BRPI1013999A2 - composto de azabiciclo e seu sal. - Google Patents
composto de azabiciclo e seu sal.Info
- Publication number
- BRPI1013999A2 BRPI1013999A2 BRPI1013999A BRPI1013999A BRPI1013999A2 BR PI1013999 A2 BRPI1013999 A2 BR PI1013999A2 BR PI1013999 A BRPI1013999 A BR PI1013999A BR PI1013999 A BRPI1013999 A BR PI1013999A BR PI1013999 A2 BRPI1013999 A2 BR PI1013999A2
- Authority
- BR
- Brazil
- Prior art keywords
- salt
- azabicyclic compound
- azabicyclic
- compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009-164196 | 2009-07-10 | ||
| JP2009164196 | 2009-07-10 | ||
| PCT/JP2010/004466 WO2011004610A1 (ja) | 2009-07-10 | 2010-07-09 | アザ二環式化合物又はその塩 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI1013999A2 true BRPI1013999A2 (pt) | 2016-04-05 |
| BRPI1013999B1 BRPI1013999B1 (pt) | 2020-06-02 |
Family
ID=43429037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1013999-0A BRPI1013999B1 (pt) | 2009-07-10 | 2010-07-09 | Composto de azabiciclo e um sal deste, produto farmacêutico e composição farmacêutica compreendendo dito composto e uso do mesmo para tratar câncer |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8779142B2 (pt) |
| EP (1) | EP2452940B1 (pt) |
| JP (1) | JP5227456B2 (pt) |
| KR (1) | KR101609412B1 (pt) |
| CN (2) | CN102471335B (pt) |
| AU (1) | AU2010269674B2 (pt) |
| BR (1) | BRPI1013999B1 (pt) |
| CA (1) | CA2767556C (pt) |
| DK (1) | DK2452940T3 (pt) |
| ES (1) | ES2527222T3 (pt) |
| MX (1) | MX2012000487A (pt) |
| MY (1) | MY152972A (pt) |
| PL (1) | PL2452940T3 (pt) |
| PT (1) | PT2452940E (pt) |
| RU (1) | RU2565078C2 (pt) |
| SG (1) | SG177306A1 (pt) |
| TW (1) | TWI460177B (pt) |
| WO (1) | WO2011004610A1 (pt) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103140490A (zh) * | 2010-07-15 | 2013-06-05 | 百时美施贵宝公司 | 氮杂吲唑化合物 |
| US9266880B2 (en) | 2010-11-12 | 2016-02-23 | Bristol-Myers Squibb Company | Substituted azaindazole compounds |
| TW201309672A (zh) * | 2011-01-07 | 2013-03-01 | Taiho Pharmaceutical Co Ltd | 新穎吲哚、吲唑衍生物或其鹽 |
| BR112013017520A2 (pt) * | 2011-01-07 | 2016-09-27 | Taiho Pharmaceutical Co Ltd | composto bicíclico ou sal do mesmo |
| US8969586B2 (en) | 2011-09-27 | 2015-03-03 | Bristol-Myers Squibb Company | Substituted bicyclic heteroaryl compounds |
| BR112014029674A2 (pt) | 2012-06-27 | 2017-06-27 | Hoffmann La Roche | composto, composição farmacêutica, método para o tratamento de uma doença, utilização de um composto, conjunto para o tratamento de uma condição mediada pela quinase pim e invenção |
| EP3037424B1 (en) | 2013-08-22 | 2017-11-08 | Taiho Pharmaceutical Co., Ltd. | Novel quinoline-substituted compound |
| HUE053617T2 (hu) | 2013-09-30 | 2021-07-28 | Taiho Pharmaceutical Co Ltd | Kombinációs rákterápia azabiciklo vegyületet felhasználva |
| CN105793421A (zh) * | 2013-10-02 | 2016-07-20 | 大鹏药品工业株式会社 | 耐性突变型90kDa热休克蛋白质 |
| KR102412146B1 (ko) | 2015-02-11 | 2022-06-22 | 주식회사 아이엔테라퓨틱스 | 소디움 채널 차단제 |
| JP6537601B2 (ja) * | 2015-05-12 | 2019-07-03 | 大鵬薬品工業株式会社 | アザ二環式化合物の結晶 |
| IL266239B2 (en) | 2016-10-31 | 2023-10-01 | Taiho Pharmaceutical Co Ltd | A selective inhibitor of EGFR with an EXON 20 insertion mutation |
| CN108976150B (zh) * | 2017-06-05 | 2022-11-18 | 重庆博腾制药科技股份有限公司 | 一种3-乙基-4-氟苯腈的制备方法 |
| ES3040843T3 (en) | 2017-06-30 | 2025-11-05 | Taiho Pharmaceutical Co Ltd | Chemotherapy for cancer using azabicyclo compound |
| HUE066587T2 (hu) | 2017-09-01 | 2024-08-28 | Taiho Pharmaceutical Co Ltd | Exon-18- és/vagy exon-21-mutáns EGFR-szelektív inhibitor |
| MA50254A (fr) | 2017-09-15 | 2020-07-22 | Taiho Pharmaceutical Co Ltd | Agent prophylactique et/ou thérapeutique pour des maladies impliquant l'expression de l'ido |
| WO2019220512A1 (ja) | 2018-05-14 | 2019-11-21 | 大鵬薬品工業株式会社 | アザ二環式化合物による悪性腫瘍の治療法 |
| WO2020206608A1 (en) | 2019-04-09 | 2020-10-15 | Ranok Therapeutics (Hangzhou) Co., Ltd. | Methods and compositions for targeted protein degradation |
| BR112022015723A2 (pt) * | 2020-02-11 | 2023-02-14 | Syngenta Crop Protection Ag | Compostos de amina cíclica pesticidamente ativos |
| KR20230088763A (ko) * | 2020-10-14 | 2023-06-20 | 라녹 테라퓨틱스 (항저우) 컴퍼니, 리미티드 | 표적 단백질 분해를 위한 방법 및 조성물 |
| CN114685492A (zh) * | 2020-12-31 | 2022-07-01 | 杭州领业医药科技有限公司 | Tas-116的晶型及其制备方法、药物组合物和用途 |
| CN116981669B (zh) * | 2021-02-05 | 2024-08-30 | 上海齐鲁制药研究中心有限公司 | 嘧啶或吡啶并杂环类腺苷受体抑制剂及其制备方法和用途 |
| CN117003754B (zh) * | 2022-04-28 | 2025-07-25 | 腾讯科技（深圳）有限公司 | 吡咯并[2,3-d]嘧啶或吡唑并[3,4-d]嘧啶衍生物及其用途 |
| EP4538257A1 (en) | 2022-06-10 | 2025-04-16 | Taiho Pharmaceutical Co., Ltd. | Analogues of azabicyclic compounds |
| JPWO2023238929A1 (pt) | 2022-06-10 | 2023-12-14 | ||
| CN115960100B (zh) * | 2022-12-28 | 2023-08-18 | 北京康立生医药技术开发有限公司 | 一种治疗胃肠道间质瘤药物皮咪特昔布的合成方法 |
| AU2024328480A1 (en) | 2023-08-24 | 2026-04-09 | Taiho Pharmaceutical Co., Ltd. | Cancer combination therapy using aza bicyclic compound and antiandrogen agent |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5451566A (en) * | 1993-11-17 | 1995-09-19 | Zeneca Limited | Herbicidal pyrrolopyridine compounds |
| KR20060070572A (ko) * | 2003-09-18 | 2006-06-23 | 콘포마 세러퓨틱스 코포레이션 | Ｈｓｐ90-저해제로서의 신규 헤테로시클릭 화합물 |
| US20070111995A1 (en) * | 2003-12-19 | 2007-05-17 | Allen David G | Pyrazolo [3,4-B] pyridine Compounds and Their Use as Phosphodiesterase Inhibitors |
| GB0425035D0 (en) * | 2004-11-12 | 2004-12-15 | Novartis Ag | Organic compounds |
| DE602006014540D1 (en) * | 2005-05-16 | 2010-07-08 | Irm Llc | Pyrrolopyridinderivate als proteinkinaseinhibitoren |
| JP5178515B2 (ja) | 2005-08-12 | 2013-04-10 | シンタ ファーマシューティカルズ コーポレーション | Ｈｓｐ９０活性を調節するピラゾール化合物 |
| EP1924557A2 (en) | 2005-09-16 | 2008-05-28 | Serenex, Inc. | Carbazole derivatives |
| US20080119457A1 (en) | 2006-08-24 | 2008-05-22 | Serenex, Inc. | Benzene, Pyridine, and Pyridazine Derivatives |
| GB0617161D0 (en) | 2006-08-31 | 2006-10-11 | Vernalis R&D Ltd | Enzyme inhibitors |
| JP5401329B2 (ja) * | 2007-03-20 | 2014-01-29 | キュリス，インコーポレイテッド | Ｈｓｐ９０インヒビターとしての縮合アミノピリジン |
| AU2008232354B9 (en) * | 2007-03-27 | 2012-07-26 | Synta Pharmaceuticals Corp. | Triazinone and diazinone derivatives useful as Hsp90 inhibitors |
| KR20110128942A (ko) | 2009-03-19 | 2011-11-30 | 사노피 | Ｈｓｐ９０ 억제 인다졸 유도체, 그를 함유하는 조성물 및 그의 용도 |
| TW201309672A (zh) | 2011-01-07 | 2013-03-01 | Taiho Pharmaceutical Co Ltd | 新穎吲哚、吲唑衍生物或其鹽 |
| BR112013017520A2 (pt) | 2011-01-07 | 2016-09-27 | Taiho Pharmaceutical Co Ltd | composto bicíclico ou sal do mesmo |
-
2010
- 2010-07-09 TW TW099122759A patent/TWI460177B/zh active
- 2010-07-09 PL PL10796921T patent/PL2452940T3/pl unknown
- 2010-07-09 AU AU2010269674A patent/AU2010269674B2/en active Active
- 2010-07-09 EP EP10796921.4A patent/EP2452940B1/en active Active
- 2010-07-09 CA CA2767556A patent/CA2767556C/en active Active
- 2010-07-09 BR BRPI1013999-0A patent/BRPI1013999B1/pt active IP Right Grant
- 2010-07-09 MY MYPI2011005616 patent/MY152972A/en unknown
- 2010-07-09 CN CN201080031144.3A patent/CN102471335B/zh active Active
- 2010-07-09 MX MX2012000487A patent/MX2012000487A/es active IP Right Grant
- 2010-07-09 DK DK10796921.4T patent/DK2452940T3/en active
- 2010-07-09 US US13/378,527 patent/US8779142B2/en active Active
- 2010-07-09 SG SG2011094851A patent/SG177306A1/en unknown
- 2010-07-09 ES ES10796921.4T patent/ES2527222T3/es active Active
- 2010-07-09 PT PT107969214T patent/PT2452940E/pt unknown
- 2010-07-09 JP JP2011521828A patent/JP5227456B2/ja active Active
- 2010-07-09 RU RU2012104700/04A patent/RU2565078C2/ru active
- 2010-07-09 CN CN201510129170.4A patent/CN104710420B/zh active Active
- 2010-07-09 KR KR1020127000485A patent/KR101609412B1/ko active Active
- 2010-07-09 WO PCT/JP2010/004466 patent/WO2011004610A1/ja not_active Ceased
-
2014
- 2014-04-01 US US14/242,063 patent/US9273045B2/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 09/07/2010, OBSERVADAS AS CONDICOES LEGAIS. |