PL2320908T3 - Proleki dolutegrawiru - Google Patents

Proleki dolutegrawiru

Info

Publication number
PL2320908T3
PL2320908T3 PL09800989T PL09800989T PL2320908T3 PL 2320908 T3 PL2320908 T3 PL 2320908T3 PL 09800989 T PL09800989 T PL 09800989T PL 09800989 T PL09800989 T PL 09800989T PL 2320908 T3 PL2320908 T3 PL 2320908T3
Authority
PL
Poland
Prior art keywords
dolutegravir
prodrugs
dolutegravir prodrugs
Prior art date
Application number
PL09800989T
Other languages
English (en)
Inventor
Brian Alvin Johns
Jason Gordon Weatherhead
Yasunori Aoyama
Toshikazu Hakogi
Original Assignee
Viiv Healthcare Co
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viiv Healthcare Co, Shionogi & Co filed Critical Viiv Healthcare Co
Publication of PL2320908T3 publication Critical patent/PL2320908T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PL09800989T 2008-07-25 2009-07-23 Proleki dolutegrawiru PL2320908T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8361208P 2008-07-25 2008-07-25
EP09800989.7A EP2320908B9 (en) 2008-07-25 2009-07-23 Dolutegravir Prodrugs
PCT/US2009/051497 WO2010011812A1 (en) 2008-07-25 2009-07-23 Chemical compounds

Publications (1)

Publication Number Publication Date
PL2320908T3 true PL2320908T3 (pl) 2014-06-30

Family

ID=41570593

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09800989T PL2320908T3 (pl) 2008-07-25 2009-07-23 Proleki dolutegrawiru

Country Status (12)

Country Link
US (1) US8217034B2 (pl)
EP (1) EP2320908B9 (pl)
CY (1) CY1114981T1 (pl)
DK (1) DK2320908T3 (pl)
ES (1) ES2448766T3 (pl)
HR (1) HRP20140223T2 (pl)
HU (1) HUE020489T4 (pl)
PL (1) PL2320908T3 (pl)
PT (1) PT2320908E (pl)
SI (1) SI2320908T1 (pl)
SM (1) SMT201400030B (pl)
WO (1) WO2010011812A1 (pl)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010011814A1 (en) 2008-07-25 2010-01-28 Smithkline Beecham Corporation Chemical compounds
AU2014277831C1 (en) * 2008-12-11 2022-10-06 Shionogi & Co. Ltd. Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates
WO2010067176A1 (en) 2008-12-11 2010-06-17 Shionogi & Co., Ltd. Maltol ether processes and intermediates
CN102245572B (zh) 2008-12-11 2015-03-25 盐野义制药株式会社 氨甲酰基吡啶酮hiv整合酶抑制剂的方法和中间体
KR101733625B1 (ko) 2008-12-11 2017-05-10 시오노기세야쿠 가부시키가이샤 카르바모일피리돈 ｈｉｖ 인테그라제 억제제 및 중간체의 합성
TWI518084B (zh) 2009-03-26 2016-01-21 鹽野義製藥股份有限公司 哌喃酮與吡啶酮衍生物之製造方法
LT3494972T (lt) * 2010-01-27 2024-03-12 Viiv Healthcare Company Dolutegraviro ir lamivudino kompozicija živ infekcijai gydyti
TWI582097B (zh) 2010-03-23 2017-05-11 Ｖｉｉｖ醫療保健公司 製備胺甲醯吡啶酮衍生物及中間體之方法
US9216995B2 (en) 2010-04-12 2015-12-22 Shionogi & Co., Ltd. Pyridone derivative having integrase inhibitory activity
ES2608377T3 (es) 2010-08-05 2017-04-10 Shionogi & Co., Ltd. Procedimiento de preparación de un compuesto que tiene actividad inhibidora de la integrasa del HIV
DK2620436T3 (en) * 2010-09-24 2018-07-30 Shionogi & Co Substituted polycyclic carbamoylpyridone derivative prodrug
US9206197B2 (en) * 2011-09-14 2015-12-08 Mapi Pharma Ltd. Amorphous form of dolutegravir
EA030003B1 (ru) 2012-12-21 2018-06-29 Джилид Сайэнс, Инк. Полициклическое карбамоилпиридоновое соединение и его фармацевтическое применение для лечения вич-инфекции
US9573965B2 (en) 2013-02-19 2017-02-21 Aurobindo Pharma Ltd Process for the preparation of Dolutegravir
EP3008044B1 (en) 2013-06-13 2018-11-21 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds as hiv integrase inhibitors
WO2015001572A2 (en) * 2013-07-04 2015-01-08 Hetero Research Foundation Process for the preparation of intermediate of dolutegravir
ES2859102T3 (es) 2013-07-12 2021-10-01 Gilead Sciences Inc Compuestos de carbamoilpiridona policíclica y su uso para el tratamiento de infecciones por VIH
NO2865735T3 (pl) 2013-07-12 2018-07-21
US9856270B2 (en) * 2013-07-17 2018-01-02 Ratiopharm Gmbh Dolutegravir salts
ES2770050T3 (es) * 2014-01-21 2020-06-30 Laurus Labs Ltd Nuevo procedimiento para la preparación de dolutegravir y sus sales farmacéuticamente aceptables
WO2015138933A1 (en) 2014-03-13 2015-09-17 Assia Chemical Industries Ltd. Solid state forms of dolutegravir sodium
NO2717902T3 (pl) 2014-06-20 2018-06-23
TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
TWI677489B (zh) 2014-06-20 2019-11-21 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
TWI695003B (zh) 2014-12-23 2020-06-01 美商基利科學股份有限公司 多環胺甲醯基吡啶酮化合物及其醫藥用途
KR20190057158A (ko) 2015-04-02 2019-05-27 길리애드 사이언시즈, 인코포레이티드 폴리시클릭-카르바모일피리돈 화합물 및 그의 제약 용도
US11117904B2 (en) * 2016-06-23 2021-09-14 Viiv Healthcare Company Compositions and methods for the delivery of therapeutics
CN106360086B (zh) * 2016-09-23 2020-06-30 皖西学院 一种皖西白鹅种鹅专用饲料组合物、制备方法及使用方法
CN108250215B (zh) * 2016-12-28 2022-04-19 华创合成制药股份有限公司 一种新型抗hiv药物及其制备方法和用途
EP3573984A4 (en) * 2017-01-26 2020-07-29 Merck Sharp & Dohme Corp. USEFUL SUBSTITUTE QUINOLIZINE DERIVATIVES AS HIV INTEGRASE INHIBITORS
CN110958883A (zh) 2017-06-30 2020-04-03 Viiv保健公司 组合及其用途和疗法
CN111386276B (zh) 2017-10-06 2023-06-23 盐野义制药株式会社 制备取代的多环吡啶酮衍生物的立体选择性方法
MY201239A (en) 2019-03-22 2024-02-13 Gilead Sciences Inc Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use
PE20221569A1 (es) 2020-02-24 2022-10-06 Gilead Sciences Inc Compuestos tetraciclicos para el tratamiento de infecciones por vih
ES3064867T3 (en) 2020-09-30 2026-04-29 Gilead Sciences Inc Bridged tricyclic carbamoylpyridone compounds for a use in the treatment of hiv
WO2022107755A1 (ja) 2020-11-17 2022-05-27 塩野義製薬株式会社 新規アクリジニウム塩およびその製造方法
US11613546B2 (en) 2021-01-19 2023-03-28 Gilead Sciences, Inc. Substituted pyridotriazine compounds and uses thereof
MX2023009445A (es) * 2021-02-16 2023-08-25 Merck Sharp & Dohme Llc Compuestos de heterociclos tetraciclicos utiles como inhibidores de la integrasa del vih.
WO2023183472A1 (en) * 2022-03-23 2023-09-28 Board Of Regents Of The University Of Nebraska Antiviral prodrugs and use thereof
CN118974266A (zh) 2022-04-04 2024-11-15 约翰内斯堡威特沃特斯兰德大学 制备手性胺中间体的对映选择性方法
TW202446773A (zh) 2022-04-06 2024-12-01 美商基利科學股份有限公司 橋聯三環胺甲醯基吡啶酮化合物及其用途
US20250122219A1 (en) 2023-10-11 2025-04-17 Gilead Sciences, Inc. Bridged tricyclic carbamoylpyridone compounds and uses thereof
US20250127801A1 (en) 2023-10-11 2025-04-24 Gilead Sciences, Inc. Bridged tricyclic carbamoylpyridone compounds and uses thereof
WO2026076265A1 (en) 2024-10-03 2026-04-09 Gilead Sciences, Inc. Combination therapy comprising bridged tricyclic carbamoylpyridone compounds and p-glycoprotein inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005117904A2 (en) 2004-04-14 2005-12-15 Gilead Sciences, Inc. Phosphonate analogs of hiv integrase inhibitor compounds
ATE516026T1 (de) 2005-02-21 2011-07-15 Shionogi & Co Bicyclisches carbamoylpyridonderivat mit hiv- integrase-hemmender wirkung
KR101363875B1 (ko) * 2005-04-28 2014-02-21 시오노기세야쿠 가부시키가이샤 Ｈｉｖ 통합효소 억제 활성을 가지는 다환식카르바모일피리돈 유도체
AR057023A1 (es) 2005-05-16 2007-11-14 Gilead Sciences Inc Compuestos heterociclicos con propiedades inhibidoras de hiv-integrasa

Also Published As

Publication number Publication date
US20110190236A1 (en) 2011-08-04
ES2448766T9 (es) 2014-09-05
HRP20140223T2 (hr) 2014-08-01
SI2320908T1 (sl) 2014-05-30
SMT201400030B (it) 2014-05-07
WO2010011812A1 (en) 2010-01-28
EP2320908A1 (en) 2011-05-18
CY1114981T1 (el) 2016-12-14
HUE020489T4 (hu) 2016-01-28
DK2320908T3 (en) 2014-03-10
HRP20140223T1 (en) 2014-04-11
US8217034B2 (en) 2012-07-10
ES2448766T3 (es) 2014-03-17
PT2320908E (pt) 2014-03-06
EP2320908A4 (en) 2011-10-26
EP2320908B1 (en) 2013-12-25
EP2320908B9 (en) 2014-06-18

Similar Documents

Publication Publication Date Title
SI2320908T1 (sl) Predzdravila dolutegravirja
EP2118052A4 (en) NEW PRODRUGS
TWI368572B (en) Printing-table arrangement
GB0808924D0 (en) Raingen
GB0807353D0 (en) Suit-match
GB0804525D0 (en) Lamstone
GB0815689D0 (en) Photbioreactors
GB0818366D0 (en) Quinolin-2-one-compounds
GB2463042B (en) Stabalizer arrangement
GB0804158D0 (en) Fencemate
GB0905127D0 (en) Novel prodrugs
GB0802462D0 (en) Aerpurifiers
GB0818782D0 (en) Haemorrid
GB0802130D0 (en) Phospin
GB0807726D0 (en) Jimini Kriket
GB0807448D0 (en) Seakite
GB0806306D0 (en) Chuff
GB0806305D0 (en) Note10002
GB0806221D0 (en) Pillexpeller
GB0805173D0 (en) Airboat
GB0804418D0 (en) Easyparker
GB0808629D0 (en) Prambrella
GB0802323D0 (en) Cable-routing
GB0809692D0 (en) Pack-it
GB0810602D0 (en) Corcost pre004