PL2261363T3 - Hamowanie ekspresji genów za pomocą sztucznych mikroRNA - Google Patents
Hamowanie ekspresji genów za pomocą sztucznych mikroRNAInfo
- Publication number
- PL2261363T3 PL2261363T3 PL10009228.7T PL10009228T PL2261363T3 PL 2261363 T3 PL2261363 T3 PL 2261363T3 PL 10009228 T PL10009228 T PL 10009228T PL 2261363 T3 PL2261363 T3 PL 2261363T3
- Authority
- PL
- Poland
- Prior art keywords
- regulation
- gene expression
- artificial micrornas
- micrornas
- artificial
- Prior art date
Links
- 108091026821 Artificial microRNA Proteins 0.000 title 1
- 230000003828 downregulation Effects 0.000 title 1
- 230000014509 gene expression Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1451207P | 2007-12-18 | 2007-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2261363T3 true PL2261363T3 (pl) | 2016-12-30 |
Family
ID=40427383
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10009228.7T PL2261363T3 (pl) | 2007-12-18 | 2008-12-17 | Hamowanie ekspresji genów za pomocą sztucznych mikroRNA |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8937217B2 (pl) |
| EP (4) | EP2261363B1 (pl) |
| BR (1) | BRPI0819526B8 (pl) |
| CA (3) | CA2709404C (pl) |
| ES (2) | ES2388489T3 (pl) |
| PL (1) | PL2261363T3 (pl) |
| WO (1) | WO2009079532A2 (pl) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8937217B2 (en) | 2007-12-18 | 2015-01-20 | E. I. Du Pont De Nemours And Company | Down-regulation of gene expression using artificial microRNAs |
| EP2865761A1 (en) | 2010-03-03 | 2015-04-29 | E. I. Du Pont de Nemours and Company | Plant seeds with altered storage compound levels, related constructs and methods involving genes encoding oxidoreductase motif polypeptides |
| MX2012012211A (es) | 2010-04-23 | 2012-12-17 | Du Pont | Composiciones de interruptores genicos y metodos de uso de las mismas. |
| US9062317B2 (en) | 2011-05-09 | 2015-06-23 | E I Du Pont De Nemours And Company | Methods and compositions for silencing gene families using artificial microRNAs |
| CA2850390A1 (en) | 2011-10-28 | 2013-05-02 | E. I. Du Pont De Nemours And Company | Methods and compositions for silencing genes using artificial micrornas |
| CA2860220C (en) | 2011-12-22 | 2021-07-13 | E. I. Du Pont De Nemours And Company | Use of the soybean or medicago truncatula sucrose synthase promoter to increase plant seed oil content |
| BR112014018009A2 (pt) * | 2012-01-23 | 2018-06-26 | Du Pont | sequência de ácido nucleico isolada, construção recombinante, célula vegetal, método para reduzir a expressão de pelo menos um gene biossintético de ácido graxo vegetal, método para reduzir a expressão de dois ou mais genes biossintéticos de ácido graxo vegetal e planta ou semente transgênica |
| EP2806730A4 (en) | 2012-01-23 | 2015-12-23 | Linnaeus Plant Sciences Inc | MODIFICATION OF THE FATTY ACID PROFILE OF CAMELINE OIL |
| EP2839007B1 (en) | 2012-04-19 | 2017-12-27 | Temasek Life Sciences Laboratory Limited | Methods for increasing cotton fiber length |
| EA201492122A1 (ru) | 2012-05-16 | 2015-10-30 | Рана Терапьютикс, Инк. | Композиции и способы для модулирования экспрессии utrn |
| BR112014028631A2 (pt) * | 2012-05-16 | 2017-10-17 | Rana Therapeutics Inc | composições e métodos para modulação da expressão da família de genes da hemoglobina |
| EA201492116A1 (ru) | 2012-05-16 | 2015-05-29 | Рана Терапьютикс, Инк. | Композиции и способы для модулирования экспрессии mecp2 |
| SG11201407483YA (en) | 2012-05-16 | 2014-12-30 | Rana Therapeutics Inc | Compositions and methods for modulating smn gene family expression |
| AU2013262699A1 (en) | 2012-05-16 | 2015-01-22 | Rana Therapeutics, Inc. | Compositions and methods for modulating ATP2A2 expression |
| US10837014B2 (en) | 2012-05-16 | 2020-11-17 | Translate Bio Ma, Inc. | Compositions and methods for modulating SMN gene family expression |
| WO2014164775A1 (en) | 2013-03-11 | 2014-10-09 | Pioneer Hi-Bred International, Inc. | Methods and compositions to improve the spread of chemical signals in plants |
| BR112015023268A2 (pt) | 2013-03-13 | 2018-05-02 | Du Pont | método para reduzir a expressão, construto de dna, método de obtenção de célula vegetal, método de obtenção de planta transgênica ou uma parte de planta |
| WO2014153254A2 (en) | 2013-03-14 | 2014-09-25 | Pioneer Hi-Bred International Inc. | Compositions and methods to control insect pests |
| CA2918911A1 (en) | 2013-07-31 | 2015-02-05 | E.I. Du Pont De Nemours And Company | Modification of soybean seed composition to enhance feed, food and other industrial applications of soybean products |
| WO2015164457A1 (en) | 2014-04-22 | 2015-10-29 | E. I. Du Pont De Nemours And Company | Plastidic carbonic anhydrase genes for oil augmentation in seeds with increased dgat expression |
| EP3842535A1 (en) | 2014-04-30 | 2021-06-30 | Fondazione Edmund Mach | Plant srna extract or plant mirna for use as immunosuppressive agent |
| WO2016044092A1 (en) | 2014-09-17 | 2016-03-24 | Pioneer Hi Bred International Inc | Compositions and methods to control insect pests |
| WO2016064347A1 (en) | 2014-10-22 | 2016-04-28 | Temasek Life Sciences Laboratory Limited | Terpene synthases from ylang ylang (cananga odorata var. fruticosa) |
| US10758558B2 (en) | 2015-02-13 | 2020-09-01 | Translate Bio Ma, Inc. | Hybrid oligonucleotides and uses thereof |
| EP3310803A1 (en) | 2015-06-16 | 2018-04-25 | Pioneer Hi-Bred International, Inc. | Compositions and methods to control insect pests |
| EP3368089B1 (en) | 2015-10-26 | 2025-11-05 | Translate Bio Ma, Inc. | Nanoparticle formulations for delivery of nucleic acid complexes |
| CA3022858A1 (en) | 2016-06-16 | 2017-12-21 | Pioneer Hi-Bred International, Inc. | Compositions and methods to control insect pests |
| WO2018013333A1 (en) | 2016-07-12 | 2018-01-18 | Pioneer Hi-Bred International, Inc. | Compositions and methods to control insect pests |
| WO2018148001A1 (en) | 2017-02-08 | 2018-08-16 | Pioneer Hi-Bred International Inc | Insecticidal combinations of plant derived insecticidal proteins and methods for their use |
| US20200165626A1 (en) | 2017-10-13 | 2020-05-28 | Pioneer Hi-Bred International, Inc. | Virus-induced gene silencing technology for insect control in maize |
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| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5569597A (en) | 1985-05-13 | 1996-10-29 | Ciba Geigy Corp. | Methods of inserting viral DNA into plant material |
| US5268463A (en) | 1986-11-11 | 1993-12-07 | Jefferson Richard A | Plant promoter α-glucuronidase gene construct |
| US5608142A (en) | 1986-12-03 | 1997-03-04 | Agracetus, Inc. | Insecticidal cotton plants |
| US5316931A (en) | 1988-02-26 | 1994-05-31 | Biosource Genetics Corp. | Plant viral vectors having heterologous subgenomic promoters for systemic expression of foreign genes |
| US5990387A (en) | 1988-06-10 | 1999-11-23 | Pioneer Hi-Bred International, Inc. | Stable transformation of plant cells |
| US5023179A (en) | 1988-11-14 | 1991-06-11 | Eric Lam | Promoter enhancer element for gene expression in plant roots |
| US5110732A (en) | 1989-03-14 | 1992-05-05 | The Rockefeller University | Selective gene expression in plants |
| EP0388186A1 (en) | 1989-03-17 | 1990-09-19 | E.I. Du Pont De Nemours And Company | External regulation of gene expression |
| US5240855A (en) | 1989-05-12 | 1993-08-31 | Pioneer Hi-Bred International, Inc. | Particle gun |
| US5879918A (en) | 1989-05-12 | 1999-03-09 | Pioneer Hi-Bred International, Inc. | Pretreatment of microprojectiles prior to using in a particle gun |
| US5322783A (en) | 1989-10-17 | 1994-06-21 | Pioneer Hi-Bred International, Inc. | Soybean transformation by microparticle bombardment |
| ATE225853T1 (de) | 1990-04-12 | 2002-10-15 | Syngenta Participations Ag | Gewebe-spezifische promotoren |
| US5498830A (en) | 1990-06-18 | 1996-03-12 | Monsanto Company | Decreased oil content in plant seeds |
| US5932782A (en) | 1990-11-14 | 1999-08-03 | Pioneer Hi-Bred International, Inc. | Plant transformation method using agrobacterium species adhered to microprojectiles |
| US5459252A (en) | 1991-01-31 | 1995-10-17 | North Carolina State University | Root specific gene promoter |
| US5399680A (en) | 1991-05-22 | 1995-03-21 | The Salk Institute For Biological Studies | Rice chitinase promoter |
| US5604121A (en) | 1991-08-27 | 1997-02-18 | Agricultural Genetics Company Limited | Proteins with insecticidal properties against homopteran insects and their use in plant protection |
| ATE276373T1 (de) | 1991-10-04 | 2004-10-15 | Univ North Carolina State | Pathogenresistente transgene pflanzen |
| US5324646A (en) | 1992-01-06 | 1994-06-28 | Pioneer Hi-Bred International, Inc. | Methods of regeneration of Medicago sativa and expressing foreign DNA in same |
| US5428148A (en) | 1992-04-24 | 1995-06-27 | Beckman Instruments, Inc. | N4 - acylated cytidinyl compounds useful in oligonucleotide synthesis |
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| JP2952041B2 (ja) | 1992-07-27 | 1999-09-20 | パイオニア ハイ−ブレッド インターナショナル,インコーポレイテッド | 培養ダイズ細胞のagrobacterium媒介形質転換の改良法 |
| IL108241A (en) | 1992-12-30 | 2000-08-13 | Biosource Genetics Corp | Plant expression system comprising a defective tobamovirus replicon integrated into the plant chromosome and a helper virus |
| US5789156A (en) | 1993-06-14 | 1998-08-04 | Basf Ag | Tetracycline-regulated transcriptional inhibitors |
| US5814618A (en) | 1993-06-14 | 1998-09-29 | Basf Aktiengesellschaft | Methods for regulating gene expression |
| US5470353A (en) | 1993-10-20 | 1995-11-28 | Hollister Incorporated | Post-operative thermal blanket |
| US5633363A (en) | 1994-06-03 | 1997-05-27 | Iowa State University, Research Foundation In | Root preferential promoter |
| US5736369A (en) | 1994-07-29 | 1998-04-07 | Pioneer Hi-Bred International, Inc. | Method for producing transgenic cereal plants |
| US5608144A (en) | 1994-08-12 | 1997-03-04 | Dna Plant Technology Corp. | Plant group 2 promoters and uses thereof |
| US5750868A (en) | 1994-12-08 | 1998-05-12 | Pioneer Hi-Bred International, Inc. | Reversible nuclear genetic system for male sterility in transgenic plants |
| US5837876A (en) | 1995-07-28 | 1998-11-17 | North Carolina State University | Root cortex specific gene promoter |
| US6072050A (en) | 1996-06-11 | 2000-06-06 | Pioneer Hi-Bred International, Inc. | Synthetic promoters |
| AU3495297A (en) | 1996-07-08 | 1998-02-02 | Pioneer Hi-Bred International, Inc. | Transformation of zygote, egg or sperm cells and recovery of transformed plants from isolated embryo sacs |
| US5981840A (en) | 1997-01-24 | 1999-11-09 | Pioneer Hi-Bred International, Inc. | Methods for agrobacterium-mediated transformation |
| EP0990040B1 (en) | 1997-07-22 | 2007-10-24 | Pioneer Hi-Bred International, Inc. | Genes controlling phytate metabolism in plants and uses thereof |
| AR014072A1 (es) | 1998-02-26 | 2001-01-31 | Pioneer Hi Bred Int | Molecula de acido nucleico aislada que tiene una secuencia nucleotidica para un promotor que es capaz de iniciar una transcripcion constitutiva en unacelula de planta, construccion adn, vector, celula huesped, metodo para expresar en forma constitutiva una secuencia nucleotidica heteroloca en una |
| EP1056862A1 (en) | 1998-02-26 | 2000-12-06 | Pioneer Hi-Bred International, Inc. | Family of maize pr-1 genes and promoters |
| SE9801630L (sv) | 1998-05-11 | 1999-11-12 | Ericsson Telefon Ab L M | Förfarande och anordning vid ett kommunikationsnät |
| ATE309362T1 (de) | 1998-08-20 | 2005-11-15 | Pioneer Hi Bred Int | Samen-bevorzugende promotoren |
| AU5788299A (en) | 1998-08-28 | 2000-03-21 | Pioneer Hi-Bred International, Inc. | Seed-preferred promoters from (end) genes |
| JP2004512020A (ja) * | 2000-06-23 | 2004-04-22 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 組換え構築物ならびにこれを遺伝子発現を減少させる際に用いる方法 |
| US7323560B2 (en) | 2000-07-17 | 2008-01-29 | E.I. Du Pont De Nemours And Company | Plastidic phosphoglucomutase genes |
| WO2002059324A2 (en) | 2001-01-12 | 2002-08-01 | Pioneer Hi-Bred International, Inc. | Novel inositol polyphosphate kinase genes and uses thereof |
| AU2002331897A1 (en) | 2001-09-27 | 2003-04-07 | Pioneer Hi-Bred International, Inc. | Phytate polynucleotides and methods of use |
| CA2492917C (en) | 2002-07-19 | 2011-10-18 | University Of South Carolina | Compositions and methods for the modulation of gene expression in plants |
| US20050120415A1 (en) * | 2003-10-09 | 2005-06-02 | E.I. Du Pont De Nemours And Company | Gene silencing |
| US20060135758A1 (en) * | 2004-08-31 | 2006-06-22 | Kunsheng Wu | Soybean polymorphisms and methods of genotyping |
| EP2765189A1 (en) | 2004-12-21 | 2014-08-13 | Monsanto Technology LLC | Recombinant DNA constructs and methods for controlling gene expression |
| US20060200878A1 (en) * | 2004-12-21 | 2006-09-07 | Linda Lutfiyya | Recombinant DNA constructs and methods for controlling gene expression |
| US8314290B2 (en) * | 2004-12-21 | 2012-11-20 | Monsanto Technology Llc | Temporal regulation of gene expression by MicroRNAs |
| KR100918296B1 (ko) | 2007-12-14 | 2009-09-18 | 한국전자통신연구원 | 착신 전환 서비스 제공 시스템 및 방법 |
| US8937217B2 (en) * | 2007-12-18 | 2015-01-20 | E. I. Du Pont De Nemours And Company | Down-regulation of gene expression using artificial microRNAs |
-
2008
- 2008-12-16 US US12/335,717 patent/US8937217B2/en active Active
- 2008-12-17 BR BRPI0819526A patent/BRPI0819526B8/pt active IP Right Grant
- 2008-12-17 US US12/809,324 patent/US20110091975A1/en not_active Abandoned
- 2008-12-17 CA CA2709404A patent/CA2709404C/en not_active Expired - Fee Related
- 2008-12-17 EP EP10009228.7A patent/EP2261363B1/en not_active Not-in-force
- 2008-12-17 CA CA2902723A patent/CA2902723C/en not_active Expired - Fee Related
- 2008-12-17 CA CA2902719A patent/CA2902719C/en not_active Expired - Fee Related
- 2008-12-17 ES ES10009217T patent/ES2388489T3/es active Active
- 2008-12-17 EP EP08862105A patent/EP2229447A2/en not_active Withdrawn
- 2008-12-17 EP EP12156244.1A patent/EP2458010B1/en not_active Not-in-force
- 2008-12-17 WO PCT/US2008/087082 patent/WO2009079532A2/en not_active Ceased
- 2008-12-17 PL PL10009228.7T patent/PL2261363T3/pl unknown
- 2008-12-17 ES ES12156244T patent/ES2421031T3/es active Active
- 2008-12-17 EP EP10009217A patent/EP2270183B1/en not_active Not-in-force
-
2014
- 2014-12-11 US US14/567,568 patent/US9546374B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009079532A2 (en) | 2009-06-25 |
| EP2261363A3 (en) | 2011-03-16 |
| BRPI0819526B1 (pt) | 2018-03-06 |
| CA2709404C (en) | 2016-10-11 |
| CA2902723A1 (en) | 2009-06-25 |
| US20150087069A1 (en) | 2015-03-26 |
| US20110091975A1 (en) | 2011-04-21 |
| ES2388489T3 (es) | 2012-10-15 |
| EP2229447A2 (en) | 2010-09-22 |
| EP2261363B1 (en) | 2016-04-20 |
| BRPI0819526A2 (pt) | 2015-03-10 |
| ES2421031T3 (es) | 2013-08-28 |
| EP2270183B1 (en) | 2012-06-13 |
| EP2270183A2 (en) | 2011-01-05 |
| CA2902723C (en) | 2016-10-18 |
| CA2902719A1 (en) | 2009-06-25 |
| EP2458010A1 (en) | 2012-05-30 |
| EP2270183A3 (en) | 2011-03-16 |
| EP2261363A2 (en) | 2010-12-15 |
| US20090155910A1 (en) | 2009-06-18 |
| BRPI0819526B8 (pt) | 2022-12-06 |
| EP2458010B1 (en) | 2013-05-01 |
| US8937217B2 (en) | 2015-01-20 |
| CA2902719C (en) | 2016-10-18 |
| CA2709404A1 (en) | 2009-06-25 |
| US9546374B2 (en) | 2017-01-17 |
| EP2261363A8 (en) | 2011-02-16 |
| WO2009079532A3 (en) | 2009-09-17 |
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