PL2135881T3 - Przeciwciała wiążące się z antygenem TAT10772 związanym z nowotworem, do diagnozowania i leczenia nowotworu - Google Patents
Przeciwciała wiążące się z antygenem TAT10772 związanym z nowotworem, do diagnozowania i leczenia nowotworuInfo
- Publication number
- PL2135881T3 PL2135881T3 PL09010789T PL09010789T PL2135881T3 PL 2135881 T3 PL2135881 T3 PL 2135881T3 PL 09010789 T PL09010789 T PL 09010789T PL 09010789 T PL09010789 T PL 09010789T PL 2135881 T3 PL2135881 T3 PL 2135881T3
- Authority
- PL
- Poland
- Prior art keywords
- tumor
- diagnosis
- treatment
- tat10772
- associated antigen
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3015—Breast
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69209205P | 2005-06-20 | 2005-06-20 | |
| US79395106P | 2006-04-21 | 2006-04-21 | |
| EP06773116A EP1910419A2 (en) | 2005-06-20 | 2006-06-14 | Compositions and methods for the diagnosis and treatment of tumor |
| EP09010789A EP2135881B1 (en) | 2005-06-20 | 2006-06-14 | Antibodies binding to the tumour associated antigen TAT10772 for the diagnosis and treatment of tumor |
Publications (1)
| Publication Number | Publication Date |
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| PL2135881T3 true PL2135881T3 (pl) | 2012-02-29 |
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Family Applications (1)
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| PL09010789T PL2135881T3 (pl) | 2005-06-20 | 2006-06-14 | Przeciwciała wiążące się z antygenem TAT10772 związanym z nowotworem, do diagnozowania i leczenia nowotworu |
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| EP (2) | EP2135881B1 (pl) |
| JP (2) | JP5196654B2 (pl) |
| KR (3) | KR101103108B1 (pl) |
| CN (1) | CN101948541B (pl) |
| AT (1) | ATE523525T1 (pl) |
| AU (2) | AU2006262603B2 (pl) |
| BR (2) | BRPI0613382A8 (pl) |
| CA (1) | CA2611778C (pl) |
| CR (2) | CR9672A (pl) |
| DK (1) | DK2135881T3 (pl) |
| EC (1) | ECSP088122A (pl) |
| ES (1) | ES2373080T3 (pl) |
| IL (1) | IL187343A (pl) |
| MA (1) | MA29615B1 (pl) |
| MX (1) | MX2007016322A (pl) |
| NO (1) | NO20080361L (pl) |
| NZ (2) | NZ583206A (pl) |
| PL (1) | PL2135881T3 (pl) |
| PT (1) | PT2135881E (pl) |
| RU (2) | RU2430112C2 (pl) |
| SG (1) | SG155947A1 (pl) |
| WO (1) | WO2007001851A2 (pl) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| ES2605443T3 (es) | 2003-11-06 | 2017-03-14 | Seattle Genetics, Inc. | Conjugados de auristatina con anticuerpos anti-HER2 o anti-CD22 y su uso en terapia |
| JP2008519863A (ja) | 2004-11-12 | 2008-06-12 | シアトル ジェネティクス インコーポレイティッド | N末端にアミノ安息香酸単位を有するオーリスタチン |
| USRE47223E1 (en) | 2005-06-20 | 2019-02-05 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| WO2007008848A2 (en) | 2005-07-07 | 2007-01-18 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus |
| ES2708763T3 (es) | 2005-07-07 | 2019-04-11 | Seattle Genetics Inc | Compuestos de monometilvalina que tienen modificaciones de la cadena lateral de fenilalanina en el extremo C |
| US7750116B1 (en) | 2006-02-18 | 2010-07-06 | Seattle Genetics, Inc. | Antibody drug conjugate metabolites |
| EP2522730A1 (en) * | 2007-03-02 | 2012-11-14 | Boehringer Ingelheim Pharma GmbH & Co. KG | Improvement of protein production |
| PE20090245A1 (es) | 2007-05-08 | 2009-03-17 | Genentech Inc | Anticuerpos anti-muc16 disenados con cisteina y conjugados de anticuerpos y farmacos |
| PT2474557E (pt) * | 2007-07-16 | 2014-12-03 | Genentech Inc | Anticorpos e imunoconjugados anti-cd79b e métodos de utilização |
| PE20140625A1 (es) | 2007-07-16 | 2014-05-29 | Genentech Inc | ANTICUERPOS ANTI-CD79b E INMUNOCONJUGADOS HUMANIZADOS |
| DK2657253T3 (en) | 2008-01-31 | 2017-10-09 | Genentech Inc | Anti-CD79b antibodies and immune conjugates and methods of use |
| AU2013203004C1 (en) * | 2008-06-25 | 2022-01-20 | Novartis Ag | Humanization of rabbit antibodies using a universal antibody framework |
| AU2020201002B2 (en) * | 2008-06-25 | 2022-04-07 | Novartis Ag | Humanization of rabbit antibodies using a universal antibody framework |
| PL2307458T3 (pl) * | 2008-06-25 | 2018-08-31 | Esbatech, An Alcon Biomedical Research Unit Llc | Humanizacja przeciwciał króliczych z zastosowaniem uniwersalnego zrębu przeciwciała |
| RU2653753C1 (ru) | 2008-06-25 | 2018-05-14 | ИЭсБиЭйТЕК, ЭН АЛЬКОН БАЙОМЕДИКАЛ РИСЕРЧ ЮНИТ ЭлЭлСи | СТАБИЛЬНЫЕ И РАСТВОРИМЫЕ АНТИТЕЛА, ИНГИБИРУЮЩИЕ TNFα |
| PT2307458T (pt) * | 2008-06-25 | 2018-07-18 | Esbatech Alcon Biomed Res Unit | Humanização de anticorpos de coelho utilizando uma estrutura de anticorpos universal |
| EP2684570A1 (en) | 2008-09-10 | 2014-01-15 | F. Hoffmann-La Roche AG | Compositions and methods for the prevention of oxidative degradation of proteins |
| ES2549769T3 (es) | 2009-03-25 | 2015-11-02 | Genentech, Inc. | Anticuerpos anti-FGFR3 y métodos que emplean los mismos |
| PE20120877A1 (es) * | 2009-04-01 | 2012-08-06 | Genentech Inc | ANTICUERPOS ANTI-FcRH5 E INMUNOCONJUGADOS |
| WO2010128032A1 (en) | 2009-05-05 | 2010-11-11 | Boehringer Ingelheim International Gmbh | Cho / cert cell lines |
| EP2491059B1 (en) | 2009-10-22 | 2015-02-25 | F.Hoffmann-La Roche Ag | Anti-hepsin antibodies and methods using same |
| CA3061784C (en) | 2009-11-13 | 2023-09-26 | Dana-Farber Cancer Institute, Inc. | Compositions, kits, and methods for the diagnosis, prognosis, monitoring, treatment and modulation of post-transplant lymphoproliferative disorders and hypoxia associated angiogenesis disorders using galectin-1 |
| TWI507524B (zh) * | 2009-11-30 | 2015-11-11 | 建南德克公司 | 診斷及治療腫瘤之組合物及方法 |
| KR101878369B1 (ko) | 2010-03-22 | 2018-07-16 | 제넨테크, 인크. | 단백질-함유 제제의 안정화에 유용한 조성물 및 방법 |
| CA2793753C (en) * | 2010-03-26 | 2018-06-05 | Memorial Sloan-Kettering Cancer Center | Antibodies to muc16 and methods of use thereof |
| BR112012027828A2 (pt) | 2010-05-03 | 2016-08-09 | Genentech Inc | composição de matéria, artigo de fabricação e método de redução da viscosidade de uma formulação contendo proteína e de preparação de uma formulação aquosa contendo proteína |
| KR101924653B1 (ko) | 2010-06-24 | 2018-12-03 | 제넨테크, 인크. | 단백질-함유 제제를 안정화시키기 위한 알킬글리코시드 함유 조성물 및 방법 |
| UY33679A (es) | 2010-10-22 | 2012-03-30 | Esbatech | Anticuerpos estables y solubles |
| CN102585010A (zh) * | 2011-01-16 | 2012-07-18 | 董贵俊 | 一种检测重组人碱性成纤维细胞生长因子(rhbFGF)的免疫胶乳微球及其制备方法 |
| US10260089B2 (en) | 2012-10-29 | 2019-04-16 | The Research Foundation Of The State University Of New York | Compositions and methods for recognition of RNA using triple helical peptide nucleic acids |
| US9353150B2 (en) | 2012-12-04 | 2016-05-31 | Massachusetts Institute Of Technology | Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment |
| EP3964237B1 (en) * | 2013-03-15 | 2026-02-18 | Regeneron Pharmaceuticals, Inc. | Biologically active molecules, conjugates thereof, and therapeutic uses |
| KR101502680B1 (ko) * | 2013-04-01 | 2015-03-17 | 중앙대학교 산학협력단 | 난소과립종양세포 진단용 펩타이드 및 이의 용도 |
| TWI725931B (zh) | 2013-06-24 | 2021-05-01 | 美商建南德克公司 | 抗fcrh5抗體 |
| BR112016002829A2 (pt) | 2013-08-12 | 2017-09-19 | Genentech Inc | Composto e processo para preparar o composto de conjugado anticorpo-¿droga, composição farmacêutica, método de tratamento do câncer, kit para o tratamento do câncer, intermediário ligante¿-droga, porção e composto de porção droga de dímero cbi |
| BR112016012410A2 (pt) | 2013-12-16 | 2017-09-26 | Genentech Inc | conjugado de droga e anticorpo, composto conjugado de droga e anticorpo, composto não-peptídico, método de tratamento de doenças em seres humanos e composição farmacêutica |
| JP6980384B2 (ja) | 2013-12-16 | 2021-12-15 | ジェネンテック, インコーポレイテッド | 1−(クロロメチル)−2,3−ジヒドロ−1h−ベンゾ[e]インドール二量体抗体−薬物コンジュゲート化合物、並びに使用及び処置の方法 |
| UA118113C2 (uk) | 2013-12-16 | 2018-11-26 | Дженентек, Інк. | Пептидоміметичні сполуки та їх кон'югати антитіла з лікарським засобом |
| HUE050159T2 (hu) | 2013-12-17 | 2020-11-30 | Genentech Inc | Anti-CD3 antitestek és alkalmazási eljárások |
| CA2979671C (en) | 2014-09-23 | 2020-03-10 | Genentech, Inc. | Methods of using anti-cd79b immunoconjugates |
| CA2961439A1 (en) | 2014-11-05 | 2016-05-12 | Genentech, Inc. | Anti-fgfr2/3 antibodies and methods using same |
| CN105675735B (zh) * | 2014-11-19 | 2018-07-17 | 上海市第六人民医院 | 乳腺癌诊断标记物组合、应用及其测定方法 |
| CA2969689A1 (en) | 2014-12-03 | 2016-06-09 | Genentech, Inc. | Quaternary amine compounds and antibody-drug conjugates thereof |
| CA2978340C (en) | 2015-03-27 | 2024-05-28 | Regeneron Pharmaceuticals, Inc. | Maytansinoid derivatives, conjugates thereof, and methods of use |
| US10017577B2 (en) | 2015-06-15 | 2018-07-10 | Genentech, Inc. | Antibodies and immunoconjugates |
| US10323094B2 (en) | 2015-06-16 | 2019-06-18 | Genentech, Inc. | Humanized and affinity matured antibodies to FcRH5 and methods of use |
| MA43354A (fr) | 2015-10-16 | 2018-08-22 | Genentech Inc | Conjugués médicamenteux à pont disulfure encombré |
| MX390630B (es) | 2016-01-25 | 2025-03-21 | Regeneron Pharma | Derivados de maitansinoide, conjugados de los mismos y metodos de uso. |
| US10918627B2 (en) | 2016-05-11 | 2021-02-16 | Massachusetts Institute Of Technology | Convergent and enantioselective total synthesis of Communesin analogs |
| CN109152843A (zh) | 2016-05-20 | 2019-01-04 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
| JP2019524706A (ja) | 2016-07-08 | 2019-09-05 | ジェネンテック, インコーポレイテッド | Muc16陽性癌治療の応答性を評価するためのヒト精巣上体タンパク質4(he4)の使用 |
| KR20190129859A (ko) * | 2017-02-10 | 2019-11-20 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 항-d 인자 항체 및 그의 용도 |
| US11932650B2 (en) | 2017-05-11 | 2024-03-19 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
| CA3067835A1 (en) * | 2017-06-22 | 2018-12-27 | Apexigen, Inc. | Anti-vista antibodies and methods of use |
| US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
| WO2019084030A1 (en) | 2017-10-24 | 2019-05-02 | Genentech, Inc. | (4-HYDROXYPYRROLIDIN-2-YL) -HYDROXAMATE COMPOUNDS AND METHODS OF USE |
| WO2019084026A1 (en) | 2017-10-24 | 2019-05-02 | Genentech, Inc. | (4-HYDROXYPYRROLIDIN-2-YL) -HETEROCYCLIC COMPOUNDS AND METHODS OF USE |
| CN108181214B (zh) * | 2018-02-09 | 2020-06-30 | 北京爱泰浦生物医药科技有限责任公司 | 使用atap肽治疗疾病的方法和组合物 |
| WO2019183523A1 (en) | 2018-03-23 | 2019-09-26 | Genentech, Inc. | Hetero-bifunctional degrader compounds and their use as modulators of targeted ubiquination (vhl) |
| CN112533957B (zh) | 2018-06-04 | 2026-01-16 | 普瑞赛格恩公司 | Muc16特异性嵌合抗原受体及其用途 |
| SG11202101811VA (en) | 2018-08-30 | 2021-03-30 | Tcr2 Therapeutics Inc | Compositions and methods for tcr reprogramming using fusion proteins |
| TW202547837A (zh) | 2018-09-11 | 2025-12-16 | 瑞士商赫孚孟拉羅股份公司 | 噻吩并-三唑并-二氮呯醋酸酯 |
| WO2020205716A1 (en) | 2019-04-01 | 2020-10-08 | Genentech, Inc. | Compositions and methods for stabilizing protein-containing formulations |
| CN109988086B (zh) * | 2019-04-04 | 2021-06-18 | 三峡大学 | 一种小分子抑制剂azin30及其在制药中的应用 |
| WO2020247054A1 (en) | 2019-06-05 | 2020-12-10 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
| WO2022182415A1 (en) | 2021-02-24 | 2022-09-01 | Massachusetts Institute Of Technology | Himastatin derivatives, and processes of preparation thereof, and uses thereof |
| US12060148B2 (en) | 2022-08-16 | 2024-08-13 | Honeywell International Inc. | Ground resonance detection and warning system and method |
| KR20250134582A (ko) | 2022-11-10 | 2025-09-11 | 이뮤비아 인코포레이티드 | Dr5 및 muc16에 결합하는 세포독성 이중특이성 항체 및 이의 용도 |
| WO2025036848A1 (en) | 2023-08-11 | 2025-02-20 | Wuxi Biologics (Shanghai) Co., Ltd. | Anti-muc16 antibodies and uses thereof |
| AR134368A1 (es) | 2023-11-17 | 2026-01-07 | Wuxi Biologics Ireland Ltd | Anticuerpos anti-muc16 y usos de los mismos |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9424449D0 (en) | 1994-12-02 | 1995-01-18 | Wellcome Found | Antibodies |
| US6037454A (en) * | 1996-11-27 | 2000-03-14 | Genentech, Inc. | Humanized anti-CD11a antibodies |
| KR20000070989A (ko) * | 1997-02-12 | 2000-11-25 | 나가야마 오사무 | 임파구계 종양의 치료제 |
| DE69829891T2 (de) * | 1997-04-07 | 2005-10-06 | Genentech, Inc., South San Francisco | Anti-VEGF Antikörper |
| US7083950B2 (en) * | 1998-09-25 | 2006-08-01 | Regeneron Pharmaceuticals, Inc. | High affinity fusion proteins and therapeutic and diagnostic methods for use |
| US20020119158A1 (en) | 1998-12-17 | 2002-08-29 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of ovarian cancer |
| US20030078399A1 (en) * | 2001-05-11 | 2003-04-24 | Sloan-Kettering Institute For Cancer Research | Nucleic acid sequence encoding ovarian antigen, CA125, and uses thereof |
| US7803915B2 (en) * | 2001-06-20 | 2010-09-28 | Genentech, Inc. | Antibody compositions for the diagnosis and treatment of tumor |
| JP2006502110A (ja) | 2002-07-03 | 2006-01-19 | イミュノジェン・インコーポレーテッド | 非放出Muc1およびMuc16に対する抗体、およびその使用 |
| DK1551876T3 (da) * | 2002-10-16 | 2011-06-14 | Purdue Pharma Lp | Antistoffer, der binder til celle-associerede ca 125/0722P og fremgangsmåder til anvendelse deraf |
| AU2003294355A1 (en) * | 2002-11-15 | 2004-06-15 | The Board Of Trustees Of The University Of Arkansas | Ca125 gene and its use for diagnostic and therapeutic interventions |
| US7563869B2 (en) | 2003-01-23 | 2009-07-21 | Ono Pharmaceutical Co., Ltd. | Substance specific to human PD-1 |
| ES2605443T3 (es) | 2003-11-06 | 2017-03-14 | Seattle Genetics, Inc. | Conjugados de auristatina con anticuerpos anti-HER2 o anti-CD22 y su uso en terapia |
| EP2168986A3 (en) * | 2004-02-19 | 2010-07-28 | Genentech, Inc. | CDR-repaired antibodies |
| JP4987698B2 (ja) | 2005-03-31 | 2012-07-25 | 中外製薬株式会社 | 癌関連抗原アナログペプチド、およびその利用 |
| AR059900A1 (es) | 2006-03-17 | 2008-05-07 | Genentech Inc | Anticuerpos anti-tat226 e inmunoconjugados |
-
2006
- 2006-06-14 US US11/452,990 patent/US7989595B2/en not_active Ceased
- 2006-06-14 NZ NZ583206A patent/NZ583206A/en not_active IP Right Cessation
- 2006-06-14 CN CN200910178901.9A patent/CN101948541B/zh not_active Expired - Lifetime
- 2006-06-14 EP EP09010789A patent/EP2135881B1/en not_active Expired - Lifetime
- 2006-06-14 KR KR1020097018856A patent/KR101103108B1/ko not_active Expired - Fee Related
- 2006-06-14 AU AU2006262603A patent/AU2006262603B2/en not_active Ceased
- 2006-06-14 AT AT09010789T patent/ATE523525T1/de active
- 2006-06-14 SG SG200906277-9A patent/SG155947A1/en unknown
- 2006-06-14 MX MX2007016322A patent/MX2007016322A/es active IP Right Grant
- 2006-06-14 BR BRPI0613382A patent/BRPI0613382A8/pt not_active Application Discontinuation
- 2006-06-14 ES ES09010789T patent/ES2373080T3/es not_active Expired - Lifetime
- 2006-06-14 CA CA2611778A patent/CA2611778C/en not_active Expired - Fee Related
- 2006-06-14 PL PL09010789T patent/PL2135881T3/pl unknown
- 2006-06-14 KR KR1020107016034A patent/KR20100084706A/ko not_active Ceased
- 2006-06-14 JP JP2008518225A patent/JP5196654B2/ja not_active Expired - Lifetime
- 2006-06-14 BR BRPI0622254-4A patent/BRPI0622254A2/pt not_active Application Discontinuation
- 2006-06-14 PT PT09010789T patent/PT2135881E/pt unknown
- 2006-06-14 RU RU2008101365/10A patent/RU2430112C2/ru not_active IP Right Cessation
- 2006-06-14 WO PCT/US2006/023099 patent/WO2007001851A2/en not_active Ceased
- 2006-06-14 DK DK09010789.7T patent/DK2135881T3/da active
- 2006-06-14 EP EP06773116A patent/EP1910419A2/en not_active Withdrawn
- 2006-06-14 NZ NZ563370A patent/NZ563370A/en not_active IP Right Cessation
- 2006-06-14 KR KR1020087001453A patent/KR100970824B1/ko not_active Expired - Fee Related
- 2006-06-14 RU RU2009136946/10A patent/RU2423382C1/ru not_active IP Right Cessation
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2007
- 2007-11-13 IL IL187343A patent/IL187343A/en not_active IP Right Cessation
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2008
- 2008-01-07 MA MA30552A patent/MA29615B1/fr unknown
- 2008-01-18 CR CR9672A patent/CR9672A/es unknown
- 2008-01-18 NO NO20080361A patent/NO20080361L/no not_active Application Discontinuation
- 2008-01-18 EC EC2008008122A patent/ECSP088122A/es unknown
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2010
- 2010-12-14 AU AU2010251794A patent/AU2010251794A1/en not_active Abandoned
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2011
- 2011-03-11 US US13/045,722 patent/US8449883B2/en active Active
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2012
- 2012-01-25 US US13/357,913 patent/US20120114673A1/en not_active Abandoned
- 2012-06-07 JP JP2012130286A patent/JP2012188449A/ja not_active Withdrawn
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2013
- 2013-07-18 US US13/945,052 patent/US20140050744A1/en not_active Abandoned
- 2013-09-10 CR CR20130455A patent/CR20130455A/es unknown
- 2013-12-17 US US14/108,820 patent/US20140314794A1/en not_active Abandoned
- 2013-12-17 US US14/109,213 patent/US20140205616A1/en not_active Abandoned
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2015
- 2015-11-19 US US14/945,980 patent/US20160296634A1/en not_active Abandoned
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