PL1957484T3 - Antagoniści receptora glukagonu, wytwarzanie i zastosowanie w lecznictwie - Google Patents

Antagoniści receptora glukagonu, wytwarzanie i zastosowanie w lecznictwie

Info

Publication number: PL1957484T3
Authority: PL; Poland
Prior art keywords: glucagon receptor; preparation; receptor antagonists; therapeutic uses; compounds
Prior art date: 2005-11-23

Application number

PL06850798T

Other languages

English (en)

Inventor

Mark Donald Chappell

Scott Eugene Conner

Philip Arthur Hipskind

Allie Edward Tripp

Guoxin Zhu

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-11-23

Filing date

2006-11-21

Publication date

2010-07-30

2006-11-21 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2010-07-30 Publication of PL1957484T3 publication Critical patent/PL1957484T3/pl

Links

229940122904 Glucagon receptor antagonist Drugs 0.000 title abstract 2
230000001225 therapeutic effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
102000051325 Glucagon Human genes 0.000 abstract 1
108060003199 Glucagon Proteins 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 abstract 1
229960004666 glucagon Drugs 0.000 abstract 1
229940125425 inverse agonist Drugs 0.000 abstract 1
208000030159 metabolic disease Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000002469 receptor inverse agonist Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Ophthalmology & Optometry (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Emergency Medicine (AREA)
Reproductive Health (AREA)
Vascular Medicine (AREA)
Child & Adolescent Psychology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Gynecology & Obstetrics (AREA)
Hospice & Palliative Care (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PL06850798T 2005-11-23 2006-11-21 Antagoniści receptora glukagonu, wytwarzanie i zastosowanie w lecznictwie PL1957484T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US73969205P	2005-11-23	2005-11-23
PCT/US2006/061132 WO2007120284A2 (en)	2005-11-23	2006-11-21	Glucagon receptor antagonists, preparation and therapeutic uses
EP06850798A EP1957484B1 (en)	2005-11-23	2006-11-21	Glucagon receptor antagonists, preparation and therapeutic uses

Publications (1)

Publication Number	Publication Date
PL1957484T3 true PL1957484T3 (pl)	2010-07-30

Family

ID=38521482

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL06850798T PL1957484T3 (pl)	2005-11-23	2006-11-21	Antagoniści receptora glukagonu, wytwarzanie i zastosowanie w lecznictwie

Country Status (16)

Country	Link
US (1)	US7807702B2 (pl)
EP (1)	EP1957484B1 (pl)
JP (1)	JP5140599B2 (pl)
CN (1)	CN101312963B (pl)
AT (1)	ATE459619T1 (pl)
AU (1)	AU2006342059B2 (pl)
BR (1)	BRPI0618745A2 (pl)
CA (1)	CA2629311C (pl)
CY (1)	CY1110922T1 (pl)
DE (1)	DE602006012725D1 (pl)
DK (1)	DK1957484T3 (pl)
ES (1)	ES2339599T3 (pl)
PL (1)	PL1957484T3 (pl)
PT (1)	PT1957484E (pl)
SI (1)	SI1957484T1 (pl)
WO (1)	WO2007120284A2 (pl)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK1758853T3 (da) *	2004-06-14	2010-04-06	Lilly Co Eli	Glucagon-receptorantagonister, fremstilling og terapeutiske anvendelser
WO2008098244A1 (en)	2007-02-09	2008-08-14	Metabasis Therapeutics, Inc.	Novel antagonists of the glucagon receptor
EP2025674A1 (de)	2007-08-15	2009-02-18	sanofi-aventis	Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CN104803891B (zh)	2008-08-13	2017-10-20	症变治疗公司	胰高血糖素拮抗剂
WO2011107494A1 (de)	2010-03-03	2011-09-09	Sanofi	Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8933024B2 (en)	2010-06-18	2015-01-13	Sanofi	Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en)	2010-06-21	2013-09-10	Sanofi	Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en)	2010-07-05	2012-04-16	Sanofi Sa	(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en)	2010-07-05	2012-06-01	Sanofi Sa	Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en)	2010-07-05	2012-04-16	Sanofi Aventis	Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
MX2013006768A (es)	2010-12-23	2013-07-22	Pfizer	Moduladores de receptor de glucagon.
ES2597972T3 (es)	2011-02-08	2017-01-24	Pfizer Inc	Modulador del receptor de glucagón
WO2012120056A1 (de)	2011-03-08	2012-09-13	Sanofi	Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683704B1 (de)	2011-03-08	2014-12-17	Sanofi	Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8710050B2 (en)	2011-03-08	2014-04-29	Sanofi	Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120054A1 (de)	2011-03-08	2012-09-13	Sanofi	Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2766349B1 (de)	2011-03-08	2016-06-01	Sanofi	Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
RU2013157388A (ru)	2011-07-22	2015-08-27	Пфайзер Инк.	Хинолинильные модуляторы глюкагонового рецептора
WO2013037390A1 (en)	2011-09-12	2013-03-21	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en)	2011-09-27	2013-04-04	Sanofi	6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP3065736B1 (en)	2013-11-04	2018-11-14	Merck Sharp & Dohme Corp.	Glucagon receptor antagonist compounds, compositions thereof, and methods of use
JP2017519000A (ja)	2014-06-12	2017-07-13	リガンド・ファーマシューティカルズ・インコーポレイテッド	グルカゴンアンタゴニスト
JP2021513564A (ja)	2018-02-13	2021-05-27	リガンド・ファーマシューティカルズ・インコーポレイテッド	グルカゴン受容体拮抗薬

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9420557D0 (en) *	1994-10-12	1994-11-30	Zeneca Ltd	Aromatic compounds
WO2002000612A1 (en) *	2000-06-23	2002-01-03	Novo Nordisk A/S	Glucagon antagonists/inverse agonists
EP1463715A1 (en)	2001-12-03	2004-10-06	Novo Nordisk A/S	Novel glucagon antagonists
JP2006500325A (ja)	2002-06-27	2006-01-05	ノボ　ノルディスク　アクティーゼルスカブ	新規なグルカゴンアンタゴニスト
AU2003291959A1 (en)	2002-12-20	2004-07-14	Novo Nordisk A/S	Novel glucagon antagonists
CN101146762A (zh)	2005-03-21	2008-03-19	默克公司	取代的芳基和杂芳基衍生物

2006
- 2006-11-21 JP JP2008542509A patent/JP5140599B2/ja not_active Expired - Fee Related
- 2006-11-21 CA CA2629311A patent/CA2629311C/en not_active Expired - Fee Related
- 2006-11-21 DE DE602006012725T patent/DE602006012725D1/de active Active
- 2006-11-21 EP EP06850798A patent/EP1957484B1/en not_active Not-in-force
- 2006-11-21 SI SI200630650T patent/SI1957484T1/sl unknown
- 2006-11-21 US US12/094,406 patent/US7807702B2/en not_active Expired - Fee Related
- 2006-11-21 DK DK06850798.7T patent/DK1957484T3/da active
- 2006-11-21 WO PCT/US2006/061132 patent/WO2007120284A2/en not_active Ceased
- 2006-11-21 AT AT06850798T patent/ATE459619T1/de active
- 2006-11-21 AU AU2006342059A patent/AU2006342059B2/en not_active Ceased
- 2006-11-21 CN CN2006800438950A patent/CN101312963B/zh not_active Expired - Fee Related
- 2006-11-21 BR BRPI0618745-5A patent/BRPI0618745A2/pt not_active IP Right Cessation
- 2006-11-21 PT PT06850798T patent/PT1957484E/pt unknown
- 2006-11-21 ES ES06850798T patent/ES2339599T3/es active Active
- 2006-11-21 PL PL06850798T patent/PL1957484T3/pl unknown
2010
- 2010-04-23 CY CY20101100366T patent/CY1110922T1/el unknown

Also Published As

Publication number	Publication date
ES2339599T3 (es)	2010-05-21
CA2629311C (en)	2014-05-06
CN101312963A (zh)	2008-11-26
JP2009519903A (ja)	2009-05-21
SI1957484T1 (sl)	2010-07-30
JP5140599B2 (ja)	2013-02-06
WO2007120284A2 (en)	2007-10-25
EP1957484B1 (en)	2010-03-03
ATE459619T1 (de)	2010-03-15
US20080300289A1 (en)	2008-12-04
BRPI0618745A2 (pt)	2011-09-13
CN101312963B (zh)	2012-03-14
PT1957484E (pt)	2010-03-29
DK1957484T3 (da)	2010-05-10
EP1957484A2 (en)	2008-08-20
WO2007120284A3 (en)	2007-12-27
AU2006342059A1 (en)	2007-10-25
AU2006342059B2 (en)	2012-05-10
DE602006012725D1 (de)	2010-04-15
CY1110922T1 (el)	2015-06-10
US7807702B2 (en)	2010-10-05
CA2629311A1 (en)	2007-10-25

Publication	Publication Date	Title
IL184932A0 (en)	2007-12-03	Glucagon receptor antagonists, preperation and therapeutic uses
WO2007106181A3 (en)	2007-12-06	Glucagon receptor antagonists, preparation and therapeutic uses
NO20070213L (no)	2007-03-12	Glucagon reseptorantagonister, fremstilling og terapeutiske anvendelser
CY1110922T1 (el)	2015-06-10	Ανταγωνιστες υποδοχεα γλυκαγονης, παρασκευη και θεραπευτικες χρησεις
WO2007120270A3 (en)	2008-02-28	Glucagon receptor antagonists, preparation and therapeutic uses
PL1735278T3 (pl)	2010-06-30	Związki receptora histaminowego H3, wytwarzanie i zastosowania terapeutyczne
ATE502939T1 (de)	2011-04-15	Disubstituierte alkyl-8-azabicycloä3.2.1üoktan- verbindungen als mu-opioid-rezeptorantagonisten
WO2005082893A3 (en)	2006-04-20	Histamine h3 receptor antagonists, preparation and therapeutic uses
WO2007114855A3 (en)	2007-11-29	Glucagon receptor antagonists, preparation and therapeutic uses
MX2007011374A (es)	2007-11-23	Derivados de pirrolidina como antagonistas del receptor histamina h3.