PL2104670T6 - Nowe pochodne triazynodionu jako modulatory receptorów GABA-B - Google Patents

Nowe pochodne triazynodionu jako modulatory receptorów GABA-B

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Publication number
PL2104670T6
PL2104670T6 PL07825747T PL07825747T PL2104670T6 PL 2104670 T6 PL2104670 T6 PL 2104670T6 PL 07825747 T PL07825747 T PL 07825747T PL 07825747 T PL07825747 T PL 07825747T PL 2104670 T6 PL2104670 T6 PL 2104670T6
Authority
PL
Poland
Prior art keywords
gaba
novel
receptor modulators
triazinedione
derivatives
Prior art date
Application number
PL07825747T
Other languages
English (en)
Other versions
PL2104670T3 (pl
Inventor
Eric Riguet
Brice Campo
Antoine Gibelin
Karim Mhalla
Original Assignee
Addex Pharmaceuticals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Addex Pharmaceuticals Sa filed Critical Addex Pharmaceuticals Sa
Publication of PL2104670T3 publication Critical patent/PL2104670T3/pl
Publication of PL2104670T6 publication Critical patent/PL2104670T6/pl

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    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
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  • Chemical & Material Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
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  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychology (AREA)
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  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
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PL07825747T 2006-11-10 2007-11-09 Nowe pochodne triazynodionu jako modulatory receptorów GABA-B PL2104670T6 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0622472.9A GB0622472D0 (en) 2006-11-10 2006-11-10 Novel heterocyclic derivatives
EP07825747.4A EP2104670B3 (en) 2006-11-10 2007-11-09 Novel triazinedione derivatives as gaba-b receptor modulators
PCT/IB2007/003660 WO2008056257A2 (en) 2006-11-10 2007-11-09 Novel triazinedione derivatives as gaba-b receptor modulators

Publications (2)

Publication Number Publication Date
PL2104670T3 PL2104670T3 (pl) 2016-08-31
PL2104670T6 true PL2104670T6 (pl) 2017-10-31

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PL07825747T PL2104670T6 (pl) 2006-11-10 2007-11-09 Nowe pochodne triazynodionu jako modulatory receptorów GABA-B

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US (3) US8344138B2 (pl)
EP (2) EP2104670B3 (pl)
JP (1) JP5373617B2 (pl)
KR (2) KR20150041184A (pl)
CN (2) CN101679354B (pl)
AU (1) AU2007319000B8 (pl)
BR (1) BRPI0718691A2 (pl)
CA (1) CA2668853C (pl)
CY (1) CY1117498T1 (pl)
DK (1) DK2104670T6 (pl)
EA (1) EA020132B1 (pl)
ES (1) ES2572610T7 (pl)
GB (1) GB0622472D0 (pl)
HU (1) HUE028274T2 (pl)
IL (1) IL198648A (pl)
NO (1) NO344044B1 (pl)
NZ (1) NZ577238A (pl)
PL (1) PL2104670T6 (pl)
SI (1) SI2104670T1 (pl)
UA (1) UA99907C2 (pl)
WO (1) WO2008056257A2 (pl)
ZA (1) ZA200903235B (pl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
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GB0622472D0 (en) * 2006-11-10 2006-12-20 Addex Pharmaceuticals Sa Novel heterocyclic derivatives
EP2419401A2 (en) * 2009-04-17 2012-02-22 XenoPort, Inc. GAMMA-AMINO-BUTYRIC ACID DERIVATIVES AS GABAb RECEPTOR LIGANDS
WO2012002096A1 (en) * 2010-06-29 2012-01-05 Kumiai Chemical Industry Co., Ltd. 6-acyl-1,2,4-triazine-3,5-dione derivative and herbicides
UA112897C2 (uk) 2012-05-09 2016-11-10 Байєр Фарма Акцієнгезелльшафт Біциклічно заміщені урацили та їх застосування для лікування і/або профілактики захворювань
US9751843B2 (en) 2013-11-08 2017-09-05 Bayer Pharma Aktiengesellschaft Substituted uracils and use thereof
CA2929763A1 (en) 2013-11-08 2015-05-14 Bayer Pharma Aktiengesellschaft Substituted uracils as chymase inhibitors
TW201623257A (zh) 2014-05-09 2016-07-01 奧利安公司 藥理活性之喹唑啉二酮衍生物
CN115583919B (zh) * 2022-04-27 2024-04-19 河北工业大学 一种6-氧烷基1,2,4-三嗪-3,5(2h,4h)-二酮类衍生物的制备方法
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CN119019341B (zh) * 2023-05-23 2025-11-18 苏州大学 一种腈类化合物及其制备方法与应用
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