PL2814829T3 - Związki enediyny, ich koniugaty oraz zastosowanie i sposoby ich wytwarzania - Google Patents

Związki enediyny, ich koniugaty oraz zastosowanie i sposoby ich wytwarzania

Info

Publication number
PL2814829T3
PL2814829T3 PL13704871T PL13704871T PL2814829T3 PL 2814829 T3 PL2814829 T3 PL 2814829T3 PL 13704871 T PL13704871 T PL 13704871T PL 13704871 T PL13704871 T PL 13704871T PL 2814829 T3 PL2814829 T3 PL 2814829T3
Authority
PL
Poland
Prior art keywords
conjugates
methods therefor
enediyne compounds
enediyne
compounds
Prior art date
Application number
PL13704871T
Other languages
English (en)
Inventor
Naidu S. Chowdari
Sanjeev Gangwar
Bilal Sufi
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47722570&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2814829(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of PL2814829T3 publication Critical patent/PL2814829T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL13704871T 2012-02-13 2013-02-08 Związki enediyny, ich koniugaty oraz zastosowanie i sposoby ich wytwarzania PL2814829T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261598143P 2012-02-13 2012-02-13
US201261653785P 2012-05-31 2012-05-31

Publications (1)

Publication Number Publication Date
PL2814829T3 true PL2814829T3 (pl) 2017-06-30

Family

ID=47722570

Family Applications (1)

Application Number Title Priority Date Filing Date
PL13704871T PL2814829T3 (pl) 2012-02-13 2013-02-08 Związki enediyny, ich koniugaty oraz zastosowanie i sposoby ich wytwarzania

Country Status (31)

Country Link
US (2) US8709431B2 (pl)
EP (1) EP2814829B1 (pl)
JP (1) JP6113194B2 (pl)
KR (1) KR101660146B1 (pl)
CN (1) CN104220441B (pl)
AR (1) AR089972A1 (pl)
AU (1) AU2013221873B2 (pl)
BR (1) BR112014019990A8 (pl)
CA (1) CA2864420C (pl)
CL (1) CL2014002096A1 (pl)
CO (1) CO7061078A2 (pl)
CY (1) CY1118899T1 (pl)
DK (1) DK2814829T3 (pl)
EA (1) EA027925B1 (pl)
ES (1) ES2615268T3 (pl)
HK (1) HK1204326A1 (pl)
HR (1) HRP20170334T1 (pl)
HU (1) HUE033704T2 (pl)
IL (1) IL233965B (pl)
LT (1) LT2814829T (pl)
MX (1) MX350539B (pl)
PE (1) PE20141791A1 (pl)
PL (1) PL2814829T3 (pl)
PT (1) PT2814829T (pl)
RS (1) RS55763B1 (pl)
SG (1) SG11201404667XA (pl)
SI (1) SI2814829T1 (pl)
SM (1) SMT201700137T1 (pl)
TW (1) TW201336851A (pl)
WO (1) WO2013122823A1 (pl)
ZA (1) ZA201406723B (pl)

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KR20160068738A (ko) * 2013-08-14 2016-06-15 윌리엄 마쉬 라이스 유니버시티 운시알라마이신의 유도체, 합성 방법 및 항종양 제제로서 이들의 용도
JP6644701B2 (ja) 2014-03-20 2020-02-12 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 安定化したフィブロネクチンベーススキャフォールド分子
KR102569813B1 (ko) 2014-11-21 2023-08-24 브리스톨-마이어스 스큅 컴퍼니 Cd73에 대항한 항체 및 그의 용도
CN113929770A (zh) 2014-11-21 2022-01-14 百时美施贵宝公司 包含修饰的重链恒定区的抗体
CN107406494B (zh) 2014-11-25 2022-03-25 百时美施贵宝公司 用于成像的新型pd-l1结合多肽
CN107531720A (zh) * 2015-01-08 2018-01-02 斯克利普斯研究院 抗癌症候选药物
CN107406496A (zh) 2015-03-10 2017-11-28 百时美施贵宝公司 可通过转谷氨酰胺酶缀合的抗体和由其制备的缀合物
JP6797137B2 (ja) 2015-05-29 2020-12-09 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｏｘ４０に対する抗体およびその使用
KR102818445B1 (ko) 2015-09-23 2025-06-10 브리스톨-마이어스 스큅 컴퍼니 글리피칸-3-결합 피브로넥틴 기반 스캐폴드 분자
CN107043406B (zh) 2015-11-03 2021-08-17 财团法人工业技术研究院 化合物、连接子-药物、及配体-药物耦合体
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CN111683686A (zh) * 2017-12-06 2020-09-18 西纳福克斯股份有限公司 烯二炔缀合物
CN110183659B (zh) * 2018-02-21 2022-04-26 香港科技大学 含有杂环的聚合物、其制备方法及其应用
US20220106400A1 (en) 2018-11-28 2022-04-07 Bristol-Myers Squibb Company Antibodies comprising modified heavy constant regions
JP7389803B2 (ja) 2018-11-30 2023-11-30 ブリストル－マイヤーズ スクイブ カンパニー グルタミンを含有する軽鎖ｃ末端に伸長部分を含む抗体およびそのコンジュゲートならびにその方法および用途
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Also Published As

Publication number Publication date
SMT201700137T1 (it) 2017-05-08
HK1204326A1 (en) 2015-11-13
DK2814829T3 (en) 2017-03-20
SG11201404667XA (en) 2014-09-26
LT2814829T (lt) 2017-02-27
BR112014019990A2 (pl) 2017-06-20
JP2015508074A (ja) 2015-03-16
HRP20170334T1 (hr) 2017-04-21
EA027925B1 (ru) 2017-09-29
IL233965B (en) 2018-01-31
CY1118899T1 (el) 2018-01-10
KR101660146B1 (ko) 2016-09-26
CN104220441A (zh) 2014-12-17
AR089972A1 (es) 2014-10-01
CO7061078A2 (es) 2014-09-19
KR20140120374A (ko) 2014-10-13
CL2014002096A1 (es) 2014-11-28
US9156850B2 (en) 2015-10-13
BR112014019990A8 (pt) 2017-07-11
WO2013122823A1 (en) 2013-08-22
AU2013221873A1 (en) 2014-10-02
CN104220441B (zh) 2017-03-29
CA2864420C (en) 2016-11-15
JP6113194B2 (ja) 2017-04-12
TW201336851A (zh) 2013-09-16
US8709431B2 (en) 2014-04-29
ES2615268T3 (es) 2017-06-06
RS55763B1 (sr) 2017-07-31
PT2814829T (pt) 2017-02-15
EA201491447A1 (ru) 2014-11-28
AU2013221873B2 (en) 2016-11-17
PE20141791A1 (es) 2014-11-19
US20130209494A1 (en) 2013-08-15
ZA201406723B (en) 2016-05-25
US20140193438A1 (en) 2014-07-10
HUE033704T2 (en) 2017-12-28
MX350539B (es) 2017-09-08
MX2014009234A (es) 2014-11-10
CA2864420A1 (en) 2013-08-22
SI2814829T1 (sl) 2017-02-28
EP2814829B1 (en) 2016-12-07
EP2814829A1 (en) 2014-12-24

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