PL2718422T3 - Pożywka hodowlana dla komórek macierzystych - Google Patents

Pożywka hodowlana dla komórek macierzystych

Info

Publication number
PL2718422T3
PL2718422T3 PL12729741T PL12729741T PL2718422T3 PL 2718422 T3 PL2718422 T3 PL 2718422T3 PL 12729741 T PL12729741 T PL 12729741T PL 12729741 T PL12729741 T PL 12729741T PL 2718422 T3 PL2718422 T3 PL 2718422T3
Authority
PL
Poland
Prior art keywords
stem cells
breeding medium
breeding
medium
stem
Prior art date
Application number
PL12729741T
Other languages
English (en)
Inventor
Johannes Carolus Clevers
Toshiro Sato
Meritxell Huch Ortega
Wouter Richard Karthaus
Original Assignee
Koninklijke Nederlandse Akademie Van Wetenschappen (Knaw)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44511945&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2718422(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US13/194,866 external-priority patent/US9752124B2/en
Application filed by Koninklijke Nederlandse Akademie Van Wetenschappen (Knaw) filed Critical Koninklijke Nederlandse Akademie Van Wetenschappen (Knaw)
Publication of PL2718422T3 publication Critical patent/PL2718422T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0679—Cells of the gastro-intestinal tract
    • C12N5/068—Stem cells; Progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0688—Cells from the lungs or the respiratory tract
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0679—Cells of the gastro-intestinal tract
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0683—Cells of the male genital tract, e.g. prostate, epididymis; Non-germinal cells from testis, e.g. Leydig cells, Sertoli cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/02—Compounds of the arachidonic acid pathway, e.g. prostaglandins, leukotrienes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/12—Hepatocyte growth factor [HGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/185—Osteoprotegerin; Osteoclast differentiation factor (ODF, RANKL)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/345—Gastrin; Cholecystokinins [CCK]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C12N2501/392—Sexual steroids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
PL12729741T 2011-06-10 2012-06-11 Pożywka hodowlana dla komórek macierzystych PL2718422T3 (pl)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201161520569P 2011-06-10 2011-06-10
US201161571663P 2011-06-30 2011-06-30
GBGB1111244.8A GB201111244D0 (en) 2011-06-30 2011-06-30 Culture media for stem cells
US201161513461P 2011-07-29 2011-07-29
US13/194,866 US9752124B2 (en) 2009-02-03 2011-07-29 Culture medium for epithelial stem cells and organoids comprising the stem cells
US201261594295P 2012-02-02 2012-02-02
EP12729741.4A EP2718422B1 (en) 2011-06-10 2012-06-11 Culture media for stem cells
PCT/IB2012/052950 WO2012168930A2 (en) 2011-06-10 2012-06-11 Culture media for stem cells

Publications (1)

Publication Number Publication Date
PL2718422T3 true PL2718422T3 (pl) 2018-04-30

Family

ID=44511945

Family Applications (2)

Application Number Title Priority Date Filing Date
PL17189470.2T PL3318627T3 (pl) 2011-06-10 2012-06-11 Pożywka hodowlana dla komórek macierzystych
PL12729741T PL2718422T3 (pl) 2011-06-10 2012-06-11 Pożywka hodowlana dla komórek macierzystych

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL17189470.2T PL3318627T3 (pl) 2011-06-10 2012-06-11 Pożywka hodowlana dla komórek macierzystych

Country Status (18)

Country Link
US (1) US20140243227A1 (pl)
EP (3) EP4324913B1 (pl)
JP (5) JP6275035B2 (pl)
KR (4) KR20230037058A (pl)
CN (3) CN104024401B (pl)
AU (5) AU2012265814B2 (pl)
CA (2) CA2838492C (pl)
DK (1) DK2718422T3 (pl)
ES (3) ES2968078T3 (pl)
GB (1) GB201111244D0 (pl)
HR (2) HRP20231442T1 (pl)
HU (2) HUE064631T2 (pl)
IL (4) IL229879B (pl)
PL (2) PL3318627T3 (pl)
PT (1) PT2718422T (pl)
RU (2) RU2714256C2 (pl)
SG (1) SG10201607552XA (pl)
WO (1) WO2012168930A2 (pl)

Families Citing this family (209)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT1993360T (lt) 2005-12-28 2017-06-12 Vertex Pharmaceuticals Incorporated N-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksochinolin-3-karboksamido kieta forma
EP2022848A1 (en) 2007-08-10 2009-02-11 Hubrecht Institut A method for identifying, expanding, and removing adult stem cells and cancer stem cells
EP2412800A1 (en) * 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Liver organoid, uses thereof and culture method for obtaining them
US9752124B2 (en) 2009-02-03 2017-09-05 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium for epithelial stem cells and organoids comprising the stem cells
US8642339B2 (en) 2009-02-03 2014-02-04 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium for epithelial stem cells and organoids comprising the stem cells
GB201111244D0 (en) * 2011-06-30 2011-08-17 Konink Nl Akademie Van Wetenschappen Knaw Culture media for stem cells
WO2011140441A2 (en) 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
US20140242038A1 (en) * 2011-10-11 2014-08-28 The Trustees Of Columbia University In The City Of New York Method for generating beta cells
ES2769786T3 (es) * 2011-10-14 2020-06-29 Recordati Ag Anticuerpos y métodos para enfermedades relacionadas con la vía Wnt
WO2013061608A1 (ja) * 2011-10-27 2013-05-02 国立大学法人東京医科歯科大学 大腸上皮幹細胞の単離・培養技術と、これを用いた大腸上皮移植技術
AU2012356133B2 (en) 2011-12-19 2018-07-26 Koninklijke Nederlandse Akademie Van Wetenschappen A rapid quantitative assay to measure CFTR function in a primary intestinal culture model
DK2844739T3 (da) * 2012-04-30 2019-09-30 Univ Health Network FREMGANGSMÅDER OG SAMMENSÆTNINGER TIL GENERERING AF PANCREATISKE PROGENITORER OG FUNKTIONELLE BETA-CELLER UD FRA hPSC'ER
JP6519851B2 (ja) * 2012-07-06 2019-05-29 京都府公立大学法人 眼細胞の分化マーカーおよび分化制御
CA3106271A1 (en) * 2013-01-25 2014-07-31 Xcell Biosciences, Inc. Methods, compositions, kits, and systems for selective enrichment of target cells
WO2014131033A1 (en) * 2013-02-25 2014-08-28 Genentech, Inc. Liquid culturing of epithelial stem cells
BR112015023261A2 (pt) * 2013-03-14 2017-07-18 Massachusetts Inst Technology composições e métodos para expansão e cultura de células-tronco epiteliais
TW201522637A (zh) * 2013-03-15 2015-06-16 Jackson Lab 非胚胎幹細胞之單離及其用途
US20160237400A1 (en) * 2013-03-15 2016-08-18 The Jackson Laboratory Isolation of non-embryonic stem cells and uses thereof
WO2014153294A1 (en) * 2013-03-17 2014-09-25 The Regents Of The University Of California Method to expand and transduce cultured human small and large intestinal stem cells
KR102668827B1 (ko) * 2013-05-08 2024-05-27 인리젠 단리된 신장 세포를 포함하는 오가노이드 및 이의 용도
JP6253265B2 (ja) * 2013-06-05 2017-12-27 学校法人関西医科大学 食道上皮幹細胞の単離方法
JP6437184B2 (ja) * 2013-06-05 2018-12-12 学校法人関西医科大学 舌上皮幹細胞の単離方法
AU2014278178B2 (en) 2013-06-11 2021-01-21 President And Fellows Of Harvard College SC-beta cells and compositions and methods for generating the same
JP6552487B2 (ja) * 2013-06-18 2019-07-31 エージェンシー フォー サイエンス, テクノロジー アンド リサーチ 癌幹細胞を培養する方法
EP2834349B1 (en) * 2013-06-20 2016-04-20 Tampereen Yliopisto P38 mapk inhibitor-containing medium and method for osteogenic differentiation
CA2920856C (en) 2013-08-09 2026-03-03 Ardelyx, Inc. Ph modulating compounds for inhibiting gastrointestinal phosphate uptake
AU2015217406A1 (en) * 2014-02-11 2016-08-25 Celularity Inc. Micro-organoids, and methods of making and using the same
WO2015156929A1 (en) * 2014-04-07 2015-10-15 The Trustees Of Columbia University In The City Of New York Method for culture of human bladder cell lines and organoids and uses thereof
TWI522467B (zh) * 2014-05-08 2016-02-21 醫療財團法人徐元智先生醫藥基金會亞東紀念醫院 體外小腸幹細胞培養基及培養方法
WO2015173425A1 (en) 2014-05-16 2015-11-19 Koninklijke Nederlandse Akademie Van Wetenschappen Improved culture method for organoids
ES2860423T3 (es) 2014-05-28 2021-10-05 Childrens Hospital Med Ct Métodos y sistemas para convertir células precursoras en tejidos gástricos mediante diferenciación dirigida
US20170233698A1 (en) * 2014-06-27 2017-08-17 The Regents Of The University Of California Cultured mammalian limbal stem cells, methods for generating the same, and uses thereof
JP2016028569A (ja) * 2014-07-16 2016-03-03 学校法人慶應義塾 がん幹細胞集団の調製方法、異種移植片の調製方法、スクリーニング方法、miR−34aの発現量を低下させる方法及びがん幹細胞増殖抑制剤
US12247224B2 (en) 2014-07-30 2025-03-11 Senthil Muthuswamy Organoids for drug screening and personalized medicine
CN107073042A (zh) 2014-09-03 2017-08-18 布里格海姆妇女医院公司 用于产生内耳毛细胞来治疗听力损失的组合物、系统和方法
CA2963945C (en) 2014-10-07 2023-01-10 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator
CN107075471A (zh) * 2014-10-08 2017-08-18 新加坡科技研究局 将干细胞分化为肝细胞谱系的方法
CA2963704A1 (en) 2014-10-17 2016-04-21 Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
GB201421094D0 (en) * 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
GB201421092D0 (en) * 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
US10926001B2 (en) 2014-12-02 2021-02-23 Polarityte, Inc. Methods related to minimally polarized functional units
CN107614678B (zh) 2014-12-18 2021-04-30 哈佛学院校长同事会 干细胞来源的β细胞的产生方法及其使用方法
US10443042B2 (en) 2014-12-18 2019-10-15 President And Fellows Of Harvard College Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof
ES2985135T3 (es) 2014-12-18 2024-11-04 Harvard College Procedimientos para generar células ß derivadas de células madre y usos de las mismas
SMT201900005T1 (it) * 2015-02-20 2019-05-10 Inst Nat Sante Rech Med Uso di una laminina per la differenziazione di cellule pluripotenti in cellule di lignaggio epatocitario
EP3263697B1 (en) * 2015-02-27 2021-03-31 Rohto Pharmaceutical Co., Ltd. Culture medium for culturing mesenchymal stem cell, method for culturing mesenchymal stem cell, and mesenchymal stem cell
US12128072B2 (en) * 2015-03-18 2024-10-29 The University Of Tokyo Hepatocytes and hepatic non-parenchymal cells, and methods for preparation thereof
CN107636149A (zh) 2015-04-03 2018-01-26 普罗帕格尼克斯公司 上皮细胞的离体增殖
US10100285B2 (en) 2015-04-03 2018-10-16 Propagenix Inc. Ex vivo proliferation of epithelial cells
US20180066223A1 (en) 2015-04-17 2018-03-08 Xcell Biosciences, Inc. Cancer cell enrichment system
CN104862272B (zh) * 2015-05-29 2018-08-10 吉林大学 Y-27632抑制剂在cd44阳性肠干细胞分选中的应用
CN105087481A (zh) * 2015-08-21 2015-11-25 深圳爱生再生医学科技有限公司 无血清培养基及干细胞的培养方法
JP6869231B2 (ja) 2015-09-11 2021-05-12 プロパジェニクス インコーポレイテッド ex vivoでの上皮細胞の増殖
EP3350313B1 (en) * 2015-09-15 2025-11-26 Agency For Science, Technology And Research (A*star) Derivation of liver organoids from human pluripotent stem cells
CN106554936B (zh) * 2015-09-30 2020-05-05 海门雨霖细胞科技有限责任公司 诱导人干细胞向肝细胞定向分化的新方法
WO2017059449A1 (en) * 2015-10-02 2017-04-06 Baylor College Of Medicine Cultivation of human noroviruses
WO2017060240A1 (en) * 2015-10-05 2017-04-13 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Method and culture medium for ex vivo culturing of epidermis-derived stem cells
CN108473547A (zh) * 2015-10-28 2018-08-31 塔夫茨大学 具有改良的蛋白质分解安定性的新颖多肽,以及制备与使用该新颖多肽的方法
CA3010610A1 (en) 2016-01-08 2017-07-13 The Brigham And Women's Hospital, Inc. Production of differentiated enteroendocrine cells and insulin producing cells
EP3208331A1 (en) * 2016-02-17 2017-08-23 PromoCell bioscience alive GmbH Biomedizinische Produkte Chemically defined medium for the culture of cancer stem cell (csc) containing cell populations
JP6376578B2 (ja) * 2016-02-18 2018-08-22 学校法人慶應義塾 細胞培養培地、培養方法、及びオルガノイド
GB201603569D0 (en) 2016-03-01 2016-04-13 Koninklijke Nederlandse Akademie Van Wetenschappen Improved differentiation method
US10213511B2 (en) 2016-03-02 2019-02-26 Frequency Therapeutics, Inc. Thermoreversible compositions for administration of therapeutic agents
US10201540B2 (en) 2016-03-02 2019-02-12 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I
US11260130B2 (en) 2016-03-02 2022-03-01 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV
US11753626B2 (en) * 2016-03-09 2023-09-12 Beijing Percans Oncology Co., Ltd. Tumor cell suspension cultures and related methods
SG11201807487WA (en) 2016-03-14 2018-09-27 Agency Science Tech & Res Generation of midbrain-specific organoids from human pluripotent stem cells
KR101983547B1 (ko) * 2016-04-04 2019-05-29 주식회사 싸이토젠 단기배양 혈중 암세포(ctc)를 활용한 개인 맞춤형 항암제 선별시스템 및 선별방법
KR101983546B1 (ko) * 2016-04-05 2019-05-29 주식회사 싸이토젠 혈중 순환 종양세포의 다중 바이오마커 및 이의 항체를 이용한 난소암 진단방법
CN109415685B (zh) 2016-05-05 2023-07-04 儿童医院医疗中心 用于体外制造胃底组织的方法和与其相关的组合物
EP3690022B1 (en) * 2016-05-18 2026-03-18 Keio University Cell culture medium for culturing organoid, culture method, and organoid
WO2018013578A1 (en) * 2016-07-11 2018-01-18 Trustees Of Tufts College Innervated artificial intestine compositions
CN106190980A (zh) * 2016-07-12 2016-12-07 张云霞 一种基于人食管癌组织用于体外培养食管癌肿瘤类器官的专用培养基及培养方法
US20190161737A1 (en) * 2016-07-27 2019-05-30 Georgetown University Process for continuous cell culture of cancer cells and cancer stem cells
JP6869554B2 (ja) * 2016-08-24 2021-05-12 学校法人慶應義塾 ヒト下痢症ウイルスの感染・増殖培養用2dオルガノイド及びその使用
JP2024174893A (ja) * 2016-11-04 2024-12-17 チルドレンズ ホスピタル メディカル センター 肝臓オルガノイド組成物ならびにその作製および使用方法
SG10202104575WA (en) 2016-11-04 2021-06-29 Childrens Hospital Med Ct Liver organoid compositions and methods of making and using same
CN106754719B (zh) * 2016-11-17 2020-04-07 上海市胸科医院 一种接种液组合物及利用其构建恶性胸腔积液来源异种移植瘤动物模型的方法
CA3045145A1 (en) * 2016-12-05 2018-06-14 Children's Hospital Medical Center Colonic organoids and methods of making and using same
AU2017386417B2 (en) 2016-12-30 2022-07-14 Frequency Therapeutics, Inc. 1H-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells
CN108396010A (zh) * 2017-02-06 2018-08-14 王琼 一种结直肠癌类器官的体外培养方法
KR20190105237A (ko) 2017-02-20 2019-09-16 고리츠다이가쿠호징 나고야시리츠다이가쿠 인공 다능성 줄기 세포 유래 장관 줄기 세포의 유지 배양
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
US12281334B2 (en) 2017-04-14 2025-04-22 Children's Hospital Medical Center Multi donor stem cell compositions and methods of making same
US11859212B2 (en) 2017-05-09 2024-01-02 Public University Corporation Nagoya City University Method for producing intestinal organoid derived from pluripotent stem cells
WO2018218344A1 (en) * 2017-05-29 2018-12-06 Stemcell Technologies Canada Inc. Compositions and methods for obtaining organoids
KR102107602B1 (ko) * 2017-05-29 2020-05-08 한양대학교 산학협력단 인간 성체 간세포 리프로그래밍 배지 조성물
JP7901964B2 (ja) * 2017-06-16 2026-08-07 イーエムベーアー-インスティテュート フュール モレクラレ バイオテクノロジー ゲゼルシャフト ミット ベシュレンクテル ハフツング 血管オルガノイド、オルガノイドの製造及び使用方法
GB201709704D0 (en) * 2017-06-19 2017-08-02 Cambridge Entpr Ltd Methods of expanding cholangiocytes
WO2019074793A1 (en) 2017-10-10 2019-04-18 Children's Hospital Medical Center OESOPHAGIAN TISSUE COMPOSITIONS AND / OR ORGANOIDS AND METHODS OF MAKING SAME
KR102118522B1 (ko) * 2017-10-25 2020-06-03 (주)셀라토즈테라퓨틱스 신규한 근골격계 줄기세포
CN107982518A (zh) * 2017-10-26 2018-05-04 南方医科大学 一种Lgr5阳性肝脏干细胞诱导方法及其检测应用
WO2019099725A1 (en) 2017-11-15 2019-05-23 Semma Therapeutics, Inc. Islet cell manufacturing compositions and methods of use
KR20200091885A (ko) 2017-11-30 2020-07-31 고쿠리츠 다이가쿠 호진 교토 다이가쿠 세포의 배양 방법
CN111670247B (zh) * 2017-12-08 2024-01-05 京诊断株式会社 制备癌球状体的方法和选择结直肠癌患者的方法
US12379372B2 (en) 2017-12-21 2025-08-05 Children's Hospital Medical Center Digitalized human organoids and methods of using same
GB201721615D0 (en) 2017-12-21 2018-02-07 Koninklijke Nederlandse Akademie Van Wetenschappen Immune cell organoid co-cultures
RU2758487C2 (ru) * 2018-01-12 2021-10-28 Селлмиг Биолабс Инк. Способы получения цитокапсул и цитокапсулярных трубок
CN108085296B (zh) * 2018-01-29 2021-04-13 清华大学 肠上皮类器官无生长因子培养方法
WO2019169351A1 (en) 2018-03-02 2019-09-06 Semma Therapeutics, Inc. Methods of enhancing stem cell differentiation into beta cells
CN110317775B (zh) * 2018-03-30 2022-06-10 中国科学院分子细胞科学卓越创新中心 用于肝细胞培养及肝脏类器官制备的培养基
US20210147811A1 (en) * 2018-04-09 2021-05-20 Cedars-Sinai Medical Center Methods for in vitro expansion of adult tissue stem cells
CN110106147B (zh) * 2018-04-18 2021-04-13 浙江大学 一种诱导人羊膜上皮细胞向视网膜感光细胞分化的方法及其应用
TWI848946B (zh) 2018-05-14 2024-07-21 中國醫藥大學 包含異種尿路上皮細胞的組合物的用途
CN110592020A (zh) * 2018-06-13 2019-12-20 北京吉尚立德生物科技有限公司 一种用于培养结直肠癌实体瘤原代细胞的培养基
EP3896154A4 (en) * 2018-06-13 2022-03-09 Genex Health Co.,Ltd PRIMARY CELL OF SOLID TUMOR IN COLORECTAL CANCER AND METHODS FOR CULTIVATION OF PRIMARY TUMOR CELL FROM ASCITES IN COLORECTAL CANCER AND RELEVANT REAGENT
CN110592018A (zh) * 2018-06-13 2019-12-20 北京吉尚立德生物科技有限公司 一种结直肠癌实体瘤原代细胞的培养方法
KR102099402B1 (ko) * 2018-06-28 2020-04-09 오가노이드사이언스 주식회사 타액선 줄기세포의 기능 강화용 배양 조성물 및 이를 이용한 타액선 줄기세포 기능 강화 방법
CA3106634A1 (en) 2018-07-26 2020-01-30 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
JP7446224B2 (ja) 2018-08-08 2024-03-08 中外製薬株式会社 がん組織またはがん組織に類似した組織の培養方法
EP3833365A4 (en) 2018-08-10 2022-05-11 Vertex Pharmaceuticals Incorporated Stem cell derived islet differentiation
WO2020037323A1 (en) 2018-08-17 2020-02-20 Frequency Therapeutics, Inc. Compositions and methods for generating hair cells by upregulating jag-1
WO2020037326A1 (en) 2018-08-17 2020-02-20 Frequency Therapeutics, Inc. Compositions and methods for generating hair cells by downregulating foxo
CN112823012A (zh) 2018-09-12 2021-05-18 儿童医院医学中心 用于产生造血干细胞及其衍生物的类器官组合物
JP2022502080A (ja) * 2018-09-19 2022-01-11 リジェネレーション バイオメディカル,インコーポレイテッド Wnt−活性化脂肪由来幹細胞装置、方法およびシステム
GB201819224D0 (en) 2018-11-26 2019-01-09 Koninklijke Nederlandse Akademie Van Wetenschappen Hepatocyte expansion methods
KR20200065892A (ko) * 2018-11-30 2020-06-09 오가노이드사이언스 주식회사 오가노이드의 생체 이식용 조성물
JP7510133B2 (ja) * 2018-12-06 2024-07-03 Jsr株式会社 肝臓オルガノイドの製造方法、肝臓オルガノイド製造用培地、肝臓オルガノイド、細胞製剤、及び被験物質の評価方法
EP3898952A4 (en) * 2018-12-21 2022-12-28 The Regents of the University of California METHODS OF PRODUCTION OF ENTERIC NEURONS AND USES THEREOF
WO2020150182A1 (en) * 2019-01-14 2020-07-23 Children's Hospital Medical Center Compositions and methods for treatment of a malabsorptive disorder
CN109880878A (zh) * 2019-01-17 2019-06-14 浙江工商大学 基于小鼠小肠类器官的食物功效成分对小肠生长特性影响的快速评价方法
WO2020152953A1 (ja) * 2019-01-23 2020-07-30 Jsr株式会社 判別装置、細胞塊の判別方法、及びコンピュータプログラム
CN111607556B (zh) * 2019-01-25 2022-06-07 中国科学院广州生物医药与健康研究院 一种培养扩增人肝祖细胞的培养基及其应用
CN111500528A (zh) * 2019-01-31 2020-08-07 中国科学院广州生物医药与健康研究院 一种淘选和扩增培养肝脏干细胞的方法及其应用
WO2020160371A1 (en) 2019-02-01 2020-08-06 The University Of Hong Kong Innervated organoid compositions and methods of making same
GB201903573D0 (en) 2019-03-15 2019-05-01 Koninklijke Nederlandse Akademie Van Wetenschappen Culture method for head and neck organoids
KR102197871B1 (ko) * 2019-03-28 2021-01-04 이화여자대학교 산학협력단 엽산, 엽산 유도체, 또는 엽산 저해제를 이용한 줄기세포의 연골세포로의 분화 유도 방법
CN111808816A (zh) * 2019-04-11 2020-10-23 北京基石生命科技有限公司 一种用于培养胃癌实体瘤原代细胞的培养基
EP3954764B8 (en) * 2019-04-11 2025-04-30 GeneX Health Co., Ltd METHOD FOR CULTURING PRIMARY GASTRIC CANCER CELLS AND GALLBLADDER AND BILATERAL DUCT CANCER CELLS, AND SUPPORTING REAGENTS
WO2020225085A1 (en) * 2019-05-03 2020-11-12 Katholieke Universiteit Leuven Medium for growth of organoids
GB201906978D0 (en) 2019-05-17 2019-07-03 Koninklijke Nederlandse Akademie Van Wetenschappen Improved culture method using integrin agonist
WO2020242256A2 (ko) * 2019-05-29 2020-12-03 연세대학교 산학협력단 인간 미뢰 오가노이드의 배양용 조성물
KR102334245B1 (ko) * 2019-05-29 2021-12-03 연세대학교 산학협력단 인간 미뢰 오가노이드의 배양용 조성물
US12534709B2 (en) 2019-05-31 2026-01-27 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
CA3141807A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
EP4012021A4 (en) * 2019-08-05 2022-11-30 Genex Health Co.,Ltd METHOD FOR CULTIVATION OF PRIMARY CELLS OF SOLID TUMORS IN LUNG CANCER AND PRIMARY TUMOR CELLS OF PLEEURAL EFFORT IN LUNG CANCER AND SUPPORTING REAGENT
EP3772538A1 (en) 2019-08-09 2021-02-10 Urosphere Method for differentiating epithelial stem cells
CN110408595A (zh) * 2019-08-23 2019-11-05 厦门博创盛世生物技术有限公司 一种用于胃癌测试的肿瘤3d类器官的培养方法
KR102360023B1 (ko) * 2019-09-04 2022-02-09 한국생명공학연구원 증식 가능한 간 오가노이드
EP3789049A1 (en) 2019-09-06 2021-03-10 QGel SA Method for obtaining healthy intestinal organoids
WO2021062408A1 (en) * 2019-09-26 2021-04-01 Duke University Systems and methods for lung cell expansion and differentiation
EP4048809B1 (en) 2019-10-22 2026-05-27 Tempus AI, Inc. Systems and methods for predicting therapeutic sensitivity
CN110699317A (zh) * 2019-10-30 2020-01-17 湖南丰晖生物科技有限公司 一种人脐带间充质干细胞无血清培养基及其制备方法与应用
CN112760284A (zh) * 2019-11-04 2021-05-07 北京基石生命科技有限公司 一种用于培养胆囊胆管癌原代细胞的培养基
CN112760280A (zh) * 2019-11-04 2021-05-07 北京基石生命科技有限公司 一种胆囊胆管癌原代细胞的培养方法
CN110628695A (zh) * 2019-11-12 2019-12-31 安徽科门生物科技有限公司 一种用于干细胞扩增的培养基
US20230257813A1 (en) * 2019-11-15 2023-08-17 Public University Corporation Yokohama City University Sensitive Detection Method for Undifferentiated Marker Genes
US11629385B2 (en) 2019-11-22 2023-04-18 Tempus Labs, Inc. Tumor organoid culture compositions, systems, and methods
JP7744340B2 (ja) 2019-12-05 2025-09-25 テンパス・エーアイ・インコーポレイテッド ハイスループット薬物スクリーニングのためのシステムおよび方法
CN114787338A (zh) 2019-12-16 2022-07-22 Jsr株式会社 增殖性肝类器官、代谢活化肝类器官和它们的使用
JP7348892B2 (ja) * 2019-12-30 2023-09-21 佛教慈濟醫療財團法人 眼疾患を予防または治療する組成物及び方法
CN111206013A (zh) * 2020-02-13 2020-05-29 上海交通大学医学院附属仁济医院 一种长时间维持人原代肝细胞的功能状态的培养方法
CN113373116B (zh) * 2020-03-10 2023-03-14 合肥中科普瑞昇生物医药科技有限公司 原代肝癌细胞培养基、原代肝癌细胞培养方法及其应用
CN113493763A (zh) * 2020-03-18 2021-10-12 四川大学华西医院 可应用于基因编辑的小鼠卵巢原代细胞培养基及体外培养方法
GB202004706D0 (en) 2020-03-31 2020-05-13 Koninklijke Nederlandse Akademie Van Wetenschappen Methods and tools for studying enteroendocrine cells
CN111471643B (zh) * 2020-04-09 2020-12-29 创芯国际生物科技(广州)有限公司 一种通用型上呼吸道粘膜类器官的培养基及培养方法
US11561178B2 (en) 2020-04-20 2023-01-24 Tempus Labs, Inc. Artificial fluorescent image systems and methods
CN111394314B (zh) * 2020-04-22 2020-12-01 创芯国际生物科技(广州)有限公司 一种肠癌类器官的培养基及培养方法
US20210395698A1 (en) * 2020-06-22 2021-12-23 Life Technologies Corporation Methods and compositions for cultivating pluripotent cell suspensions
GB2596787B8 (en) * 2020-06-26 2026-07-22 Genome Res Ltd Culture of organoids
CN111909889B (zh) * 2020-07-23 2024-08-16 创芯国际生物科技(广州)有限公司 一种低成本小鼠肠类器官培养基及培养方法
CN111944739B (zh) * 2020-08-20 2021-11-26 创芯国际生物科技(广州)有限公司 一种类器官培养基质材料及其制备方法和应用
CN114480250B (zh) * 2020-11-12 2023-09-08 四川大学华西医院 构建原位原发胃癌动物模型的方法
CN112626005B (zh) * 2020-12-01 2023-06-09 保信亚太生物科技(深圳)有限公司 呼吸道类器官培养体系及博卡病毒感染模型的构建方法
KR102296986B1 (ko) 2021-01-21 2021-08-31 정덕수 우태아혈청 성분의 유해함을 극복하기 위한 화학적으로 정의된 줄기세포배양액 개발
CN112813028B (zh) * 2021-01-27 2022-07-15 杭州艾名医学科技有限公司 一种用于结直肠癌类器官培养的培养液及其制备方法
JP7808832B2 (ja) * 2021-04-20 2026-01-30 国立大学法人東京農工大学 ネコ乳腺腫瘍オルガノイド培地用組成物及びネコ乳腺腫瘍オルガノイドの製造方法
CN115074388B (zh) * 2021-06-29 2023-04-28 北京大学深圳医院 母源因子诱导的2c样全能干细胞及其转化应用
CN113717933B (zh) * 2021-07-05 2023-10-13 浙江大学 Fgf7在制备干细胞扩增与表型维持试剂中的应用
GB202109913D0 (en) 2021-07-09 2021-08-25 Stichting Hubrecht Organoid Tech Organoid-derived monolayers and uses thereof
CN114149958B (zh) * 2021-09-28 2022-09-02 创芯国际生物科技(广州)有限公司 一种鼻咽拭子取材培养鼻粘膜类器官的方法与应用
EP4410958A4 (en) * 2021-09-30 2025-11-12 Jsr Corp PROCESS FOR THE PRODUCTION OF ORGANOIDS, CULTURE MEDIUM FOR THE PRODUCTION OF ORGANOIDS, ORGANOID AND PROCESS FOR EVALUATING TEST SUBSTANCE
WO2023076292A1 (en) * 2021-10-25 2023-05-04 Satellite Biosciences, Inc. Culture media and conditions for in vitro expansion and/or maturation of hepatocytes
CN114134102A (zh) * 2021-11-10 2022-03-04 杭州同创越诚基因科技有限公司 从结肠黏膜组织中分离隐窝并诱导产生结肠类器官的方法
CN114058588A (zh) * 2021-11-12 2022-02-18 复旦大学附属中山医院 一种人源性肠腺瘤类器官的制备方法
CN114107388A (zh) * 2021-11-12 2022-03-01 复旦大学附属中山医院 一种腺病毒转染类器官的方法
CN114107208A (zh) * 2021-11-12 2022-03-01 复旦大学附属中山医院 一种人源性类器官库的制备方法
WO2023150319A1 (en) * 2022-02-04 2023-08-10 Arizona Board Of Regents On Behalf Of The University Of Arizona Organoids derived from human colonic cells and methods of making and using the same
JP2025506031A (ja) * 2022-02-09 2025-03-05 コリア リサーチ インスティテュート オブ バイオサイエンス アンド バイオテクノロジー 3次元腸管オルガノイド由来の腸幹細胞集合体の培養のための化学的組成が明確な2次元培養法
CN116694551A (zh) * 2022-02-24 2023-09-05 清华大学 诱导性成熟肝脏细胞及其制备的方法
WO2023171702A1 (ja) * 2022-03-08 2023-09-14 慶應義塾 オルガノイドの製造方法
GB202204266D0 (en) 2022-03-25 2022-05-11 Stichting Hubrecht Organoid Tech Methods for co-culturing genotoxic bacteria and organoids
KR102445484B1 (ko) * 2022-03-30 2022-09-20 오가노이드사이언스 주식회사 장 오가노이드 제조용 배지 조성물
WO2023196215A1 (en) * 2022-04-05 2023-10-12 Xcell Biosciences, Inc. Cell populations adapted to a tumor microenvironment
WO2023230297A1 (en) * 2022-05-27 2023-11-30 The Trustees Of Columbia University In The City Of New York Compositions and methods for improving squamous epithelial organoids and their production
CN115058390B (zh) * 2022-07-14 2023-01-31 北京中科细胞控股有限公司 肾源干细胞的制备方法
WO2024030482A1 (en) * 2022-08-02 2024-02-08 Lundquist Institute For Biomedical Innovation At Harbor-Ucla Medical Center Preparation and use of functional human tissues
CN115418353A (zh) * 2022-08-17 2022-12-02 复旦大学附属肿瘤医院 一种结直肠腹膜转移癌类器官移瘤模型构建及其应用
CN115637251A (zh) * 2022-11-04 2023-01-24 中国人民解放军海军军医大学第一附属医院 一种诱导肠道类器官定向分化为肠吸收细胞的方法及其应用
WO2024112170A1 (ko) * 2022-11-24 2024-05-30 한국생명공학연구원 박막 코팅된 표면 위에서 장 줄기세포를 무이종 배양하는 법
CN115820537B (zh) * 2022-11-28 2023-12-12 创芯国际生物科技(广州)有限公司 一种颅咽管瘤类器官、培养基及培养方法
CN116355850A (zh) * 2023-02-28 2023-06-30 中国医学科学院基础医学研究所 结直肠癌类器官的构建方法及其应用
CN116355852A (zh) * 2023-03-16 2023-06-30 江南大学 一种Caco-2+NCI-H716与Beta-TC-6双层共培养细胞模型的构建方法及应用
JP2024153474A (ja) * 2023-04-17 2024-10-29 国立大学法人 大分大学 培地サプリメント及び培養キット
CN121969740A (zh) * 2023-05-25 2026-05-01 南加利福尼亚大学 肾单位祖细胞克隆扩增、肾单位类器官的生成以及多囊肾病的快速可扩展建模的新型培养条件
CN116496980A (zh) * 2023-06-28 2023-07-28 北京嘉士腾医学检验实验室有限公司 一种炎症性肠病肠道隐窝分离液、分离方法及体外3d类器官培养方法
EP4495227A1 (en) 2023-07-18 2025-01-22 HUB Organoids IP B.V. Co-cultures of organoids and stromal cells
WO2025090290A1 (en) 2023-10-24 2025-05-01 Corning Incorporated Polyvinylpyrrolidine-based hydrogels for 3d cell culture
AU2024369604A1 (en) 2023-11-02 2026-05-14 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Method for expanding liver cells
CN119220496B (zh) * 2023-11-09 2025-08-12 北京大学人民医院 一种用于小鼠骨肉瘤类器官培养的培养基及培养方法
CN118291365B (zh) * 2024-02-06 2026-07-24 同济大学 一种组合物及利用其培养信号组织者和微器官的方法
CN117866884A (zh) * 2024-03-13 2024-04-12 中国医学科学院北京协和医院 一种糖原累积症IIIa型心肌细胞模型的构建方法
WO2025211257A1 (ja) * 2024-04-01 2025-10-09 慶應義塾 オルガノイド製造用培地及びその使用
CN118240750B (zh) * 2024-05-28 2024-08-13 淇嘉科技(苏州)有限公司 具有免疫细胞的结肠类器官构建方法
TWI897580B (zh) * 2024-08-08 2025-09-11 國璽幹細胞應用技術股份有限公司 用於治療傷口修復的醫藥組合物及其製備方法
WO2026099481A1 (en) * 2024-11-11 2026-05-15 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Method for producing cells having an acinar cell phenotype
CN119265134A (zh) * 2024-12-11 2025-01-07 苏州先觉生物科技有限公司 适用于器官/类器官循环培养的系统、方法及类器官
EP4779306A1 (en) 2025-01-17 2026-07-22 HUB Organoids IP B.V. Co-cultures of organoids, stromal cells and immune cells
CN120330136B (zh) * 2025-06-13 2025-10-03 南京兰伯艾克斯生物科技有限公司 一种干细胞克隆培养方法及无血清培养基

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69523750T2 (de) * 1994-05-04 2002-08-01 Mount Sinai Hospital Corp., Toronto Modulatoren der cytokine der tgf-beta überfamilie und verfahren zu ihrer bestimmung
FR2794473B1 (fr) * 1999-06-03 2003-09-26 Centre Nat Rech Scient Procede de multiplication de cellules souches
US20070010008A1 (en) * 2005-06-29 2007-01-11 Tissuetech, Inc. Ex vivo expansion of primary animal cells
US8492148B2 (en) * 2005-02-23 2013-07-23 Foundation For Biomedical Research & Innovation Method for amplification of endothelial progenitor cell in vitro
JP2006325444A (ja) * 2005-05-24 2006-12-07 Toyobo Co Ltd 細胞増殖培地
WO2007030693A2 (en) * 2005-09-08 2007-03-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods for promoting stem cell proliferation and survival
JP2007116926A (ja) * 2005-10-25 2007-05-17 Reprocell Inc 体外における幹細胞の維持と純化に関する方法、組成物およびシステム
GEP20135796B (en) * 2006-03-07 2013-04-10 Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation
JP2008061569A (ja) * 2006-09-07 2008-03-21 Toyobo Co Ltd 幹細胞の培養方法及びその培地
RU2323252C1 (ru) * 2006-10-25 2008-04-27 Антонина Ивановна Колесникова Способ культивирования мезенхимальных стволовых клеток человека ex vivo
EP2022848A1 (en) 2007-08-10 2009-02-11 Hubrecht Institut A method for identifying, expanding, and removing adult stem cells and cancer stem cells
WO2010016766A2 (en) 2008-08-08 2010-02-11 Koninklijke Nederlandse Akademie Van Wetenschappen Antibodies recognizing endogenous human lgr5 and/or lgr6
US8642339B2 (en) * 2009-02-03 2014-02-04 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium for epithelial stem cells and organoids comprising the stem cells
GB201111244D0 (en) * 2011-06-30 2011-08-17 Konink Nl Akademie Van Wetenschappen Knaw Culture media for stem cells
EP2412800A1 (en) * 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Liver organoid, uses thereof and culture method for obtaining them
EP2486126B1 (en) * 2009-10-06 2017-12-06 SNU R & DB Foundation Method for differentiation into retinal cells from stem cells
JP5875119B2 (ja) * 2010-07-30 2016-03-02 国立大学法人九州大学 有機電界発光素子
US9732319B2 (en) * 2010-12-22 2017-08-15 Fate Therapeutics, Inc. Cell culture platform for single cell sorting and enhanced reprogramming of iPSCs

Also Published As

Publication number Publication date
EP3318627C0 (en) 2023-10-25
JP6275035B2 (ja) 2018-02-07
GB201111244D0 (en) 2011-08-17
AU2012265814B2 (en) 2017-04-27
HK1255258A1 (en) 2019-08-09
JP2025090784A (ja) 2025-06-17
IL267447B (en) 2020-06-30
RU2013158140A (ru) 2015-07-20
RU2714256C2 (ru) 2020-02-13
PL3318627T3 (pl) 2024-03-11
CN109136163A (zh) 2019-01-04
SG10201607552XA (en) 2016-10-28
EP3318627A1 (en) 2018-05-09
HRP20171760T1 (hr) 2018-02-09
WO2012168930A3 (en) 2013-04-11
AU2020200515B2 (en) 2022-10-06
IL275204B (en) 2022-03-01
AU2017208270A1 (en) 2017-08-10
AU2023200027A1 (en) 2023-02-09
JP7275196B2 (ja) 2023-05-17
AU2012265814A1 (en) 2014-01-09
NZ619314A (en) 2016-01-29
EP4324913A3 (en) 2024-04-03
CN104024401B (zh) 2018-07-27
HUE064631T2 (hu) 2024-04-28
CA2838492A1 (en) 2012-12-13
IL290485A (en) 2022-04-01
PT2718422T (pt) 2017-11-27
DK2718422T3 (da) 2017-11-27
AU2017208270B2 (en) 2019-10-24
EP2718422A2 (en) 2014-04-16
KR20200120956A (ko) 2020-10-22
JP2018085999A (ja) 2018-06-07
JP2014516562A (ja) 2014-07-17
US20140243227A1 (en) 2014-08-28
HUE037174T2 (hu) 2018-08-28
IL267447A (en) 2019-08-29
JP2021121214A (ja) 2021-08-26
KR102167396B1 (ko) 2020-10-21
WO2012168930A2 (en) 2012-12-13
RU2020105325A (ru) 2020-04-10
IL229879B (en) 2019-07-31
JP2023099163A (ja) 2023-07-11
EP4324913A2 (en) 2024-02-21
EP2718422B1 (en) 2017-09-06
ES3075364T3 (en) 2026-08-04
HRP20231442T1 (hr) 2024-03-01
KR20250009555A (ko) 2025-01-17
KR20140037210A (ko) 2014-03-26
IL275204A (en) 2020-07-30
CA3220440A1 (en) 2012-12-13
CN119372130A (zh) 2025-01-28
AU2026200493A1 (en) 2026-02-12
AU2012265814A2 (en) 2014-01-16
AU2020200515A1 (en) 2020-02-13
EP3318627B1 (en) 2023-10-25
CN104024401A (zh) 2014-09-03
ES2650980T3 (es) 2018-01-23
CA2838492C (en) 2024-01-02
ES2968078T3 (es) 2024-05-07
EP4324913C0 (en) 2026-06-03
CN109136163B (zh) 2024-07-12
EP4324913B1 (en) 2026-06-03
KR20230037058A (ko) 2023-03-15

Similar Documents

Publication Publication Date Title
HUE064631T2 (hu) Tenyésztõ tápközeg õssejtekhez
IL246262A0 (en) Media for cell culture
EP2681306A4 (en) CELL CULTURE SYSTEM
DK3401319T3 (da) Celledyrkningsmedium
PL3415616T3 (pl) Sposób odmładzania komórek
DK3673906T3 (da) Glycosylceramidsyntase-hæmmere
DOP2012000282A (es) Indoles sustituidos como inhibidores ezh2
HUE040455T2 (hu) T-sejt aktiválás inhibitorai
EP2788470A4 (en) CLOSED BIOREACTORS
EP2749642A4 (en) INDUCED MALIGNE STEM CELLS
DK2837680T3 (da) Mammaliacellekultur
DK2675794T3 (da) Selektive fak-inhibitorer
DK2710007T3 (da) Kinasehæmmere
DK2776436T3 (da) Nye forbindelser
EP2753366A4 (en) IMPROVED PHOTOCATALYTIC CELLS
DK2775557T3 (da) Brændselscelle
EP2766311A4 (en) FLOATING DONOR
BR112013019995A2 (pt) bio-óleo estável
EP2727114A4 (en) SWITCHABLE MEMORY
BR112014010125A2 (pt) sistema eletroquímico
EP2794841A4 (en) BIOREACTOR
EP2757623A4 (en) FUEL CELL
EP2717689A4 (en) NEW SGLT HEMMER
DK2681530T3 (da) Gennemstrømmelig målecelle
DE112011105455T8 (de) Brennstoffzelle