PL2441466T3 - Środek hamujący MIC-1 - Google Patents

Środek hamujący MIC-1

Info

Publication number
PL2441466T3
PL2441466T3 PL11183884T PL11183884T PL2441466T3 PL 2441466 T3 PL2441466 T3 PL 2441466T3 PL 11183884 T PL11183884 T PL 11183884T PL 11183884 T PL11183884 T PL 11183884T PL 2441466 T3 PL2441466 T3 PL 2441466T3
Authority
PL
Poland
Prior art keywords
mic
inhibiting agent
inhibiting
agent
Prior art date
Application number
PL11183884T
Other languages
English (en)
Inventor
Samuel Norbet Breit
Asne Rhoda Bauskin
Original Assignee
St Vincents Hospital Sydney Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35149777&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2441466(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from AU2004901957A external-priority patent/AU2004901957A0/en
Application filed by St Vincents Hospital Sydney Ltd filed Critical St Vincents Hospital Sydney Ltd
Publication of PL2441466T3 publication Critical patent/PL2441466T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/02—Nutritional disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/30—Psychoses; Psychiatry
    • G01N2800/303—Eating disorders, e.g. anorexia, bulimia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PL11183884T 2004-04-13 2005-04-13 Środek hamujący MIC-1 PL2441466T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2004901957A AU2004901957A0 (en) 2004-04-13 Method for modulating appetite
EP05729508.1A EP1734986B1 (en) 2004-04-13 2005-04-13 Method for modulating appetite
EP11183884.3A EP2441466B1 (en) 2004-04-13 2005-04-13 MIC-1 inhibiting agent

Publications (1)

Publication Number Publication Date
PL2441466T3 true PL2441466T3 (pl) 2015-01-30

Family

ID=35149777

Family Applications (2)

Application Number Title Priority Date Filing Date
PL11183884T PL2441466T3 (pl) 2004-04-13 2005-04-13 Środek hamujący MIC-1
PL15163748T PL2929891T3 (pl) 2004-04-13 2005-04-13 Sposób modulowania apetytu

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL15163748T PL2929891T3 (pl) 2004-04-13 2005-04-13 Sposób modulowania apetytu

Country Status (11)

Country Link
US (7) US8192735B2 (pl)
EP (4) EP2774620A1 (pl)
JP (4) JP5448338B2 (pl)
CA (2) CA2561877C (pl)
CY (1) CY1115731T1 (pl)
DK (2) DK2929891T3 (pl)
ES (3) ES2788868T3 (pl)
PL (2) PL2441466T3 (pl)
PT (2) PT2441466E (pl)
SI (1) SI2441466T1 (pl)
WO (1) WO2005099746A1 (pl)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2441466T3 (pl) 2004-04-13 2015-01-30 St Vincents Hospital Sydney Ltd Środek hamujący MIC-1
MX2009000914A (es) * 2006-08-04 2009-06-18 Hannover Med Hochschule Medios y metodos para evaluar el riesgo de intervenciones cardiacas basadas en el factor 15 de diferenciacion del crecimiento.
CN101854947A (zh) * 2007-08-16 2010-10-06 圣文森特医院悉尼有限公司 用于调节巨噬细胞抑制因子(mic-1)活性的药剂和方法
CN101896192A (zh) * 2007-10-09 2010-11-24 圣文森特医院悉尼有限公司 一种通过去除或灭活巨噬细胞抑制因子-1而治疗恶病质的方法
CN102203619B (zh) 2008-10-31 2015-12-16 圣文森特医院悉尼有限公司 慢性肾病中的预测方法
US10752664B2 (en) 2011-04-08 2020-08-25 Amgen Inc. Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (GDF-15)
AU2013211846A1 (en) 2012-01-26 2014-08-14 Amgen Inc. Growth differentiation factor 15 (GDF-15) polypeptides
JP6254146B2 (ja) 2012-03-27 2017-12-27 エヌジーエム バイオファーマシューティカルス，インコーポレーテッド 代謝障害を治療するための組成物および方法
AU2013322628B2 (en) 2012-09-26 2017-03-02 Julius-Maximilians-Universitat Wurzburg Monoclonal antibodies to growth and differentiation factor 15 (GDF-15)
AU2013364133B2 (en) 2012-12-21 2018-10-11 Aveo Pharmaceuticals, Inc. Anti-GDF15 antibodies
US9161966B2 (en) 2013-01-30 2015-10-20 Ngm Biopharmaceuticals, Inc. GDF15 mutein polypeptides
JP6272907B2 (ja) 2013-01-30 2018-01-31 エヌジーエム バイオファーマシューティカルズ インコーポレイテッド 代謝障害の処置における組成物及び使用方法
HUE050630T2 (hu) 2013-07-31 2020-12-28 Amgen Inc Növekedési differenciációs faktor 15 (GDF15) konstrukciók
HUE047398T2 (hu) 2014-03-26 2020-04-28 Univ Wuerzburg J Maximilians Növekedési és differenciálódási faktor 15 (GDF-15) elleni monoklonális antitestek és azok alkalmazásai rákos sorvadás és rák kezelésére
GB2524552B (en) * 2014-03-26 2017-07-12 Julius-Maximilians-Universitãt Wurzburg Monoclonal antibodies to growth and differentiation factor 15 (GDF-15), and use thereof for treating cancer
GB2524553C (en) * 2014-03-26 2017-07-19 Julius-Maximilians-Universitãt Würzburg Monoclonal antibodies to growth and differentiation factor 15 (GDF-15), and uses thereof for treating cancer cachexia
CA2952032C (en) * 2014-06-20 2023-03-14 Aveo Pharmaceuticals, Inc. Treatment of chronic kidney disease and other renal dysfunction using a gdf15 modulator
JP6910800B2 (ja) * 2014-06-20 2021-07-28 アベオ ファーマシューティカルズ， インコーポレイテッド Ｇｄｆ１５調節剤を用いたうっ血性心不全及びその他の心機能不全の治療
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
SG11201609706VA (en) * 2014-06-23 2017-01-27 Novartis Ag Site specific protein modifications
TW201613958A (en) 2014-06-24 2016-04-16 Novo Nordisk As MIC-1 fusion proteins and uses thereof
EA035581B1 (ru) 2014-07-30 2020-07-10 НДжМ БИОФАРМАСЬЮТИКАЛЗ, ИНК. Композиции и способы применения для лечения метаболических расстройств
HUE054670T2 (hu) * 2014-09-25 2021-09-28 Aveo Pharmaceuticals Inc Módszer cachexia visszafordítására és túlélés megnövelésére egy GDF15 modulátor és egy rákellenes szer adagolásával
DK3212226T3 (da) 2014-10-31 2020-06-15 Ngm Biopharmaceuticals Inc Sammensætninger og anvendelsesfremgangsmåder til behandling af metaboliske lidelser
EP3237440A1 (en) * 2014-12-22 2017-11-01 Novo Nordisk A/S Alpha-1-antitrypsin (a1at) fusion proteins and uses thereof
ES2968226T3 (es) 2015-10-02 2024-05-08 Univ Wuerzburg J Maximilians GDF-15 como marcador de diagnóstico para predecir la evolución clínica de un tratamiento con bloqueadores de puntos de control inmunitario
GB201517528D0 (en) 2015-10-02 2015-11-18 Julius Maximillians Universitãt Würzburg GDF-15 as a diagnosis marker for melanoma
EP3355919B1 (en) 2015-10-02 2022-12-07 Julius-Maximilians-Universität Würzburg Combination therapy using inhibitors of human growth and differentiation factor 15 (gdf-15) and immune checkpoint blockers
US11105818B2 (en) 2016-01-15 2021-08-31 Novo Nordisk A/S MIC-1 receptor and uses thereof
WO2017150314A1 (ja) * 2016-02-29 2017-09-08 公立大学法人横浜市立大学 去勢抵抗性前立腺癌を検出する方法及び検出試薬
TWI897070B (zh) 2016-03-31 2025-09-11 美商恩格姆生物製藥公司 結合蛋白質及其使用方法
JP7138567B2 (ja) 2016-04-27 2022-09-16 ノバルティス アーゲー 成長分化因子１５に対する抗体およびそれらの使用
WO2017202936A1 (en) 2016-05-24 2017-11-30 Novo Nordisk A/S Mic-1 compounds and use thereof
WO2018071493A1 (en) * 2016-10-12 2018-04-19 Janssen Biotech, Inc. Methods for screening for modulators of gdf15-like biological activity
EP3551214B1 (en) * 2016-12-06 2024-03-13 St Vincent's Hospital Sydney Limited Treatment of obesity and eating disorders
GB201700567D0 (en) 2017-01-12 2017-03-01 Genagon Therapeutics Ab Therapeutic agents
TWI710377B (zh) 2017-05-23 2020-11-21 丹麥商諾佛 儂迪克股份有限公司 Ｍｉｃ－１化合物及其用途
WO2019004550A1 (ko) * 2017-06-26 2019-01-03 강원대학교 산학협력단 Mic-1 단백질에 특이적으로 결합하는 항체 및 이의 용도
JP7127422B2 (ja) 2017-08-30 2022-08-30 東ソー株式会社 癌を検出する方法及び検出試薬
EP3681529A1 (en) 2017-09-10 2020-07-22 Novo Nordisk A/S Mic-1 and glp-1 for use in the treatment of obesity
CA3096097A1 (en) 2018-04-09 2019-10-17 Amgen Inc. Growth differentiation factor 15 fusion proteins
BR112021003173A2 (pt) 2018-08-20 2021-05-11 Pfizer Inc. anticorpos anti-gdf15, composições e métodos de uso
US11810670B2 (en) 2018-11-13 2023-11-07 CurieAI, Inc. Intelligent health monitoring
EP4041281B1 (en) 2019-10-04 2025-11-26 Amgen Inc. Use of gdf15 for treating cardiometabolic syndrome and other conditions
EP4065597A4 (en) 2019-11-26 2024-01-24 Yuhan Corporation LONG-ACTING GDF15 FUSION PROTEIN AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
AU2021376864A1 (en) 2020-11-10 2023-06-29 Catalym Gmbh Anti-gdf15 antibody and a dosage regimen for the treatment of cancer
KR20230165285A (ko) 2021-03-31 2023-12-05 캠브리지 엔터프라이즈 리미티드 Gdf15 신호전달의 치료적 억제제
US20240238380A1 (en) 2021-05-21 2024-07-18 Yuhan Corporation Composition for combination therapy comprising growth differentiation factor-15 variant and glucagon-like peptide-1 receptor agonist
JP2024519951A (ja) 2021-05-21 2024-05-21 ユハン コーポレーション ＧＤＦ１５変異体を含む非アルコール性脂肪性肝疾患または非アルコール性脂肪性肝炎の予防または治療用組成物｛Ｃｏｍｐｏｓｉｔｉｏｎ Ｆｏｒ Ｐｒｅｖｅｎｔｉｎｇ ｏｒ Ｔｒｅａｔｉｎｇ Ｎｏｎ－Ａｌｃｏｈｏｌｉｃ Ｆａｔｔｙ Ｌｉｖｅｒ Ｄｉｓｅａｓｅ ｏｒ Ｎｏｎ－Ａｌｃｏｈｏｌｉｃ Ｓｔｅａｔｏｈｅｐａｔｉｔｉｓ Ｃｏｍｐｒｉｓｉｎｇ Ｇｒｏｗｔｈ Ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ Ｆａｃｔｏｒ－１５ Ｖａｒｉａｎｔ｝
EP4384545A1 (en) 2021-08-10 2024-06-19 BYOMass Inc. Anti-gdf15 antibodies, compositions and uses thereof
US20250382359A1 (en) 2021-12-22 2025-12-18 Byomass Inc. Targeting gdf15-gfral pathway
WO2023154953A1 (en) 2022-02-14 2023-08-17 Ngm Biopharmaceuticals, Inc. Gdf15 polypeptides for treating and preventing autoimmune diseases

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ES2324433T3 (es) 1995-06-22 2009-08-06 St Vincent's Hospital Sydney Limited Tgf-beta novedoso similar a citocina.
AU8591198A (en) 1997-07-31 1999-02-22 Johns Hopkins University School Of Medicine, The Growth differentiation factor-15
EP2128260A3 (en) 1998-10-07 2010-06-16 STRYKER CORPORATION (a Michigan corporation) Modified TGF-beta superfamily proteins
ES2346918T3 (es) * 2000-04-20 2010-10-21 St Vincent's Hospital Sydney Limited Ensayo para diagnostico que involucra a la citoquina-1 (mic-1) inhibidora de macrofagos.
AU2001288770A1 (en) * 2000-09-08 2002-03-22 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services A non-steroidal anti-inflammatory drug activated gene with anti-tumorigenic properties
CA2390820A1 (en) * 2002-06-17 2003-12-17 St. Vincent's Hospital Sydney Limited Methods of diagnosis, prognosis and treatment of cardiovascular disease
PL2441466T3 (pl) 2004-04-13 2015-01-30 St Vincents Hospital Sydney Ltd Środek hamujący MIC-1
US7863239B2 (en) * 2005-01-24 2011-01-04 Pepscan Systems B.V. Binding compounds, immunogenic compounds and peptidomimetics
CA2752157A1 (en) 2009-02-12 2010-08-19 Stryker Corporation Peripheral administration of proteins including tgf-.beta. superfamily members for systemic treatment of disorders and disease

Also Published As

Publication number Publication date
CA2561877A1 (en) 2005-10-27
JP2014051511A (ja) 2014-03-20
ES2555956T3 (es) 2016-01-11
EP1734986B1 (en) 2015-11-11
CA2905125A1 (en) 2005-10-27
ES2518865T3 (es) 2014-11-05
US20250109192A1 (en) 2025-04-03
US20180346560A1 (en) 2018-12-06
US20090004181A1 (en) 2009-01-01
WO2005099746A1 (en) 2005-10-27
EP2441466B1 (en) 2014-07-23
JP2013209376A (ja) 2013-10-10
JP5806275B2 (ja) 2015-11-10
US20110123454A1 (en) 2011-05-26
PT2441466E (pt) 2014-09-09
ES2788868T3 (es) 2020-10-23
US8192735B2 (en) 2012-06-05
EP2929891B1 (en) 2020-03-11
EP1734986A1 (en) 2006-12-27
SI2441466T1 (sl) 2015-01-30
JP5767667B2 (ja) 2015-08-19
PT2929891T (pt) 2020-04-08
US8946146B2 (en) 2015-02-03
US20150183861A1 (en) 2015-07-02
US20160289320A1 (en) 2016-10-06
EP2929891A1 (en) 2015-10-14
US20210340243A1 (en) 2021-11-04
DK2441466T3 (da) 2014-10-27
JP5448338B2 (ja) 2014-03-19
CA2905125C (en) 2017-02-07
EP2441466A1 (en) 2012-04-18
DK2929891T3 (da) 2020-05-11
HK1215932A1 (en) 2016-09-30
HK1168274A1 (en) 2012-12-28
EP2774620A1 (en) 2014-09-10
CY1115731T1 (el) 2017-01-25
EP1734986A4 (en) 2009-07-22
CA2561877C (en) 2017-03-14
PL2929891T3 (pl) 2020-08-24
JP2007532586A (ja) 2007-11-15
JP2011190262A (ja) 2011-09-29

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