PL1957484T3 - Antagoniści receptora glukagonu, wytwarzanie i zastosowanie w lecznictwie - Google Patents

Antagoniści receptora glukagonu, wytwarzanie i zastosowanie w lecznictwie

Info

Publication number: PL1957484T3
Authority: PL; Poland
Prior art keywords: glucagon receptor; preparation; receptor antagonists; therapeutic uses; compounds
Prior art date: 2005-11-23

Application number

PL06850798T

Other languages

English (en)

Inventor

Mark Donald Chappell

Scott Eugene Conner

Philip Arthur Hipskind

Allie Edward Tripp

Guoxin Zhu

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-11-23

Filing date

2006-11-21

Publication date

2010-07-30

2006-11-21 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2010-07-30 Publication of PL1957484T3 publication Critical patent/PL1957484T3/pl

Links

229940122904 Glucagon receptor antagonist Drugs 0.000 title abstract 2
230000001225 therapeutic effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
102000051325 Glucagon Human genes 0.000 abstract 1
108060003199 Glucagon Proteins 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 abstract 1
229960004666 glucagon Drugs 0.000 abstract 1
229940125425 inverse agonist Drugs 0.000 abstract 1
208000030159 metabolic disease Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000002469 receptor inverse agonist Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Ophthalmology & Optometry (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Gynecology & Obstetrics (AREA)
Pulmonology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Nutrition Science (AREA)
Emergency Medicine (AREA)
Reproductive Health (AREA)
Child & Adolescent Psychology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PL06850798T 2005-11-23 2006-11-21 Antagoniści receptora glukagonu, wytwarzanie i zastosowanie w lecznictwie PL1957484T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US73969205P	2005-11-23	2005-11-23
PCT/US2006/061132 WO2007120284A2 (en)	2005-11-23	2006-11-21	Glucagon receptor antagonists, preparation and therapeutic uses
EP06850798A EP1957484B1 (en)	2005-11-23	2006-11-21	Glucagon receptor antagonists, preparation and therapeutic uses

Publications (1)

Publication Number	Publication Date
PL1957484T3 true PL1957484T3 (pl)	2010-07-30

Family

ID=38521482

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL06850798T PL1957484T3 (pl)	2005-11-23	2006-11-21	Antagoniści receptora glukagonu, wytwarzanie i zastosowanie w lecznictwie

Country Status (16)

Country	Link
US (1)	US7807702B2 (pl)
EP (1)	EP1957484B1 (pl)
JP (1)	JP5140599B2 (pl)
CN (1)	CN101312963B (pl)
AT (1)	ATE459619T1 (pl)
AU (1)	AU2006342059B2 (pl)
BR (1)	BRPI0618745A2 (pl)
CA (1)	CA2629311C (pl)
CY (1)	CY1110922T1 (pl)
DE (1)	DE602006012725D1 (pl)
DK (1)	DK1957484T3 (pl)
ES (1)	ES2339599T3 (pl)
PL (1)	PL1957484T3 (pl)
PT (1)	PT1957484E (pl)
SI (1)	SI1957484T1 (pl)
WO (1)	WO2007120284A2 (pl)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1968921B (zh) *	2004-06-14	2011-11-23	伊莱利利公司	胰高血糖素受体拮抗剂、制备和治疗用途
KR20200123866A (ko)	2007-02-09	2020-10-30	메타베이시스 테라퓨틱스, 인크.	글루카곤 수용체의 길항제
EP2025674A1 (de)	2007-08-15	2009-02-18	sanofi-aventis	Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PT2799428T (pt)	2008-08-13	2017-02-17	Metabasis Therapeutics Inc	Antagonistas de glicagina
WO2011107494A1 (de)	2010-03-03	2011-09-09	Sanofi	Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2582709B1 (de)	2010-06-18	2018-01-24	Sanofi	Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en)	2010-06-21	2013-09-10	Sanofi	Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en)	2010-07-05	2012-04-16	Sanofi Sa	(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en)	2010-07-05	2012-04-16	Sanofi Aventis	Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en)	2010-07-05	2012-06-01	Sanofi Sa	Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
NZ611529A (en)	2010-12-23	2015-06-26	Pfizer	Glucagon receptor modulators
WO2012107850A1 (en)	2011-02-08	2012-08-16	Pfizer Inc.	Glucagon receptor modulator
US8828994B2 (en)	2011-03-08	2014-09-09	Sanofi	Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683699B1 (de)	2011-03-08	2015-06-24	Sanofi	Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2766349B1 (de)	2011-03-08	2016-06-01	Sanofi	Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120056A1 (de)	2011-03-08	2012-09-13	Sanofi	Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683704B1 (de)	2011-03-08	2014-12-17	Sanofi	Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8927577B2 (en)	2011-07-22	2015-01-06	Pfizer Inc.	Quinolinyl glucagon receptor modulators
WO2013037390A1 (en)	2011-09-12	2013-03-21	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en)	2011-09-27	2013-04-04	Sanofi	6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP3065736B1 (en)	2013-11-04	2018-11-14	Merck Sharp & Dohme Corp.	Glucagon receptor antagonist compounds, compositions thereof, and methods of use
WO2015191900A1 (en)	2014-06-12	2015-12-17	Ligand Pharmaceuticals, Inc.	Glucagon antagonists
WO2019160940A1 (en)	2018-02-13	2019-08-22	Ligand Pharmaceuticals Incorporated	Glucagon receptor antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9420557D0 (en) *	1994-10-12	1994-11-30	Zeneca Ltd	Aromatic compounds
HUP0301501A2 (hu) *	2000-06-23	2003-08-28	Novo Nordisk A/S	Glükagon antaagonista/inverz agonista vegyületek, ezeket tartalmazó gyógyászati készítmények, valamint a vegyületek alkalmazása gyógyászati készítmények előállítására
JP2005511683A (ja)	2001-12-03	2005-04-28	ノボ　ノルディスク　アクティーゼルスカブ	新規なグルカゴンアンタゴニスト
EP1519723A1 (en)	2002-06-27	2005-04-06	Novo Nordisk A/S	Novel glucagon antagonists/inverse agonists
WO2004056763A2 (en)	2002-12-20	2004-07-08	Novo Nordisk A/S	Novel glucagon antagonists
US8318760B2 (en)	2005-03-21	2012-11-27	Merck Sharp & Dohme Corp.	Substituted aryl and heteroaryl derivatives, compositions containing such compounds and methods of use

2006
- 2006-11-21 AT AT06850798T patent/ATE459619T1/de active
- 2006-11-21 AU AU2006342059A patent/AU2006342059B2/en not_active Ceased
- 2006-11-21 US US12/094,406 patent/US7807702B2/en not_active Expired - Fee Related
- 2006-11-21 CN CN2006800438950A patent/CN101312963B/zh not_active Expired - Fee Related
- 2006-11-21 BR BRPI0618745-5A patent/BRPI0618745A2/pt not_active IP Right Cessation
- 2006-11-21 DK DK06850798.7T patent/DK1957484T3/da active
- 2006-11-21 PL PL06850798T patent/PL1957484T3/pl unknown
- 2006-11-21 ES ES06850798T patent/ES2339599T3/es active Active
- 2006-11-21 PT PT06850798T patent/PT1957484E/pt unknown
- 2006-11-21 SI SI200630650T patent/SI1957484T1/sl unknown
- 2006-11-21 EP EP06850798A patent/EP1957484B1/en not_active Not-in-force
- 2006-11-21 JP JP2008542509A patent/JP5140599B2/ja not_active Expired - Fee Related
- 2006-11-21 WO PCT/US2006/061132 patent/WO2007120284A2/en not_active Ceased
- 2006-11-21 DE DE602006012725T patent/DE602006012725D1/de active Active
- 2006-11-21 CA CA2629311A patent/CA2629311C/en not_active Expired - Fee Related
2010
- 2010-04-23 CY CY20101100366T patent/CY1110922T1/el unknown

Also Published As

Publication number	Publication date
CY1110922T1 (el)	2015-06-10
JP2009519903A (ja)	2009-05-21
AU2006342059B2 (en)	2012-05-10
US20080300289A1 (en)	2008-12-04
BRPI0618745A2 (pt)	2011-09-13
PT1957484E (pt)	2010-03-29
SI1957484T1 (sl)	2010-07-30
US7807702B2 (en)	2010-10-05
ATE459619T1 (de)	2010-03-15
DE602006012725D1 (de)	2010-04-15
EP1957484B1 (en)	2010-03-03
CN101312963B (zh)	2012-03-14
ES2339599T3 (es)	2010-05-21
WO2007120284A2 (en)	2007-10-25
WO2007120284A3 (en)	2007-12-27
CA2629311A1 (en)	2007-10-25
AU2006342059A1 (en)	2007-10-25
CA2629311C (en)	2014-05-06
JP5140599B2 (ja)	2013-02-06
CN101312963A (zh)	2008-11-26
EP1957484A2 (en)	2008-08-20
DK1957484T3 (da)	2010-05-10

Publication	Publication Date	Title
IL184932A0 (en)	2007-12-03	Glucagon receptor antagonists, preperation and therapeutic uses
WO2007106181A3 (en)	2007-12-06	Glucagon receptor antagonists, preparation and therapeutic uses
NO20070213L (no)	2007-03-12	Glucagon reseptorantagonister, fremstilling og terapeutiske anvendelser
CY1110922T1 (el)	2015-06-10	Ανταγωνιστες υποδοχεα γλυκαγονης, παρασκευη και θεραπευτικες χρησεις
WO2007120270A3 (en)	2008-02-28	Glucagon receptor antagonists, preparation and therapeutic uses
PL1735278T3 (pl)	2010-06-30	Związki receptora histaminowego H3, wytwarzanie i zastosowania terapeutyczne
WO2005082893A3 (en)	2006-04-20	Histamine h3 receptor antagonists, preparation and therapeutic uses
WO2007114855A3 (en)	2007-11-29	Glucagon receptor antagonists, preparation and therapeutic uses
PL1861360T3 (pl)	2010-04-30	Pochodne pirolidyny jako antagoniści receptora histaminowego H3