PL2452940T3 - Związek azabicykliczny i jego sól - Google Patents

Związek azabicykliczny i jego sól

Info

Publication number
PL2452940T3
PL2452940T3 PL10796921T PL10796921T PL2452940T3 PL 2452940 T3 PL2452940 T3 PL 2452940T3 PL 10796921 T PL10796921 T PL 10796921T PL 10796921 T PL10796921 T PL 10796921T PL 2452940 T3 PL2452940 T3 PL 2452940T3
Authority
PL
Poland
Prior art keywords
salt
azabicyclo compound
azabicyclo
compound
Prior art date
Application number
PL10796921T
Other languages
English (en)
Inventor
Makoto Kitade
Shuichi Ohkubo
Chihoko Yoshimura
Satoshi Yamashita
Hiromi Oshiumi
Takao Uno
Yuichi Kawai
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of PL2452940T3 publication Critical patent/PL2452940T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/08Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PL10796921T 2009-07-10 2010-07-09 Związek azabicykliczny i jego sól PL2452940T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009164196 2009-07-10
PCT/JP2010/004466 WO2011004610A1 (ja) 2009-07-10 2010-07-09 アザ二環式化合物又はその塩
EP10796921.4A EP2452940B1 (en) 2009-07-10 2010-07-09 Azabicyclo compound and salt thereof

Publications (1)

Publication Number Publication Date
PL2452940T3 true PL2452940T3 (pl) 2015-05-29

Family

ID=43429037

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10796921T PL2452940T3 (pl) 2009-07-10 2010-07-09 Związek azabicykliczny i jego sól

Country Status (18)

Country Link
US (2) US8779142B2 (pl)
EP (1) EP2452940B1 (pl)
JP (1) JP5227456B2 (pl)
KR (1) KR101609412B1 (pl)
CN (2) CN102471335B (pl)
AU (1) AU2010269674B2 (pl)
BR (1) BRPI1013999B1 (pl)
CA (1) CA2767556C (pl)
DK (1) DK2452940T3 (pl)
ES (1) ES2527222T3 (pl)
MX (1) MX2012000487A (pl)
MY (1) MY152972A (pl)
PL (1) PL2452940T3 (pl)
PT (1) PT2452940E (pl)
RU (1) RU2565078C2 (pl)
SG (1) SG177306A1 (pl)
TW (1) TWI460177B (pl)
WO (1) WO2011004610A1 (pl)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8673922B2 (en) 2010-07-15 2014-03-18 Bristol-Myers Squibb Company Azaindazole compounds
WO2012064815A1 (en) * 2010-11-12 2012-05-18 Bristol-Myers Squibb Company Substituted azaindazole compounds
ES2589557T3 (es) * 2011-01-07 2016-11-15 Taiho Pharmaceutical Co., Ltd. Nuevos derivados de indol o indazol y sales de los mismos
EP2662357B1 (en) * 2011-01-07 2016-08-03 Taiho Pharmaceutical Co., Ltd. Bicyclic compounds or salts thereof for use in the treatment of cancer
WO2013049263A1 (en) 2011-09-27 2013-04-04 Bristol-Myers Squibb Company Substituted bicyclic heteroaryl compounds
EP2867232B1 (en) 2012-06-27 2018-08-08 F.Hoffmann-La Roche Ag 5-azaindazole compounds and methods of use
EP3037424B1 (en) 2013-08-22 2017-11-08 Taiho Pharmaceutical Co., Ltd. Novel quinoline-substituted compound
DK3053578T3 (da) 2013-09-30 2021-02-01 Taiho Pharmaceutical Co Ltd Kombinationscancerterapi ved hjælp af azabicycloforbindelse
US10100095B2 (en) 2013-10-02 2018-10-16 Taiho Pharmaceutical Co., Ltd. Resistant mutant 90 kDa heat shock protein
KR102412146B1 (ko) 2015-02-11 2022-06-22 주식회사 아이엔테라퓨틱스 소디움 채널 차단제
CN107531707B (zh) * 2015-05-12 2020-01-10 大鹏药品工业株式会社 氮杂二环式化合物的结晶
JOP20190073A1 (ar) 2016-10-31 2019-04-07 Taiho Pharmaceutical Co Ltd مثبط انتقائي لمستقبل عامل نمو بشروي (egfr) لطافر إدخال exon 20
CN108976150B (zh) * 2017-06-05 2022-11-18 重庆博腾制药科技股份有限公司 一种3-乙基-4-氟苯腈的制备方法
KR102599698B1 (ko) * 2017-06-30 2023-11-07 다이호야쿠힌고교 가부시키가이샤 아자 2 고리형 화합물을 사용한 암 화학 요법
JP7065103B2 (ja) 2017-09-01 2022-05-11 大鵬薬品工業株式会社 エクソン18及び/又はエクソン21変異型egfr選択的阻害剤
KR102403289B1 (ko) 2017-09-15 2022-05-30 다이호야쿠힌고교 가부시키가이샤 Ido 의 발현이 관여하는 질환의 예방 및/또는 치료제
AU2018423606B2 (en) 2018-05-14 2024-10-10 Taiho Pharmaceutical Co., Ltd. Method of treating malignant tumor by azabicyclic compound
WO2020206608A1 (en) 2019-04-09 2020-10-15 Ranok Therapeutics (Hangzhou) Co., Ltd. Methods and compositions for targeted protein degradation
WO2021160680A1 (en) * 2020-02-11 2021-08-19 Syngenta Crop Protection Ag Pesticidally active cyclic amine compounds
CA3195464A1 (en) * 2020-10-14 2022-04-21 Weiwen Ying Methods and compositions for targeted protein degradation
CN114685492A (zh) * 2020-12-31 2022-07-01 杭州领业医药科技有限公司 Tas-116的晶型及其制备方法、药物组合物和用途
WO2022166796A1 (zh) * 2021-02-05 2022-08-11 上海齐鲁制药研究中心有限公司 嘧啶或吡啶并杂环类腺苷受体抑制剂及其制备方法和用途
CN117003754B (zh) * 2022-04-28 2025-07-25 腾讯科技(深圳)有限公司 吡咯并[2,3-d]嘧啶或吡唑并[3,4-d]嘧啶衍生物及其用途
CN119365442A (zh) 2022-06-10 2025-01-24 大鹏药品工业株式会社 氮杂双环式化合物的类似物
WO2023238929A1 (ja) 2022-06-10 2023-12-14 大鵬薬品工業株式会社 ピミテスピブを含有する医薬組成物
CN115960100B (zh) * 2022-12-28 2023-08-18 北京康立生医药技术开发有限公司 一种治疗胃肠道间质瘤药物皮咪特昔布的合成方法
WO2025041853A1 (ja) * 2023-08-24 2025-02-27 大鵬薬品工業株式会社 アザ二環式化合物と抗アンドロゲン剤を用いたがん併用療法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5451566A (en) * 1993-11-17 1995-09-19 Zeneca Limited Herbicidal pyrrolopyridine compounds
EP2145888A1 (en) * 2003-09-18 2010-01-20 Conforma Therapeutics Corporation Deazapurine derivatives as HSP90-Inhibitors
WO2005058892A1 (en) * 2003-12-19 2005-06-30 Glaxo Group Limited Pyrazolo [3,4-b] pyridine compounds, and their use as phosphodiesterase inhibitors
GB0425035D0 (en) * 2004-11-12 2004-12-15 Novartis Ag Organic compounds
AU2006247322A1 (en) * 2005-05-16 2006-11-23 Irm Llc Pyrrolopyridine derivatives as protein kinase inhibitors
EP1934185A1 (en) 2005-08-12 2008-06-25 Synta Pharmaceuticals Corporation Pyrazole compounds that modulate hsp90 activity
JP2009508872A (ja) 2005-09-16 2009-03-05 セレネックス, インコーポレイテッド カルバゾール誘導体
WO2008024978A2 (en) 2006-08-24 2008-02-28 Serenex, Inc. Tetrahydroindolone and tetrahydroindazolone derivatives
GB0617161D0 (en) 2006-08-31 2006-10-11 Vernalis R&D Ltd Enzyme inhibitors
NZ579635A (en) * 2007-03-20 2011-07-29 Curis Inc Fused amino pyridine as hsp90 inhibitors
ES2395114T3 (es) * 2007-03-27 2013-02-08 Synta Pharmaceuticals Corporation Derivados de triazinona y de diazinona útiles como inhibidores de Hsp90
WO2010106290A1 (fr) * 2009-03-19 2010-09-23 Sanofi-Aventis Derives d'indazole inhibiteurs d'hsp90, compositions les contenant et utilisation
EP2662357B1 (en) 2011-01-07 2016-08-03 Taiho Pharmaceutical Co., Ltd. Bicyclic compounds or salts thereof for use in the treatment of cancer
ES2589557T3 (es) 2011-01-07 2016-11-15 Taiho Pharmaceutical Co., Ltd. Nuevos derivados de indol o indazol y sales de los mismos

Also Published As

Publication number Publication date
EP2452940A4 (en) 2012-12-12
BRPI1013999A2 (pt) 2016-04-05
MY152972A (en) 2014-12-15
EP2452940A1 (en) 2012-05-16
US20120108589A1 (en) 2012-05-03
CN102471335A (zh) 2012-05-23
RU2012104700A (ru) 2013-08-20
CA2767556C (en) 2017-11-28
US9273045B2 (en) 2016-03-01
WO2011004610A1 (ja) 2011-01-13
BRPI1013999B1 (pt) 2020-06-02
KR20120035181A (ko) 2012-04-13
MX2012000487A (es) 2012-01-27
US8779142B2 (en) 2014-07-15
AU2010269674B2 (en) 2014-01-16
TW201105670A (en) 2011-02-16
HK1164869A1 (en) 2012-09-28
CN102471335B (zh) 2015-09-30
PT2452940E (pt) 2015-02-27
JP5227456B2 (ja) 2013-07-03
EP2452940B1 (en) 2014-12-17
SG177306A1 (en) 2012-02-28
AU2010269674A2 (en) 2012-02-16
KR101609412B1 (ko) 2016-04-05
CN104710420B (zh) 2016-07-27
AU2010269674A1 (en) 2012-01-19
RU2565078C2 (ru) 2015-10-20
TWI460177B (zh) 2014-11-11
ES2527222T3 (es) 2015-01-21
US20140303162A1 (en) 2014-10-09
JPWO2011004610A1 (ja) 2012-12-20
CN104710420A (zh) 2015-06-17
DK2452940T3 (en) 2015-01-12
CA2767556A1 (en) 2011-01-13

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