PL2739316T3 - Radioznakowane inhibitory antygenu błonowego specyficznego dla prostaty - Google Patents
Radioznakowane inhibitory antygenu błonowego specyficznego dla prostatyInfo
- Publication number
- PL2739316T3 PL2739316T3 PL12822647T PL12822647T PL2739316T3 PL 2739316 T3 PL2739316 T3 PL 2739316T3 PL 12822647 T PL12822647 T PL 12822647T PL 12822647 T PL12822647 T PL 12822647T PL 2739316 T3 PL2739316 T3 PL 2739316T3
- Authority
- PL
- Poland
- Prior art keywords
- prostate specific
- specific membrane
- membrane antigen
- antigen inhibitors
- radiolabeled
- Prior art date
Links
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 title 1
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Optics & Photonics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161515674P | 2011-08-05 | 2011-08-05 | |
| PCT/US2012/049644 WO2013022797A1 (en) | 2011-08-05 | 2012-08-03 | Radiolabeled prostate specific membrane antigen inhibitors |
| EP12822647.9A EP2739316B1 (en) | 2011-08-05 | 2012-08-03 | Radiolabeled prostate specific membrane antigen inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2739316T3 true PL2739316T3 (pl) | 2019-09-30 |
Family
ID=47627059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12822647T PL2739316T3 (pl) | 2011-08-05 | 2012-08-03 | Radioznakowane inhibitory antygenu błonowego specyficznego dla prostaty |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8926944B2 (pl) |
| EP (2) | EP3505192A1 (pl) |
| JP (1) | JP5843338B2 (pl) |
| AU (1) | AU2012294639B2 (pl) |
| CA (1) | CA2844151C (pl) |
| ES (1) | ES2732060T3 (pl) |
| HU (1) | HUE045028T2 (pl) |
| PL (1) | PL2739316T3 (pl) |
| TR (1) | TR201910084T4 (pl) |
| WO (1) | WO2013022797A1 (pl) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2097111B1 (en) | 2006-11-08 | 2015-07-15 | Molecular Insight Pharmaceuticals, Inc. | Heterodimers of glutamic acid |
| AU2008219065B2 (en) | 2007-02-19 | 2014-01-30 | Marine Polymer Technologies, Inc. | Hemostatic compositions and therapeutic regimens |
| PL2187965T3 (pl) | 2007-08-17 | 2020-05-18 | Purdue Research Foundation | Koniugaty wiążący psma ligand-łącznik i sposoby ich zastosowania |
| US8562945B2 (en) * | 2008-01-09 | 2013-10-22 | Molecular Insight Pharmaceuticals, Inc. | Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof |
| WO2017053268A1 (en) * | 2015-09-21 | 2017-03-30 | Serrano-Ojeda Pedro Anastacio | Glutamine-high z element compounds for treating cancer |
| US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| WO2013028664A1 (en) | 2011-08-22 | 2013-02-28 | Siemens Medical Solutions Usa, Inc. | Psma imaging agents |
| EP2800471A4 (en) | 2012-01-06 | 2015-11-04 | Molecular Insight Pharm Inc | METAL COMPLEX OF POLY (CARBOXYL) AMINE CONTAINING LIGANDS HAVING AFFINITY FOR CARBON IX ANHYDRASE |
| EA201590783A1 (ru) | 2012-11-15 | 2015-11-30 | Эндосайт, Инк. | Конъюгаты для доставки лекарственных средств и способы лечения заболеваний, вызванных клетками, экспрессирующими psma |
| EP3939972A1 (en) * | 2013-01-14 | 2022-01-19 | Molecular Insight Pharmaceuticals, Inc. | Triazine based radiopharmaceuticals and radioimaging agents |
| US10232058B2 (en) | 2013-10-14 | 2019-03-19 | The Johns Hopkins University | Prostate-specific membrane antigen-targeted photosensitizers for photodynamic therapy |
| EP3456700A1 (en) * | 2013-10-18 | 2019-03-20 | Deutsches Krebsforschungszentrum | Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
| EP2862857A1 (en) | 2013-10-18 | 2015-04-22 | Deutsches Krebsforschungszentrum | Labeled inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
| EP3533473A3 (en) * | 2013-11-14 | 2019-12-18 | Endocyte, Inc. | Compounds for positron emission tomography |
| JP2017503763A (ja) * | 2013-12-03 | 2017-02-02 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｇｃｃ発現細胞を撮像するための化合物及び組成物 |
| CN106660943B (zh) | 2014-05-06 | 2020-03-17 | 约翰霍普金斯大学 | 用于psma靶向的成像和放射疗法的金属/放射性金属标记的psma抑制物 |
| JP2017530109A (ja) * | 2014-09-08 | 2017-10-12 | モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド | 前立腺癌についてのｐｓｍａを標的とした放射性核種治療中の臓器の保護 |
| EP3209336B1 (en) | 2014-10-20 | 2019-12-11 | Deutsches Krebsforschungszentrum | 18f-tagged inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
| EP3011976A1 (en) | 2014-10-20 | 2016-04-27 | Deutsches Krebsforschungszentrum | 18F-tagged inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents |
| WO2016065142A2 (en) | 2014-10-22 | 2016-04-28 | The Johns Hopkins University | New scaffolds and multifunctional intermediates for imaging psma and cancer therapy |
| US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
| EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
| US10869940B2 (en) | 2015-06-12 | 2020-12-22 | The Board Of Trustees Of The Leland Stanford Junior University | Targeted photoacoustic compounds, formulations, and uses thereof |
| KR102233726B1 (ko) | 2015-09-30 | 2021-03-31 | 도이체스 크렙스포르슝스첸트룸 | 전립선 특이적 막 항원（psma)의 18f-태그된 저해제 및 전립선암에 대한 조영제로서 이의 용도 |
| KR101639599B1 (ko) * | 2015-11-09 | 2016-07-14 | 서울대학교산학협력단 | 펩타이드 싸이오우레아 유도체, 이를 포함하는 방사성 동위원소 표지 화합물 및 이를 유효 성분으로 함유하는 전립선암 치료 또는 진단용 약학적 조성물 |
| US10688200B2 (en) * | 2015-12-31 | 2020-06-23 | Five Eleven Pharma Inc. | Urea-based prostate specific membrane antigen (PSMA) inhibitors for imaging and therapy |
| RS65188B1 (sr) * | 2016-03-22 | 2024-03-29 | Univ Johns Hopkins | Sredstva sa visokim afinitetom za ciljano dejstvo na membranski antigen specifičan za prostatu za endoradioterapiju kancera prostate |
| FI127538B (en) * | 2016-06-22 | 2018-08-31 | Dextech Medical Ab | MODIFIED Dextran Conjugates |
| CN109843339B (zh) | 2016-06-23 | 2023-07-07 | 康奈尔大学 | 影响肿瘤杀伤的双重靶向构建体 |
| US10806806B2 (en) | 2016-06-23 | 2020-10-20 | Cornell University | Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies |
| MX2019005742A (es) | 2016-11-23 | 2019-09-13 | Cancer Targeted Tech Llc | Inhibidores de antigeno de membrana especifico de la prostata (psma) de union a albumina. |
| ES2814555T3 (es) | 2016-11-28 | 2021-03-29 | Bayer Pharma AG | Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética |
| WO2018108287A1 (en) * | 2016-12-15 | 2018-06-21 | The European Atomic Energy Community (Euratom), Represented By The European Commission | Treatment of pmsa expressing cancers |
| EP3609541A4 (en) * | 2017-04-05 | 2021-04-07 | Cornell University | Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies |
| WO2018204477A1 (en) | 2017-05-02 | 2018-11-08 | Cornell University | Methods and reagents for tumor targeting with greater efficacy and less toxicity |
| CA3060143A1 (en) | 2017-05-24 | 2018-11-29 | Itm Isotopen Technologien Munchen Ag | Novel psma-binding agents and uses thereof |
| WO2018233798A1 (en) | 2017-06-20 | 2018-12-27 | ITM Isotopen Technologien München AG | Novel psma-binding agents and uses thereof |
| CN111032632B (zh) * | 2017-05-30 | 2024-04-12 | 约翰霍普金斯大学 | 用于前列腺癌的腔内放射疗法的前列腺特异性膜抗原靶向的高亲和力剂 |
| WO2018236115A1 (ko) * | 2017-06-19 | 2018-12-27 | (주)퓨쳐켐 | 전립선암 진단을 위한 18f-표지된 화합물 및 그의 용도 |
| DK3643707T3 (da) | 2017-06-19 | 2022-05-09 | Futurechem Co Ltd | 18f-mærket forbindelse til diagnosticering af prostatkræft, og anvendelse deraf |
| US20200297877A1 (en) * | 2017-12-13 | 2020-09-24 | Sciencons AS | Complex comprising a psma-targeting compound linked to a lead or thorium radionuclide |
| US11813340B2 (en) | 2018-02-06 | 2023-11-14 | The Johns Hopkins University | PSMA targeted radiohalogenated urea-polyaminocarboxylates for cancer radiotherapy |
| HRP20230604T1 (hr) | 2018-03-30 | 2023-09-29 | Futurechem Co., Ltd. | Radiofarmaceutik usmjeren na psma, namijenjen dijagnosticiranju i liječenju raka prostate |
| CN112368024A (zh) | 2018-04-17 | 2021-02-12 | 恩多塞特公司 | 治疗癌症的方法 |
| EP3590911A1 (en) * | 2018-07-01 | 2020-01-08 | Studiengesellschaft Kohle MbH | Reagent and process for the site-specific deoxyfluorination of peptides |
| EP3856261A1 (en) | 2018-09-28 | 2021-08-04 | Universität Heidelberg | Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of psma-expressing cancers |
| KR102934987B1 (ko) | 2018-11-23 | 2026-03-09 | 바이엘 악티엔게젤샤프트 | 조영 매체의 제형 및 그의 제조 방법 |
| WO2020108753A1 (en) | 2018-11-28 | 2020-06-04 | ITM Isotopen Technologien München AG | Novel tumor antigen binding agents and uses thereof |
| CN113747927B (zh) | 2019-02-14 | 2024-10-18 | 德国癌症研究中心 | 包含淀粉酶可切割接头的前列腺特异性膜抗原(psma)配体 |
| WO2020165420A1 (en) * | 2019-02-14 | 2020-08-20 | Ruprecht-Karls-Universität Heidelberg | Prostate specific membrane antigen (psma) ligands with improved tissue specificity |
| CN114364405B (zh) * | 2019-04-26 | 2024-07-16 | 五一一制药股份有限公司 | 作为诊断剂和放射性核素治疗剂的前列腺特异性膜抗原(psma)抑制剂 |
| CN114096264B (zh) | 2019-05-20 | 2025-03-14 | 因多塞特股份有限公司 | 制备psma缀合物的方法 |
| PH12021553284A1 (en) * | 2019-07-02 | 2022-08-01 | Advanced Accelerator Applications Italy Srl | Prostate specific membrane antigen (psma) ligands and uses thereof |
| WO2021013978A1 (en) | 2019-07-25 | 2021-01-28 | Bayer As | Targeted radiopharmaceuticals for the diagnosis and treatment of prostate cancer |
| CA3155519A1 (en) * | 2019-10-29 | 2021-05-06 | Steve Shih-Lin Huang | Psma-targeting imaging agents |
| DE102019135564B4 (de) * | 2019-12-20 | 2022-05-19 | Johannes-Gutenberg-Universität Mainz | Verbindung für Smart-Drug-Delivery und pharmazeutisches Kit für duale nuklearmedizinisch-cytotoxische Theranostik |
| WO2022096103A1 (en) | 2020-11-05 | 2022-05-12 | ITM Isotopen Technologien München AG | Combination of para-aminohippuric acid (pah) and radiolabeled complexes for treating cancer |
| EP4244216A1 (en) | 2020-11-12 | 2023-09-20 | ABX Advanced Biochemical Compounds GmbH | Ligands of prostate specific membrane antigen (psma) containing heteroaromatic linker building blocks |
| WO2022111800A1 (en) | 2020-11-25 | 2022-06-02 | Itm Solucin Gmbh | Stable formulations for radionuclide complexes |
| EP4023250A1 (en) * | 2021-01-04 | 2022-07-06 | Technische Universität München | Dual mode radiotracer and -therapeutics |
| CN116745323A (zh) | 2021-01-22 | 2023-09-12 | 拜耳股份有限公司 | Lrrc15抗体及其缀合物 |
| US20240299596A1 (en) * | 2021-06-17 | 2024-09-12 | Mayo Foundation For Medical Education And Research | Methods and materials for combining biologics with multiple chelators |
| CN118852043A (zh) * | 2021-09-03 | 2024-10-29 | 晶核生物医药科技(南京)有限公司 | 一种肽脲素衍生物、含其的药物组合物及其应用 |
| US20250332265A1 (en) * | 2021-11-09 | 2025-10-30 | Case Western Reserve University | Psma targeted conjugate compounds and uses thereof |
| WO2023208928A1 (en) | 2022-04-26 | 2023-11-02 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Dosage of psma-ligands for fluorescence based detection of cancerous tissue |
| WO2023222679A1 (en) | 2022-05-17 | 2023-11-23 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Prostate specific membrane antigen (psma) ligands |
| CN119156234A (zh) | 2022-05-17 | 2024-12-17 | 德国癌症研究中心公共法律基金会 | 前列腺特异性膜抗原（psma）配体 |
| EP4525937A1 (en) | 2022-05-17 | 2025-03-26 | Deutsches Krebsforschungszentrum | Prostate specific membrane antigen (psma) ligands with improved renal clearance |
| KR20250016195A (ko) | 2022-05-17 | 2025-02-03 | 도이체스크레브스포르슝스젠트룸스티프퉁데스외펜트리헨레크츠 | 전립선-특이적 막 항원(psma) 리간드 |
| EP4282438A1 (en) * | 2022-05-23 | 2023-11-29 | ABX Advanced Biochemical Compounds GmbH | Functionalized bisaminothiol derivatives, complexes with these bisaminothiol derivatives and use of said complexes as diagnostics and therapeutics |
| AU2023413150A1 (en) * | 2022-12-21 | 2025-06-26 | Mayo Foundation For Medical Education And Research | Methods and materials for combining biologics with multiple chelators |
| CN116507630A (zh) * | 2023-02-14 | 2023-07-28 | 北京师范大学 | 含硝基芳香杂环基团的psma靶向放射性金属配合物及其制备 |
| WO2025029946A1 (en) | 2023-07-31 | 2025-02-06 | Curium Us Llc | [177lu] lutetium-psma i&t composition and dosimetry, kit, method of making, and method of using thereof |
| WO2025088147A1 (en) | 2023-10-27 | 2025-05-01 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Theranostic psma-targeting ligands for the diagnosis and treatment of psma-expressing cancers and their solid phase synthesis |
| KR20250062978A (ko) * | 2023-10-31 | 2025-05-08 | 서울대학교병원 | 신규한 전립선 특이적 막 항원 리간드 및 이의 용도 |
| WO2025218879A1 (en) | 2024-04-15 | 2025-10-23 | Itm Technologies Munich Se | Stable formulations comprising 225-actinium labeled complexes and methods for preparing the same |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003060523A1 (en) * | 2002-01-10 | 2003-07-24 | Johns Hopkins University | Imaging agents and methods of imaging naaladase of psma |
| EP2097111B1 (en) * | 2006-11-08 | 2015-07-15 | Molecular Insight Pharmaceuticals, Inc. | Heterodimers of glutamic acid |
| ES2700234T3 (es) * | 2007-06-26 | 2019-02-14 | Univ Johns Hopkins | Inhibidores marcados del antígeno de membrana específico de la próstata (PSMA), evaluación biológica y uso como agentes para la obtención de imágenes |
| JP2012511024A (ja) * | 2008-12-05 | 2012-05-17 | モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド | 癌の治療及び撮像用のｃａ−ｉｘ特異性放射性医薬品 |
| US9056841B2 (en) * | 2009-03-19 | 2015-06-16 | The Johns Hopkins University | PSMA-targeting compounds and uses thereof |
-
2012
- 2012-08-03 AU AU2012294639A patent/AU2012294639B2/en active Active
- 2012-08-03 JP JP2014524142A patent/JP5843338B2/ja active Active
- 2012-08-03 EP EP19155531.7A patent/EP3505192A1/en not_active Withdrawn
- 2012-08-03 PL PL12822647T patent/PL2739316T3/pl unknown
- 2012-08-03 EP EP12822647.9A patent/EP2739316B1/en active Active
- 2012-08-03 HU HUE12822647A patent/HUE045028T2/hu unknown
- 2012-08-03 US US13/566,849 patent/US8926944B2/en active Active
- 2012-08-03 ES ES12822647T patent/ES2732060T3/es active Active
- 2012-08-03 CA CA2844151A patent/CA2844151C/en active Active
- 2012-08-03 TR TR2019/10084T patent/TR201910084T4/tr unknown
- 2012-08-03 WO PCT/US2012/049644 patent/WO2013022797A1/en not_active Ceased
-
2014
- 2014-11-25 US US14/553,157 patent/US9388144B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2844151C (en) | 2022-11-29 |
| JP2014524419A (ja) | 2014-09-22 |
| ES2732060T3 (es) | 2019-11-20 |
| EP2739316A4 (en) | 2015-03-11 |
| US20130034494A1 (en) | 2013-02-07 |
| EP2739316B1 (en) | 2019-04-10 |
| EP2739316A1 (en) | 2014-06-11 |
| AU2012294639B2 (en) | 2017-10-26 |
| US20150078998A1 (en) | 2015-03-19 |
| WO2013022797A1 (en) | 2013-02-14 |
| US9388144B2 (en) | 2016-07-12 |
| HUE045028T2 (hu) | 2019-12-30 |
| JP5843338B2 (ja) | 2016-01-13 |
| CA2844151A1 (en) | 2013-02-14 |
| US8926944B2 (en) | 2015-01-06 |
| AU2012294639A8 (en) | 2014-03-06 |
| TR201910084T4 (tr) | 2019-08-21 |
| AU2012294639A1 (en) | 2014-02-27 |
| EP3505192A1 (en) | 2019-07-03 |
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