PL2036892T3 - Pochodne 1,2,4,5-tetrahydro-3H-benzazepin, sposób ich wytwarzania i zawierające je kompozycje farmaceutyczne - Google Patents

Pochodne 1,2,4,5-tetrahydro-3H-benzazepin, sposób ich wytwarzania i zawierające je kompozycje farmaceutyczne

Info

Publication number: PL2036892T3
Authority: PL; Poland
Prior art keywords: tetrahydro; preparation; pharmaceutical compositions; compositions containing; benzazepine derivatives
Prior art date: 2007-09-11

Application number

PL08290851T

Other languages

English (en)

Inventor

Jean-Louis Peglion

Bertrand Goument

AIMéE DESSINGES

Pascal Caignard

Jean-Paul Vilaine

Catherine Thollon

Nicole Villeneuve

Stefano Chimenti

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-09-11

Filing date

2008-09-11

Publication date

2010-08-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39323822&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2036892(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-09-11 Application filed by Servier Lab filed Critical Servier Lab

2010-08-31 Publication of PL2036892T3 publication Critical patent/PL2036892T3/pl

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B55/00—Racemisation; Complete or partial inversion
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Ophthalmology & Optometry (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

PL08290851T 2007-09-11 2008-09-11 Pochodne 1,2,4,5-tetrahydro-3H-benzazepin, sposób ich wytwarzania i zawierające je kompozycje farmaceutyczne PL2036892T3 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0706346A FR2920773B1 (fr)	2007-09-11	2007-09-11	Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP08290851A EP2036892B1 (fr)	2007-09-11	2008-09-11	Dérivés de 1,2,4,5-tétrahydro-3H-benzazépines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
PL2036892T3 true PL2036892T3 (pl)	2010-08-31

Family

ID=39323822

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL08290851T PL2036892T3 (pl)	2007-09-11	2008-09-11	Pochodne 1,2,4,5-tetrahydro-3H-benzazepin, sposób ich wytwarzania i zawierające je kompozycje farmaceutyczne

Country Status (45)

Country	Link
US (1)	US8076325B2 (pl)
EP (1)	EP2036892B1 (pl)
JP (1)	JP4932805B2 (pl)
KR (1)	KR101078076B1 (pl)
CN (1)	CN101386594B (pl)
AP (1)	AP2384A (pl)
AR (1)	AR068386A1 (pl)
AT (1)	ATE460401T1 (pl)
AU (1)	AU2008207585B2 (pl)
BR (1)	BRPI0804091B8 (pl)
CA (1)	CA2639349C (pl)
CL (1)	CL2008002654A1 (pl)
CO (1)	CO6020016A1 (pl)
CR (1)	CR10229A (pl)
CU (1)	CU23706B7 (pl)
CY (1)	CY1110034T1 (pl)
DE (1)	DE602008000786D1 (pl)
DK (1)	DK2036892T3 (pl)
EA (1)	EA014756B1 (pl)
EC (1)	ECSP088731A (pl)
ES (1)	ES2342511T3 (pl)
FR (1)	FR2920773B1 (pl)
HN (1)	HN2008001393A (pl)
HR (1)	HRP20100259T1 (pl)
JO (1)	JO2652B1 (pl)
MA (1)	MA30315B1 (pl)
ME (1)	ME00981B (pl)
MX (1)	MX2008011164A (pl)
MY (1)	MY143079A (pl)
NI (1)	NI200800247A (pl)
NZ (1)	NZ571143A (pl)
PA (1)	PA8795301A1 (pl)
PE (1)	PE20090620A1 (pl)
PL (1)	PL2036892T3 (pl)
PT (1)	PT2036892E (pl)
PY (1)	PY08034070A (pl)
RS (1)	RS51305B (pl)
SA (1)	SA08290567B1 (pl)
SG (1)	SG151172A1 (pl)
SI (1)	SI2036892T1 (pl)
TW (1)	TWI374029B (pl)
UA (1)	UA100003C2 (pl)
UY (1)	UY31305A1 (pl)
WO (1)	WO2009066041A2 (pl)
ZA (1)	ZA200807586B (pl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2961105B1 (fr) *	2010-06-15	2013-02-08	Servier Lab	Utilisation de l'association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion de l'angiotensine pour le traitement de l'insuffisance cardiaque
EP2567959B1 (en)	2011-09-12	2014-04-16	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
FR2984320B1 (fr) *	2011-12-20	2013-11-29	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2984319B1 (fr) *	2011-12-20	2013-12-27	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2988720B1 (fr) *	2012-03-27	2014-03-14	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
TWI654180B (zh)	2012-06-29	2019-03-21	美商艾佛艾姆希公司	殺真菌之雜環羧醯胺
FR3003859B1 (fr) *	2013-03-26	2015-03-13	Servier Lab	"procede de synthese de derives de la 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one et application a la synthese de l'ivabradine"
EP3021946A2 (en)	2013-07-16	2016-05-25	Karakossian, Movses	Hcn inhibitors affecting ganglion cell function and visual function
FR3020810B1 (fr) *	2014-05-06	2016-05-06	Servier Lab	Nouveau sel de l'ivabradine et son procede de preparation.
WO2017104739A1 (ja)	2015-12-17	2017-06-22	エーザイ・アール・アンド・ディー・マネジメント株式会社	乳がん治療剤
FR3046793B1 (fr) *	2016-01-14	2018-01-05	Les Laboratoires Servier	Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US12569497B2 (en) *	2017-04-27	2026-03-10	The University Of Hong Kong	Use of HCN inhibitors for treatment of cancer
CN112724001B (zh) *	2019-10-28	2022-12-13	鲁南制药集团股份有限公司	一种伊伐布雷定手性中间体化合物
CN113372274B (zh) *	2020-03-10	2023-03-24	鲁南制药集团股份有限公司	一种伊伐布雷定的制备方法
CN113372273B (zh) *	2020-03-10	2023-05-09	鲁南制药集团股份有限公司	一种伊伐布雷定中间体化合物iv
EP4361143A4 (en) *	2021-08-31	2025-05-28	Eisai R&D Management Co., Ltd.	Process for the preparation of a monocyclic pyridine derivative

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3119874A1 (de) *	1981-05-19	1982-12-09	Dr. Karl Thomae Gmbh, 7950 Biberach	"benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
DE3418270A1 (de) *	1984-05-17	1985-11-21	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
GB8707120D0 (en) *	1987-03-25	1987-04-29	Pfizer Ltd	Antiarrhythmic agents
JPH02193971A (ja) *	1989-01-20	1990-07-31	Yamanouchi Pharmaceut Co Ltd	トリ置換―２，３，４，５―テトラヒドロベンズアゼピン誘導体とその中間体
FR2681862B1 (fr) *	1991-09-27	1993-11-12	Adir Cie	Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
WO1994027971A1 (en) *	1993-05-27	1994-12-08	Smithkline Beecham Laboratoires Pharmaceutiques	Anti-arrhythmic n-substituted 3-benzazepines or isoquinolines
TW527355B (en) *	1997-07-02	2003-04-11	Bristol Myers Squibb Co	Inhibitors of farnesyl protein transferase
US6514964B1 (en) *	1999-09-27	2003-02-04	Amgen Inc.	Fused cycloheptane and fused azacycloheptane compounds and their methods of use
FR2882554B1 (fr) *	2005-02-28	2007-05-04	Servier Lab	Forme critalline beta d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2894826B1 (fr)	2005-12-21	2010-10-22	Servier Lab	Nouvelle association d'un inhibiteur du courant if sinusal et d'un inhibiteur calcique et les compositions pharmaceutiques qui la contiennent

2007
- 2007-09-11 FR FR0706346A patent/FR2920773B1/fr not_active Expired - Fee Related
2008
- 2008-08-19 PE PE2008001405A patent/PE20090620A1/es active IP Right Grant
- 2008-08-20 CR CR10229A patent/CR10229A/es unknown
- 2008-08-20 SG SG200806160-8A patent/SG151172A1/en unknown
- 2008-08-21 UY UY31305A patent/UY31305A1/es active IP Right Grant
- 2008-08-26 AP AP2008004589A patent/AP2384A/xx active
- 2008-08-27 MY MYPI20083304A patent/MY143079A/en unknown
- 2008-08-28 AU AU2008207585A patent/AU2008207585B2/en not_active Ceased
- 2008-09-01 MX MX2008011164A patent/MX2008011164A/es active IP Right Grant
- 2008-09-02 CA CA2639349A patent/CA2639349C/fr not_active Expired - Fee Related
- 2008-09-02 TW TW097133661A patent/TWI374029B/zh not_active IP Right Cessation
- 2008-09-03 ZA ZA2008/07586A patent/ZA200807586B/en unknown
- 2008-09-04 UA UAA200810902A patent/UA100003C2/ru unknown
- 2008-09-05 JP JP2008227956A patent/JP4932805B2/ja not_active Expired - Fee Related
- 2008-09-08 HN HN2008001393A patent/HN2008001393A/es unknown
- 2008-09-08 CL CL2008002654A patent/CL2008002654A1/es unknown
- 2008-09-08 MA MA31219A patent/MA30315B1/fr unknown
- 2008-09-09 PA PA20088795301A patent/PA8795301A1/es unknown
- 2008-09-09 US US12/283,110 patent/US8076325B2/en not_active Expired - Fee Related
- 2008-09-09 AR ARP080103906A patent/AR068386A1/es active IP Right Grant
- 2008-09-10 EA EA200801828A patent/EA014756B1/ru unknown
- 2008-09-10 JO JO2008404A patent/JO2652B1/en active
- 2008-09-10 NZ NZ571143A patent/NZ571143A/en not_active IP Right Cessation
- 2008-09-10 SA SA08290567A patent/SA08290567B1/ar unknown
- 2008-09-10 NI NI200800247A patent/NI200800247A/es unknown
- 2008-09-10 KR KR1020080089213A patent/KR101078076B1/ko not_active Expired - Fee Related
- 2008-09-10 EC EC2008008731A patent/ECSP088731A/es unknown
- 2008-09-11 ES ES08290851T patent/ES2342511T3/es active Active
- 2008-09-11 AT AT08290851T patent/ATE460401T1/de active
- 2008-09-11 RS RSP-2010/0245A patent/RS51305B/sr unknown
- 2008-09-11 DE DE602008000786T patent/DE602008000786D1/de active Active
- 2008-09-11 CU CU20080165A patent/CU23706B7/es active IP Right Grant
- 2008-09-11 ME MEP-2010-45A patent/ME00981B/me unknown
- 2008-09-11 CO CO08095781A patent/CO6020016A1/es active IP Right Grant
- 2008-09-11 CN CN2008102135506A patent/CN101386594B/zh not_active Expired - Fee Related
- 2008-09-11 EP EP08290851A patent/EP2036892B1/fr active Active
- 2008-09-11 PY PY200808034070A patent/PY08034070A/es unknown
- 2008-09-11 PL PL08290851T patent/PL2036892T3/pl unknown
- 2008-09-11 SI SI200830030T patent/SI2036892T1/sl unknown
- 2008-09-11 WO PCT/FR2008/001268 patent/WO2009066041A2/fr not_active Ceased
- 2008-09-11 BR BRPI0804091A patent/BRPI0804091B8/pt not_active IP Right Cessation
- 2008-09-11 DK DK08290851.8T patent/DK2036892T3/da active
- 2008-09-11 PT PT08290851T patent/PT2036892E/pt unknown
2010
- 2010-05-11 HR HR20100259T patent/HRP20100259T1/hr unknown
- 2010-05-17 CY CY20101100438T patent/CY1110034T1/el unknown

Also Published As

Publication number	Publication date
EA200801828A2 (ru)	2009-04-28
AP2008004589A0 (en)	2008-08-31
FR2920773B1 (fr)	2009-10-23
ZA200807586B (en)	2011-04-28
ES2342511T3 (es)	2010-07-07
EP2036892A1 (fr)	2009-03-18
US20090069296A1 (en)	2009-03-12
JO2652B1 (en)	2012-06-17
CA2639349C (fr)	2011-03-22
JP4932805B2 (ja)	2012-05-16
MY143079A (en)	2011-02-28
PE20090620A1 (es)	2009-05-30
PA8795301A1 (es)	2009-04-23
BRPI0804091B8 (pt)	2021-05-25
ECSP088731A (es)	2008-10-31
US8076325B2 (en)	2011-12-13
TWI374029B (en)	2012-10-11
CN101386594B (zh)	2012-05-16
TW200918076A (en)	2009-05-01
CO6020016A1 (es)	2009-03-31
EA014756B1 (ru)	2011-02-28
CY1110034T1 (el)	2015-01-14
SI2036892T1 (sl)	2010-06-30
CU23706B7 (es)	2011-10-05
EP2036892B1 (fr)	2010-03-10
MX2008011164A (es)	2009-03-10
SA08290567B1 (ar)	2011-06-22
AU2008207585A1 (en)	2009-03-26
FR2920773A1 (fr)	2009-03-13
CR10229A (es)	2008-11-26
HK1129667A1 (en)	2009-12-04
SG151172A1 (en)	2009-04-30
NZ571143A (en)	2010-04-30
DE602008000786D1 (de)	2010-04-22
EA200801828A3 (ru)	2009-08-28
CA2639349A1 (fr)	2009-03-11
HRP20100259T1 (hr)	2010-06-30
DK2036892T3 (da)	2010-06-07
CL2008002654A1 (es)	2009-03-20
NI200800247A (es)	2011-01-10
CN101386594A (zh)	2009-03-18
ME00981B (me)	2012-06-20
PT2036892E (pt)	2010-05-10
HN2008001393A (es)	2011-05-11
CU20080165A7 (es)	2011-03-21
PY08034070A (es)	2014-02-03
AU2008207585B2 (en)	2013-08-22
WO2009066041A2 (fr)	2009-05-28
AP2384A (en)	2012-03-21
ATE460401T1 (de)	2010-03-15
JP2009108032A (ja)	2009-05-21
WO2009066041A3 (fr)	2009-12-17
MA30315B1 (fr)	2009-04-01
KR20090027164A (ko)	2009-03-16
UA100003C2 (ru)	2012-11-12
UY31305A1 (es)	2008-10-31
BRPI0804091A2 (pt)	2009-05-05
AR068386A1 (es)	2009-11-11
KR101078076B1 (ko)	2011-10-28
BRPI0804091B1 (pt)	2020-09-29
RS51305B (sr)	2010-12-31

Publication	Publication Date	Title
PL2036892T3 (pl)	2010-08-31	Pochodne 1,2,4,5-tetrahydro-3H-benzazepin, sposób ich wytwarzania i zawierające je kompozycje farmaceutyczne
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DK1984009T3 (da)	2013-01-28	Farmaceutiske sammensætninger med forbedret stabilitet
BRPI0810928A2 (pt)	2019-09-24	"composição farmacêutica"
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IL194546A0 (en)	2009-08-03	Arylaminopyridine derivatives and pharmaceutical compositions containing them
DK3492069T3 (da)	2022-03-14	Farmaceutiske sammensætninger omfattende jern-oxy-hydroxid
IL199853A (en)	2015-02-26	Converged history of 5-Hydroxy-Admentil-2-Reindeer and Pharmaceutical Preparation containing them
IL190292A (en)	2017-01-31	History of pyridopyrimidinone and their pharmaceutical preparations
IL192826A0 (en)	2009-02-11	Thiazole derivatives, their preparation and pharmaceutical compositions containing them
IL203915A (en)	2016-04-21	Annotations of 2-Benzylphenyl-6-Hydroxymethyl-Tetrahydro-2 H-Pyrene-3,4,5-Triol
IL203578A (en)	2014-02-27	History of pyrimidine-4 - carboxamide, their preparation and their pharmaceutical preparations
IL200206A (en)	2015-09-24	The history of quinaxaline, their preparation and their pharmaceutical preparations
IL177533A (en)	2010-12-30	Benzimidazole derivatives, their preparation and pharmaceutical compositions comprising them
IL193240A0 (en)	2009-08-03	Dihydrodiazepine derivatives and pharmaceutical compositions containing the same
PL1861387T3 (pl)	2014-08-29	Pochodne benzoimidazolu i ich kompozycje farmaceutyczne
IL195813A0 (en)	2009-09-22	Substituted aminopyrazolopyridines and salts thereof, their preparations and pharmaceutical compositions comprising them
IL193772A0 (en)	2009-08-03	4-oxoquinoline derivatives,methods for the preparation thereof and pharmaceutical compositions containing the same
DK2966175T3 (da)	2019-07-01	Farmaceutiske sammensætninger indeholdende cortexolon-17-alpha-propionat
IL206808A (en)	2015-08-31	Indolyl-pyridone history, their pharmaceutical preparations and their uses
IL206594A (en)	2015-05-31	The history of azinone-tetrahydropyridoindole and its containing pharmaceutical preparations
IL193211A (en)	2013-07-31	Derivatives of Indzol-Troaril and pharmaceutical preparations containing them
BRPI0807078A2 (pt)	2014-04-08	Composto, e, formulação farmacêutica
IL187391A0 (en)	2008-02-09	Thiazole derivatives, their preparation and use and pharmaceutical compositions containing them
BRPI0907228A2 (pt)	2015-07-14	Compostos de tienopiridazina, suas preparações, composições farmacêuticas e usos