의 모듈레이터로서 신 2기치환된페닐피페리딘/피페라진
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CA2584833A1 (en) *	2004-10-13	2006-04-20	Neurosearch Sweden Ab	Process for the synthesis of 4-(3-sulfonylphenyl)-piperidines
RU2008101923A (ru) *	2005-08-05	2009-09-10	Астразенека Аб (Se)	Трициклические бензимидазолы и их применение в качестве модуляторов метаботропного глутаматного рецептора
WO2007065655A1 (en)	2005-12-07	2007-06-14	Neurosearch Sweden Ab	Disubstituted phenylpiperidines as modulators of cortical catecholaminergic neurotransmission

2005
- 2005-10-13 SE SE0502254A patent/SE529246C2/sv unknown
2006
- 2006-10-12 ZA ZA200802238A patent/ZA200802238B/xx unknown
- 2006-10-12 CA CA002625663A patent/CA2625663A1/en not_active Abandoned
- 2006-10-12 WO PCT/EP2006/009866 patent/WO2007042295A1/en not_active Ceased
- 2006-10-12 RU RU2008108618/04A patent/RU2418787C2/ru not_active IP Right Cessation
- 2006-10-12 DK DK06806224.9T patent/DK1948606T3/da active
- 2006-10-12 CN CN2006800352682A patent/CN101273014B/zh not_active Expired - Fee Related
- 2006-10-12 NZ NZ566015A patent/NZ566015A/en not_active IP Right Cessation
- 2006-10-12 KR KR1020087008815A patent/KR20080046720A/ko not_active Abandoned
- 2006-10-12 MY MYPI20081021A patent/MY143241A/en unknown
- 2006-10-12 HR HR20110196T patent/HRP20110196T1/hr unknown
- 2006-10-12 AU AU2006301432A patent/AU2006301432B2/en not_active Ceased
- 2006-10-12 BR BRPI0617355-1A patent/BRPI0617355A2/pt not_active IP Right Cessation
- 2006-10-12 EP EP06806224A patent/EP1948606B1/en not_active Not-in-force
- 2006-10-12 AT AT06806224T patent/ATE494277T1/de active
- 2006-10-12 JP JP2008534935A patent/JP4857346B2/ja not_active Expired - Fee Related
- 2006-10-12 ES ES06806224T patent/ES2358537T3/es active Active
- 2006-10-12 US US12/089,412 patent/US8501777B2/en not_active Expired - Fee Related
- 2006-10-12 PL PL06806224T patent/PL1948606T3/pl unknown
- 2006-10-12 DE DE602006019470T patent/DE602006019470D1/de active Active
- 2006-12-10 UA UAA200801380A patent/UA93380C2/ru unknown
2008
- 2008-02-05 IL IL189298A patent/IL189298A0/en unknown
- 2008-05-09 NO NO20082174A patent/NO20082174L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU2006301432A1 (en)	2007-04-19
ES2358537T3 (es)	2011-05-11
DE602006019470D1 (de)	2011-02-17
JP4857346B2 (ja)	2012-01-18
MY143241A (en)	2011-04-15
EP1948606A1 (en)	2008-07-30
BRPI0617355A2 (pt)	2011-07-26
CN101273014A (zh)	2008-09-24
JP2009511525A (ja)	2009-03-19
ATE494277T1 (de)	2011-01-15
SE0502254L (sv)	2007-04-14
KR20080046720A (ko)	2008-05-27
HK1125097A1 (en)	2009-07-31
ZA200802238B (en)	2009-10-28
US8501777B2 (en)	2013-08-06
CN101273014B (zh)	2011-01-12
AU2006301432B2 (en)	2011-12-15
NZ566015A (en)	2010-11-26
RU2008108618A (ru)	2009-11-20
US20080234321A1 (en)	2008-09-25
WO2007042295A1 (en)	2007-04-19
HRP20110196T1 (hr)	2011-05-31
EP1948606B1 (en)	2011-01-05
SE529246C2 (sv)	2007-06-12
NO20082174L (no)	2008-07-11
IL189298A0 (en)	2008-06-05
CA2625663A1 (en)	2007-04-19
UA93380C2 (en)	2011-02-10
DK1948606T3 (da)	2011-04-04
RU2418787C2 (ru)	2011-05-20

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TW200510301A (en)	2005-03-16	Novel compounds
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