PL2049157T3 - Polimeryczne koniugaty doksorubicyny o uwalnianiu leku regulowanym za pomocą pH i sposób wytwarzania - Google Patents

Polimeryczne koniugaty doksorubicyny o uwalnianiu leku regulowanym za pomocą pH i sposób wytwarzania

Info

Publication number
PL2049157T3
PL2049157T3 PL07785504T PL07785504T PL2049157T3 PL 2049157 T3 PL2049157 T3 PL 2049157T3 PL 07785504 T PL07785504 T PL 07785504T PL 07785504 T PL07785504 T PL 07785504T PL 2049157 T3 PL2049157 T3 PL 2049157T3
Authority
PL
Poland
Prior art keywords
preparation
drug release
hpma
doxorubicin
release polymeric
Prior art date
Application number
PL07785504T
Other languages
English (en)
Inventor
Tomas Etrych
Karel Ulbrich
Original Assignee
Zentiva Ks
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva Ks filed Critical Zentiva Ks
Publication of PL2049157T3 publication Critical patent/PL2049157T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
PL07785504T 2006-08-09 2007-08-08 Polimeryczne koniugaty doksorubicyny o uwalnianiu leku regulowanym za pomocą pH i sposób wytwarzania PL2049157T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CZ20060505A CZ2006505A3 (cs) 2006-08-09 2006-08-09 Polymerní konjugáty doxorubicinu s pH-rízeným uvolnováním léciva a zpusob jejich prípravy
PCT/CZ2007/000077 WO2008017277A2 (en) 2006-08-09 2007-08-08 Polymeric conjugates of doxorubicin with ph-regulated release of the drug and a method of preparing
EP07785504A EP2049157B1 (en) 2006-08-09 2007-08-08 Polymeric conjugates of doxorubicin with ph-regulated release of the drug and a method of preparing

Publications (1)

Publication Number Publication Date
PL2049157T3 true PL2049157T3 (pl) 2011-04-29

Family

ID=38828704

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07785504T PL2049157T3 (pl) 2006-08-09 2007-08-08 Polimeryczne koniugaty doksorubicyny o uwalnianiu leku regulowanym za pomocą pH i sposób wytwarzania

Country Status (11)

Country Link
US (1) US20100190928A1 (pl)
EP (1) EP2049157B1 (pl)
AT (1) ATE495759T1 (pl)
CZ (1) CZ2006505A3 (pl)
DE (1) DE602007012111D1 (pl)
EA (1) EA200900295A1 (pl)
ES (1) ES2356991T3 (pl)
PL (1) PL2049157T3 (pl)
PT (1) PT2049157E (pl)
UA (1) UA95814C2 (pl)
WO (1) WO2008017277A2 (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090311182A1 (en) * 2004-03-31 2009-12-17 Dong Wang Macromolecular Delivery Systems for Non-Invasive Imaging, Evaluation and Treatment of Arthritis and Other Inflammatory Diseases
CZ303072B6 (cs) * 2009-02-13 2012-03-21 Zentiva, K.S. Polymerní konjugáty paclitaxelu a docetaxelu s pH rízeným uvolnováním kancerostatika
CN102740795B (zh) * 2009-09-09 2016-11-02 内布拉斯加大学董事委员会 用于检测和治疗植入物松动和骨质溶解的组合物和方法
CN103936945B (zh) * 2013-01-23 2017-02-08 中国科学院化学研究所 一类高效抗肿瘤靶向药物载体及其制备方法
CN105963706B (zh) * 2016-04-15 2019-03-15 四川大学 一种支化hpma共聚物-dox偶联物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4619457B2 (ja) * 1993-11-18 2011-01-26 シルテックス、メディカル、リミテッド 徐放性製剤
US6060518A (en) * 1996-08-16 2000-05-09 Supratek Pharma Inc. Polymer compositions for chemotherapy and methods of treatment using the same
CZ293787B6 (cs) * 2001-12-20 2004-07-14 Zentiva, A.S. pH senzitivní polymerní konjugáty antracyklinového kancerostatika pro cílenou terapii
CZ297827B6 (cs) * 2005-09-05 2007-04-04 Zentiva, A. S. Zpusob prípravy polymerních konjugátu doxorubicinu s pH-rízeným uvolnováním léciva

Also Published As

Publication number Publication date
EP2049157A2 (en) 2009-04-22
CZ299053B6 (cs) 2008-04-09
UA95814C2 (ru) 2011-09-12
DE602007012111D1 (de) 2011-03-03
WO2008017277A3 (en) 2008-03-27
EP2049157B1 (en) 2011-01-19
ES2356991T3 (es) 2011-04-15
CZ2006505A3 (cs) 2008-04-09
EA200900295A1 (ru) 2009-06-30
PT2049157E (pt) 2011-02-23
US20100190928A1 (en) 2010-07-29
WO2008017277A2 (en) 2008-02-14
ATE495759T1 (de) 2011-02-15

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