PL2320908T3 - Proleki dolutegrawiru - Google Patents
Proleki dolutegrawiruInfo
- Publication number
- PL2320908T3 PL2320908T3 PL09800989T PL09800989T PL2320908T3 PL 2320908 T3 PL2320908 T3 PL 2320908T3 PL 09800989 T PL09800989 T PL 09800989T PL 09800989 T PL09800989 T PL 09800989T PL 2320908 T3 PL2320908 T3 PL 2320908T3
- Authority
- PL
- Poland
- Prior art keywords
- dolutegravir
- prodrugs
- dolutegravir prodrugs
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8361208P | 2008-07-25 | 2008-07-25 | |
| PCT/US2009/051497 WO2010011812A1 (en) | 2008-07-25 | 2009-07-23 | Chemical compounds |
| EP09800989.7A EP2320908B9 (en) | 2008-07-25 | 2009-07-23 | Dolutegravir Prodrugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2320908T3 true PL2320908T3 (pl) | 2014-06-30 |
Family
ID=41570593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09800989T PL2320908T3 (pl) | 2008-07-25 | 2009-07-23 | Proleki dolutegrawiru |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8217034B2 (pl) |
| EP (1) | EP2320908B9 (pl) |
| CY (1) | CY1114981T1 (pl) |
| DK (1) | DK2320908T3 (pl) |
| ES (1) | ES2448766T3 (pl) |
| HR (1) | HRP20140223T2 (pl) |
| HU (1) | HUE020489T4 (pl) |
| PL (1) | PL2320908T3 (pl) |
| PT (1) | PT2320908E (pl) |
| SI (1) | SI2320908T1 (pl) |
| SM (1) | SMT201400030B (pl) |
| WO (1) | WO2010011812A1 (pl) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101695807B1 (ko) | 2008-07-25 | 2017-01-13 | 비이브 헬쓰케어 컴퍼니 | 화합물 |
| AU2014277831C1 (en) * | 2008-12-11 | 2022-10-06 | Shionogi & Co. Ltd. | Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates |
| KR101682058B1 (ko) * | 2008-12-11 | 2016-12-02 | 비이브 헬쓰케어 컴퍼니 | 카르바모일피리돈 ｈｉｖ 인테그라제 억제제를 위한 제조방법 및 중간체 |
| CN102239155A (zh) | 2008-12-11 | 2011-11-09 | 盐野义制药株式会社 | 生产麦芽糖醇醚的方法和中间体 |
| EP3210603A1 (en) | 2008-12-11 | 2017-08-30 | Shionogi & Co., Ltd | Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates |
| TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| LT2932970T (lt) | 2010-01-27 | 2018-06-25 | Viiv Healthcare Company | Antivirusinė terapija |
| TWI582097B (zh) | 2010-03-23 | 2017-05-11 | Ｖｉｉｖ醫療保健公司 | 製備胺甲醯吡啶酮衍生物及中間體之方法 |
| US9216995B2 (en) | 2010-04-12 | 2015-12-22 | Shionogi & Co., Ltd. | Pyridone derivative having integrase inhibitory activity |
| PL3456721T3 (pl) * | 2010-08-05 | 2021-10-25 | Shionogi & Co., Ltd | Sposób wytwarzania związków wykazujących działanie hamujące integrazę hiv |
| US8987441B2 (en) * | 2010-09-24 | 2015-03-24 | Shionogi & Co., Ltd. | Substituted polycyclic carbamoyl pyridone derivative prodrug |
| PL2742051T3 (pl) | 2011-09-14 | 2017-06-30 | Mapi Pharma Limited | Amorficzna postać soli sodowej dolutegrawiru |
| PL3608325T3 (pl) | 2012-12-21 | 2022-11-07 | Gilead Sciences, Inc. | Policykliczne związki karbamoilopirydonu i ich zastosowanie farmaceutyczne |
| WO2014128545A2 (en) | 2013-02-19 | 2014-08-28 | Aurobindo Pharma Limited | An improved process for the preparation of dolutegravir |
| WO2014200880A1 (en) | 2013-06-13 | 2014-12-18 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
| EP3016935B1 (en) | 2013-07-04 | 2018-09-05 | Hetero Research Foundation | Process for the preparation of intermediate of dolutegravir |
| HUE037347T2 (hu) | 2013-07-12 | 2018-08-28 | Gilead Sciences Inc | Policiklusos karmaboilpiridon vegyületek és alkalmazásuk HIV fertõzések kezelésére |
| NO2865735T3 (pl) | 2013-07-12 | 2018-07-21 | ||
| WO2015009927A1 (en) * | 2013-07-17 | 2015-01-22 | Ratiopharm Gmbh | Dolutegravir salts |
| IN2014CH00247A (pl) | 2014-01-21 | 2015-08-14 | Laurus Labs Private Ltd | |
| WO2015138933A1 (en) | 2014-03-13 | 2015-09-17 | Assia Chemical Industries Ltd. | Solid state forms of dolutegravir sodium |
| TWI744723B (zh) | 2014-06-20 | 2021-11-01 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
| TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
| NO2717902T3 (pl) | 2014-06-20 | 2018-06-23 | ||
| TWI695003B (zh) | 2014-12-23 | 2020-06-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
| ES2837383T3 (es) | 2015-04-02 | 2021-06-30 | Gilead Sciences Inc | Compuestos de carbamoilpiridonas policíclicos y su utilización farmacéutica |
| US11117904B2 (en) * | 2016-06-23 | 2021-09-14 | Viiv Healthcare Company | Compositions and methods for the delivery of therapeutics |
| CN106360086B (zh) * | 2016-09-23 | 2020-06-30 | 皖西学院 | 一种皖西白鹅种鹅专用饲料组合物、制备方法及使用方法 |
| CN108250215B (zh) * | 2016-12-28 | 2022-04-19 | 华创合成制药股份有限公司 | 一种新型抗hiv药物及其制备方法和用途 |
| US10786488B2 (en) | 2017-01-26 | 2020-09-29 | Merck Sharp & Dohme Corp. | Substituted quinolizine derivatives useful as HIV integrase inhibitors |
| BR112019027915A2 (pt) | 2017-06-30 | 2020-07-14 | Viiv Healthcare Company | composição de carboidrato de baixo teor glicêmico disponível, composição nutricional líquida, e, uso de uma composição de carboidrato |
| SG11202002789XA (en) | 2017-10-06 | 2020-04-29 | Shionogi & Co | Stereoselective process for preparing substituted polycyclic pyridone derivatives |
| CN119462659A (zh) | 2019-03-22 | 2025-02-18 | 吉利德科学公司 | 桥连三环氨基甲酰基吡啶酮化合物及其药学用途 |
| PE20221569A1 (es) | 2020-02-24 | 2022-10-06 | Gilead Sciences Inc | Compuestos tetraciclicos para el tratamiento de infecciones por vih |
| WO2022072520A1 (en) | 2020-09-30 | 2022-04-07 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and uses thereof |
| EP4249077A4 (en) | 2020-11-17 | 2025-02-12 | Shionogi & Co., Ltd | NEW ACRIDINIUM SALT AND METHOD FOR THE PRODUCTION THEREOF |
| LT4196479T (lt) | 2021-01-19 | 2023-12-11 | Gilead Sciences, Inc. | Pakeistieji piridotriazino junginiai ir jų panaudojimo būdai |
| KR20230147131A (ko) * | 2021-02-16 | 2023-10-20 | 머크 샤프 앤드 돔 엘엘씨 | Hiv 인테그라제 억제제로서 유용한 테트라시클릭 헤테로사이클 화합물 |
| WO2023183472A1 (en) * | 2022-03-23 | 2023-09-28 | Board Of Regents Of The University Of Nebraska | Antiviral prodrugs and use thereof |
| CN118974266A (zh) | 2022-04-04 | 2024-11-15 | 约翰内斯堡威特沃特斯兰德大学 | 制备手性胺中间体的对映选择性方法 |
| TW202446773A (zh) | 2022-04-06 | 2024-12-01 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
| WO2025080850A1 (en) | 2023-10-11 | 2025-04-17 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and uses thereof |
| TW202530227A (zh) | 2023-10-11 | 2025-08-01 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080076738A1 (en) * | 2004-04-14 | 2008-03-27 | Cai Zhenhong R | Phosphonate Analogs Of Hiv Integrase Inhibitor Compounds |
| WO2006088173A1 (ja) | 2005-02-21 | 2006-08-24 | Shionogi & Co., Ltd. | Ｈｉｖインテグラーゼ阻害活性を有する２環性カルバモイルピリドン誘導体 |
| US8129385B2 (en) | 2005-04-28 | 2012-03-06 | Shionogi & Co., Ltd. | Substituted 5-hydroxy-3,4,6,9,9a, 10-hexanhydro-2h-1-oxa04a,8a-diaza-anthracene-6,10-dioness |
| TW200716632A (en) * | 2005-05-16 | 2007-05-01 | Gilead Sciences Inc | Integrase inhibitor compounds |
-
2009
- 2009-07-23 US US13/054,633 patent/US8217034B2/en active Active
- 2009-07-23 WO PCT/US2009/051497 patent/WO2010011812A1/en not_active Ceased
- 2009-07-23 DK DK09800989.7T patent/DK2320908T3/en active
- 2009-07-23 EP EP09800989.7A patent/EP2320908B9/en active Active
- 2009-07-23 HU HUE09800989A patent/HUE020489T4/hu unknown
- 2009-07-23 PT PT98009897T patent/PT2320908E/pt unknown
- 2009-07-23 SI SI200930888T patent/SI2320908T1/sl unknown
- 2009-07-23 ES ES09800989.7T patent/ES2448766T3/es active Active
- 2009-07-23 PL PL09800989T patent/PL2320908T3/pl unknown
- 2009-07-23 HR HRP20140223AT patent/HRP20140223T2/hr unknown
-
2014
- 2014-03-13 SM SM201400030T patent/SMT201400030B/xx unknown
- 2014-03-18 CY CY20141100217T patent/CY1114981T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1114981T1 (el) | 2016-12-14 |
| DK2320908T3 (en) | 2014-03-10 |
| ES2448766T3 (es) | 2014-03-17 |
| HRP20140223T1 (en) | 2014-04-11 |
| EP2320908A1 (en) | 2011-05-18 |
| SMT201400030B (it) | 2014-05-07 |
| EP2320908B1 (en) | 2013-12-25 |
| US8217034B2 (en) | 2012-07-10 |
| PT2320908E (pt) | 2014-03-06 |
| HUE020489T4 (hu) | 2016-01-28 |
| HRP20140223T2 (hr) | 2014-08-01 |
| SI2320908T1 (sl) | 2014-05-30 |
| US20110190236A1 (en) | 2011-08-04 |
| ES2448766T9 (es) | 2014-09-05 |
| EP2320908B9 (en) | 2014-06-18 |
| EP2320908A4 (en) | 2011-10-26 |
| WO2010011812A1 (en) | 2010-01-28 |
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