PL2222678T3 - Sposoby wytwarzania związków morfinanowych (+)-'nal' - Google Patents

Sposoby wytwarzania związków morfinanowych (+)-'nal'

Info

Publication number
PL2222678T3
PL2222678T3 PL08862059.6T PL08862059T PL2222678T3 PL 2222678 T3 PL2222678 T3 PL 2222678T3 PL 08862059 T PL08862059 T PL 08862059T PL 2222678 T3 PL2222678 T3 PL 2222678T3
Authority
PL
Poland
Prior art keywords
nal
processes
production
morphinan compounds
morphinan
Prior art date
Application number
PL08862059.6T
Other languages
English (en)
Inventor
Peter X. Wang
Tao Jiang
Gary L. Cantrell
David W. Berberich
Bobby N. Trawick
Subo Liao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of PL2222678T3 publication Critical patent/PL2222678T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL08862059.6T 2007-12-17 2008-12-17 Sposoby wytwarzania związków morfinanowych (+)-'nal' PL2222678T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1410207P 2007-12-17 2007-12-17

Publications (1)

Publication Number Publication Date
PL2222678T3 true PL2222678T3 (pl) 2016-09-30

Family

ID=40340537

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08862059.6T PL2222678T3 (pl) 2007-12-17 2008-12-17 Sposoby wytwarzania związków morfinanowych (+)-'nal'

Country Status (9)

Country Link
US (1) US8067596B2 (pl)
EP (1) EP2222678B1 (pl)
JP (2) JP5587204B2 (pl)
AU (1) AU2008338906B2 (pl)
CA (1) CA2709886C (pl)
ES (1) ES2569655T3 (pl)
NZ (1) NZ586194A (pl)
PL (1) PL2222678T3 (pl)
WO (1) WO2009079013A1 (pl)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
AU2010266209B2 (en) 2009-07-02 2013-09-26 Kempharm, Inc. Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, methods of making and use thereof
WO2012018871A1 (en) * 2010-08-04 2012-02-09 Mallinckrodt Llc Tandem process for preparing n-alkyl morphinans
CN103619847A (zh) 2011-05-06 2014-03-05 布鲁克大学 通过金属催化n-脱甲基化/官能化以及分子内基团转移制备吗啡类似物的方法
RU2639877C2 (ru) * 2012-08-03 2017-12-25 Джонсон Мэтти Паблик Лимитед Компани Способ получения оксикодона
JP6100917B2 (ja) 2012-12-14 2017-03-22 パーデュー、ファーマ、リミテッド、パートナーシップ ピリドンモルフィナン類似体およびオピオイド受容体に対する生物活性
ES2621305T3 (es) 2012-12-14 2017-07-03 Purdue Pharma Lp Morfinanos espirocíclicos y su uso
US8937084B2 (en) 2012-12-14 2015-01-20 Purdue Pharma L.P. Nitrogen containing morphinan derivatives and the use thereof
EP2941430B1 (en) 2012-12-28 2017-04-26 Purdue Pharma LP 7,8-cyclicmorphinan analogs
ES2653265T3 (es) 2012-12-28 2018-02-06 Purdue Pharma Lp Morfinanos sustituidos y el uso de éstos
US9062062B1 (en) 2013-12-18 2015-06-23 Cody Laboratories, Inc. Synthesis of oxycodone hydrochloride
US10227354B2 (en) 2013-12-18 2019-03-12 Cody Laboratories, Inc. Conversion of oxycodone base to oxycodone hydrochloride
US8846923B1 (en) 2013-12-18 2014-09-30 Cody Laboratories, Inc. Preparation of 14-hydroxycodeinone sulfate
US9994571B2 (en) 2013-12-26 2018-06-12 Purdue Pharma L.P. 10-substituted morphinan hydantoins
US9862726B2 (en) 2013-12-26 2018-01-09 Purdue Pharma L.P. Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
WO2015097546A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. Propellane-based compounds and their use as opioid receptor modulators
US9850252B2 (en) 2014-11-25 2017-12-26 Kempharm, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone, prodrugs, methods of making and use thereof
WO2016187522A1 (en) * 2015-05-20 2016-11-24 Noramco, Inc. Process for the preparation of oxymorphone freebase
WO2019118583A1 (en) * 2017-12-12 2019-06-20 Xalud Therapeutics, Inc. Halogenated derivatives of morphinans and uses thereof
WO2021195209A1 (en) * 2020-03-24 2021-09-30 University Of Padova Morphinan isomers and their structural modifications as nmdar antagonists and neuroplastogens
WO2021249708A1 (en) 2020-06-10 2021-12-16 Research Center Pharmaceutical Engineering Gmbh Processes for preparing nor-opioid compounds and opioid antagonists by electrochemical n-demethylation
EP4714955A1 (en) * 2023-05-18 2026-03-25 Shaoxing Zejun Pharmaceuticals Co., Ltd Versatile intermediate for opioid derivatives, and preparation method therefor and use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL26896A (en) * 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
US4322426A (en) * 1980-04-28 1982-03-30 E. I. Du Pont De Nemours And Company 17-Substituted-6-desoxy-7,8-dihydro-6α-methylnoroxymorphone narcotic antagonists
US4472253A (en) * 1981-08-17 1984-09-18 The Florida Board Of Regents On Behalf Of The Florida State University Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative
EP0158476B1 (en) * 1984-03-27 1991-01-23 Mallinckrodt, Inc. (a Delaware corporation) Preparation of noroxymorphone from morphine
SE9401728D0 (sv) * 1994-05-18 1994-05-18 Astra Ab New compounds II
US5869669A (en) 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
ATE493417T1 (de) 2005-06-16 2011-01-15 Mallinckrodt Inc Synthetische route zu 14-hydroxylopiaten über 1- halogenthebain oder analoga

Also Published As

Publication number Publication date
WO2009079013A1 (en) 2009-06-25
NZ586194A (en) 2012-07-27
JP2011506609A (ja) 2011-03-03
CA2709886A1 (en) 2009-06-25
EP2222678A1 (en) 2010-09-01
EP2222678B1 (en) 2016-03-09
US20090156820A1 (en) 2009-06-18
ES2569655T3 (es) 2016-05-12
JP5587204B2 (ja) 2014-09-10
CA2709886C (en) 2016-10-25
JP2014055179A (ja) 2014-03-27
AU2008338906A1 (en) 2009-06-25
US8067596B2 (en) 2011-11-29
AU2008338906B2 (en) 2013-06-27

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