PL2320908T3 - Proleki dolutegrawiru - Google Patents
Proleki dolutegrawiruInfo
- Publication number
- PL2320908T3 PL2320908T3 PL09800989T PL09800989T PL2320908T3 PL 2320908 T3 PL2320908 T3 PL 2320908T3 PL 09800989 T PL09800989 T PL 09800989T PL 09800989 T PL09800989 T PL 09800989T PL 2320908 T3 PL2320908 T3 PL 2320908T3
- Authority
- PL
- Poland
- Prior art keywords
- dolutegravir
- prodrugs
- dolutegravir prodrugs
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8361208P | 2008-07-25 | 2008-07-25 | |
| PCT/US2009/051497 WO2010011812A1 (en) | 2008-07-25 | 2009-07-23 | Chemical compounds |
| EP09800989.7A EP2320908B9 (en) | 2008-07-25 | 2009-07-23 | Dolutegravir Prodrugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2320908T3 true PL2320908T3 (pl) | 2014-06-30 |
Family
ID=41570593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09800989T PL2320908T3 (pl) | 2008-07-25 | 2009-07-23 | Proleki dolutegrawiru |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8217034B2 (pl) |
| EP (1) | EP2320908B9 (pl) |
| CY (1) | CY1114981T1 (pl) |
| DK (1) | DK2320908T3 (pl) |
| ES (1) | ES2448766T3 (pl) |
| HR (1) | HRP20140223T2 (pl) |
| HU (1) | HUE020489T4 (pl) |
| PL (1) | PL2320908T3 (pl) |
| PT (1) | PT2320908E (pl) |
| SI (1) | SI2320908T1 (pl) |
| SM (1) | SMT201400030B (pl) |
| WO (1) | WO2010011812A1 (pl) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2660239B1 (en) | 2008-07-25 | 2016-11-23 | VIIV Healthcare Company | Chemical compounds as synthetic intermediates |
| ES2645773T3 (es) | 2008-12-11 | 2017-12-07 | Shionogi & Co., Ltd. | Procedimientos e intermediarios de éter de maltol |
| AU2014277831C1 (en) * | 2008-12-11 | 2022-10-06 | Shionogi & Co. Ltd. | Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates |
| SG171308A1 (en) * | 2008-12-11 | 2011-07-28 | Shionogi & Co | Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates |
| EP3617194B1 (en) * | 2008-12-11 | 2023-11-08 | VIIV Healthcare Company | Processes and intermediates for carbamoylpyridone hiv integrase inhibitors |
| TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| EP3351249A1 (en) | 2010-01-27 | 2018-07-25 | VIIV Healthcare Company | Antiviral therapy |
| TWI582097B (zh) | 2010-03-23 | 2017-05-11 | Ｖｉｉｖ醫療保健公司 | 製備胺甲醯吡啶酮衍生物及中間體之方法 |
| WO2011129095A1 (ja) * | 2010-04-12 | 2011-10-20 | 塩野義製薬株式会社 | インテグラーゼ阻害活性を有するピリドン誘導体 |
| SMT202100268T1 (it) | 2010-08-05 | 2021-07-12 | Shionogi & Co | Metodo per produrre composti aventi attività di inibizione di integrasi di hiv. |
| LT2620436T (lt) * | 2010-09-24 | 2018-08-10 | Shionogi & Co., Ltd. | Pakeistojo policiklinio karbamoilpiridono darinio provaistas |
| PL2742051T3 (pl) * | 2011-09-14 | 2017-06-30 | Mapi Pharma Limited | Amorficzna postać soli sodowej dolutegrawiru |
| EA030003B1 (ru) | 2012-12-21 | 2018-06-29 | Джилид Сайэнс, Инк. | Полициклическое карбамоилпиридоновое соединение и его фармацевтическое применение для лечения вич-инфекции |
| WO2014128545A2 (en) | 2013-02-19 | 2014-08-28 | Aurobindo Pharma Limited | An improved process for the preparation of dolutegravir |
| US9951079B2 (en) | 2013-06-13 | 2018-04-24 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as HIV integrase inhibitors |
| EP3016935B1 (en) | 2013-07-04 | 2018-09-05 | Hetero Research Foundation | Process for the preparation of intermediate of dolutegravir |
| DK3019503T3 (da) | 2013-07-12 | 2017-11-20 | Gilead Sciences Inc | Polycykliske-carbamoylpyridon-forbindelser og anvendelse deraf til behandling af hiv-infektioner |
| NO2865735T3 (pl) | 2013-07-12 | 2018-07-21 | ||
| EP3022209B1 (en) * | 2013-07-17 | 2018-03-07 | ratiopharm GmbH | Dolutegravir potassium salt |
| US9856271B2 (en) * | 2014-01-21 | 2018-01-02 | Laurus Labs Limited | Process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof |
| WO2015138933A1 (en) | 2014-03-13 | 2015-09-17 | Assia Chemical Industries Ltd. | Solid state forms of dolutegravir sodium |
| TWI744723B (zh) | 2014-06-20 | 2021-11-01 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
| TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
| NO2717902T3 (pl) | 2014-06-20 | 2018-06-23 | ||
| TWI695003B (zh) | 2014-12-23 | 2020-06-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
| CA2980362C (en) | 2015-04-02 | 2020-02-25 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
| JP7160466B2 (ja) * | 2016-06-23 | 2022-10-25 | ヴィーブ ヘルスケア カンパニー | 治療薬の送達のための組成物及び方法 |
| CN106360086B (zh) * | 2016-09-23 | 2020-06-30 | 皖西学院 | 一种皖西白鹅种鹅专用饲料组合物、制备方法及使用方法 |
| CN108250215B (zh) * | 2016-12-28 | 2022-04-19 | 华创合成制药股份有限公司 | 一种新型抗hiv药物及其制备方法和用途 |
| WO2018140368A1 (en) | 2017-01-26 | 2018-08-02 | Merck Sharp & Dohme Corp. | Substituted quinolizine derivatives useful as hiv integrase inhibitors |
| RU2755710C2 (ru) | 2017-06-30 | 2021-09-20 | Вайв Хелткер Компани | Комбинация, ее применение и способы лечения с использованием указанной комбинации |
| US11286262B2 (en) | 2017-10-06 | 2022-03-29 | Shionogi & Co., Ltd. | Stereoselective process for preparing substituted polycyclic pyridone derivatives |
| KR20240151256A (ko) | 2019-03-22 | 2024-10-17 | 길리애드 사이언시즈, 인코포레이티드 | 가교된 트리시클릭 카르바모일피리돈 화합물 및 그의 제약 용도 |
| EP4110783A1 (en) | 2020-02-24 | 2023-01-04 | Gilead Sciences, Inc. | Tetracyclic compounds for treating hiv infection |
| CN116390924B (zh) | 2020-09-30 | 2025-11-07 | 吉利德科学公司 | 桥连三环氨基甲酰基吡啶酮化合物及其用途 |
| WO2022107755A1 (ja) | 2020-11-17 | 2022-05-27 | 塩野義製薬株式会社 | 新規アクリジニウム塩およびその製造方法 |
| CR20260070A (es) | 2021-01-19 | 2026-04-24 | Gilead Sciences Inc | COMPUESTOS DE PIRIDOTRIAZINA SUSTITUIDOS Y USOS DE ESTOS (Divisional 2023-0315) |
| US11958864B2 (en) * | 2021-02-16 | 2024-04-16 | Merck Sharp & Dohme Llc | Tetracyclic heterocycle compounds useful as HIV integrase inhibitors |
| WO2023183472A1 (en) * | 2022-03-23 | 2023-09-28 | Board Of Regents Of The University Of Nebraska | Antiviral prodrugs and use thereof |
| CN118974266A (zh) | 2022-04-04 | 2024-11-15 | 约翰内斯堡威特沃特斯兰德大学 | 制备手性胺中间体的对映选择性方法 |
| TWI856796B (zh) | 2022-04-06 | 2024-09-21 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
| CN120936599A (zh) * | 2023-01-18 | 2025-11-11 | 歌礼生物科技（杭州）有限公司 | 整合酶抑制剂及其应用 |
| IL327206A (en) | 2023-10-11 | 2026-05-01 | Gilead Sciences Inc | Bridged tricyclic carbamoylpyridone compounds and their uses |
| AU2024360779A1 (en) | 2023-10-11 | 2026-04-16 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and uses thereof |
| WO2026076265A1 (en) | 2024-10-03 | 2026-04-09 | Gilead Sciences, Inc. | Combination therapy comprising bridged tricyclic carbamoylpyridone compounds and p-glycoprotein inhibitors |
| WO2026128357A1 (en) | 2024-12-09 | 2026-06-18 | Gilead Sciences, Inc. | Methods and compositions for treating viral infections |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1742642T1 (sl) | 2004-04-14 | 2009-04-30 | Gilead Sciences Inc | Fosfonatni analogi inhibitorskih spojin HIV integraze |
| WO2006088173A1 (ja) | 2005-02-21 | 2006-08-24 | Shionogi & Co., Ltd. | Ｈｉｖインテグラーゼ阻害活性を有する２環性カルバモイルピリドン誘導体 |
| DK3187225T3 (da) * | 2005-04-28 | 2022-02-28 | Viiv Healthcare Co | Polycyklisk carbamoylpyridonderivat med hiv-integrasehæmmende aktivitet |
| US20070072831A1 (en) | 2005-05-16 | 2007-03-29 | Gilead Sciences, Inc. | Integrase inhibitor compounds |
-
2009
- 2009-07-23 WO PCT/US2009/051497 patent/WO2010011812A1/en not_active Ceased
- 2009-07-23 US US13/054,633 patent/US8217034B2/en active Active
- 2009-07-23 DK DK09800989.7T patent/DK2320908T3/en active
- 2009-07-23 HR HRP20140223AT patent/HRP20140223T2/hr unknown
- 2009-07-23 SI SI200930888T patent/SI2320908T1/sl unknown
- 2009-07-23 PL PL09800989T patent/PL2320908T3/pl unknown
- 2009-07-23 PT PT98009897T patent/PT2320908E/pt unknown
- 2009-07-23 HU HUE09800989A patent/HUE020489T4/hu unknown
- 2009-07-23 EP EP09800989.7A patent/EP2320908B9/en active Active
- 2009-07-23 ES ES09800989.7T patent/ES2448766T3/es active Active
-
2014
- 2014-03-13 SM SM201400030T patent/SMT201400030B/xx unknown
- 2014-03-18 CY CY20141100217T patent/CY1114981T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2320908A4 (en) | 2011-10-26 |
| US8217034B2 (en) | 2012-07-10 |
| CY1114981T1 (el) | 2016-12-14 |
| EP2320908B1 (en) | 2013-12-25 |
| SI2320908T1 (sl) | 2014-05-30 |
| SMT201400030B (it) | 2014-05-07 |
| EP2320908A1 (en) | 2011-05-18 |
| ES2448766T9 (es) | 2014-09-05 |
| ES2448766T3 (es) | 2014-03-17 |
| WO2010011812A1 (en) | 2010-01-28 |
| DK2320908T3 (en) | 2014-03-10 |
| PT2320908E (pt) | 2014-03-06 |
| HUE020489T4 (hu) | 2016-01-28 |
| HRP20140223T1 (en) | 2014-04-11 |
| US20110190236A1 (en) | 2011-08-04 |
| EP2320908B9 (en) | 2014-06-18 |
| HRP20140223T2 (hr) | 2014-08-01 |
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