PL2065388T3 - Pochodna pirazolopirymidynowa - Google Patents

Pochodna pirazolopirymidynowa

Info

Publication number: PL2065388T3
Authority: PL; Poland
Prior art keywords: formula; compound represented; hsp90; compound; antitumor activity
Prior art date: 2006-09-19

Application number

PL07807337T

Other languages

English (en)

Inventor

Satoru Ohsuki

Atsushi Tengeiji

Masahiro Ikeda

Yoshihiro Shibata

Chikahiro Nagata

Takashi Shimada

Original Assignee

Daiichi Sankyo Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-09-19

Filing date

2007-09-14

Publication date

2012-02-29

2007-09-14 Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd

2012-02-29 Publication of PL2065388T3 publication Critical patent/PL2065388T3/pl

Links

OGEBRHQLRGFBNV-RZDIXWSQSA-N chembl2036808 Chemical class C12=NC(NCCCC)=NC=C2C(C=2C=CC(F)=CC=2)=NN1C[C@H]1CC[C@H](N)CC1 OGEBRHQLRGFBNV-RZDIXWSQSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 7
101710113864 Heat shock protein 90 Proteins 0.000 abstract 3
102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 abstract 3
230000000259 anti-tumor effect Effects 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
230000002401 inhibitory effect Effects 0.000 abstract 2
108091006112 ATPases Proteins 0.000 abstract 1
102000057290 Adenosine Triphosphatases Human genes 0.000 abstract 1
108010006519 Molecular Chaperones Proteins 0.000 abstract 1
102000005431 Molecular Chaperones Human genes 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000003481 heat shock protein 90 inhibitor Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
-1 pyrazolopyrimidine compound Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/16—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/20—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

PL07807337T 2006-09-19 2007-09-14 Pochodna pirazolopirymidynowa PL2065388T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP2006253465		2006-09-19
EP07807337A EP2065388B1 (en)	2006-09-19	2007-09-14	Pyrazolopyrimidine derivative
PCT/JP2007/067933 WO2008035629A1 (en)	2006-09-19	2007-09-14	Pyrazolopyrimidine derivative

Publications (1)

Publication Number	Publication Date
PL2065388T3 true PL2065388T3 (pl)	2012-02-29

Family

ID=39200455

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL07807337T PL2065388T3 (pl)	2006-09-19	2007-09-14	Pochodna pirazolopirymidynowa

Country Status (25)

Country	Link
US (1)	US8158638B2 (pl)
EP (1)	EP2065388B1 (pl)
JP (1)	JP5252636B2 (pl)
KR (2)	KR101485199B1 (pl)
CN (1)	CN101541811B (pl)
AT (1)	ATE523513T1 (pl)
AU (1)	AU2007298286B2 (pl)
BR (1)	BRPI0717176A2 (pl)
CA (1)	CA2663965C (pl)
CO (1)	CO6210702A2 (pl)
CY (1)	CY1112191T1 (pl)
DK (1)	DK2065388T3 (pl)
ES (1)	ES2373160T3 (pl)
IL (1)	IL197513A (pl)
MX (1)	MX2009002998A (pl)
MY (1)	MY145041A (pl)
NO (1)	NO20091495L (pl)
NZ (1)	NZ575564A (pl)
PL (1)	PL2065388T3 (pl)
PT (1)	PT2065388E (pl)
RU (1)	RU2420530C2 (pl)
SI (1)	SI2065388T1 (pl)
TW (1)	TWI388563B (pl)
WO (1)	WO2008035629A1 (pl)
ZA (1)	ZA200901921B (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2520966C2 (ru) *	2009-02-25	2014-06-27	Дайити Санкио Компани, Лимитед	Производное трициклического пиразолопиримидина
US8343983B2 (en) *	2009-03-31	2013-01-01	Arqule, Inc.	Substituted pyrazolo-pyrimidine compounds
AR077405A1 (es)	2009-07-10	2011-08-24	Sanofi Aventis	Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr)	2009-09-03	2011-11-25	Sanofi Aventis	Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
JPWO2012026433A1 (ja) *	2010-08-23	2013-10-28	第一三共株式会社	三環性ピラゾロピリミジン誘導体のフリー体結晶
CA2809120C (en)	2010-08-23	2015-10-13	Daiichi Sankyo Company, Limited	Crystal of tricyclic pyrazolopyrimidine derivative
CA2928568A1 (en)	2013-07-26	2015-01-29	Update Pharma Inc.	Combinatorial methods to improve the therapeutic benefit of bisantrene
CN114380738A (zh) *	2021-09-28	2022-04-22	都创(重庆)医药科技有限公司	一种3-溴-4-氯-2-甲基吡啶的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2220509C (en) *	1995-05-31	2005-07-05	Eisai Co., Ltd.	Fused polycyclic heterocycle derivatives
GB9615934D0 (en)	1996-07-30	1996-09-11	Netlon Ltd	Integral tube
WO1998043991A1 (en) *	1997-04-02	1998-10-08	Amersham Pharmacia Biotech Uk Limited	Tricyclic base analogues
JP2001526639A (ja) *	1997-04-02	2001-12-18	アマーシャム・ファルマシア・バイオテック・ユーケイ・リミテッド	三環式塩基類似体
RU2342388C2 (ru)	2002-11-22	2008-12-27	Джапан Тобакко Инк.	Конденсированные бициклические азотсодержащие гетероциклы, обладающие dgat ингибирующим действием
KR20060123707A (ko) *	2003-08-27	2006-12-04	바이오타, 인코포레이티드	치료제로서의 신규 트리시클릭 뉴클레오시드 또는뉴클레오티드
NZ546611A (en)	2003-09-18	2010-02-26	Conforma Therapeutics Corp	Novel heterocyclic compounds as HSP90-inhibitors
TW200612918A (en)	2004-07-29	2006-05-01	Threshold Pharmaceuticals Inc	Lonidamine analogs

2007
- 2007-09-14 DK DK07807337.6T patent/DK2065388T3/da active
- 2007-09-14 KR KR1020097005525A patent/KR101485199B1/ko not_active Expired - Fee Related
- 2007-09-14 JP JP2008535335A patent/JP5252636B2/ja not_active Expired - Fee Related
- 2007-09-14 BR BRPI0717176-5A patent/BRPI0717176A2/pt not_active IP Right Cessation
- 2007-09-14 AU AU2007298286A patent/AU2007298286B2/en not_active Ceased
- 2007-09-14 KR KR20147027308A patent/KR20140127367A/ko not_active Ceased
- 2007-09-14 RU RU2009114731/04A patent/RU2420530C2/ru not_active IP Right Cessation
- 2007-09-14 CN CN200780042951.3A patent/CN101541811B/zh not_active Expired - Fee Related
- 2007-09-14 US US12/442,094 patent/US8158638B2/en not_active Expired - Fee Related
- 2007-09-14 PT PT07807337T patent/PT2065388E/pt unknown
- 2007-09-14 AT AT07807337T patent/ATE523513T1/de active
- 2007-09-14 ES ES07807337T patent/ES2373160T3/es active Active
- 2007-09-14 WO PCT/JP2007/067933 patent/WO2008035629A1/ja not_active Ceased
- 2007-09-14 CA CA2663965A patent/CA2663965C/en not_active Expired - Fee Related
- 2007-09-14 SI SI200730765T patent/SI2065388T1/sl unknown
- 2007-09-14 EP EP07807337A patent/EP2065388B1/en not_active Not-in-force
- 2007-09-14 NZ NZ575564A patent/NZ575564A/en not_active IP Right Cessation
- 2007-09-14 MX MX2009002998A patent/MX2009002998A/es active IP Right Grant
- 2007-09-14 PL PL07807337T patent/PL2065388T3/pl unknown
- 2007-09-19 TW TW096134774A patent/TWI388563B/zh not_active IP Right Cessation
2009
- 2009-03-10 IL IL197513A patent/IL197513A/en not_active IP Right Cessation
- 2009-03-17 MY MYPI20091088A patent/MY145041A/en unknown
- 2009-03-18 ZA ZA200901921A patent/ZA200901921B/xx unknown
- 2009-04-16 NO NO20091495A patent/NO20091495L/no not_active Application Discontinuation
- 2009-04-17 CO CO09039060A patent/CO6210702A2/es active IP Right Grant
2011
- 2011-12-07 CY CY20111101220T patent/CY1112191T1/el unknown

Also Published As

Publication number	Publication date
JP5252636B2 (ja)	2013-07-31
MY145041A (en)	2011-12-15
WO2008035629A1 (en)	2008-03-27
CA2663965A1 (en)	2008-03-27
SI2065388T1 (sl)	2012-03-30
MX2009002998A (es)	2009-04-02
BRPI0717176A2 (pt)	2013-10-15
TW200823223A (en)	2008-06-01
NO20091495L (no)	2009-06-18
US8158638B2 (en)	2012-04-17
ZA200901921B (en)	2009-12-30
IL197513A0 (en)	2009-12-24
PT2065388E (pt)	2011-11-10
ES2373160T3 (es)	2012-02-01
IL197513A (en)	2014-01-30
CA2663965C (en)	2012-06-12
KR20140127367A (ko)	2014-11-03
RU2009114731A (ru)	2010-10-27
KR101485199B1 (ko)	2015-01-22
RU2420530C2 (ru)	2011-06-10
AU2007298286B2 (en)	2011-02-03
CY1112191T1 (el)	2015-12-09
US20100113410A1 (en)	2010-05-06
EP2065388A4 (en)	2009-11-18
JPWO2008035629A1 (ja)	2010-01-28
DK2065388T3 (da)	2012-01-09
KR20090066274A (ko)	2009-06-23
EP2065388B1 (en)	2011-09-07
ATE523513T1 (de)	2011-09-15
TWI388563B (zh)	2013-03-11
CN101541811B (zh)	2014-07-09
NZ575564A (en)	2011-02-25
CO6210702A2 (es)	2010-10-20
EP2065388A1 (en)	2009-06-03
CN101541811A (zh)	2009-09-23
AU2007298286A1 (en)	2008-03-27
HK1127476A1 (en)	2009-09-25

Publication	Publication Date	Title
CY1112191T1 (el)	2015-12-09	Παραγωγο πυραζολοπυριμιδινης
IL184872A0 (en)	2007-12-03	Pyrazole derivatives, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments for treatment and prevention of cancers
IL185063A0 (en)	2007-12-03	Pyrazole derivatives, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments for treatment and prevention of cancers
UA95644C2 (ru)	2011-08-25	Пиридазиноновые производные, фармацевтическая композиция и способ лечения заболеваний
MX2007002398A (es)	2007-05-15	Nuevas composiciones farmaceuticas para el tratamiento de cancer.
TW200833663A (en)	2008-08-16	Therapeutic agents
MY149512A (en)	2013-09-13	Pyrazolylaminopyridine derivatives useful as kinase inhibitors
MX2009000657A (es)	2009-05-28	Composiciones y metodos para el tratamiento de mucositis.
WO2005110994A8 (en)	2006-12-21	Substituted pyrazolyl urea derivatives useful in the treatment of cancer
MXPA05007352A (es)	2006-02-17	Compuestos triciclicos inhibidores de proteina quinasa para mejorar la eficacia de agentes antineoplasicos y terapia de radiacion.
MY155695A (en)	2015-11-13	Quinoxalinedione derivatives
MX2009005292A (es)	2009-08-13	Metodo de radiosensibilizacion de tumores usando un agente radiosensibilizante.
MX2010009022A (es)	2010-09-07	Derivados 16 alfa, 17 alfa-acetal glucocorticoesteroideos y su uso.
TW200736229A (en)	2007-10-01	Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors
UA96759C2 (en)	2011-12-12	2-ARYLINDOLE DERIVATIVES AS mPGES-I INHIBITORS
MX2007014920A (es)	2008-04-09	Politerapia que comprende diarilureas para el tratamiento de enfermedades.
EP2215054B8 (en)	2012-02-08	Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
TW200738659A (en)	2007-10-16	Novel compounds
MXPA05010020A (es)	2005-11-17	Derivados de oxamida.
TW200631606A (en)	2006-09-16	Organic compounds
MX2011008677A (es)	2011-09-08	Derivados de pirazolopirimidina triciclicos.
WO2006093832A3 (en)	2007-03-22	Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
MX2009013482A (es)	2010-01-27	Derivados de [1,10]-fenantrolina para el tratamiento de enfermedades neurodegenerativas o hematologicas.
MX2009005912A (es)	2009-07-22	Derivados de etilamina-fenilo heterociclilo sustituidos, su preparacion y uso como medicamentos.
IL191670A0 (en)	2008-12-29	Compounds for the inhibition of apoptosis