PL1996556T3 - Pochodne benzimidazolu i ich zastosowanie do modulowania kompleksu receptorowego GAEAA - Google Patents

Pochodne benzimidazolu i ich zastosowanie do modulowania kompleksu receptorowego GAEAA

Info

Publication number: PL1996556T3
Authority: PL; Poland
Prior art keywords: receptor complex; benzimidazole derivatives; gabaa receptor; modulating; compounds
Prior art date: 2005-12-05

Application number

PL06830303T

Other languages

English (en)

Inventor

Janus S Larsen

Lene Teuber

Philip K Ahring

Elsebet Östergaard Nielsen

Naheed Mirza

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-12-05

Filing date

2006-12-04

Publication date

2010-05-31

2006-12-04 Application filed by Neurosearch As filed Critical Neurosearch As

2010-05-31 Publication of PL1996556T3 publication Critical patent/PL1996556T3/pl

Links

102000027484 GABAA receptors Human genes 0.000 title abstract 2
108091008681 GABAA receptors Proteins 0.000 title abstract 2
229940058303 antinematodal benzimidazole derivative Drugs 0.000 title abstract 2
125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title abstract 2
208000015114 central nervous system disease Diseases 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
208000019901 Anxiety disease Diseases 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Addiction (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Anesthesiology (AREA)
Child & Adolescent Psychology (AREA)
Vascular Medicine (AREA)
Nutrition Science (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Otolaryngology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

PL06830303T 2005-12-05 2006-12-04 Pochodne benzimidazolu i ich zastosowanie do modulowania kompleksu receptorowego GAEAA PL1996556T3 (pl)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
DKPA200501719		2005-12-05
US74253505P	2005-12-06	2005-12-06
DKPA200601326		2006-10-12
US85129106P	2006-10-13	2006-10-13
EP06830303A EP1996556B1 (en)	2005-12-05	2006-12-04	Benzimidazole derivatives and their use for modulating the gabaa receptor complex
PCT/EP2006/069237 WO2007065864A1 (en)	2005-12-05	2006-12-04	Benzimidazole derivatives and their use for modulating the gabaa receptor complex

Publications (1)

Publication Number	Publication Date
PL1996556T3 true PL1996556T3 (pl)	2010-05-31

Family

ID=37873123

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL06830303T PL1996556T3 (pl)	2005-12-05	2006-12-04	Pochodne benzimidazolu i ich zastosowanie do modulowania kompleksu receptorowego GAEAA

Country Status (14)

Country	Link
US (1)	US7923464B2 (pl)
EP (1)	EP1996556B1 (pl)
JP (1)	JP2009518292A (pl)
KR (1)	KR20080077620A (pl)
AT (1)	ATE449077T1 (pl)
AU (1)	AU2006324046A1 (pl)
CA (1)	CA2632395A1 (pl)
DE (1)	DE602006010602D1 (pl)
DK (1)	DK1996556T3 (pl)
ES (1)	ES2335438T3 (pl)
IL (1)	IL189974A0 (pl)
NO (1)	NO20083045L (pl)
PL (1)	PL1996556T3 (pl)
WO (1)	WO2007065864A1 (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI391381B (zh)	2006-03-24	2013-04-01	Neurosearch As	新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途
JP2011507905A (ja) *	2007-12-21	2011-03-10	ワイス・エルエルシー	ベンズイミダゾール化合物
CA2721452A1 (en) *	2008-04-16	2009-10-22	Biolipox Ab	Bis-aryl compounds for use as medicaments
WO2010039668A2 (en) *	2008-10-01	2010-04-08	The Regents Of The University Of California	Inhibitors of cyclin kinase inhibitor p21
WO2010055125A1 (en) *	2008-11-14	2010-05-20	Neurosearch A/S	Benzimidazole derivatives and their use for modulating the gabaa receptor complex
WO2010055127A1 (en) *	2008-11-14	2010-05-20	Neurosearch A/S	Benzimidazole derivatives and their use for modulating the gabaa receptor complex
IL275725B (en) *	2012-08-21	2022-08-01	Sage Therapeutics Inc	Treatment methods for epilepsy and status epilepticus

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK40192D0 (da) *	1992-03-26	1992-03-26	Neurosearch As	Imidazolforbindelser, deres fremstilling og anvendelse
PL183853B1 (pl)	1995-04-21	2002-07-31	Neurosearch As	Nowa pochodna benzimidazolu i środek farmaceutyczny
AU726447B2 (en) *	1996-10-21	2000-11-09	Neurosearch A/S	1-phenyl-benzimidazole compounds and their use as BAGA-A receptor modulators
CA2304379A1 (en)	1997-10-10	1999-04-22	Neurosearch A/S	Benzimidazole compounds, pharmaceutical compositions containing the compounds and their use
DE60025604T2 (de) *	1999-06-22	2006-07-27	Neurosearch A/S	Benzimidazol-derivate und diese enthaltende pharmazeutische zusammensetzungen
WO2002050057A1 (en)	2000-12-20	2002-06-27	Neurosearch A/S	Novel benzimidazole derivatives for the treatment of gaba-alpha mediated disorders
JP2006522070A (ja)	2003-04-03	2006-09-28	ニューロサーチ、アクティーゼルスカブ	ベンズイミダゾール誘導体及びこれをｇａｂａａ受容体複合体をモジュレートするために使用する方法
US7335777B2 (en) *	2003-04-03	2008-02-26	Neurosearch A/S	Benzimidazole derivatives and their use for modulating the GABAA receptor complex
MXPA06002018A (es) *	2003-08-21	2006-05-31	Osi Pharm Inc	Bencimidazolilo n-sustituidos inhibidores de c-kit.
US7700638B2 (en) *	2003-10-23	2010-04-20	N. V. Organon	1,5,7-trisubstituted benzimidazole derivatives and their use for modulating the GABAA receptor complex
KR20070086865A (ko) *	2004-12-01	2007-08-27	오에스아이 파마슈티컬스, 인코포레이티드	Ｎ-치환된 벤즈이미다졸일 ｃ-ｋｉｔ 억제제 및 조합적인벤즈이미다졸 라이브러리
CA2604516A1 (en)	2005-04-13	2006-10-19	Neurosearch A/S	Benzimidazole derivatives and their use for modulating the gabaa receptor complex
US7776900B2 (en) *	2005-04-19	2010-08-17	Neurosearch A/S	Benzimidazole derivatives and their use for modulating the GABAAreceptor complex
TWI391381B (zh)	2006-03-24	2013-04-01	Neurosearch As	新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途

2006
- 2006-12-04 US US12/085,769 patent/US7923464B2/en not_active Expired - Fee Related
- 2006-12-04 JP JP2008542778A patent/JP2009518292A/ja not_active Abandoned
- 2006-12-04 AT AT06830303T patent/ATE449077T1/de active
- 2006-12-04 DK DK06830303.1T patent/DK1996556T3/da active
- 2006-12-04 AU AU2006324046A patent/AU2006324046A1/en not_active Abandoned
- 2006-12-04 ES ES06830303T patent/ES2335438T3/es active Active
- 2006-12-04 WO PCT/EP2006/069237 patent/WO2007065864A1/en not_active Ceased
- 2006-12-04 PL PL06830303T patent/PL1996556T3/pl unknown
- 2006-12-04 DE DE602006010602T patent/DE602006010602D1/de active Active
- 2006-12-04 CA CA002632395A patent/CA2632395A1/en not_active Abandoned
- 2006-12-04 EP EP06830303A patent/EP1996556B1/en not_active Not-in-force
- 2006-12-04 KR KR1020087013766A patent/KR20080077620A/ko not_active Withdrawn
2008
- 2008-03-06 IL IL189974A patent/IL189974A0/en unknown
- 2008-07-04 NO NO20083045A patent/NO20083045L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
ES2335438T3 (es)	2010-03-26
JP2009518292A (ja)	2009-05-07
DK1996556T3 (da)	2010-04-06
US7923464B2 (en)	2011-04-12
CA2632395A1 (en)	2007-06-14
ATE449077T1 (de)	2009-12-15
NO20083045L (no)	2008-09-04
EP1996556B1 (en)	2009-11-18
KR20080077620A (ko)	2008-08-25
IL189974A0 (en)	2008-08-07
EP1996556A1 (en)	2008-12-03
WO2007065864A1 (en)	2007-06-14
AU2006324046A1 (en)	2007-06-14
US20090048321A1 (en)	2009-02-19
DE602006010602D1 (de)	2009-12-31

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