PL2132221T3 - Przyłączone do matrycy peptydomimetyki - Google Patents

Przyłączone do matrycy peptydomimetyki

Info

Publication number
PL2132221T3
PL2132221T3 PL07701901T PL07701901T PL2132221T3 PL 2132221 T3 PL2132221 T3 PL 2132221T3 PL 07701901 T PL07701901 T PL 07701901T PL 07701901 T PL07701901 T PL 07701901T PL 2132221 T3 PL2132221 T3 PL 2132221T3
Authority
PL
Poland
Prior art keywords
tyr
template
dpro
cys
ala
Prior art date
Application number
PL07701901T
Other languages
English (en)
Inventor
Steven J Demarco
Reshmi Mukherjee
Kerstin Moehle
John Anthony Robinson
Heiko Henze
Barbara Romagnoli
Daniel Obrecht
Frank Gombert
Christian Ludin
Jan Wim Vrijbloed
Original Assignee
Polyphor Ltd
Univ Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polyphor Ltd, Univ Zuerich filed Critical Polyphor Ltd
Publication of PL2132221T3 publication Critical patent/PL2132221T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Non-Reversible Transmitting Devices (AREA)
PL07701901T 2007-02-28 2007-02-28 Przyłączone do matrycy peptydomimetyki PL2132221T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07701901A EP2132221B1 (en) 2007-02-28 2007-02-28 Template-fixed peptidomimetics
PCT/CH2007/000101 WO2008104090A1 (en) 2007-02-28 2007-02-28 Template-fixed peptidomimetics

Publications (1)

Publication Number Publication Date
PL2132221T3 true PL2132221T3 (pl) 2011-04-29

Family

ID=37891752

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07701901T PL2132221T3 (pl) 2007-02-28 2007-02-28 Przyłączone do matrycy peptydomimetyki

Country Status (20)

Country Link
US (7) US8399611B2 (pl)
EP (1) EP2132221B1 (pl)
JP (1) JP5140686B2 (pl)
KR (1) KR101479148B1 (pl)
CN (1) CN101641372B (pl)
AT (1) ATE475667T1 (pl)
AU (1) AU2007348171B2 (pl)
BR (1) BRPI0721259C1 (pl)
CA (1) CA2679414C (pl)
DE (1) DE602007008150D1 (pl)
DK (1) DK2132221T3 (pl)
EA (1) EA017583B1 (pl)
ES (1) ES2349879T3 (pl)
IL (1) IL200312A (pl)
MX (1) MX2009008843A (pl)
NO (1) NO342598B1 (pl)
NZ (1) NZ579875A (pl)
PL (1) PL2132221T3 (pl)
PT (1) PT2132221E (pl)
WO (1) WO2008104090A1 (pl)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007079597A1 (en) 2006-01-16 2007-07-19 Polyphor Ltd. Template - fixed peptidomimetics with antimicrobial activity
WO2008092281A1 (en) 2007-01-29 2008-08-07 Polyphor Ltd. Template-fixed peptidomimetics
PL2132221T3 (pl) * 2007-02-28 2011-04-29 Polyphor Ltd Przyłączone do matrycy peptydomimetyki
WO2010127704A1 (en) * 2009-05-07 2010-11-11 Polyphor Ag Beta-hairpin peptidomimetics having cxcr4 antagonizing activity
WO2011066869A1 (en) * 2009-12-04 2011-06-09 Polyphor Ag Beta-hairpin peptidomimetics
RU2638802C2 (ru) 2011-05-16 2017-12-15 Джензим Корпорейшн Применение антагонистов cxcr4
AU2012266355B2 (en) * 2011-06-07 2016-06-09 Polyphor Ag Beta - hairpin peptidomimetics as CXC4 antagonists
JP6294227B2 (ja) * 2011-10-07 2018-03-14 ポリフォー・アクチェンゲゼルシャフトＰｏｌｙｐｈｏｒ Ａｇ Ｆｐｒ１の阻害剤としてのテンプレート固定ペプチド模倣薬
JP6047231B2 (ja) * 2012-06-06 2016-12-21 ポリフォー・アクチェンゲゼルシャフトＰｏｌｙｐｈｏｒ Ａｇ β−ヘアピンペプチド模倣薬
EP2882770B1 (en) * 2012-08-08 2017-05-31 Polyphor AG Combinations with a backbone-cyclized peptide
WO2019156137A1 (ja) 2018-02-08 2019-08-15 株式会社ステムリム 乾癬の治療薬
JP7405345B2 (ja) * 2018-10-05 2023-12-26 株式会社ステムリム 間葉系幹細胞の動員活性を有するペプチド
US12304933B2 (en) 2018-10-05 2025-05-20 StemRIM Inc. Disease treatment drug based on mesenchymal-stem-cell mobilization
JP2023549921A (ja) 2020-11-19 2023-11-29 スペクシス アーゲー がんを治療するためのペプチドｃｘｃｒ４阻害剤およびタキサンを含む医薬組み合わせ
WO2022184320A2 (en) 2021-03-03 2022-09-09 Spexis Ag Medical use of cyclic peptides
WO2023285677A1 (en) 2021-07-16 2023-01-19 Spexis Ag Pharmaceutical combinations for treating cancer
WO2023285681A1 (en) 2021-07-16 2023-01-19 Spexis Ag Pharmaceutical combinations for treating cancer
WO2025068348A1 (en) 2023-09-27 2025-04-03 Spexis Ag Pharmaceutical combination of cxcr4 and pd-1 inhibitors for treating cancer
WO2025068346A1 (en) 2023-09-27 2025-04-03 Spexis Ag Pharmaceutical combination of cxcr4, pd-1 and fak inhibitors for treating cancer

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9917475B1 (pt) * 1999-08-30 2013-07-23 processo para a manufatura de compostos, e, modificação do processo.
ES2527339T3 (es) 2001-02-23 2015-01-23 Polyphor Ltd. Peptidomiméticos fijados a patrón con actividad antimicrobiana
CN101157924A (zh) 2001-12-11 2008-04-09 人体基因组科学有限公司 嗜中性白细胞因子α
AU2003202914A1 (en) * 2002-01-07 2003-07-24 Sequoia Pharmaceuticals Broad spectrum inhibitors
JP4221368B2 (ja) 2002-08-20 2009-02-12 ポリファー リミテッド 抗菌活性を有するテンプレート結合ペプチド擬似体
US7855179B2 (en) 2002-10-02 2010-12-21 Polyphor Ltd. Template-fixed peptidomimetics with antimicrobial activity
WO2004096839A1 (en) 2003-05-02 2004-11-11 Polyphor Ag Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity
ATE395355T1 (de) 2003-05-02 2008-05-15 Polyphor Ag Matrizenfixierte peptidmimetika als medikamente gegen hiv und krebs
US7681235B2 (en) 2003-05-19 2010-03-16 Radware Ltd. Dynamic network protection
CN100595277C (zh) 2003-11-15 2010-03-24 波利弗尔有限公司 模板固定的β发夹环模拟物及其在噬菌体展示中的用途
EP1856140B1 (en) 2005-02-17 2013-12-25 Polyphor Ltd. Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity
WO2006117011A1 (en) 2005-05-02 2006-11-09 Polyphor Ltd. Dye conjugates of template-fixed peptidomimetics
WO2007079597A1 (en) 2006-01-16 2007-07-19 Polyphor Ltd. Template - fixed peptidomimetics with antimicrobial activity
WO2008092281A1 (en) 2007-01-29 2008-08-07 Polyphor Ltd. Template-fixed peptidomimetics
PL2132221T3 (pl) 2007-02-28 2011-04-29 Polyphor Ltd Przyłączone do matrycy peptydomimetyki
AU2008360223B2 (en) 2008-08-08 2014-06-19 Polyphor Ag Template-fixed peptidomimetics
WO2010060479A1 (en) 2008-11-26 2010-06-03 Polyphor Ag Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity
WO2010127704A1 (en) 2009-05-07 2010-11-11 Polyphor Ag Beta-hairpin peptidomimetics having cxcr4 antagonizing activity
JP5727479B2 (ja) 2009-08-05 2015-06-03 ポリフォー・アクチェンゲゼルシャフトＰｏｌｙｐｈｏｒ Ａｇ コンホメーションを固定された、合成マクロ環化合物
WO2011060832A1 (en) 2009-11-20 2011-05-26 Polyphor Ag Template-fixed peptidomimetics with ccr10 antagonistic activity
WO2011066869A1 (en) 2009-12-04 2011-06-09 Polyphor Ag Beta-hairpin peptidomimetics
WO2011095218A1 (en) 2010-02-05 2011-08-11 Polyphor Ag Template-fixed pep tidomime tics with cxcr7 modulating activity
US8629112B2 (en) 2010-02-05 2014-01-14 Frank Otto Gombert Template-fixed peptidomimetics with CXCR7 modulating activity
US8895499B2 (en) 2010-08-05 2014-11-25 Polyphor Ag β-hairpin peptidomimetics
AU2012266355B2 (en) 2011-06-07 2016-06-09 Polyphor Ag Beta - hairpin peptidomimetics as CXC4 antagonists
JP6294227B2 (ja) 2011-10-07 2018-03-14 ポリフォー・アクチェンゲゼルシャフトＰｏｌｙｐｈｏｒ Ａｇ Ｆｐｒ１の阻害剤としてのテンプレート固定ペプチド模倣薬
EP2836485B1 (en) 2012-03-17 2018-01-10 Polyphor Ag Conformationally constrained, fully synthetic macrocyclic compounds
JP6047231B2 (ja) 2012-06-06 2016-12-21 ポリフォー・アクチェンゲゼルシャフトＰｏｌｙｐｈｏｒ Ａｇ β−ヘアピンペプチド模倣薬
EP2882770B1 (en) 2012-08-08 2017-05-31 Polyphor AG Combinations with a backbone-cyclized peptide
HUE036289T2 (hu) 2012-08-08 2018-06-28 Polyphor Ag Gerinc-ciklizált peptidet tartalmazó kombinációk
NZ712736A (en) 2013-03-30 2021-07-30 Polyphor Ag Beta-hairpin peptidomimetics
BR112015024939A2 (pt) 2013-03-30 2017-07-18 Polyphor Ag composto, diastereoisômero ou epímero de um composto, composição farmacêutica, uso de um composto, processo para a preparação de um composto, e, método para tratamento de uma infecção
US10273267B2 (en) 2013-12-27 2019-04-30 Polyphor Ag Beta-hairpin peptidomimetics as selective elastase inhibitors
EP3087087B1 (en) 2013-12-27 2021-07-21 Polyphor Ag Beta-hairpin peptidomimetics as selective elastase inhibitors

Also Published As

Publication number Publication date
AU2007348171A1 (en) 2008-09-04
DE602007008150D1 (de) 2010-09-09
EA017583B1 (ru) 2013-01-30
US8921325B2 (en) 2014-12-30
CN101641372B (zh) 2012-11-28
US20170096453A1 (en) 2017-04-06
US20100048463A1 (en) 2010-02-25
NO20093064L (no) 2009-09-28
US20190100558A1 (en) 2019-04-04
ATE475667T1 (de) 2010-08-15
BRPI0721259B8 (pt) 2020-09-15
US20200399317A1 (en) 2020-12-24
NZ579875A (en) 2012-02-24
JP5140686B2 (ja) 2013-02-06
EP2132221A1 (en) 2009-12-16
EP2132221B1 (en) 2010-07-28
AU2007348171B2 (en) 2012-09-06
ES2349879T3 (es) 2011-01-12
KR20100014596A (ko) 2010-02-10
DK2132221T3 (da) 2010-11-22
BRPI0721259C1 (pt) 2021-05-25
US10144765B2 (en) 2018-12-04
US20130150299A1 (en) 2013-06-13
US9556234B2 (en) 2017-01-31
CA2679414C (en) 2014-10-28
HK1138011A1 (en) 2010-08-13
IL200312A (en) 2014-11-30
US8399611B2 (en) 2013-03-19
CA2679414A1 (en) 2008-09-04
CN101641372A (zh) 2010-02-03
PT2132221E (pt) 2010-10-26
NO342598B1 (no) 2018-06-18
US10787486B2 (en) 2020-09-29
US11421001B2 (en) 2022-08-23
US20150080317A1 (en) 2015-03-19
WO2008104090A1 (en) 2008-09-04
BRPI0721259B1 (pt) 2020-04-07
EA200901178A1 (ru) 2010-04-30
MX2009008843A (es) 2009-08-28
IL200312A0 (en) 2010-04-29
US20180127467A1 (en) 2018-05-10
BRPI0721259A2 (pt) 2013-01-15
US9879047B2 (en) 2018-01-30
JP2010519331A (ja) 2010-06-03
KR101479148B1 (ko) 2015-01-05

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