IT1179866B - Derivati del triptofano farmaceuticamente attivi e composizioni farmaceutiche che li contengono - Google Patents

Derivati del triptofano farmaceuticamente attivi e composizioni farmaceutiche che li contengono

Info

Publication number
IT1179866B
IT1179866B IT68241/84A IT6824184A IT1179866B IT 1179866 B IT1179866 B IT 1179866B IT 68241/84 A IT68241/84 A IT 68241/84A IT 6824184 A IT6824184 A IT 6824184A IT 1179866 B IT1179866 B IT 1179866B
Authority
IT
Italy
Prior art keywords
group
substituted
derivatives
triptophane
pharmaceutical compositions
Prior art date
Application number
IT68241/84A
Other languages
English (en)
Other versions
IT8468241A0 (it
IT8468241A1 (it
Inventor
Francesco Makovec
Rolando Chiste
Luigi Rovati
Original Assignee
Rotta Research Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rotta Research Lab filed Critical Rotta Research Lab
Publication of IT8468241A0 publication Critical patent/IT8468241A0/it
Priority to IT68241/84A priority Critical patent/IT1179866B/it
Priority to IE302985A priority patent/IE58502B1/en
Priority to JP61500191A priority patent/JPS62501292A/ja
Priority to PCT/EP1985/000672 priority patent/WO1986003489A1/en
Priority to DE8686900106T priority patent/DE3587122T2/de
Priority to AT86900106T priority patent/ATE85976T1/de
Priority to EP86900106A priority patent/EP0237522B1/en
Priority to AU52099/86A priority patent/AU589938B2/en
Priority to CA000497174A priority patent/CA1256441A/en
Priority to ES549822A priority patent/ES8706630A1/es
Priority to ZA859526A priority patent/ZA859526B/xx
Priority to PT81674A priority patent/PT81674B/pt
Publication of IT8468241A1 publication Critical patent/IT8468241A1/it
Priority to DK381486A priority patent/DK168564B1/da
Application granted granted Critical
Publication of IT1179866B publication Critical patent/IT1179866B/it
Priority to US07/217,116 priority patent/US4870097A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT68241/84A 1984-12-12 1984-12-12 Derivati del triptofano farmaceuticamente attivi e composizioni farmaceutiche che li contengono IT1179866B (it)

Priority Applications (14)

Application Number Priority Date Filing Date Title
IT68241/84A IT1179866B (it) 1984-12-12 1984-12-12 Derivati del triptofano farmaceuticamente attivi e composizioni farmaceutiche che li contengono
IE302985A IE58502B1 (en) 1984-12-12 1985-12-02 Pharmaceutically active derivatives of tryptophan and pharmaceutical compostitions containing them
EP86900106A EP0237522B1 (en) 1984-12-12 1985-12-05 Pharmaceutically active derivatives of tryptophan and pharmaceutical compositions containing them
PCT/EP1985/000672 WO1986003489A1 (en) 1984-12-12 1985-12-05 Pharmaceutically active derivatives of tryptophan and pharmaceutical compositions containing them
DE8686900106T DE3587122T2 (de) 1984-12-12 1985-12-05 Pharmakologisch aktive derivate von tryptophan und diese enthaltende pharmazeutische zusammensetzungen.
AT86900106T ATE85976T1 (de) 1984-12-12 1985-12-05 Pharmakologisch aktive derivate von tryptophan und diese enthaltende pharmazeutische zusammensetzungen.
JP61500191A JPS62501292A (ja) 1984-12-12 1985-12-05 トリプトファンの医薬的活性誘導体および該誘導体を含有する医薬組成物
AU52099/86A AU589938B2 (en) 1984-12-12 1985-12-05 Tryptophan derivatives
CA000497174A CA1256441A (en) 1984-12-12 1985-12-09 Pharmaceutically active derivatives of tryptophan and pharmaceutical compositions containing them
ES549822A ES8706630A1 (es) 1984-12-12 1985-12-11 Procedimiento para la preparacion de derivados n-acilados del-triptofano
ZA859526A ZA859526B (en) 1984-12-12 1985-12-12 Pharmaceutically active derivatives of tryptophan and pharmaceutical compositions containing them
PT81674A PT81674B (pt) 1984-12-12 1985-12-12 Processo para a preparacao de derivados n-acilados de l-triptofano farmaceuticamente activos, das composicoes farmaceuticas e de um produto farmaceutico que os contem, aplicaveis para aliviar a dor em seres humanos
DK381486A DK168564B1 (da) 1984-12-12 1986-08-11 Anvendelse af N-acylerede derivater af L-tryptophan til fremstilling af et lægemiddel til lindring af human smerte, farmaceutiske præparater indeholdende dem, samt sådanne nye farmaceutisk aktive derivater
US07/217,116 US4870097A (en) 1984-12-12 1988-07-11 Pharmaceutical use of derivatives of tryptophan

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT68241/84A IT1179866B (it) 1984-12-12 1984-12-12 Derivati del triptofano farmaceuticamente attivi e composizioni farmaceutiche che li contengono

Publications (3)

Publication Number Publication Date
IT8468241A0 IT8468241A0 (it) 1984-12-12
IT8468241A1 IT8468241A1 (it) 1986-06-12
IT1179866B true IT1179866B (it) 1987-09-16

Family

ID=11308641

Family Applications (1)

Application Number Title Priority Date Filing Date
IT68241/84A IT1179866B (it) 1984-12-12 1984-12-12 Derivati del triptofano farmaceuticamente attivi e composizioni farmaceutiche che li contengono

Country Status (14)

Country Link
US (1) US4870097A (it)
EP (1) EP0237522B1 (it)
JP (1) JPS62501292A (it)
AT (1) ATE85976T1 (it)
AU (1) AU589938B2 (it)
CA (1) CA1256441A (it)
DE (1) DE3587122T2 (it)
DK (1) DK168564B1 (it)
ES (1) ES8706630A1 (it)
IE (1) IE58502B1 (it)
IT (1) IT1179866B (it)
PT (1) PT81674B (it)
WO (1) WO1986003489A1 (it)
ZA (1) ZA859526B (it)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4814463A (en) * 1985-12-31 1989-03-21 Biomeasure, Inc. CCK antagonists
US4880938A (en) * 1986-06-16 1989-11-14 Merck & Co., Inc. Amino acid analogs
US5089638A (en) * 1986-06-16 1992-02-18 Merck & Co., Inc. Amino acid analogs as CCK-antagonists
SE8901149D0 (sv) * 1989-04-03 1989-04-03 Pharmacia Ab Medel foer inducering respektive foerhindrande av pupillkonstriktion i oegat
US5484814A (en) * 1991-02-28 1996-01-16 Merrell Dow Pharmaceuticals Inc. NMDA antagonists
US5360814A (en) * 1991-02-28 1994-11-01 Merrell Dow Pharmaceuticals Inc. NMDA antagonists
DK0624569T3 (da) * 1991-02-28 1998-10-26 Merrell Pharma Inc MMDA-antagonister
US20030199523A1 (en) * 2002-02-28 2003-10-23 Snutch Terrance P. Heterocyclic calcium in channel blockers
US7989589B2 (en) 2002-09-20 2011-08-02 The Trustees Of The University Of Pennsylvania Compstatin analogs with improved activity
US8168584B2 (en) 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
CN101325963B (zh) 2005-10-08 2016-01-27 博泰迪亚制药公司 用于眼部病症的补体抑制素和其类似物
ES2390828T3 (es) 2005-11-28 2012-11-16 The Trustees Of The University Of Pennsylvania Análogos potentes de la compstatina
EP2148691B1 (en) 2007-02-05 2015-05-20 Apellis Pharmaceuticals, Inc. Compstatin analogues for use in the treatment of inflammatory conditions of the respiratory system
CA2760839C (en) 2009-05-01 2019-02-12 The Trustees Of The University Of Pennsylvania Modified compstatin with peptide backbone and c-terminal modifications
CA2813049A1 (en) 2010-09-23 2012-03-29 The Trustees Of The University Of Pennsylvania Modified compstatin with improved stability and binding properties
JP2014503592A (ja) 2011-01-26 2014-02-13 ニコ ワールドワイド，インコーポレイテッド 片頭痛の療法
RU2653439C9 (ru) 2011-05-11 2018-10-16 Апеллис Фармасьютикалс, Инк. Клеточно-реактивные аналоги компстатина, аналоги компстатина длительного действия или аналоги компстатина нацеленного действия и их применение
CA2840270C (en) 2011-06-22 2023-09-26 Apellis Pharmaceuticals, Inc. Methods of treating chronic disorders with complement inhibitors
PL2753636T3 (pl) 2011-09-07 2020-05-18 The Trustees Of The University Of Pennsylvania Analogi kompstatyny o ulepszonych właściwościach farmakokinetycznych
US10035822B2 (en) 2012-11-15 2018-07-31 Apellis Pharmaceuticals, Inc. Cell-reactive, long-acting, or targeted compstatin analogs and related compositions and methods
WO2014152391A1 (en) 2013-03-15 2014-09-25 Apellis Pharmaceuticals, Inc. Cell-penetrating compstatin analogs and uses thereof
US10213476B2 (en) 2014-03-17 2019-02-26 The Trustees Of The University Of Pennsylvania Compstatin analogs with improved potency and pharmacokinetic properties
KR20180090785A (ko) 2015-10-07 2018-08-13 아펠리스 파마슈티컬스 인코포레이티드 투여 요법
WO2017083859A1 (en) * 2015-11-12 2017-05-18 The Trustees Of Columbia University In The City Of New York Rational drug design targeting resistant gram-negative bacterial infections to polymyxin-class antibiotics
BR112019020955A2 (pt) 2017-04-07 2020-05-05 Apellis Pharmaceuticals, Inc. regimes de dosagem e composições e métodos relacionados
WO2018200381A1 (en) 2017-04-25 2018-11-01 Temple Otorongo Llc Pharmaceutical composition comprising tryptophan and phyllokinin derivative for use in treating psychiatric and psychological conditions
JP2021507884A (ja) 2017-12-15 2021-02-25 アペリス・ファーマシューティカルズ・インコーポレイテッドＡｐｅｌｌｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 投与レジメンならびに関連組成物および方法
HUE057693T2 (hu) 2018-04-06 2022-05-28 Univ Pennsylvania Fokozott oldhatóságú és javított farmakokinetikai tulajdonságú kompsztatin analógok

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1055518B (it) * 1971-05-18 1982-01-11 Rotta Research Lab Derivatives del triptofano
US4482567A (en) * 1982-10-07 1984-11-13 Research Foundation For Mental Hygiene, Inc. N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics

Also Published As

Publication number Publication date
JPS62501292A (ja) 1987-05-21
EP0237522A1 (en) 1987-09-23
PT81674A (en) 1986-01-01
IE853029L (en) 1986-06-12
AU5209986A (en) 1986-07-01
US4870097A (en) 1989-09-26
DE3587122T2 (de) 1993-07-15
DE3587122D1 (de) 1993-04-01
DK168564B1 (da) 1994-04-25
ATE85976T1 (de) 1993-03-15
ES549822A0 (es) 1987-06-01
IT8468241A0 (it) 1984-12-12
AU589938B2 (en) 1989-10-26
DK381486A (da) 1986-08-11
IT8468241A1 (it) 1986-06-12
DK381486D0 (da) 1986-08-11
WO1986003489A1 (en) 1986-06-19
ES8706630A1 (es) 1987-06-01
IE58502B1 (en) 1993-10-06
CA1256441A (en) 1989-06-27
PT81674B (pt) 1987-10-20
ZA859526B (en) 1986-08-27
EP0237522B1 (en) 1993-02-24

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