PL2094699T3 - Nowe pochodne imidazolonów, ich wytwarzanie jako leków, kompozycje farmaceutyczne i zastosowanie jako inhibitorów kinaz białkowych, zwłaszcza cdc7 - Google Patents

Nowe pochodne imidazolonów, ich wytwarzanie jako leków, kompozycje farmaceutyczne i zastosowanie jako inhibitorów kinaz białkowych, zwłaszcza cdc7

Info

Publication number
PL2094699T3
PL2094699T3 PL07858418T PL07858418T PL2094699T3 PL 2094699 T3 PL2094699 T3 PL 2094699T3 PL 07858418 T PL07858418 T PL 07858418T PL 07858418 T PL07858418 T PL 07858418T PL 2094699 T3 PL2094699 T3 PL 2094699T3
Authority
PL
Poland
Prior art keywords
drugs
preparation
pharmaceutical compositions
protein kinase
kinase inhibitors
Prior art date
Application number
PL07858418T
Other languages
English (en)
Inventor
Vincent Leroy
Eric Bacque
Emmanuel Conseiller
Anke Steinmetz
Baptiste Ronan
Jean-Philippe Letallec
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PL2094699T3 publication Critical patent/PL2094699T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL07858418T 2006-10-12 2007-10-10 Nowe pochodne imidazolonów, ich wytwarzanie jako leków, kompozycje farmaceutyczne i zastosowanie jako inhibitorów kinaz białkowych, zwłaszcza cdc7 PL2094699T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0608924A FR2907120B1 (fr) 2006-10-12 2006-10-12 Nouveaux derives imidazolones,leur preparation a titre de medicaments,compositions pharmaceutiques,utilisation comme inhibiteurs de proteines kinases notamment cdc7
PCT/FR2007/001651 WO2008046982A2 (fr) 2006-10-12 2007-10-10 Nouveaux derives imidazolones, leur preparation a titre de medicaments, compositions pharmaceutiques, utilisation comme inhibiteurs de proteines kinases notamment cdc7
EP07858418A EP2094699B1 (fr) 2006-10-12 2007-10-10 Nouveaux derives imidazolones, leur preparation a titre de medicaments, compositions pharmaceutiques, utilisation comme inhibiteurs de proteines kinases notamment cdc7

Publications (1)

Publication Number Publication Date
PL2094699T3 true PL2094699T3 (pl) 2011-12-30

Family

ID=37964098

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07858418T PL2094699T3 (pl) 2006-10-12 2007-10-10 Nowe pochodne imidazolonów, ich wytwarzanie jako leków, kompozycje farmaceutyczne i zastosowanie jako inhibitorów kinaz białkowych, zwłaszcza cdc7

Country Status (29)

Country Link
US (1) US8314121B2 (pl)
EP (1) EP2094699B1 (pl)
JP (1) JP2010505922A (pl)
KR (1) KR101552361B1 (pl)
CN (1) CN101522678A (pl)
AR (1) AR063249A1 (pl)
AT (1) ATE517105T1 (pl)
AU (1) AU2007311833B2 (pl)
BR (1) BRPI0719790A2 (pl)
CA (1) CA2660166C (pl)
CL (1) CL2007002934A1 (pl)
CO (1) CO6160310A2 (pl)
CY (1) CY1112066T1 (pl)
DK (1) DK2094699T3 (pl)
EA (1) EA018496B1 (pl)
ES (1) ES2370049T3 (pl)
FR (1) FR2907120B1 (pl)
HR (1) HRP20110759T1 (pl)
IL (1) IL197452A (pl)
MA (1) MA30877B1 (pl)
MX (1) MX2009003283A (pl)
NO (1) NO20091486L (pl)
PL (1) PL2094699T3 (pl)
PT (1) PT2094699E (pl)
RS (1) RS51985B (pl)
SI (1) SI2094699T1 (pl)
TW (1) TW200821310A (pl)
UY (1) UY30642A1 (pl)
WO (1) WO2008046982A2 (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2423204A4 (en) 2009-04-20 2013-01-09 Sbi Biotech Co Ltd THIAZOLIDINONDERIVAT
JP2012533553A (ja) * 2009-07-15 2012-12-27 アボット・ラボラトリーズ ピロロピリジン系キナーゼ阻害薬
RU2607453C2 (ru) * 2009-12-04 2017-01-10 Сенхва Байосайенсиз, Инк. Пиразолопиримидины и родственные гетероциклы как ск2 ингибиторы
CA2795422A1 (en) * 2010-04-19 2011-10-27 Abbvie Inc. Pyrrolopyridine inhibitors of kinases
CN103459388B (zh) 2011-03-31 2015-11-25 卡尔那生物科学株式会社 新型呋喃酮衍生物
JP6569908B2 (ja) 2014-01-31 2019-09-04 カルナバイオサイエンス株式会社 抗がん剤組成物
GB201807147D0 (en) 2018-05-01 2018-06-13 Oncologica Uk Ltd Therapeutic combination
JP7579781B2 (ja) 2018-09-24 2024-11-08 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー Ｃｄｃ７阻害剤を含む癌の治療方法
EP4083037A4 (en) * 2019-12-26 2024-01-24 Yonsei University, University-Industry Foundation(UIF). Pyrrolidine derivative, and pharmaceutical composition for preventing or treating beta-amyloid or tau protein-associated diseases containing same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6335342B1 (en) 2000-06-19 2002-01-01 Pharmacia & Upjohn S.P.A. Azaindole derivatives, process for their preparation, and their use as antitumor agents
EP1599475A2 (en) 2003-03-06 2005-11-30 Eisai Co., Ltd. Jnk inhibitors
DE602004014163D1 (de) * 2003-08-08 2008-07-10 Pfizer Italia Srl Pyrimidylpyrrolderivate, die als kinaseinhibitoren wirken
WO2005103050A2 (en) 2004-04-02 2005-11-03 Vertex Pharmaceuticals Incorporated Azaindoles useful as inhibitors of rock and other protein kinases
AU2005293831B2 (en) * 2004-10-14 2011-01-06 F. Hoffmann-La Roche Ag Novel Azaindole thiazolinones as anti-cancer agents
US7371862B2 (en) * 2005-11-11 2008-05-13 Pfizer Italia S.R.L. Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them

Also Published As

Publication number Publication date
FR2907120A1 (fr) 2008-04-18
IL197452A (en) 2015-10-29
PT2094699E (pt) 2011-10-24
EA200970364A1 (ru) 2009-10-30
RS51985B (sr) 2012-02-29
MX2009003283A (es) 2009-04-08
SI2094699T1 (sl) 2011-11-30
UY30642A1 (es) 2008-05-31
EP2094699B1 (fr) 2011-07-20
AU2007311833A1 (en) 2008-04-24
CA2660166C (fr) 2015-12-29
WO2008046982A2 (fr) 2008-04-24
AU2007311833B2 (en) 2013-05-02
ES2370049T3 (es) 2011-12-12
MA30877B1 (fr) 2009-11-02
NO20091486L (no) 2009-04-16
JP2010505922A (ja) 2010-02-25
US20090253679A1 (en) 2009-10-08
TW200821310A (en) 2008-05-16
CO6160310A2 (es) 2010-05-20
EP2094699A2 (fr) 2009-09-02
CY1112066T1 (el) 2015-11-04
CN101522678A (zh) 2009-09-02
CA2660166A1 (fr) 2008-04-24
KR20090064571A (ko) 2009-06-19
HRP20110759T1 (hr) 2011-11-30
BRPI0719790A2 (pt) 2014-11-25
ATE517105T1 (de) 2011-08-15
FR2907120B1 (fr) 2013-01-11
EA018496B1 (ru) 2013-08-30
KR101552361B1 (ko) 2015-09-10
IL197452A0 (en) 2009-12-24
WO2008046982A3 (fr) 2008-06-19
US8314121B2 (en) 2012-11-20
CL2007002934A1 (es) 2008-05-30
DK2094699T3 (da) 2011-11-07
AR063249A1 (es) 2009-01-14

Similar Documents

Publication Publication Date Title
IL197452A0 (en) New imidazolone derivatives, preparation thereof as drugs, pharmaceutical compositions, and use thereof as protein kinase inhibitors, in particular cdc7
IL196280A0 (en) Use of ampk-activating imidazole derivatives, preparation process therefor and pharmaceutical compositions comprising them
IL228017A0 (en) Quinazolinone derivatives donated at position 5 as anti-cancer agents
EP1984370A4 (en) PROTEIN KINASE ACTIVITY INHIBITING IMIDAZOPYRIDINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF
IL204442A (en) Inhibitors of atpase-0fif, medicinal preparations containing them and their use
IL206952A (en) History of Aminodia Hydrothiazine, medicinal preparations containing them, and their use in the preparation of medicines
IL177533A (en) Benzimidazole derivatives, their preparation and pharmaceutical compositions comprising them
IL192442A0 (en) Novel cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
IL199187A (en) Indole history, pharmaceuticals including them and their use in the manufacture of medicines
IL197933A (en) Knaase inhibitors, pharmaceuticals containing them and their uses
IL203578A (en) History of pyrimidine-4 - carboxamide, their preparation and their pharmaceutical preparations
IL204521A0 (en) Oxadiazole derivatives, their preparation and pharmaceutical compositions containing them
IL194546A0 (en) Arylaminopyridine derivatives and pharmaceutical compositions containing them
IL193467A0 (en) Substituted indazole derivatives, their manufacture and use as pharmaceutical agents
IL208355A (en) Annotations 7,3-Dihydroporin-6,2-Discussion, Processes for their Preparation, Pharmaceutical Preparations Containing them and their Use in Medication Preparation
IL193762A (en) The effective compounds in inhibiting dgat1-related disorders, their medicinal products and their use in the preparation of drugs
IL182054A0 (en) Novel bis-azaindole derivatives, preparation and pharmaceutical use thereof as kinase inhibitors
IL180286A0 (en) Novel cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
IL206394A (en) Derivatives of 2-Benzylpyridine Filtration as Met Kinase Inhibitors, Process for their Preparation, Medication and Use
IL193772A0 (en) 4-oxoquinoline derivatives,methods for the preparation thereof and pharmaceutical compositions containing the same
PL1861387T3 (pl) Pochodne benzoimidazolu i ich kompozycje farmaceutyczne
IL211018A (en) Inhibitors, processes for making them, medicinal preparations containing them and their use
IL192826A0 (en) Thiazole derivatives, their preparation and pharmaceutical compositions containing them
IL195813A0 (en) Substituted aminopyrazolopyridines and salts thereof, their preparations and pharmaceutical compositions comprising them
ZA201008387B (en) Azacarboline derivatives,preparation thereof,and therapeutic use thereof as kinase inhibitors