ATE523513T1 - Pyrazolopyrimidinderivat - Google Patents

Pyrazolopyrimidinderivat

Info

Publication number: ATE523513T1
Authority: AT; Austria
Prior art keywords: formula; compound represented; hsp90; pyrazolopyrimideine; derivative
Prior art date: 2006-09-19

Application number

AT07807337T

Other languages

English (en)

Inventor

Satoru Ohsuki

Atsushi Tengeiji

Masahiro Ikeda

Yoshihiro Shibata

Chikahiro Nagata

Takashi Shimada

Original Assignee

Daiichi Sankyo Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-09-19

Filing date

2007-09-14

Publication date

2011-09-15

2007-09-14 Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd

2011-09-15 Application granted granted Critical

2011-09-15 Publication of ATE523513T1 publication Critical patent/ATE523513T1/de

Links

150000001875 compounds Chemical class 0.000 abstract 7
101710113864 Heat shock protein 90 Proteins 0.000 abstract 3
102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 abstract 3
230000000259 anti-tumor effect Effects 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
230000002401 inhibitory effect Effects 0.000 abstract 2
108091006112 ATPases Proteins 0.000 abstract 1
102000057290 Adenosine Triphosphatases Human genes 0.000 abstract 1
108010006519 Molecular Chaperones Proteins 0.000 abstract 1
102000005431 Molecular Chaperones Human genes 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000003481 heat shock protein 90 inhibitor Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
-1 pyrazolopyrimidine compound Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/16—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/20—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT07807337T 2006-09-19 2007-09-14 Pyrazolopyrimidinderivat ATE523513T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2006253465		2006-09-19
PCT/JP2007/067933 WO2008035629A1 (en)	2006-09-19	2007-09-14	Pyrazolopyrimidine derivative

Publications (1)

Publication Number	Publication Date
ATE523513T1 true ATE523513T1 (de)	2011-09-15

Family

ID=39200455

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07807337T ATE523513T1 (de)	2006-09-19	2007-09-14	Pyrazolopyrimidinderivat

Country Status (25)

Country	Link
US (1)	US8158638B2 (de)
EP (1)	EP2065388B1 (de)
JP (1)	JP5252636B2 (de)
KR (2)	KR20140127367A (de)
CN (1)	CN101541811B (de)
AT (1)	ATE523513T1 (de)
AU (1)	AU2007298286B2 (de)
BR (1)	BRPI0717176A2 (de)
CA (1)	CA2663965C (de)
CO (1)	CO6210702A2 (de)
CY (1)	CY1112191T1 (de)
DK (1)	DK2065388T3 (de)
ES (1)	ES2373160T3 (de)
IL (1)	IL197513A (de)
MX (1)	MX2009002998A (de)
MY (1)	MY145041A (de)
NO (1)	NO20091495L (de)
NZ (1)	NZ575564A (de)
PL (1)	PL2065388T3 (de)
PT (1)	PT2065388E (de)
RU (1)	RU2420530C2 (de)
SI (1)	SI2065388T1 (de)
TW (1)	TWI388563B (de)
WO (1)	WO2008035629A1 (de)
ZA (1)	ZA200901921B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR20110131190A (ko)	2009-02-25	2011-12-06	다이이찌 산쿄 가부시키가이샤	3 고리성 피라졸로피리미딘 유도체
AU2010232647A1 (en) *	2009-03-31	2011-10-20	Arqule, Inc.	Peri-fused pyrazolo-pyrimidine compounds
AR077405A1 (es)	2009-07-10	2011-08-24	Sanofi Aventis	Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr)	2009-09-03	2011-11-25	Sanofi Aventis	Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
JP5701884B2 (ja) *	2010-08-23	2015-04-15	第一三共株式会社	三環性ピラゾロピリミジン誘導体の結晶
BR112013004258A2 (pt) *	2010-08-23	2016-08-02	Daiichi Sankyo Co Ltd	cristal, composição farmacêutica, e, agente anticâncer
AU2014293013A1 (en)	2013-07-26	2016-03-17	Race Oncology Ltd.	Combinatorial methods to improve the therapeutic benefit of bisantrene
CN114380738A (zh) *	2021-09-28	2022-04-22	都创(重庆)医药科技有限公司	一种3-溴-4-氯-2-甲基吡啶的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2220509C (en) *	1995-05-31	2005-07-05	Eisai Co., Ltd.	Fused polycyclic heterocycle derivatives
GB9615934D0 (en)	1996-07-30	1996-09-11	Netlon Ltd	Integral tube
JP2001526639A (ja) *	1997-04-02	2001-12-18	アマーシャム・ファルマシア・バイオテック・ユーケイ・リミテッド	三環式塩基類似体
EP0973788A1 (de) *	1997-04-02	2000-01-26	Amersham Pharmacia Biotech UK Limited	Trizyklische basenanaloge
EP1562956A4 (de)	2002-11-22	2007-10-10	Japan Tobacco Inc	Kondensierte bicyclische, stickstoffhaltigeheterocyclen
WO2005021568A2 (en)	2003-08-27	2005-03-10	Biota, Inc.	Novel tricyclic nucleosides or nucleotides as therapeutic agents
NZ546611A (en)	2003-09-18	2010-02-26	Conforma Therapeutics Corp	Novel heterocyclic compounds as HSP90-inhibitors
TW200612918A (en)	2004-07-29	2006-05-01	Threshold Pharmaceuticals Inc	Lonidamine analogs

2007
- 2007-09-14 JP JP2008535335A patent/JP5252636B2/ja not_active Expired - Fee Related
- 2007-09-14 SI SI200730765T patent/SI2065388T1/sl unknown
- 2007-09-14 US US12/442,094 patent/US8158638B2/en not_active Expired - Fee Related
- 2007-09-14 EP EP07807337A patent/EP2065388B1/de not_active Not-in-force
- 2007-09-14 DK DK07807337.6T patent/DK2065388T3/da active
- 2007-09-14 AT AT07807337T patent/ATE523513T1/de active
- 2007-09-14 KR KR20147027308A patent/KR20140127367A/ko not_active Ceased
- 2007-09-14 PT PT07807337T patent/PT2065388E/pt unknown
- 2007-09-14 PL PL07807337T patent/PL2065388T3/pl unknown
- 2007-09-14 MX MX2009002998A patent/MX2009002998A/es active IP Right Grant
- 2007-09-14 NZ NZ575564A patent/NZ575564A/en not_active IP Right Cessation
- 2007-09-14 KR KR1020097005525A patent/KR101485199B1/ko not_active Expired - Fee Related
- 2007-09-14 BR BRPI0717176-5A patent/BRPI0717176A2/pt not_active IP Right Cessation
- 2007-09-14 CA CA2663965A patent/CA2663965C/en not_active Expired - Fee Related
- 2007-09-14 ES ES07807337T patent/ES2373160T3/es active Active
- 2007-09-14 AU AU2007298286A patent/AU2007298286B2/en not_active Ceased
- 2007-09-14 RU RU2009114731/04A patent/RU2420530C2/ru not_active IP Right Cessation
- 2007-09-14 WO PCT/JP2007/067933 patent/WO2008035629A1/ja not_active Ceased
- 2007-09-14 CN CN200780042951.3A patent/CN101541811B/zh not_active Expired - Fee Related
- 2007-09-19 TW TW096134774A patent/TWI388563B/zh not_active IP Right Cessation
2009
- 2009-03-10 IL IL197513A patent/IL197513A/en not_active IP Right Cessation
- 2009-03-17 MY MYPI20091088A patent/MY145041A/en unknown
- 2009-03-18 ZA ZA200901921A patent/ZA200901921B/xx unknown
- 2009-04-16 NO NO20091495A patent/NO20091495L/no not_active Application Discontinuation
- 2009-04-17 CO CO09039060A patent/CO6210702A2/es active IP Right Grant
2011
- 2011-12-07 CY CY20111101220T patent/CY1112191T1/el unknown

Also Published As

Publication number	Publication date
CY1112191T1 (el)	2015-12-09
MX2009002998A (es)	2009-04-02
AU2007298286B2 (en)	2011-02-03
EP2065388B1 (de)	2011-09-07
WO2008035629A1 (en)	2008-03-27
JPWO2008035629A1 (ja)	2010-01-28
AU2007298286A1 (en)	2008-03-27
US8158638B2 (en)	2012-04-17
EP2065388A1 (de)	2009-06-03
PL2065388T3 (pl)	2012-02-29
MY145041A (en)	2011-12-15
TWI388563B (zh)	2013-03-11
JP5252636B2 (ja)	2013-07-31
BRPI0717176A2 (pt)	2013-10-15
CN101541811B (zh)	2014-07-09
KR101485199B1 (ko)	2015-01-22
NZ575564A (en)	2011-02-25
CA2663965C (en)	2012-06-12
IL197513A0 (en)	2009-12-24
HK1127476A1 (en)	2009-09-25
SI2065388T1 (sl)	2012-03-30
RU2009114731A (ru)	2010-10-27
NO20091495L (no)	2009-06-18
DK2065388T3 (da)	2012-01-09
CA2663965A1 (en)	2008-03-27
CO6210702A2 (es)	2010-10-20
PT2065388E (pt)	2011-11-10
IL197513A (en)	2014-01-30
KR20090066274A (ko)	2009-06-23
ES2373160T3 (es)	2012-02-01
US20100113410A1 (en)	2010-05-06
KR20140127367A (ko)	2014-11-03
TW200823223A (en)	2008-06-01
CN101541811A (zh)	2009-09-23
ZA200901921B (en)	2009-12-30
RU2420530C2 (ru)	2011-06-10
EP2065388A4 (de)	2009-11-18

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2012-04-15

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