PL2718416T3 - Namnażanie komórek macierzystych w bioreaktorach włóknisto-kapilarnych - Google Patents

Namnażanie komórek macierzystych w bioreaktorach włóknisto-kapilarnych

Info

Publication number
PL2718416T3
PL2718416T3 PL12727636T PL12727636T PL2718416T3 PL 2718416 T3 PL2718416 T3 PL 2718416T3 PL 12727636 T PL12727636 T PL 12727636T PL 12727636 T PL12727636 T PL 12727636T PL 2718416 T3 PL2718416 T3 PL 2718416T3
Authority
PL
Poland
Prior art keywords
expansion
stem cells
hollow fiber
fiber bioreactors
bioreactors
Prior art date
Application number
PL12727636T
Other languages
English (en)
Inventor
Jozef Albert Martha Pinxteren
David CRAEYE
Original Assignee
ReGenesys BVBA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ReGenesys BVBA filed Critical ReGenesys BVBA
Publication of PL2718416T3 publication Critical patent/PL2718416T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/06—Tubular
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/10—Hollow fibers or tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/16—Hollow fibers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/00—3D culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Dispersion Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PL12727636T 2011-06-06 2012-06-06 Namnażanie komórek macierzystych w bioreaktorach włóknisto-kapilarnych PL2718416T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161493737P 2011-06-06 2011-06-06
EP12727636.8A EP2718416B1 (en) 2011-06-06 2012-06-06 Expansion of stem cells in hollow fiber bioreactors
PCT/EP2012/060690 WO2012168295A1 (en) 2011-06-06 2012-06-06 Expansion of stem cells in hollow fiber bioreactors

Publications (1)

Publication Number Publication Date
PL2718416T3 true PL2718416T3 (pl) 2020-05-18

Family

ID=46298394

Family Applications (1)

Application Number Title Priority Date Filing Date
PL12727636T PL2718416T3 (pl) 2011-06-06 2012-06-06 Namnażanie komórek macierzystych w bioreaktorach włóknisto-kapilarnych

Country Status (15)

Country Link
US (3) US20120308531A1 (pl)
EP (2) EP2718416B1 (pl)
JP (6) JP6182135B2 (pl)
KR (2) KR102073530B1 (pl)
CN (2) CN103732733A (pl)
AU (3) AU2012266404B2 (pl)
BR (1) BR112013031368B1 (pl)
CA (1) CA2837419C (pl)
DK (1) DK2718416T3 (pl)
ES (1) ES2763331T3 (pl)
HU (1) HUE047474T2 (pl)
IL (2) IL229608A0 (pl)
PL (1) PL2718416T3 (pl)
SG (3) SG195299A1 (pl)
WO (1) WO2012168295A1 (pl)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009205886B2 (en) 2008-01-18 2015-08-27 Katholieke Universiteit Leuven Stem cell aggregates and methods for making and using
SG185526A1 (en) 2010-05-12 2012-12-28 Abt Holding Co Modulation of splenocytes in cell therapy
WO2012048276A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
PL2718416T3 (pl) * 2011-06-06 2020-05-18 ReGenesys BVBA Namnażanie komórek macierzystych w bioreaktorach włóknisto-kapilarnych
IL289870B2 (en) 2013-04-12 2023-03-01 Lafrancesca Saverio Improving organs for transplantation
WO2015073913A1 (en) 2013-11-16 2015-05-21 Terumo Bct, Inc. Expanding cells in a bioreactor
NL2011895C2 (en) * 2013-12-04 2015-06-08 Mikhail Alexandrovich Ponomarenko Fluidic device and perfusion system for in vitro tissue reconstruction.
DE102013226042A1 (de) * 2013-12-16 2015-06-18 Helmholtz-Zentrum Dresden - Rossendorf E.V. Vorrichtung und Verfahren zur Gewinnung von 2- und 3-wertigen Metallionen aus primären und sekundären Rohstoffen mit Hilfe von mikrobiellen Metaboliten
WO2015148704A1 (en) 2014-03-25 2015-10-01 Terumo Bct, Inc. Passive replacement of media
US10625234B2 (en) 2014-08-28 2020-04-21 StemoniX Inc. Method of fabricating cell arrays and uses thereof
EP3198006B1 (en) * 2014-09-26 2021-03-24 Terumo BCT, Inc. Scheduled feed
SG11201705866XA (en) * 2015-01-26 2017-08-30 Ube Industries Method, device and kit for mass cultivation of cells using polyimide porous membrane
EP3291822A1 (en) 2015-05-05 2018-03-14 Katholieke Universiteit Leuven Improved methods for pancreatic islet transplantation
WO2016183350A1 (en) * 2015-05-13 2016-11-17 Terumobct, Inc. Cell expansion
US11248212B2 (en) 2015-06-30 2022-02-15 StemoniX Inc. Surface energy directed cell self assembly
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
US10760053B2 (en) 2015-10-15 2020-09-01 StemoniX Inc. Method of manufacturing or differentiating mammalian pluripotent stem cells or progenitor cells using a hollow fiber bioreactor
NZ745530A (en) 2016-01-21 2023-03-31 Abt Holding Co Stem cells for wound healing
DK3430119T3 (da) 2016-03-14 2023-09-18 Omnibrx Biotechnologies Private Ltd Et bioreaktorsystem og dets funktion
CN105754948A (zh) * 2016-04-15 2016-07-13 浙江大学 结肠癌细胞的体外拟组织化培养方法
JP6987080B2 (ja) 2016-05-05 2021-12-22 サウスウェスト リサーチ インスティテュート 細胞増殖のための三次元バイオリアクター及び関連用途
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
FR3053051B1 (fr) 2016-06-24 2022-11-11 Cellprothera Cassette et automate de culture cellulaire
CN108384717A (zh) 2017-02-03 2018-08-10 财团法人工业技术研究院 细胞培养载体模块与细胞培养系统
CN117247899A (zh) 2017-03-31 2023-12-19 泰尔茂比司特公司 细胞扩增
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
WO2019051225A1 (en) * 2017-09-11 2019-03-14 Symbiocelltech, Llc ADAPTATION OF HOLLOW FIBER CELL CELL TECHNOLOGY FOR THE PREPARATION OF NEO-ISLANDS OR EXOSOMES FROM STEM CELLS
US20210163872A1 (en) * 2018-01-12 2021-06-03 Rutgers, The State University Of New Jersey Cell Reprogramming Therapy
US11149244B2 (en) 2018-04-04 2021-10-19 Southwest Research Institute Three-dimensional bioreactor for T-cell activation and expansion for immunotherapy
CA3100776A1 (en) * 2018-05-18 2019-11-21 Children's National Medical Center System of cell expansion and methods of using the same
FR3081168B1 (fr) * 2018-05-21 2022-03-11 Univ Bordeaux Systeme de culture cellulaire en bioreacteur
JP7376576B2 (ja) 2018-09-24 2023-11-08 サウスウェスト リサーチ インスティテュート 三次元バイオリアクター
WO2020097559A2 (en) * 2018-11-08 2020-05-14 University Of Notre Dame Du Lac Catalytic hydrogel membrane reactor for treatment of aqueous contaminants
CN109679834B (zh) * 2019-01-07 2020-06-05 赵涌 用于体外规模化生产红细胞的中空纤维管和方法
GB201906298D0 (en) * 2019-05-03 2019-06-19 Arborea Ltd Bioreactor device and methods
CN110117527A (zh) * 2019-05-15 2019-08-13 刘宝全 一种干细胞代谢废物的强化排出方法
EP4061923A4 (en) * 2019-11-22 2024-01-03 Cutiss AG Methods and systems for producing skin grafts
US11492580B2 (en) 2020-05-12 2022-11-08 Southwest Research Institute Method using a three-dimensional bioprocessor
KR20210138976A (ko) * 2020-05-13 2021-11-22 아주대학교산학협력단 중공섬유와 나노섬유로 만들어진 나노시트 복합체를 이용한 바이오리액터
JP7798804B2 (ja) * 2020-06-10 2026-01-14 武田薬品工業株式会社 ウイルス形質導入のための半自動化ホローファイバーシステム
AU2022205633A1 (en) * 2021-01-08 2023-07-20 Shayne Guiliano Methods for culturing antibody secreting cells
EP4314244B1 (en) 2021-03-23 2025-07-23 Terumo BCT, Inc. Cell capture and expansion
AU2022377625B2 (en) 2021-10-28 2025-01-02 Southwest Research Institute Devices for cell separation
CN113736658B (zh) * 2021-11-03 2022-01-25 北京国卫生物科技有限公司 人脐带间充质干细胞长期大规模扩增生物反应系统
JP2024537531A (ja) 2021-11-05 2024-10-10 株式会社ヘリオス 拡大培養したイヌ前駆細胞および関連する方法
US12209689B2 (en) 2022-02-28 2025-01-28 Terumo Kabushiki Kaisha Multiple-tube pinch valve assembly
US20250207098A1 (en) * 2022-03-29 2025-06-26 National University Corporation Tokai National Higher Education And Research System Method for cultivating mesenchymal stem cell
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device
US20240076597A1 (en) * 2022-09-02 2024-03-07 Terumo Bct, Inc. Methods for cell expansion, differentiation, and/or harvesting of natural killer cells using hollow-fiber membranes
WO2024209200A1 (en) 2023-04-06 2024-10-10 Kalvotech Limited Hollow fibres
US20250283043A1 (en) * 2024-03-11 2025-09-11 Terumo Bct, Inc. Methods for differentiation of induced pluripotent stem cells using hollow fiber bioreactors

Family Cites Families (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3883393A (en) 1972-05-18 1975-05-13 Us Health Education & Welfare Cell culture on semi-permeable tubular membranes
US3821087A (en) 1972-05-18 1974-06-28 Dedrick R Cell culture on semi-permeable tubular membranes
US3997396A (en) 1973-07-02 1976-12-14 Monsanto Company Method for the in vitro propagation and maintenance of cells
US4200689A (en) 1977-11-11 1980-04-29 United States Of America Method of cell culture using a dual circuit, woven artificial capillary bundle
US4184922A (en) 1977-11-11 1980-01-22 The Government Of The United States Dual circuit, woven artificial capillary bundle for cell culture
US4220725A (en) 1978-04-03 1980-09-02 United States Of America Capillary cell culture device
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
US4804628A (en) 1984-10-09 1989-02-14 Endotronics, Inc. Hollow fiber cell culture device and method of operation
US5192553A (en) 1987-11-12 1993-03-09 Biocyte Corporation Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use
US4999298A (en) 1988-04-27 1991-03-12 W. R. Grace & Co.-Conn. Hollow fiber bioreactor culture system and method
JPH04500909A (ja) 1988-09-21 1992-02-20 アニマル　バイオテクノロジー　ケンブリッジ　リミティド 家畜からの多能性胚細胞系の誘導
US5162225A (en) 1989-03-17 1992-11-10 The Dow Chemical Company Growth of cells in hollow fibers in an agitated vessel
US7037721B1 (en) 1990-01-29 2006-05-02 Hy-Gene Biomedical, Inc. Protein-free defined media for the growth of normal human keratinocytes
US5656421A (en) 1990-02-15 1997-08-12 Unisyn Technologies, Inc. Multi-bioreactor hollow fiber cell propagation system and method
US5126238A (en) 1990-02-15 1992-06-30 Unisyn Fibertec Corporation Hollow fiber cell propagation system and method
US5061620A (en) 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5635387A (en) 1990-04-23 1997-06-03 Cellpro, Inc. Methods and device for culturing human hematopoietic cells and their precursors
AU7954191A (en) 1990-05-30 1991-12-31 Cellco, Inc. Culturing bone marrow cells for adoptive immunotherapy
US5811094A (en) 1990-11-16 1998-09-22 Osiris Therapeutics, Inc. Connective tissue regeneration using human mesenchymal stem cell preparations
US5837539A (en) 1990-11-16 1998-11-17 Osiris Therapeutics, Inc. Monoclonal antibodies for human mesenchymal stem cells
GB2254289B (en) 1991-04-05 1995-03-22 Gerber Garment Technology Inc Readily transferrable adherent tape and methods of use and making
US5851832A (en) 1991-07-08 1998-12-22 Neurospheres, Ltd. In vitro growth and proliferation of multipotent neural stem cells and their progeny
AU2882992A (en) 1991-11-06 1993-06-07 Arthur A. Axelrad Cell culture medium
US5433909A (en) 1992-03-13 1995-07-18 Atrium Medical Corporation Method of making controlled porosity expanded polytetrafluoroethylene products
US5460964A (en) 1992-04-03 1995-10-24 Regents Of The University Of Minnesota Method for culturing hematopoietic cells
US5340740A (en) 1992-05-15 1994-08-23 North Carolina State University Method of producing an avian embryonic stem cell culture and the avian embryonic stem cell culture produced by the process
AU4543193A (en) 1992-06-22 1994-01-24 Henry E. Young Scar inhibitory factor and use thereof
US5849553A (en) 1992-07-27 1998-12-15 California Institute Of Technology Mammalian multipotent neural stem cells
US5564183A (en) 1992-09-30 1996-10-15 Matsushita Electric Industrial Co., Ltd. Producing system of printed circuit board and method therefor
US7153684B1 (en) 1992-10-08 2006-12-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
US5453357A (en) 1992-10-08 1995-09-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
US5766951A (en) 1992-11-12 1998-06-16 Quality Biological, Inc. Serum-free medium supporting growth and proliferation of normal bone marrow cells
US5872094A (en) 1993-01-06 1999-02-16 The General Hospital Corporation Method for attaching cartilaginous tissue, cartilage matrix protein or link protein to a surface
US5766948A (en) 1993-01-06 1998-06-16 The Regents Of The University Of California Method for production of neuroblasts
AU7564494A (en) 1993-08-13 1995-03-14 Smith & Nephew Richards Inc. Microporous polymeric foams and microtextured surfaces
US6037174A (en) 1993-08-23 2000-03-14 Nexell Therapeutics, Inc. Preparation of serum-free suspensions of human hematopoietic cells or precursor cells
US5409813A (en) 1993-09-30 1995-04-25 Systemix, Inc. Method for mammalian cell separation from a mixture of cell populations
US6432711B1 (en) 1993-11-03 2002-08-13 Diacrin, Inc. Embryonic stem cells capable of differentiating into desired cell lines
WO1995013088A1 (en) 1993-11-12 1995-05-18 Regents Of The University Of Minnesota Stroma-derived stem cell growth factors
AU687059B2 (en) 1994-02-09 1998-02-19 Genespan Corporation High performance cell culture bioreactor and method
US5622857A (en) 1995-08-08 1997-04-22 Genespan Corporation High performance cell culture bioreactor and method
FR2726003B1 (fr) 1994-10-21 2002-10-18 Agronomique Inst Nat Rech Milieu de culture de cellules embryonnaires totipotentes aviaires, procede de culture de ces cellules, et cellules embryonnaires totipotentes aviaires
US5677136A (en) 1994-11-14 1997-10-14 Systemix, Inc. Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof
US5874301A (en) 1994-11-21 1999-02-23 National Jewish Center For Immunology And Respiratory Medicine Embryonic cell populations and methods to isolate such populations
US5914268A (en) 1994-11-21 1999-06-22 National Jewish Center For Immunology & Respiratory Medicine Embryonic cell populations and methods to isolate such populations
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5736396A (en) 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
US5837670A (en) 1995-04-18 1998-11-17 Hartshorn; Richard Timothy Detergent compositions having suds suppressing properties
US5908782A (en) 1995-06-05 1999-06-01 Osiris Therapeutics, Inc. Chemically defined medium for human mesenchymal stem cells
US5712154A (en) 1995-06-07 1998-01-27 W.R. Grace & Co.-Conn. Dual fiber bioreactor
US6015554A (en) 1995-06-07 2000-01-18 Systemix, Inc. Method of reconstituting human lymphoid and dendritic cells
US6680166B1 (en) 1995-06-07 2004-01-20 Claudy Jean Paul Mullon Dual fiber bioreactor
US5627070A (en) 1995-07-26 1997-05-06 Celltherapy, Inc. Cell growing device for in vitro cell population expansion
US6190910B1 (en) 1996-05-21 2001-02-20 The Institute Of Physical And Chemical Research Mouse embryonic stem cell lines
US5753506A (en) 1996-05-23 1998-05-19 Cns Stem Cell Technology, Inc. Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
US5827740A (en) 1996-07-30 1998-10-27 Osiris Therapeutics, Inc. Adipogenic differentiation of human mesenchymal stem cells
US5945337A (en) 1996-10-18 1999-08-31 Quality Biological, Inc. Method for culturing CD34+ cells in a serum-free medium
GB9704749D0 (en) 1997-03-07 1997-04-23 Univ London Tissue Implant
US6361996B1 (en) 1997-05-07 2002-03-26 University Of Utah Research Foundation Neuroepithelial stem cells and glial-restricted intermediate precursors
WO1998059035A2 (en) 1997-06-25 1998-12-30 The Goverment Of The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services, National Institutes Of Health Serum-free cell growth medium
JP4371179B2 (ja) 1997-07-04 2009-11-25 ユニバーシティー オブ ユタ リサーチ ファンデーション 系列限定ニューロン前駆体
US5968829A (en) 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
AU9508998A (en) * 1997-09-25 1999-04-12 Glycotech Corp. Methods and compositions for binding hematopoietic stem cells
US6001585A (en) 1997-11-14 1999-12-14 Cellex Biosciences, Inc. Micro hollow fiber bioreactor
DE69903800T2 (de) 1998-03-18 2003-10-02 Massachusetts Institute Of Technology, Cambridge Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane
US6080581A (en) 1998-07-02 2000-06-27 Charles Daniel Anderson Culture vessel for growing or culturing cells, cellular aggregates, tissues and organoids and methods for using same
US6875607B1 (en) 1998-11-09 2005-04-05 Es Cell International Pte Ltd Embryonic stem cells
CA2348687A1 (en) 1998-11-09 2000-05-18 Consorzio Per La Gestione Del Centro Di Biotecnologie Avanzate Serum free medium for chondrocyte-like cells
BR0009403A (pt) 1999-02-04 2001-11-27 Technion Res & Dev Foundation Método de expansão/conservação das células detronco hemopoiéticas indiferenciadas ou dascélulas progenitoras, método de preparação deum meio condicionado de célula estomacal útil naexpansão/conservação das células de troncohemopoiéticas indiferenciadas ou das célulasprogenitoras, método de transplante de célulasde tronco hemopoiéticas indiferenciadas ou decélulas progenitoras em um recipiente, tampão debiorreator e biorreator
US20050153442A1 (en) 1999-03-10 2005-07-14 Adam Katz Adipose-derived stem cells and lattices
WO2002064748A2 (en) 2001-02-14 2002-08-22 Furcht Leo T Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
US8147824B2 (en) * 1999-08-05 2012-04-03 Athersys, Inc. Immunomodulatory properties of multipotent adult progenitor cells and uses thereof
US7015037B1 (en) * 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
WO2001011011A2 (en) * 1999-08-05 2001-02-15 Mcl Llc Multipotent adult stem cells and methods for isolation
US6471689B1 (en) 1999-08-16 2002-10-29 Thomas Jefferson University Implantable drug delivery catheter system with capillary interface
AUPQ319199A0 (en) 1999-09-30 1999-10-28 Unisearch Limited Method and apparatus for culturing cells
US20010044413A1 (en) 1999-12-01 2001-11-22 Glenn Pierce In situ bioreactors and methods of use thereof
EP2298867A3 (en) 2000-06-20 2013-01-16 ES Cell International Pte Ltd. Method of controlling differentiation of embryonic stem (ES) cells by culturing ES cells in the presence of bmp-2 pathway antagonists
US7560280B2 (en) 2000-11-03 2009-07-14 Kourion Therapeutics Gmbh Human cord blood derived unrestricted somatic stem cells (USSC)
US6566126B2 (en) 2001-06-22 2003-05-20 Fibercell Systems, Inc. Apparatus and method for growing cells
EP1421181A1 (en) 2001-08-23 2004-05-26 Reliance Life Sciences Pvt., Ltd. ISOLATION OF INNER CELL MASS FOR THE ESTABLISHMENT OF HUMAN EMBRYONIC STEM CELL (hESC) LINES
US9969980B2 (en) 2001-09-21 2018-05-15 Garnet Biotherapeutics Cell populations which co-express CD49c and CD90
US6703279B2 (en) 2002-01-04 2004-03-09 Promos Technologies, Inc. Semiconductor device having contact of Si-Ge combined with cobalt silicide
EP1478734A4 (en) 2002-01-25 2006-04-05 Genzyme Corp NON-SERUM MEDIUM FOR CHONDROCYTES AND METHODS OF USE THEREOF
US7145057B2 (en) 2002-02-01 2006-12-05 Origen Therapeutics, Inc. Chimeric bird from embryonic stem cells
AU2003230695A1 (en) 2002-03-20 2003-10-08 Sara Griffin Sports training device
ATE408666T1 (de) 2002-05-28 2008-10-15 Toyo Boseki Verfahren zur kultur, zum speichern und zur induzierung von differenzierung von zellen und gerät zur verwendung in diesem verfahren, und dazugehöriges gebrauchsverfahren.
GB0221481D0 (en) 2002-09-16 2002-10-23 Richards John M Grip for hand held instruments
DE10326750B4 (de) 2003-06-13 2006-07-27 Gerlach, Jörg, Dr.med. Verfahren zur Herstellung einer Zellpräparation und derart hergestellte Zellpräparationen
DE10326748B4 (de) 2003-06-13 2006-11-23 Gerlach, Jörg, Dr.med. Nervenzellkulturbioreaktor und hybrides Nervenzellsystem
WO2005007799A2 (en) 2003-07-17 2005-01-27 Gamida-Cell Ltd. Methods for ex-vivo expanding stem/progenitor cells
CN101248172A (zh) * 2005-01-28 2008-08-20 诺瓦塞拉有限公司 胚胎干细胞培养方法
US20080206733A1 (en) 2005-02-03 2008-08-28 National University Corporation Okayama University Method of Inducing Differentiation of Embryo-Stem Cell Into Hepatocyte and Hepatocyte Induced by the Method
GB2443370A (en) 2005-07-29 2008-04-30 Australian Stem Cell Ct Ltd Compositions and methods for growth of pluripotent cells
AU2006287306A1 (en) 2005-09-09 2007-03-15 Duke University Tissue engineering methods and compositions
CN101326281A (zh) * 2005-10-13 2008-12-17 人类起源公司 用源自胎盘的干细胞制备少突胶质细胞
US20100233130A1 (en) 2006-02-06 2010-09-16 Pluristem Ltd. Method and Apparatus for Maintenance and Expansion of Hematopoietic Stem Cells From Mononuclear Cells
AU2007265147B2 (en) 2006-06-26 2013-11-07 Terumo Bct, Inc. Method of culturing mesenchymal stem cells
DE102006031871B4 (de) 2006-07-10 2008-10-23 Gerlach, Jörg, Dr.med. 3-D Petri-Schale zur Züchtung und Untersuchung von Zellen
JP5149313B2 (ja) 2007-03-01 2013-02-20 テルモ ビーシーティー、インコーポレーテッド 細胞増殖装置と共に使用するためのディスポーザブル配管セット、および無菌サンプリング方法
ES2665024T3 (es) 2007-03-05 2018-04-24 Terumo Bct, Inc. Métodos para controlar el movimiento celular en biorreactores de fibra hueca
JP2010519937A (ja) * 2007-03-05 2010-06-10 カリディアンビーシーティー、インコーポレーテッド 細胞増殖システムおよび使用方法
EP2118263A2 (en) 2007-03-14 2009-11-18 CaridianBCT, Inc. Cell expansion apparatus with plate bioreactor
JP5524824B2 (ja) * 2007-04-06 2014-06-18 テルモ ビーシーティー、インコーポレーテッド 改良されたバイオリアクタ表面
WO2008128165A2 (en) 2007-04-13 2008-10-23 Caridianbct, Inc. Cell expansion system and methods of use
EP2559756B1 (en) * 2007-07-01 2019-12-18 Janssen Biotech, Inc. Single pluripotent stem cell culture
MX2010003019A (es) 2007-09-19 2010-04-30 Pluristem Ltd Celulas adherentes de los tejidos adiposo y de placenta y uso de las mismas en la terapia.
AU2009205886B2 (en) * 2008-01-18 2015-08-27 Katholieke Universiteit Leuven Stem cell aggregates and methods for making and using
US8321145B2 (en) 2008-08-12 2012-11-27 Terumo Bct, Inc. Predictor of when to harvest cells grown in a bioreactor
EP2168668A1 (en) 2008-09-25 2010-03-31 Gambro Lundia AB Membrane for cell expansion
US8673637B2 (en) 2008-10-16 2014-03-18 The Board Of Trustees Of The Leland Stanford Junior University Human multipotent germ line stem cells expressing a germ line marker and a pluripotency marker produced by co-culture of testicular tissue
WO2010149597A2 (en) 2009-06-18 2010-12-29 Cellartis Ab 3D CULTURING SYSTEMS FOR GROWTH AND DIFFERENTIATION OF HUMAN PLURIPOTENT STEM (hPS) CELLS
US9550975B2 (en) * 2009-07-15 2017-01-24 Mari Dezawa SSEA-3 pluripotent stem cell isolated from body tissue
WO2011011500A1 (en) * 2009-07-21 2011-01-27 Abt Holding Company Use of stem cells to reduce leukocyte extravasation
PL2718416T3 (pl) * 2011-06-06 2020-05-18 ReGenesys BVBA Namnażanie komórek macierzystych w bioreaktorach włóknisto-kapilarnych

Also Published As

Publication number Publication date
SG10201604543PA (en) 2016-07-28
AU2012266404B2 (en) 2016-08-11
JP2022058910A (ja) 2022-04-12
JP2020108392A (ja) 2020-07-16
AU2016256782A1 (en) 2016-12-01
EP2718416A1 (en) 2014-04-16
KR102073530B1 (ko) 2020-02-04
KR101955053B1 (ko) 2019-03-06
SG195299A1 (en) 2013-12-30
JP6182135B2 (ja) 2017-08-16
CA2837419C (en) 2021-07-13
US20120308531A1 (en) 2012-12-06
BR112013031368A2 (pt) 2020-06-23
IL281686A (en) 2021-05-31
DK2718416T3 (da) 2020-02-24
CA2837419A1 (en) 2012-12-13
KR20190026038A (ko) 2019-03-12
AU2018223029A1 (en) 2018-09-20
JP2018161147A (ja) 2018-10-18
NZ618651A (en) 2015-07-31
EP2718416B1 (en) 2019-11-13
CN103732733A (zh) 2014-04-16
JP6502997B2 (ja) 2019-04-17
EP3572497A1 (en) 2019-11-27
US20170022472A1 (en) 2017-01-26
HUE047474T2 (hu) 2020-04-28
ES2763331T3 (es) 2020-05-28
JP2014519825A (ja) 2014-08-21
IL229608A0 (en) 2014-01-30
JP2017121257A (ja) 2017-07-13
KR20140089310A (ko) 2014-07-14
CN108410797A (zh) 2018-08-17
BR112013031368B1 (pt) 2021-12-07
WO2012168295A1 (en) 2012-12-13
US20250019647A1 (en) 2025-01-16
JP2024164160A (ja) 2024-11-26
SG10201914092XA (en) 2020-03-30
AU2016256782B2 (en) 2018-05-31

Similar Documents

Publication Publication Date Title
IL281686A (en) Expansion of stem cells in hollow fiber bioreactors
IL288509A (en) Mammalian cell culture
IL234095A0 (en) Growth of mesenchymal stem cells in culture
IL216902B (en) Methods for culturing stem and progentitor cells
PL2611907T3 (pl) Różnicowanie pluripotencjalnych komórek macierzystych
FI20096288A0 (fi) Formulations and methods for culturing stem cells
IL221481A0 (en) Method of efficiently establishing induced pluripotent stem cells
PT2486048T (pt) Métodos de produção de glicoproteínas em culturas de células de mamíferos utilizando glicocorticoides
HUE037174T2 (hu) Tenyésztõ tápközeg õssejtekhez
GB201110042D0 (en) Growth of cells
EP2700707A4 (en) CELL CULTURE METHOD AND CELL CULTURE KIT
IL231668A0 (en) A method for in vitro expansion of hematopoietic stem cells and progenitor cells
GB2504996A8 (en) Stem cell culture method
SG11201406622UA (en) An in vitro method for culturing stem cells
EP2643454A4 (en) EXPANSION OF HEMATOPOETIC STEM CELLS
IL234833A0 (en) A process for the ex-vivo expansion of hematopoietic progenitor cells in a bioreactor
ZA201504388B (en) Method for culturing pluripotent stem cells
GB201112292D0 (en) Stem cell culture method
GB0916476D0 (en) Stem cell culture methods
GB0901069D0 (en) Stem cell culture methods
EG27087A (en) New technique for differentiation of stem cells using non-ionized
AU2011903899A0 (en) Cell culture & expansion
GB201120446D0 (en) Mammalian cell transformation method