|
US4352883A
(en)
|
1979-03-28 |
1982-10-05 |
Damon Corporation |
Encapsulation of biological material
|
|
US4353888A
(en)
|
1980-12-23 |
1982-10-12 |
Sefton Michael V |
Encapsulation of live animal cells
|
|
US4407957A
(en)
*
|
1981-03-13 |
1983-10-04 |
Damon Corporation |
Reversible microencapsulation of a core material
|
|
US5525464A
(en)
*
|
1987-04-01 |
1996-06-11 |
Hyseq, Inc. |
Method of sequencing by hybridization of oligonucleotide probes
|
|
US4883666A
(en)
*
|
1987-04-29 |
1989-11-28 |
Massachusetts Institute Of Technology |
Controlled drug delivery system for treatment of neural disorders
|
|
US5283187A
(en)
*
|
1987-11-17 |
1994-02-01 |
Brown University Research Foundation |
Cell culture-containing tubular capsule produced by co-extrusion
|
|
US5158881A
(en)
*
|
1987-11-17 |
1992-10-27 |
Brown University Research Foundation |
Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
|
|
DE3829766A1
(de)
|
1988-09-01 |
1990-03-22 |
Akzo Gmbh |
Verfahren zur herstellung von membranen
|
|
DE3829752A1
(de)
|
1988-09-01 |
1990-03-22 |
Akzo Gmbh |
Integrale asymmetrische polyaethersulfonmembran, verfahren zur herstellung und verwendung zur ultrafiltration und mikrofiltration
|
|
US5082670A
(en)
|
1988-12-15 |
1992-01-21 |
The Regents Of The University Of California |
Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system
|
|
US5800992A
(en)
|
1989-06-07 |
1998-09-01 |
Fodor; Stephen P.A. |
Method of detecting nucleic acids
|
|
US5143854A
(en)
*
|
1989-06-07 |
1992-09-01 |
Affymax Technologies N.V. |
Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
|
|
US5194596A
(en)
*
|
1989-07-27 |
1993-03-16 |
California Biotechnology Inc. |
Production of vascular endothelial cell growth factor
|
|
US5350836A
(en)
*
|
1989-10-12 |
1994-09-27 |
Ohio University |
Growth hormone antagonists
|
|
GB8927546D0
(en)
|
1989-12-06 |
1990-02-07 |
Ciba Geigy |
Process for the production of biologically active tgf-beta
|
|
US5084350A
(en)
|
1990-02-16 |
1992-01-28 |
The Royal Institution For The Advance Of Learning (Mcgill University) |
Method for encapsulating biologically active material including cells
|
|
US5618531A
(en)
*
|
1990-10-19 |
1997-04-08 |
New York University |
Method for increasing the viability of cells which are administered to the brain or spinal cord
|
|
SG47470A1
(en)
|
1991-04-25 |
1998-04-17 |
Univ Brown Res Found |
Implantable biocompatible immunoisolatory vehicle for delivery of a selected therapeutic products
|
|
WO1993000951A1
(en)
|
1991-07-02 |
1993-01-21 |
Inhale, Inc. |
Method and device for delivering aerosolized medicaments
|
|
WO1993006116A1
(en)
|
1991-09-20 |
1993-04-01 |
Syntex-Synergen Neuroscience Joint Venture |
Glial derived neurotrophic factor
|
|
US5939524A
(en)
|
1991-12-09 |
1999-08-17 |
The Scripps Research Institute |
Platelet GPIII P1A1 and P1A2 epitopes, their preparation and use
|
|
US5414135A
(en)
*
|
1991-12-30 |
1995-05-09 |
Sterling Winthrop Inc. |
Vinyl sulfone coupling of polyoxyalkylenes to proteins
|
|
US5785049A
(en)
|
1994-09-21 |
1998-07-28 |
Inhale Therapeutic Systems |
Method and apparatus for dispersion of dry powder medicaments
|
|
ATE220327T1
(de)
|
1992-09-29 |
2002-07-15 |
Inhale Therapeutic Syst |
Pulmonale abgabe von aktiven fragmenten des parathormons
|
|
US5349056A
(en)
|
1992-10-09 |
1994-09-20 |
Regeneron Pharmaceuticals |
Modified ciliary neurotrophic factors
|
|
US6472178B1
(en)
|
1998-02-27 |
2002-10-29 |
Regeneron Pharmaceuticals, Inc. |
Nucleic acids encoding a modified ciliary neurotrophic factor and method of making thereof
|
|
CA2092271C
(en)
*
|
1993-03-09 |
2009-10-13 |
Eddie Reed |
Use of g-csf for treating taxol side-effects
|
|
SG48813A1
(en)
|
1993-08-12 |
1998-05-18 |
Cytotherapeutics Inc |
Improved composition and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
|
|
DE4339605A1
(de)
|
1993-11-20 |
1995-05-24 |
Beiersdorf Ag |
Desodorierende Wirkstoffkombinationen auf der Basis von alpha, omega-Alkandicarbonsäuren und Fettsäurepartialglyceriden
|
|
US5834029A
(en)
|
1994-07-20 |
1998-11-10 |
Cytotherapeutics, Inc. |
Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment
|
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
US5795716A
(en)
|
1994-10-21 |
1998-08-18 |
Chee; Mark S. |
Computer-aided visualization and analysis system for sequence evaluation
|
|
US5770577A
(en)
|
1994-11-14 |
1998-06-23 |
Amgen Inc. |
BDNF and NT-3 polypeptides selectively linked to polyethylene glycol
|
|
US5780014A
(en)
|
1995-04-14 |
1998-07-14 |
Inhale Therapeutic Systems |
Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
|
|
US5654007A
(en)
|
1995-06-07 |
1997-08-05 |
Inhale Therapeutic Systems |
Methods and system for processing dispersible fine powders
|
|
US5739307A
(en)
|
1995-08-28 |
1998-04-14 |
Washington University |
Polynucleotide encoding neurturin neurotrophic factor
|
|
US5733729A
(en)
|
1995-09-14 |
1998-03-31 |
Affymetrix, Inc. |
Computer-aided probability base calling for arrays of nucleic acid probes on chips
|
|
US6184200B1
(en)
|
1995-09-28 |
2001-02-06 |
Amgen Inc. |
Truncated glial cell line-derived neurotrophic factor
|
|
US6063757A
(en)
|
1995-11-29 |
2000-05-16 |
Urso; Richard G. |
Wound treatment method with nerve growth factor
|
|
WO1997019693A1
(en)
|
1995-11-29 |
1997-06-05 |
Amgen Inc. |
Method for treating sensory neuropathy using glial cell line-derived neurotrophic factor (gdnf) protein product
|
|
US5641749A
(en)
*
|
1995-11-29 |
1997-06-24 |
Amgen Inc. |
Method for treating retinal ganglion cell injury using glial cell line-derived neurothrophic factor (GDNF) protein product
|
|
JP4019432B2
(ja)
*
|
1995-12-21 |
2007-12-12 |
味の素株式会社 |
ヒトアクチビンａのリフォールディング方法
|
|
US6299895B1
(en)
|
1997-03-24 |
2001-10-09 |
Neurotech S.A. |
Device and method for treating ophthalmic diseases
|
|
US6677135B1
(en)
|
1996-05-08 |
2004-01-13 |
Biogen, Inc. |
Ret ligand (RetL) for stimulating neutral and renal growth
|
|
US5754524A
(en)
|
1996-08-30 |
1998-05-19 |
Wark; Barry J. |
Computerized method and system for analysis of an electrophoresis gel test
|
|
US6083725A
(en)
|
1996-09-13 |
2000-07-04 |
Transkaryotic Therapies, Inc. |
Tranfected human cells expressing human α-galactosidase A protein
|
|
AU736670B2
(en)
*
|
1996-09-26 |
2001-08-02 |
Medical Research Council |
Chaperone fragments
|
|
KR100195886B1
(ko)
|
1996-11-01 |
1999-06-15 |
김상조 |
당뇨병 치료용 의약조성물
|
|
WO1998032869A1
(en)
|
1997-01-29 |
1998-07-30 |
Neurosearch A/S |
Expression vectors and methods for in vivo expression of therapeutic polypeptides
|
|
CN1269805A
(zh)
|
1997-07-14 |
2000-10-11 |
博尔德生物技术公司 |
生长激素和相关蛋白的衍生物
|
|
GB9718908D0
(en)
|
1997-09-05 |
1997-11-12 |
Rowett Research Services Limit |
Proteins
|
|
US6653098B1
(en)
|
1998-02-23 |
2003-11-25 |
G. D. Searle & Co. |
Method of producing mouse and human endostatin
|
|
ES2262317T3
(es)
|
1998-03-23 |
2006-11-16 |
Genentech, Inc. |
Gfr-alfa3 y sus usos.
|
|
US20020055467A1
(en)
|
1998-07-06 |
2002-05-09 |
Johansen Teit E. |
Novel neurotrophic factors
|
|
US6593133B1
(en)
|
1998-07-06 |
2003-07-15 |
Nsgene A/S |
Neurotrophic factors
|
|
US7067473B1
(en)
|
1998-07-14 |
2006-06-27 |
Janssen Pharmaceutica N.V. |
Neurotrophic growth factor
|
|
DE69933771T2
(de)
|
1998-07-14 |
2007-09-13 |
Janssen Pharmaceutica N.V. |
Neurotrophischer wachstumsfaktor
|
|
AU771239C
(en)
|
1998-09-14 |
2004-10-14 |
Soren Buus |
A method of producing a functional immunoglobulin superfamily protein
|
|
JP2003524381A
(ja)
|
1998-09-22 |
2003-08-19 |
ユニヴァーシティ オブ メリーランド，ボルチモア |
システインノット成長因子ミュータント
|
|
US20020002269A1
(en)
|
1998-09-29 |
2002-01-03 |
Jeffrey D. Milbrandt |
Artemin, a neurotrophic factor
|
|
WO2000034475A2
(en)
|
1998-12-09 |
2000-06-15 |
Amgen Inc. |
Grnf4, a gdnf-related neurotrophic factor
|
|
ES2289630T3
(es)
|
1999-03-08 |
2008-02-01 |
Genentech, Inc. |
Composiciones y procedimientos para el diagnostico de tumores.
|
|
US6361771B1
(en)
|
1999-04-06 |
2002-03-26 |
Neurotech S.A. |
ARPE-19 as a platform cell line for encapsulated cell-based delivery
|
|
MXPA01010692A
(es)
*
|
1999-04-22 |
2004-09-06 |
Univ Zuerich |
Matrices de proteina modificadas para ingenieria de tejidos o liberacion controlada.
|
|
DK1185648T3
(da)
|
1999-06-02 |
2007-07-30 |
Genentech Inc |
Fremgangsmåder og sammensætninger til inhibition af neoplastisk cellevækst
|
|
WO2001030375A2
(en)
*
|
1999-10-29 |
2001-05-03 |
Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh |
Use of gdnf for treating corneal defects
|
|
US6866851B1
(en)
|
1999-12-28 |
2005-03-15 |
Washington University |
GFRα1-RET specific agonists and methods therefor
|
|
AU2001289307A1
(en)
|
2000-04-06 |
2001-10-23 |
Pharmacia Corporation |
Chemically-modified myelopoietin conjugates
|
|
IL152804A0
(en)
|
2000-05-16 |
2003-06-24 |
Bolder Biotechnology Inc |
Methods for refolding proteins containing free cysteine residues
|
|
CA2327208A1
(en)
*
|
2000-11-30 |
2002-05-30 |
The Government Of The United States Of America |
Methods of increasing distribution of therapeutic agents
|
|
IL140110A0
(en)
|
2000-12-05 |
2002-02-10 |
Applied Research Systems |
Improvement of homogeneity and secretion of recombinant proteins in mammalian systems
|
|
IL156559A0
(en)
*
|
2000-12-22 |
2004-01-04 |
Genentech Inc |
New use of artemin, a member of the gdnf ligand family
|
|
US7442370B2
(en)
|
2001-02-01 |
2008-10-28 |
Biogen Idec Ma Inc. |
Polymer conjugates of mutated neublastin
|
|
TR200301208T2
(tr)
|
2001-02-01 |
2005-05-23 |
Biogen, Inc. |
Nublastin polimer eşlenikleri ve bunları kullanma yöntemleri.
|
|
US6969360B1
(en)
|
2001-02-13 |
2005-11-29 |
Northwestern University |
Spinal proprioception methods and related systems
|
|
US7276580B2
(en)
*
|
2001-03-12 |
2007-10-02 |
Biogen Idec Ma Inc. |
Neurotrophic factors
|
|
US20040077543A1
(en)
*
|
2001-03-28 |
2004-04-22 |
Sah Dinah W. Y. |
Treatment using neublastin polypeptides
|
|
ES2374971T3
(es)
|
2001-03-28 |
2012-02-23 |
Biogen Idec Ma Inc. |
Uso de polipéptidos de neublastina para el tratamiento del dolor neuropático.
|
|
CA2740056A1
(en)
*
|
2001-04-24 |
2002-11-21 |
Purdue Research Foundation |
Methods and compositions for treating mammalian nerve tissue injuries
|
|
US7250495B2
(en)
*
|
2001-06-20 |
2007-07-31 |
Genentech, Inc. |
PRO20044 polypeptides
|
|
US20040028613A1
(en)
*
|
2001-06-25 |
2004-02-12 |
Nastech Pharmaceutical Company Inc |
Dopamine agonist formulations for enhanced central nervous system delivery
|
|
US7827106B2
(en)
*
|
2001-07-10 |
2010-11-02 |
American Express Travel Related Services Company, Inc. |
System and method for manufacturing a punch-out RFID transaction device
|
|
US7129085B2
(en)
*
|
2001-10-11 |
2006-10-31 |
Bristol-Myers Squibb Company |
Polynucleotides encoding a human leucine-rich repeat domain containing protein, HLLRCR-1
|
|
EP1314739A1
(en)
|
2001-11-22 |
2003-05-28 |
Bayer Ag |
Process for renaturation of recombinant, disulfide containing proteins at high protein concentrations in the presence of amines
|
|
GB0205022D0
(en)
*
|
2002-03-04 |
2002-04-17 |
Univ Cambridge Tech |
Materials and methods for the treatment of cns damage
|
|
JP4310608B2
(ja)
|
2002-04-25 |
2009-08-12 |
東洋紡績株式会社 |
Ｈｓｐ７０ファミリータンパク質基質結合ドメインフラグメントの利用方法
|
|
DE10229175A1
(de)
|
2002-06-28 |
2004-01-15 |
Valeo Klimasysteme Gmbh |
Zylinderklappe mit strukturierter rauher Oberfläche
|
|
WO2004094592A2
(en)
|
2003-04-18 |
2004-11-04 |
Biogen Idec Ma Inc. |
Polymer-conjugated glycosylated neublastin
|
|
ATE423134T1
(de)
|
2003-06-10 |
2009-03-15 |
Nsgene As |
Verbesserte sezernierung von neublastin
|
|
US7598059B2
(en)
*
|
2003-10-02 |
2009-10-06 |
Biogen Idec Ma Inc. |
Neublastin expression constructs
|
|
ES2342397T3
(es)
|
2003-10-20 |
2010-07-06 |
Nsgene A/S |
Vector virico para su uso en terapia genica in vivo de la enfermedad de parkinson.
|
|
WO2005072764A2
(en)
*
|
2004-01-16 |
2005-08-11 |
Novocell, Inc. |
Fibrin-bound angiogenic factors to stimulate vascularization of transplant site of encapsulated cells
|
|
US20060014288A1
(en)
*
|
2004-06-23 |
2006-01-19 |
Tissuegene, Inc. |
Nerve regeneration
|
|
US7598356B2
(en)
*
|
2004-07-08 |
2009-10-06 |
Board of Regents of the University of Nebraska by and on behalf of the University of Nebraska Medical Center |
Method for purifying a protein of the cystine-knot superfamily
|
|
KR101215697B1
(ko)
|
2004-08-19 |
2012-12-28 |
바이오겐 아이덱 엠에이 인코포레이티드 |
뉴블라스틴 변형체
|
|
KR101241551B1
(ko)
|
2004-08-19 |
2013-03-11 |
바이오겐 아이덱 엠에이 인코포레이티드 |
전환 성장 인자 베타 패밀리 단백질의 리폴딩
|
|
EP1937295A2
(en)
|
2005-10-11 |
2008-07-02 |
NS Gene A/S |
Treatment of retinopathies using gfr 3 agonists
|
|
TWI501774B
(zh)
|
2006-02-27 |
2015-10-01 |
Biogen Idec Inc |
神經性病症之治療
|
|
ES2450065T3
(es)
*
|
2006-03-01 |
2014-03-21 |
Biogen Idec Ma Inc. |
Composiciones y métodos para la administración de proteínas de la familia de ligandos del GDNF
|
|
PL2019683T5
(pl)
*
|
2006-04-25 |
2022-12-05 |
The Regents Of The University Of California |
Podawanie czynników wzrostu do leczenia zaburzeń OUN
|
|
ES2476253T3
(es)
|
2007-05-01 |
2014-07-14 |
Biogen Idec Ma Inc. |
P�ptidos de neublastina para su uso en el aumento de la vascularizaci�n en tejido con flujo sanguíneo deteriorado
|
|
WO2009020964A2
(en)
|
2007-08-08 |
2009-02-12 |
Biogen Idec Ma Inc. |
Anti-neublastin antibodies and uses thereof
|