PL2342205T3 - Podstawione tricykliczne pochodne kwasowe jako antagoniści receptora S1P1 użyteczni w leczeniu zaburzeń autoimmunologicznych i zapalnych - Google Patents

Podstawione tricykliczne pochodne kwasowe jako antagoniści receptora S1P1 użyteczni w leczeniu zaburzeń autoimmunologicznych i zapalnych

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Publication number
PL2342205T3
PL2342205T3 PL09789210.3T PL09789210T PL2342205T3 PL 2342205 T3 PL2342205 T3 PL 2342205T3 PL 09789210 T PL09789210 T PL 09789210T PL 2342205 T3 PL2342205 T3 PL 2342205T3
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PL
Poland
Prior art keywords
autoimmune
treatment
acid derivatives
receptor agonists
inflammatory disorders
Prior art date
Application number
PL09789210.3T
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English (en)
Other versions
PL2342205T4 (pl
Inventor
Robert M. Jones
Daniel J. Buzard
Andrew M. Kawasaki
Sun Hee Kim
Lars THORESEN
Juerg Lehmann
Xiuwen Zhu
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Filing date
Publication date
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Publication of PL2342205T4 publication Critical patent/PL2342205T4/pl
Publication of PL2342205T3 publication Critical patent/PL2342205T3/pl

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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PL09789210.3T 2008-08-27 2009-08-26 Podstawione tricykliczne pochodne kwasowe jako antagoniści receptora S1P1 użyteczni w leczeniu zaburzeń autoimmunologicznych i zapalnych PL2342205T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19031108P 2008-08-27 2008-08-27
US26951909P 2009-06-24 2009-06-24

Publications (2)

Publication Number Publication Date
PL2342205T4 PL2342205T4 (pl) 2016-12-30
PL2342205T3 true PL2342205T3 (pl) 2016-12-30

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PL09789210.3T PL2342205T3 (pl) 2008-08-27 2009-08-26 Podstawione tricykliczne pochodne kwasowe jako antagoniści receptora S1P1 użyteczni w leczeniu zaburzeń autoimmunologicznych i zapalnych

Country Status (23)

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US (3) US8415484B2 (pl)
EP (1) EP2342205B1 (pl)
JP (2) JP5726737B2 (pl)
KR (2) KR101800595B1 (pl)
CN (2) CN102197038B (pl)
AU (1) AU2009288738B9 (pl)
BR (1) BRPI0917923B1 (pl)
CA (1) CA2733671C (pl)
CY (1) CY1117830T1 (pl)
EA (1) EA036955B1 (pl)
ES (1) ES2583630T3 (pl)
HR (1) HRP20160890T1 (pl)
HU (1) HUE031479T2 (pl)
IL (2) IL211107A0 (pl)
MX (1) MX2011002199A (pl)
NZ (1) NZ591001A (pl)
PL (1) PL2342205T3 (pl)
PT (1) PT2342205T (pl)
RS (1) RS54970B1 (pl)
SI (1) SI2342205T1 (pl)
SM (1) SMT201600318B (pl)
WO (1) WO2010027431A1 (pl)
ZA (1) ZA201101524B (pl)

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KR101728374B1 (ko) 2008-07-23 2017-04-19 아레나 파마슈티칼스, 인크. 자가면역성 및 염증성의 장애의 치료에 유용한 치환된 1,2,3,4-테트라히드로시클로펜타[ｂ]인돌-3-일)아세트산 유도체
PL2342205T3 (pl) 2008-08-27 2016-12-30 Podstawione tricykliczne pochodne kwasowe jako antagoniści receptora S1P1 użyteczni w leczeniu zaburzeń autoimmunologicznych i zapalnych
WO2011005295A1 (en) * 2009-06-24 2011-01-13 Arena Pharmaceuticals, Inc. Modulators of the sphingosine-1-phosphate (s1p) receptor useful for the treatment of disorders related thereto
CN103221391B (zh) 2010-01-27 2018-07-06 艾尼纳制药公司 (R)-2-(7-(4-环戊基-3-(三氟甲基)苄基氧基)-1,2,3,4-四氢环戊二烯并[b]吲哚-3-基)乙酸及其盐的制备方法
ES2558087T3 (es) * 2010-03-03 2016-02-01 Arena Pharmaceuticals, Inc. Procesos para la preparación de moduladores del receptor S1P1 y formas cristalinas de los mismos
CN104710426B (zh) * 2014-12-12 2017-08-01 常州大学 苯并吡咯里西啶生物碱及其制备方法和用途
CN104478885B (zh) * 2014-12-12 2017-08-01 常州大学 9‑氨基‑9a‑烯丙基苯并吡咯里西啶生物碱的制备方法
CA3002540C (en) * 2015-01-06 2023-11-07 Arena Pharmaceuticals, Inc. Use of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid for treating conditions related to the s1p1 receptor
WO2016209809A1 (en) 2015-06-22 2016-12-29 Arena Pharmaceuticals, Inc. Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid(compound1) for use in sipi receptor-associated disorders
US11534424B2 (en) 2017-02-16 2022-12-27 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
AU2018222747A1 (en) * 2017-02-16 2019-09-05 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations
ES2987794T3 (es) 2018-06-06 2024-11-18 Arena Pharm Inc Procedimientos de tratamiento de afecciones relacionadas con el receptor S1P1
US11555015B2 (en) * 2018-09-06 2023-01-17 Arena Pharmaceuticals, Inc. Compounds useful in the treatment of autoimmune and inflammatory disorders
CN113185446A (zh) * 2018-12-06 2021-07-30 上海济煜医药科技有限公司 作为免疫调节的芳环衍生物及其制备方法和应用
WO2020140957A1 (en) * 2019-01-04 2020-07-09 Ascentage Pharma (Suzhou) Co., Ltd. Method for preparing sulfonamides drugs
CA3124701A1 (en) * 2019-01-08 2020-07-16 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor
WO2021213393A1 (en) * 2020-04-20 2021-10-28 Zebrapeutics Inc. Method of treating ship1-mediated diseases using pelorol derivatives
CN112812052B (zh) * 2021-02-02 2023-12-01 成都阿奇生物医药科技有限公司 一种治疗溃疡性结肠炎的化合物及其制备方法和用途

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