PL2017278T3 - Pochodne dihydropirazolopirymidynonu - Google Patents
Pochodne dihydropirazolopirymidynonuInfo
- Publication number
- PL2017278T3 PL2017278T3 PL07742851T PL07742851T PL2017278T3 PL 2017278 T3 PL2017278 T3 PL 2017278T3 PL 07742851 T PL07742851 T PL 07742851T PL 07742851 T PL07742851 T PL 07742851T PL 2017278 T3 PL2017278 T3 PL 2017278T3
- Authority
- PL
- Poland
- Prior art keywords
- dihydropyrazolopyrimidinone
- derivative
- dihydropyrazolopyrimidinone derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006124208 | 2006-04-27 | ||
| EP07742851.4A EP2017278B1 (en) | 2006-04-27 | 2007-04-25 | Dihydropyrazolopyrimidinone derivative |
| PCT/JP2007/059416 WO2007126128A1 (ja) | 2006-04-27 | 2007-04-25 | ジヒドロピラゾロピリミジノン誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2017278T3 true PL2017278T3 (pl) | 2017-10-31 |
Family
ID=38655640
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL07742851T PL2017278T3 (pl) | 2006-04-27 | 2007-04-25 | Pochodne dihydropirazolopirymidynonu |
| PL07742843T PL2016080T3 (pl) | 2006-04-27 | 2007-04-25 | Pochodne dihydropirazolopirymidynonu |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL07742843T PL2016080T3 (pl) | 2006-04-27 | 2007-04-25 | Pochodne dihydropirazolopirymidynonu |
Country Status (38)
| Country | Link |
|---|---|
| US (4) | US7935708B2 (pl) |
| EP (2) | EP2017278B1 (pl) |
| JP (2) | JP4513919B2 (pl) |
| KR (1) | KR101409161B1 (pl) |
| CN (1) | CN101432284B (pl) |
| AR (1) | AR060635A1 (pl) |
| AT (1) | ATE475662T1 (pl) |
| AU (1) | AU2007244185B2 (pl) |
| BR (1) | BRPI0710081A2 (pl) |
| CA (1) | CA2650119C (pl) |
| CR (1) | CR10359A (pl) |
| CY (2) | CY1111069T1 (pl) |
| DE (1) | DE602007008085D1 (pl) |
| DK (2) | DK2017278T3 (pl) |
| DO (1) | DOP2007000084A (pl) |
| EC (1) | ECSP088812A (pl) |
| ES (2) | ES2609087T3 (pl) |
| GT (1) | GT200800211A (pl) |
| HN (1) | HN2008001532A (pl) |
| HR (2) | HRP20100563T1 (pl) |
| HU (1) | HUE032987T2 (pl) |
| IL (1) | IL194367A (pl) |
| LT (1) | LT2017278T (pl) |
| MA (1) | MA30428B1 (pl) |
| MX (1) | MX2008013063A (pl) |
| MY (1) | MY145408A (pl) |
| NO (1) | NO341617B1 (pl) |
| NZ (1) | NZ571196A (pl) |
| PE (1) | PE20080695A1 (pl) |
| PL (2) | PL2017278T3 (pl) |
| PT (2) | PT2017278T (pl) |
| RU (1) | RU2437885C2 (pl) |
| SI (2) | SI2017278T1 (pl) |
| SV (1) | SV2009003060A (pl) |
| TW (1) | TWI409262B (pl) |
| UA (1) | UA96152C2 (pl) |
| WO (2) | WO2007126128A1 (pl) |
| ZA (1) | ZA200807748B (pl) |
Families Citing this family (81)
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| AR060635A1 (es) * | 2006-04-27 | 2008-07-02 | Banyu Pharma Co Ltd | Derivados de 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-ona, composiciones farmaceuticas que los comprenden y su uso en el tratamiento del cancer |
| EP2155752B1 (en) * | 2007-04-25 | 2018-09-19 | Merck Sharp & Dohme Corp. | Polymorph of dihydropyrazolopyrimidinone derivative as weel kinase.inhibitor |
| WO2008141385A1 (en) * | 2007-05-21 | 2008-11-27 | Biota Scientific Management Pty Ltd | Viral polymerase inhibitors |
| JPWO2009054332A1 (ja) * | 2007-10-23 | 2011-03-03 | 萬有製薬株式会社 | ピリドン置換ジヒドロピラゾロピリミジノン誘導体 |
| EP2303885B1 (en) * | 2008-06-12 | 2013-07-03 | Merck Sharp & Dohme Corp. | Process for producing bicycloaniline derivatives |
| WO2010067888A1 (en) | 2008-12-12 | 2010-06-17 | Banyu Pharmaceutical Co.,Ltd. | Dihydropyrimidopyrimidine derivatives |
| WO2010076887A1 (en) * | 2009-01-05 | 2010-07-08 | Banyu Pharmaceutical Co.,Ltd. | Predictive biomarkers useful for cancer therapy mediated by a wee1 inhibitor |
| JP2012518598A (ja) * | 2009-02-25 | 2012-08-16 | Msd株式会社 | ピリミドピリミドインダゾール誘導体 |
| US20120157342A1 (en) * | 2009-09-02 | 2012-06-21 | Shinji Mizuarai | Predictive biomarkers useful for cancer therapy mediated by a wee1 inhibitor |
| ES2524161T3 (es) | 2009-09-15 | 2014-12-04 | Merck Sharp & Dohme Corp. | Preparación de formas hemihidratadas cristalinas de dihidropirazolopirimidinona |
| CA2817968C (en) | 2010-11-16 | 2019-03-12 | Array Biopharma Inc. | Combination of checkpoint kinase 1 inhibitors and wee 1 kinase inhibitors |
| US9207360B2 (en) * | 2011-04-27 | 2015-12-08 | Zeno Corporation | Polymerizable compound, polymerizable composition, polymer, and optically anisotropic body |
| US8796289B2 (en) | 2011-07-19 | 2014-08-05 | Abbvie Inc. | Pyridazino[4,5-D]pyrimidin-5(6H)-one inhibitors of kinases |
| US9345705B2 (en) | 2011-09-15 | 2016-05-24 | Merck Sharp & Dohme Corp. | Compositions and methods for treating cancer |
| CN104011049A (zh) | 2011-10-20 | 2014-08-27 | 艾伯维公司 | 激酶的吡啶并嘧啶酮抑制剂 |
| EP2817308B1 (en) * | 2012-02-23 | 2016-09-07 | AbbVie Inc. | Pyridopyrimidinone inhibitors of kinases |
| WO2014062454A1 (en) * | 2012-10-15 | 2014-04-24 | Merck Sharp & Dohme Corp. | Compositions and methods for treating cancer |
| RS56680B1 (sr) * | 2012-11-28 | 2018-03-30 | Merck Sharp & Dohme | Kompozicije i postupci za lečenje kancera |
| AU2014251087B2 (en) | 2013-04-09 | 2019-05-02 | Lixte Biotechnology, Inc. | Formulations of oxabicycloheptanes and oxabicycloheptenes |
| GB201306610D0 (en) * | 2013-04-11 | 2013-05-29 | Almac Discovery Ltd | Pharmaceutical compounds |
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| JP6023902B1 (ja) * | 2014-12-17 | 2016-11-09 | Delta−Fly Pharma株式会社 | 高齢又は末期の癌患者を治療又は寛解するための医薬組成物 |
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| TW201710257A (zh) | 2015-04-17 | 2017-03-16 | 艾伯維有限公司 | Tnf信號傳遞之三環調節劑 |
| TW201706258A (zh) | 2015-04-17 | 2017-02-16 | 艾伯維有限公司 | 作為tnf信號傳遞調節劑之吲唑酮 |
| DK3345907T3 (da) * | 2015-09-01 | 2020-06-22 | Taiho Pharmaceutical Co Ltd | Pyrazolo[3,4-d]pyrimidinforbindelser eller salte deraf |
| CN105130986B (zh) * | 2015-09-30 | 2017-07-18 | 广州科擎新药开发有限公司 | 嘧啶或吡啶并吡啶酮类化合物及其应用 |
| AU2016344040B2 (en) * | 2015-11-01 | 2020-12-10 | The Regents Of The University Of Colorado, A Body Corporate | Wee 1 kinase inhibitors and methods of making and using the same |
| GB201612092D0 (en) * | 2016-07-12 | 2016-08-24 | Almac Discovery Ltd | Pharmaceutical compounds |
| BR112019003320B1 (pt) | 2016-09-15 | 2024-02-20 | Boehringer Ingelheim International Gmbh | Compostos de heteroaril carboxamida, sal farmaceuticamente aceitável dos mesmos, composição farmacêutica e seus usos como inibidores de ripk2 |
| CN106719769A (zh) * | 2016-11-28 | 2017-05-31 | 山东农业大学 | 一种含香菇多糖、苯醚甲环唑和噻虫啉的病虫兼治农药组合物 |
| NZ754522A (en) | 2016-12-08 | 2025-11-28 | Lixte Biotechnology Inc | Oxabicycloheptanes for modulation of immune response |
| US10954253B2 (en) | 2017-01-23 | 2021-03-23 | Shijiazhuang Sagacity New Drug Development Co., Ltd. | 1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one derivative as Wee1 inhibitor |
| GB201703881D0 (en) * | 2017-03-10 | 2017-04-26 | Almac Discovery Ltd | Pharmaceutical compounds |
| EP3604306B1 (en) * | 2017-03-23 | 2022-10-26 | Shanghai de Novo Pharmatech Co., Ltd. | Macrocyclic derivative of pyrazol[3,4-d]pyrimidin-3-one, pharmaceutical composition and use thereof |
| AU2018243667A1 (en) | 2017-03-31 | 2019-10-17 | Seagen Inc. | Combinations of Chk1- and Wee1 - inhibitors |
| CN111094253B (zh) * | 2017-08-01 | 2023-08-29 | 里科瑞尔姆Ip控股有限责任公司 | 1,2-二氢-3H-吡唑并[3,4-d]嘧啶-3-酮类似物 |
| WO2019037678A1 (zh) * | 2017-08-24 | 2019-02-28 | 上海迪诺医药科技有限公司 | 吡唑并[3,4-d]嘧啶-3-酮衍生物、其药物组合物及应用 |
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| CN109810111B (zh) * | 2017-11-20 | 2023-10-27 | 上海医药集团股份有限公司 | 一种吡唑酮并嘧啶类化合物、其制备方法及应用 |
| CN111315747B (zh) * | 2018-01-05 | 2023-05-02 | 四川科伦博泰生物医药股份有限公司 | 二氢吡唑酮并嘧啶类化合物及其制备方法和用途 |
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| AU2019227823B2 (en) * | 2018-02-28 | 2024-12-12 | The Regents Of The University Of Colorado, A Body Corporate | WEE1 kinase inhibitors and methods of treating cancer using the same |
| MX2020009372A (es) * | 2018-03-09 | 2020-10-14 | Recurium Ip Holdings Llc | 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-onas sustituidas. |
| CN108653282B (zh) * | 2018-06-28 | 2020-08-14 | 中国科学院昆明植物研究所 | 苯并噻唑类及苯并吡咯类化合物在制备抗肿瘤药物中的应用 |
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| CN111662283B (zh) * | 2019-03-07 | 2021-11-16 | 湖南化工研究院有限公司 | 咪唑并吡啶类化合物及其中间体、制备方法与应用 |
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| CA3180664A1 (en) * | 2020-06-17 | 2021-12-23 | Yuli Xie | Pyrazolo[3,4-d]pyrimidine-3-one derivative as wee-1 inhibitor |
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| CN116848117B (zh) * | 2021-02-09 | 2026-01-02 | 微境生物医药科技(上海)有限公司 | 作为Wee-1抑制剂的稠环化合物 |
| WO2022171088A1 (zh) * | 2021-02-09 | 2022-08-18 | 微境生物医药科技(上海)有限公司 | 吡唑并[3,4-d]嘧啶-3-酮衍生物 |
| CN115197221B (zh) * | 2021-04-02 | 2024-05-24 | 轩竹(北京)医药科技有限公司 | 二氢吡唑并嘧啶酮类大环衍生物及其用途 |
| AU2022265718A1 (en) | 2021-04-29 | 2023-11-02 | Novartis Ag | Deubiquitinase-targeting chimeras and related methods |
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| EP4349838A4 (en) | 2021-05-28 | 2025-08-13 | Jiangsu Tasly Diyi Pharmaceutical Co Ltd | WEE1 INHIBITOR AND ITS USE |
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| CN115838375A (zh) * | 2021-09-18 | 2023-03-24 | 优领医药科技(香港)有限公司 | 含嘧啶并二氢吡唑啉酮类衍生物、其药学上可接受的盐及其制备方法和应用 |
| CN113735863A (zh) * | 2021-09-29 | 2021-12-03 | 武汉九州钰民医药科技有限公司 | Wee1抑制剂adavosertib的制备工艺 |
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