PL2615089T3 - Związki pirazolochinolinowe - Google Patents
Związki pirazolochinolinoweInfo
- Publication number
- PL2615089T3 PL2615089T3 PL11823618.1T PL11823618T PL2615089T3 PL 2615089 T3 PL2615089 T3 PL 2615089T3 PL 11823618 T PL11823618 T PL 11823618T PL 2615089 T3 PL2615089 T3 PL 2615089T3
- Authority
- PL
- Poland
- Prior art keywords
- pyrazoloquinoline
- compounds
- pyrazoloquinoline compounds
- Prior art date
Links
- UXYHZIYEDDINQH-UHFFFAOYSA-N C1=CNC2=C3C=NN=C3C=CC2=C1 Chemical class C1=CNC2=C3C=NN=C3C=CC2=C1 UXYHZIYEDDINQH-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010200403 | 2010-09-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2615089T3 true PL2615089T3 (pl) | 2016-10-31 |
Family
ID=45810740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11823618.1T PL2615089T3 (pl) | 2010-09-07 | 2011-09-07 | Związki pirazolochinolinowe |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8822448B2 (pl) |
| EP (1) | EP2615089B1 (pl) |
| JP (1) | JP5888237B2 (pl) |
| KR (1) | KR101860583B1 (pl) |
| CN (1) | CN103097383B (pl) |
| BR (1) | BR112013005444B1 (pl) |
| CA (1) | CA2810696C (pl) |
| CY (1) | CY1117547T1 (pl) |
| DK (1) | DK2615089T3 (pl) |
| EA (1) | EA023493B1 (pl) |
| ES (1) | ES2583528T3 (pl) |
| HR (1) | HRP20160473T1 (pl) |
| HU (1) | HUE028038T2 (pl) |
| MX (1) | MX2013002584A (pl) |
| PL (1) | PL2615089T3 (pl) |
| RS (1) | RS54834B1 (pl) |
| SI (1) | SI2615089T1 (pl) |
| WO (1) | WO2012033144A1 (pl) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9169246B2 (en) * | 2011-09-26 | 2015-10-27 | Sanofi | Pyrazoloquinolinone derivatives, preparation thereof and therapeutic use thereof |
| ES2527188T3 (es) * | 2011-09-26 | 2015-01-21 | Sanofi | Derivados de pirazolquinolinona, su preparación y su uso terapéutico |
| JP6042060B2 (ja) * | 2011-09-26 | 2016-12-14 | サノフイ | ピラゾロキノリノン誘導体、その調製および治療上の使用 |
| PL2769980T3 (pl) | 2011-10-07 | 2016-07-29 | Eisai R&D Man Co Ltd | Pochodna pirazolochinoliny jako inhibitory PDE9 |
| CN102786525B (zh) | 2012-08-08 | 2014-12-17 | 中山大学 | N-取代吡唑并[3,4-d]嘧啶酮类化合物、其制备方法及其应用 |
| AU2014250392B2 (en) * | 2013-04-05 | 2018-03-01 | Eisai R&D Management Co., Ltd. | Salt of pyrazoloquinoline derivative, and crystal thereof |
| PE20151718A1 (es) | 2013-04-05 | 2015-11-22 | Eisai Randd Man Co Ltd | Compuestos piridinilpirazoloquinolina |
| US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
| AR102849A1 (es) * | 2015-03-09 | 2017-03-29 | Astellas Pharma Inc | Compuesto de piridina bicíclica |
| US10919914B2 (en) | 2016-06-08 | 2021-02-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| CN110545812A (zh) | 2017-06-01 | 2019-12-06 | 卫材R&D管理有限公司 | 包含pde9抑制剂的药物组合物 |
| IL270394B (en) | 2017-06-01 | 2022-08-01 | Eisai R&D Man Co Ltd | Dementia therapeutic agent combining pyrazoloquinoline derivative and memantine |
| CA3061884A1 (en) | 2017-06-01 | 2019-10-29 | Eisai R&D Management Co., Ltd. | Lewy body disease therapeutic agent containing pyrazoloquinoline derivative |
| SG11201909595VA (en) | 2017-06-01 | 2019-11-28 | Eisai R&D Man Co Ltd | Dementia therapeutic agent combining pyrazoloquinoline derivative and donepezil |
| US20240368133A1 (en) * | 2021-07-30 | 2024-11-07 | Confo Therapeutics N.V. | Compounds for the Treatment of Pain, in Particular, Neuropathic Pain, and/or Other Diseases or Disorders that are Associated with AT2R and/or AT2R Mediated Signaling |
| KR20240101561A (ko) | 2021-10-14 | 2024-07-02 | 인사이트 코포레이션 | Kras의 저해제로서의 퀴놀린 화합물 |
| KR20240161147A (ko) | 2022-03-14 | 2024-11-12 | 슬랩 파마슈티컬스 엘엘씨 | 다중 사이클릭 화합물 |
| WO2025036472A1 (en) * | 2023-08-16 | 2025-02-20 | Pharmaengine, Inc. | Spirocyclic mta-cooperative prmts inhibitor |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5192768A (en) | 1990-09-14 | 1993-03-09 | Kyowa Hakko Kogyo Co., Ltd. | Pyrazoloquinoline derivatives |
| JPH05132484A (ja) * | 1991-04-26 | 1993-05-28 | Otsuka Pharmaceut Factory Inc | ピラゾロキノリン及びピラゾロナフチリジン誘導体 |
| JP2005508978A (ja) | 2001-11-02 | 2005-04-07 | ファイザー・プロダクツ・インク | Ｐｄｅ９阻害薬によるインスリン抵抗性症候群及び２型糖尿病の治療 |
| HN2002000317A (es) | 2001-11-02 | 2003-05-21 | Pfizer | Inhibidores de pde9 para tratamiento de trastornos cardiovasculares |
| DE10238723A1 (de) | 2002-08-23 | 2004-03-11 | Bayer Ag | Phenyl-substituierte Pyrazolyprimidine |
| NZ541232A (en) | 2003-01-09 | 2008-02-29 | Astellas Pharma Inc | Pyrrolopyridazine derivatives |
| US20050245563A1 (en) | 2003-05-29 | 2005-11-03 | Millennium Pharmaceuticals, Inc. | Chk-1 inhibitors |
| JP2006045118A (ja) | 2004-08-04 | 2006-02-16 | Mochida Pharmaceut Co Ltd | 新規ピラゾロキノロン誘導体 |
| CA2612176C (en) | 2005-06-14 | 2015-02-17 | Aska Pharmaceutical Co., Ltd. | Dihydrothieno[2,3-d]pyramidine-6-carboxylic acid derivatives as pde9 inhibitors |
| WO2007115232A2 (en) | 2006-03-30 | 2007-10-11 | Chemocentryx, Inc. | Cxcr4 modulators |
| JP5193866B2 (ja) | 2006-08-08 | 2013-05-08 | あすか製薬株式会社 | キナゾリン誘導体 |
| EP2123301A4 (en) | 2006-12-13 | 2010-11-03 | Aska Pharm Co Ltd | Therapeutic agent for urinary tract disease |
| WO2008072779A1 (ja) * | 2006-12-13 | 2008-06-19 | Aska Pharmaceutical Co., Ltd. | キノキサリン誘導体 |
| MX2009011830A (es) | 2007-05-11 | 2009-11-13 | Pfizer | Compuestos amino-heterociclicos. |
| JP5498392B2 (ja) | 2007-11-30 | 2014-05-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １，５−ジヒドロ−ピラゾロ［３，４−ｄ］ピリミジン−４−オン誘導体及びｃｎｓ障害の治療のためのｐｄｅ９ａモジュレーターとしてのそれらの使用 |
| UA105362C2 (en) | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
| CN102143965A (zh) | 2008-09-08 | 2011-08-03 | 贝林格尔.英格海姆国际有限公司 | 吡唑并嘧啶酮及其在治疗中枢神经系统疾病中的用途 |
| US9259564B2 (en) | 2009-01-22 | 2016-02-16 | Avent, Inc. | Enteral feeding assembly with lock assembly |
| TWI404721B (zh) | 2009-01-26 | 2013-08-11 | Pfizer | 胺基－雜環化合物 |
-
2011
- 2011-09-07 HR HRP20160473TT patent/HRP20160473T1/hr unknown
- 2011-09-07 EP EP11823618.1A patent/EP2615089B1/en active Active
- 2011-09-07 BR BR112013005444-1A patent/BR112013005444B1/pt not_active IP Right Cessation
- 2011-09-07 ES ES11823618.1T patent/ES2583528T3/es active Active
- 2011-09-07 CA CA2810696A patent/CA2810696C/en active Active
- 2011-09-07 CN CN201180043183.XA patent/CN103097383B/zh not_active Expired - Fee Related
- 2011-09-07 JP JP2012533012A patent/JP5888237B2/ja not_active Expired - Fee Related
- 2011-09-07 MX MX2013002584A patent/MX2013002584A/es active IP Right Grant
- 2011-09-07 RS RS20160364A patent/RS54834B1/sr unknown
- 2011-09-07 DK DK11823618.1T patent/DK2615089T3/en active
- 2011-09-07 SI SI201130826A patent/SI2615089T1/sl unknown
- 2011-09-07 HU HUE11823618A patent/HUE028038T2/en unknown
- 2011-09-07 EA EA201390353A patent/EA023493B1/ru not_active IP Right Cessation
- 2011-09-07 KR KR1020137005776A patent/KR101860583B1/ko not_active Expired - Fee Related
- 2011-09-07 PL PL11823618.1T patent/PL2615089T3/pl unknown
- 2011-09-07 WO PCT/JP2011/070410 patent/WO2012033144A1/ja not_active Ceased
-
2013
- 2013-03-07 US US13/788,907 patent/US8822448B2/en active Active
-
2016
- 2016-05-24 CY CY20161100451T patent/CY1117547T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2615089A4 (en) | 2014-01-01 |
| KR101860583B1 (ko) | 2018-05-23 |
| JP5888237B2 (ja) | 2016-03-16 |
| EP2615089B1 (en) | 2016-04-27 |
| EA201390353A1 (ru) | 2013-08-30 |
| BR112013005444A2 (pt) | 2017-09-19 |
| CA2810696A1 (en) | 2012-03-15 |
| JPWO2012033144A1 (ja) | 2014-01-20 |
| MX2013002584A (es) | 2013-04-29 |
| RS54834B1 (sr) | 2016-10-31 |
| HRP20160473T1 (hr) | 2016-07-29 |
| US20130225553A1 (en) | 2013-08-29 |
| WO2012033144A1 (ja) | 2012-03-15 |
| BR112013005444B1 (pt) | 2019-07-09 |
| CN103097383B (zh) | 2015-09-16 |
| HUE028038T2 (en) | 2016-11-28 |
| CA2810696C (en) | 2018-09-18 |
| US8822448B2 (en) | 2014-09-02 |
| ES2583528T3 (es) | 2016-09-21 |
| SI2615089T1 (sl) | 2016-08-31 |
| KR20130106358A (ko) | 2013-09-27 |
| EP2615089A1 (en) | 2013-07-17 |
| CY1117547T1 (el) | 2017-04-26 |
| EA023493B1 (ru) | 2016-06-30 |
| CN103097383A (zh) | 2013-05-08 |
| DK2615089T3 (en) | 2016-06-06 |
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