PL2344509T3 - Sposoby wytwarzania buprenorfiny przy zmniejszonym tworzeniu zanieczyszczeń - Google Patents
Sposoby wytwarzania buprenorfiny przy zmniejszonym tworzeniu zanieczyszczeńInfo
- Publication number
- PL2344509T3 PL2344509T3 PL09745146T PL09745146T PL2344509T3 PL 2344509 T3 PL2344509 T3 PL 2344509T3 PL 09745146 T PL09745146 T PL 09745146T PL 09745146 T PL09745146 T PL 09745146T PL 2344509 T3 PL2344509 T3 PL 2344509T3
- Authority
- PL
- Poland
- Prior art keywords
- buprenorphine
- processes
- production
- reduced impurity
- impurity formation
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 title 1
- 229960001736 buprenorphine Drugs 0.000 title 1
- 239000012535 impurity Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19477708P | 2008-09-30 | 2008-09-30 | |
| EP09745146.2A EP2344509B1 (en) | 2008-09-30 | 2009-09-29 | Processes for the production of buprenorphine with reduced impurity formation |
| PCT/US2009/005375 WO2010039220A1 (en) | 2008-09-30 | 2009-09-29 | Processes for the production of buprenorphine with reduced impurity formation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2344509T3 true PL2344509T3 (pl) | 2016-04-29 |
Family
ID=41381682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09745146T PL2344509T3 (pl) | 2008-09-30 | 2009-09-29 | Sposoby wytwarzania buprenorfiny przy zmniejszonym tworzeniu zanieczyszczeń |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8232397B2 (pl) |
| EP (1) | EP2344509B1 (pl) |
| AU (1) | AU2009300390B2 (pl) |
| CA (1) | CA2738761C (pl) |
| ES (1) | ES2560778T3 (pl) |
| PL (1) | PL2344509T3 (pl) |
| WO (1) | WO2010039220A1 (pl) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080125592A1 (en) * | 2006-10-17 | 2008-05-29 | Penick Corporation | Process for preparing oxymorphone, naltrexone, and buprenorphine |
| CA2674915C (en) | 2006-10-17 | 2015-06-30 | Penick Corporation | Process for preparing oxymorphone |
| WO2010039216A1 (en) | 2008-09-30 | 2010-04-08 | Mallinckrodt Inc. | Processes for the alkylation of norbuprenorphine with reduced impurity formation |
| CA3026884C (en) | 2011-10-03 | 2020-10-27 | Johnson Matthey Public Limited Company | Process for preparing buprenorphine |
| RU2503677C1 (ru) * | 2012-08-21 | 2014-01-10 | Федеральное государственное бюджетное учреждение науки Институт элементоорганических соединений им. А.Н. Несмеянова Российской академии наук (ИНЭОС РАН) | 3,6-диметокси-17-метил-7альфа-(трифторацетил)-4,5альфа-эпокси-6альфа,14альфа-этеноизоморфинан и способ его получения |
| US9834562B2 (en) | 2012-12-31 | 2017-12-05 | Rhodes Technologies | 7 beta-substituted 6a, 14a-ethenomorphinans and 7beta-substituted 6a, 14a-ethanomorphinans |
| ES2699730T3 (es) * | 2013-06-11 | 2019-02-12 | Rusan Pharma Ltd | Proceso industrial para la preparación de buprenorfina y sus derivados |
| WO2015100092A2 (en) * | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | 7-beta analogs of orvinols |
| US11542481B2 (en) | 2017-01-19 | 2023-01-03 | Donald Danforth Plant Science Center | Morphinan N-demethylase isolated from the methylobacterium thebainfresser and methods of use thereof |
| GB201716830D0 (en) * | 2017-10-13 | 2017-11-29 | Cambrex Charles City Inc | New Process |
| GB201719667D0 (en) * | 2017-11-27 | 2018-01-10 | Johnson Matthey Plc | Process |
| GB2591302A (en) | 2020-01-27 | 2021-07-28 | Azad Pharma Ag | Process for the synthesis of buprenorphine |
| US20250154160A1 (en) | 2021-12-16 | 2025-05-15 | Arevipharma Gmbh | Method of making buprenorphine and precursor compounds thereof |
| EP4424687A1 (en) | 2023-03-03 | 2024-09-04 | EUROAPI Hungary Limited Liability Company | Novel process for synthesizing opioid derivatives |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3474101A (en) | 1960-09-05 | 1969-10-21 | Reckitt & Sons Ltd | Thebaine and oripavine derivatives |
| GB902659A (en) | 1961-02-02 | 1962-08-09 | J F Macfarlan & Company Ltd | A process for the production of a derivative of thebaine |
| US3763167A (en) | 1970-06-24 | 1973-10-02 | Us Army | Process of purifying oripavines |
| US3905981A (en) | 1973-10-12 | 1975-09-16 | Research Corp | N-dealkylation of tertiary amines |
| GB1593191A (en) | 1977-03-23 | 1981-07-15 | Reckitt & Colmann Prod Ltd | Derivatives of morphine |
| EP0040074B1 (en) | 1980-05-08 | 1985-07-31 | Northeastern University | N-substituted aporphines, a method of inducing emesis and a method of controlling psychosis utilising the same |
| US4613668A (en) | 1983-12-22 | 1986-09-23 | The United States Of America As Represented By The Department Of Health And Human Services | Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl |
| US5633259A (en) | 1992-09-21 | 1997-05-27 | United Biomedical, Inc. | Method for identification of low/non-addictive opioid analgesics and the use of said analgesics for treatment of opioid addiction |
| DE19606761A1 (de) | 1996-02-23 | 1997-08-28 | Bayer Ag | Verbessertes Verfahren zur Herstellung von Halogenmethylcyclopropanen und besonders reine Halogenmethylcyclopropane |
| US6291675B1 (en) | 1996-05-21 | 2001-09-18 | The United States As Represented By The Department Of Health And Human Services | Methods of o-demethylation and n-deprotection |
| KR100204659B1 (ko) | 1996-05-28 | 1999-06-15 | 강재헌 | 신규한 부프레노핀계 진통제용 화합물 |
| AUPQ968300A0 (en) | 2000-08-25 | 2000-09-21 | Glaxo Wellcome Australia Ltd | Chemical methods |
| CN1233645C (zh) | 2001-09-14 | 2005-12-28 | 中国人民解放军军事医学科学院毒物药物研究所 | 新的东罂粟碱衍生物及其医药用途 |
| US20030194420A1 (en) | 2002-04-11 | 2003-10-16 | Richard Holl | Process for loading a drug delivery device |
| GB2388369B (en) | 2002-05-10 | 2004-05-05 | Reckitt Benckiser Healthcare | Demethylation of thebaine derivative |
| GB0421687D0 (en) | 2004-09-30 | 2004-11-03 | Johnson Matthey Plc | Preparation of opiate analgesics |
| CN1939920B (zh) | 2005-09-29 | 2011-08-31 | 中国人民解放军军事医学科学院毒物药物研究所 | 东罂粟碱类化合物及其医药用途 |
| JP2009522357A (ja) | 2006-01-05 | 2009-06-11 | マリンクロッド・インコーポレイテッド | ブプレノルフィンのための出発物質としてのオリパビンの使用 |
| CA2674915C (en) | 2006-10-17 | 2015-06-30 | Penick Corporation | Process for preparing oxymorphone |
-
2009
- 2009-09-29 AU AU2009300390A patent/AU2009300390B2/en active Active
- 2009-09-29 EP EP09745146.2A patent/EP2344509B1/en active Active
- 2009-09-29 ES ES09745146.2T patent/ES2560778T3/es active Active
- 2009-09-29 PL PL09745146T patent/PL2344509T3/pl unknown
- 2009-09-29 US US12/586,855 patent/US8232397B2/en active Active
- 2009-09-29 WO PCT/US2009/005375 patent/WO2010039220A1/en not_active Ceased
- 2009-09-29 CA CA2738761A patent/CA2738761C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009300390A1 (en) | 2010-04-08 |
| US8232397B2 (en) | 2012-07-31 |
| ES2560778T3 (es) | 2016-02-22 |
| US20100087647A1 (en) | 2010-04-08 |
| EP2344509A1 (en) | 2011-07-20 |
| EP2344509B1 (en) | 2015-11-11 |
| WO2010039220A1 (en) | 2010-04-08 |
| CA2738761C (en) | 2019-10-29 |
| CA2738761A1 (en) | 2010-04-08 |
| AU2009300390B2 (en) | 2015-05-14 |
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