PL2148691T3 - Analogi kompstatyny do stosowania w leczeniu stanów zapalnych układu oddechowego - Google Patents
Analogi kompstatyny do stosowania w leczeniu stanów zapalnych układu oddechowegoInfo
- Publication number
- PL2148691T3 PL2148691T3 PL08725157T PL08725157T PL2148691T3 PL 2148691 T3 PL2148691 T3 PL 2148691T3 PL 08725157 T PL08725157 T PL 08725157T PL 08725157 T PL08725157 T PL 08725157T PL 2148691 T3 PL2148691 T3 PL 2148691T3
- Authority
- PL
- Poland
- Prior art keywords
- treatment
- respiratory system
- inflammatory conditions
- compstatin analogues
- compstatin
- Prior art date
Links
- RDTRHBCZFDCUPW-KWICJJCGSA-N 2-[(4r,7s,10s,13s,19s,22s,25s,28s,31s,34r)-4-[[(2s,3r)-1-amino-3-hydroxy-1-oxobutan-2-yl]carbamoyl]-34-[[(2s,3s)-2-amino-3-methylpentanoyl]amino]-25-(3-amino-3-oxopropyl)-7-[3-(diaminomethylideneamino)propyl]-10,13-bis(1h-imidazol-5-ylmethyl)-19-(1h-indol Chemical class C([C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CSSC[C@@H](C(N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)NCC(=O)N[C@@H](CC=2NC=NC=2)C(=O)N1)C(C)C)C(C)C)=O)NC(=O)[C@@H](N)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)C1=CN=CN1 RDTRHBCZFDCUPW-KWICJJCGSA-N 0.000 title 1
- 230000004968 inflammatory condition Effects 0.000 title 1
- 210000002345 respiratory system Anatomy 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89947407P | 2007-02-05 | 2007-02-05 | |
| EP20080725157 EP2148691B1 (en) | 2007-02-05 | 2008-02-05 | Compstatin analogues for use in the treatment of inflammatory conditions of the respiratory system |
| PCT/US2008/001483 WO2008097525A2 (en) | 2007-02-05 | 2008-02-05 | Local complement inhibition for treatment of complement-mediated disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2148691T3 true PL2148691T3 (pl) | 2015-12-31 |
Family
ID=39682303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL08725157T PL2148691T3 (pl) | 2007-02-05 | 2008-02-05 | Analogi kompstatyny do stosowania w leczeniu stanów zapalnych układu oddechowego |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US8580735B2 (pl) |
| EP (2) | EP2148691B1 (pl) |
| AU (1) | AU2008214359B2 (pl) |
| DK (1) | DK2148691T3 (pl) |
| ES (1) | ES2545775T3 (pl) |
| HU (1) | HUE026001T2 (pl) |
| PL (1) | PL2148691T3 (pl) |
| WO (1) | WO2008097525A2 (pl) |
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| JP2010505946A (ja) | 2006-10-10 | 2010-02-25 | アカデミシュ ジーケンハウス ビイ デ ユニヴェアズィテート ファン アムステルダム | 神経再生改善のための補体阻害 |
| CA2680833A1 (en) * | 2007-04-30 | 2008-11-13 | Alcon Research, Ltd. | Treatment of age-related macular degeneration using inhibitors of complement factor d |
| US20110142837A1 (en) * | 2007-07-20 | 2011-06-16 | Trustees Of The University Of Pennsylvania | Method Of Treating Acute Respiratory Distress Syndrome |
| US20110182877A1 (en) * | 2007-10-02 | 2011-07-28 | Potentia Pharmaceuticals, Inc. | Sustained delivery of compstatin analogs from gels |
| WO2010022149A1 (en) * | 2008-08-20 | 2010-02-25 | The Trustees Of The University Of Pennsylvania | Complement inhibitors for treatment of injury form intracerebral hemorrhage |
| US8445190B2 (en) * | 2008-09-30 | 2013-05-21 | The Trustees Of The University Of Pennsylvania | Method of inhibiting biomaterial-induced procoagulant activity using complement inhibitors |
| WO2010126833A1 (en) * | 2009-04-27 | 2010-11-04 | Jerini Ophthalmic Inc. | Sustained release formulations of peptidomimetic drugs and uses thereof |
| WO2011163394A2 (en) | 2010-06-22 | 2011-12-29 | Apellis Pharmaceuticals, Inc. | Compstatin analogs for treatment of neuropathic pain |
| WO2012095519A1 (en) | 2011-01-13 | 2012-07-19 | Leibniz-Institut Für Naturstoff-Forschung Und Infektionsbiologie | Potent inhibitors of complement activation |
| ES2915265T3 (es) | 2011-05-11 | 2022-06-21 | Apellis Pharmaceuticals Inc | Análogos de compstatina reactivos con células, de acción prolongada o dirigidos y usos de los mismos |
| BR112013033272A2 (pt) * | 2011-06-22 | 2020-11-10 | Apellis Pharmaceuticals, Inc. | composição farmaceutica compreendendo um inibidor do complemento e um agente anti-th17, e usos dos mesmos |
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| US9056874B2 (en) | 2012-05-04 | 2015-06-16 | Novartis Ag | Complement pathway modulators and uses thereof |
| US9579360B2 (en) * | 2012-06-20 | 2017-02-28 | The Trustees Of The University Of Pennsylvania | Methods of treating or preventing periodontitis and diseases associated with periodontitis |
| KR102073312B1 (ko) * | 2012-06-27 | 2020-02-05 | 엘지전자 주식회사 | 당뇨망막병증 진단용 마커 및 이의 용도 |
| JP6538561B2 (ja) | 2012-10-25 | 2019-07-03 | バイオベラティブ・ユーエスエイ・インコーポレイテッド | 抗補体C1s抗体とそれらの用途 |
| CN116063483A (zh) | 2012-11-02 | 2023-05-05 | 美国比奥维拉迪维股份有限公司 | 抗补体C1s抗体和其用途 |
| EP3660033B9 (en) | 2012-11-15 | 2022-06-22 | Apellis Pharmaceuticals, Inc. | Long-acting compstatin analogs and related compositions and methods |
| WO2014143638A1 (en) | 2013-03-14 | 2014-09-18 | Novartis Ag | 2-(1h-indol-4-ylmethyl)-3h-imidazo[4,5-b]pyridine-6-carbonitrile derivatives as complement factor b inhibitors useful for the treatment of ophthalmic diseases |
| US10308687B2 (en) | 2013-03-15 | 2019-06-04 | Apellis Pharmaceuticals, Inc. | Cell-penetrating compstatin analogs and uses thereof |
| EP3089963A1 (en) | 2013-10-30 | 2016-11-09 | Novartis AG | 2-benzyl-benzimidazole complement factor b inhibitors and uses thereof |
| US9408871B2 (en) * | 2013-11-08 | 2016-08-09 | The University Of British Columbia | Methods for inhibiting complement activation and uses thereof |
| AU2015278744B2 (en) * | 2014-06-25 | 2018-09-27 | Alcon Inc. | Compositions and methods for visualization of the vitreous |
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| US11723864B2 (en) | 2015-05-29 | 2023-08-15 | The Texas A&M University System | Antimicrobial and anti-inflammatory compositions |
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-
2008
- 2008-02-05 EP EP20080725157 patent/EP2148691B1/en active Active
- 2008-02-05 EP EP15168039.4A patent/EP2979729A3/en not_active Withdrawn
- 2008-02-05 DK DK08725157.5T patent/DK2148691T3/en active
- 2008-02-05 HU HUE08725157A patent/HUE026001T2/en unknown
- 2008-02-05 AU AU2008214359A patent/AU2008214359B2/en not_active Ceased
- 2008-02-05 WO PCT/US2008/001483 patent/WO2008097525A2/en not_active Ceased
- 2008-02-05 PL PL08725157T patent/PL2148691T3/pl unknown
- 2008-02-05 US US12/525,799 patent/US8580735B2/en active Active
- 2008-02-05 ES ES08725157.5T patent/ES2545775T3/es active Active
-
2013
- 2013-10-11 US US14/052,545 patent/US20140050739A1/en not_active Abandoned
-
2017
- 2017-11-21 US US15/820,207 patent/US20180333488A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008097525A2 (en) | 2008-08-14 |
| WO2008097525A3 (en) | 2011-07-21 |
| AU2008214359B2 (en) | 2014-01-16 |
| EP2148691B1 (en) | 2015-05-20 |
| DK2148691T3 (en) | 2015-08-17 |
| EP2979729A3 (en) | 2016-05-11 |
| US8580735B2 (en) | 2013-11-12 |
| US20140050739A1 (en) | 2014-02-20 |
| US20180333488A1 (en) | 2018-11-22 |
| US20100166862A1 (en) | 2010-07-01 |
| EP2148691A2 (en) | 2010-02-03 |
| HUE026001T2 (en) | 2016-04-28 |
| AU2008214359A1 (en) | 2008-08-14 |
| ES2545775T3 (es) | 2015-09-15 |
| EP2148691A4 (en) | 2012-07-18 |
| EP2979729A2 (en) | 2016-02-03 |
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