PL2893040T3 - Sposoby wykrywania rzadkich mutacji i wariantu liczby kopii - Google Patents

Sposoby wykrywania rzadkich mutacji i wariantu liczby kopii

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Publication number
PL2893040T3
PL2893040T3 PL13834427T PL13834427T PL2893040T3 PL 2893040 T3 PL2893040 T3 PL 2893040T3 PL 13834427 T PL13834427 T PL 13834427T PL 13834427 T PL13834427 T PL 13834427T PL 2893040 T3 PL2893040 T3 PL 2893040T3
Authority
PL
Poland
Prior art keywords
methods
copy number
number variation
rare mutations
detect rare
Prior art date
Application number
PL13834427T
Other languages
English (en)
Inventor
AmirAli TALASAZ
Helmy Eltoukhy
Original Assignee
Guardant Health Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50237580&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2893040(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Guardant Health Inc filed Critical Guardant Health Inc
Publication of PL2893040T3 publication Critical patent/PL2893040T3/pl

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B99/00—Subject matter not provided for in other groups of this subclass
    • C—CHEMISTRY; METALLURGY
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/165—Mathematical modelling, e.g. logarithm, ratio
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2545/00—Reactions characterised by their quantitative nature
    • C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
    • C12Q2545/114—Reactions characterised by their quantitative nature the purpose being quantitative analysis involving a quantitation step
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Medical Informatics (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Indexing, Searching, Synchronizing, And The Amount Of Synchronization Travel Of Record Carriers (AREA)
PL13834427T 2012-09-04 2013-09-04 Sposoby wykrywania rzadkich mutacji i wariantu liczby kopii PL2893040T3 (pl)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201261696734P 2012-09-04 2012-09-04
US201261704400P 2012-09-21 2012-09-21
US201361793997P 2013-03-15 2013-03-15
US201361845987P 2013-07-13 2013-07-13
PCT/US2013/058061 WO2014039556A1 (en) 2012-09-04 2013-09-04 Systems and methods to detect rare mutations and copy number variation
EP13834427.0A EP2893040B1 (en) 2012-09-04 2013-09-04 Methods to detect rare mutations and copy number variation

Publications (1)

Publication Number Publication Date
PL2893040T3 true PL2893040T3 (pl) 2019-05-31

Family

ID=50237580

Family Applications (2)

Application Number Title Priority Date Filing Date
PL13834427T PL2893040T3 (pl) 2012-09-04 2013-09-04 Sposoby wykrywania rzadkich mutacji i wariantu liczby kopii
PL19192885T PL3591073T3 (pl) 2012-09-04 2013-09-04 Sposoby wykrywania rzadkich mutacji i zmienności liczby kopii

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL19192885T PL3591073T3 (pl) 2012-09-04 2013-09-04 Sposoby wykrywania rzadkich mutacji i zmienności liczby kopii

Country Status (17)

Country Link
US (31) US10041127B2 (pl)
EP (6) EP4036247B1 (pl)
JP (6) JP6275145B2 (pl)
KR (6) KR102028375B1 (pl)
CN (2) CN110872617A (pl)
CA (2) CA3190199A1 (pl)
DE (1) DE202013012824U1 (pl)
DK (1) DK2893040T5 (pl)
ES (5) ES2984550T3 (pl)
GB (2) GB2510725B (pl)
HK (1) HK1225416B (pl)
IL (3) IL305303A (pl)
MX (1) MX367963B (pl)
PL (2) PL2893040T3 (pl)
PT (1) PT2893040T (pl)
SG (2) SG11201501662TA (pl)
WO (1) WO2014039556A1 (pl)

Families Citing this family (406)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10083273B2 (en) 2005-07-29 2018-09-25 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US10081839B2 (en) 2005-07-29 2018-09-25 Natera, Inc System and method for cleaning noisy genetic data and determining chromosome copy number
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
ES2640776T3 (es) 2009-09-30 2017-11-06 Natera, Inc. Métodos para denominar de forma no invasiva ploidía prenatal
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
EP2854058A3 (en) 2010-05-18 2015-10-28 Natera, Inc. Methods for non-invasive pre-natal ploidy calling
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US12655483B2 (en) 2010-05-18 2026-06-16 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
US8916344B2 (en) 2010-11-15 2014-12-23 Exact Sciences Corporation Methylation assay
AU2011348100B2 (en) 2010-12-22 2016-08-25 Natera, Inc. Methods for non-invasive prenatal paternity testing
EP3225697A3 (en) 2010-12-30 2017-11-22 Foundation Medicine, Inc. Optimization of multigene analysis of tumor samples
JP6153874B2 (ja) 2011-02-09 2017-06-28 ナテラ， インコーポレイテッド 非侵襲的出生前倍数性呼び出しのための方法
US9260753B2 (en) 2011-03-24 2016-02-16 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
EP3246416B1 (en) 2011-04-15 2024-06-05 The Johns Hopkins University Safe sequencing system
WO2012177792A2 (en) 2011-06-24 2012-12-27 Sequenom, Inc. Methods and processes for non-invasive assessment of a genetic variation
US20130079241A1 (en) 2011-09-15 2013-03-28 Jianhua Luo Methods for Diagnosing Prostate Cancer and Predicting Prostate Cancer Relapse
EP2764458B1 (en) 2011-10-06 2021-04-07 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2013052913A2 (en) 2011-10-06 2013-04-11 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
ES2929923T3 (es) 2012-01-20 2022-12-02 Sequenom Inc Procesos de diagnóstico que condicionan las condiciones experimentales
SMT202100154T1 (it) 2012-02-17 2021-05-07 Hutchinson Fred Cancer Res Composizioni e metodi per identificare precisamente mutazioni
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
WO2013142389A1 (en) 2012-03-20 2013-09-26 University Of Washington Through Its Center For Commercialization Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing
WO2013166517A1 (en) * 2012-05-04 2013-11-07 Complete Genomics, Inc. Methods for determining absolute genome-wide copy number variations of complex tumors
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US11261494B2 (en) 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
US10497461B2 (en) 2012-06-22 2019-12-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
PL2893040T3 (pl) 2012-09-04 2019-05-31 Guardant Health Inc Sposoby wykrywania rzadkich mutacji i wariantu liczby kopii
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2014070462A1 (en) 2012-10-29 2014-05-08 The Johns Hopkins University Papanicolaou test for ovarian and endometrial cancers
US9218450B2 (en) * 2012-11-29 2015-12-22 Roche Molecular Systems, Inc. Accurate and fast mapping of reads to genome
CN105531375B (zh) 2012-12-10 2020-03-03 分析生物科学有限公司 靶向基因组分析的方法
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP2971179B1 (en) 2013-03-14 2019-01-09 Mayo Foundation for Medical Education and Research Detecting neoplasm
ES2980689T3 (es) 2013-03-15 2024-10-02 Guardant Health Inc Métodos para la secuenciación de polinucleótidos libres de células
EP2971130A4 (en) 2013-03-15 2016-10-05 Nugen Technologies Inc SEQUENTIAL SEQUENCING
EP4187543A1 (en) 2013-04-03 2023-05-31 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
AU2014268377B2 (en) 2013-05-24 2020-10-08 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
DK3011051T3 (en) 2013-06-21 2019-04-23 Sequenom Inc Method for non-invasive evaluation of genetic variations
US10262755B2 (en) 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
US10577655B2 (en) 2013-09-27 2020-03-03 Natera, Inc. Cell free DNA diagnostic testing standards
US10964409B2 (en) 2013-10-04 2021-03-30 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
JP6680680B2 (ja) 2013-10-07 2020-04-15 セクエノム， インコーポレイテッド 染色体変化の非侵襲性評価のための方法およびプロセス
JP6534191B2 (ja) 2013-10-21 2019-06-26 ベリナタ ヘルス インコーポレイテッド コピー数変動を決定することにおける検出の感度を向上させるための方法
KR102205950B1 (ko) 2013-11-07 2021-01-22 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 인간 마이크로바이옴 및 그의 성분의 분석을 위한 무세포 핵산
JP6525473B2 (ja) 2013-11-13 2019-06-05 ニューゲン テクノロジーズ， インコーポレイテッド 複製物配列決定リードを同定するための組成物および方法
CN111534580B (zh) 2013-12-28 2024-06-04 夸登特健康公司 用于检测遗传变异的方法和系统
DK3090062T3 (da) 2013-12-30 2020-09-21 Univ Pittsburgh Commonwealth Sys Higher Education Fusionsgener associeret med fremadskridende prostatakræft
US12492429B2 (en) 2014-04-21 2025-12-09 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
RU2717641C2 (ru) 2014-04-21 2020-03-24 Натера, Инк. Обнаружение мутаций и плоидности в хромосомных сегментах
WO2015175705A1 (en) 2014-05-13 2015-11-19 Board Of Regents, The University Of Texas System Gene mutations and copy number alterations of egfr, kras and met
WO2015181718A1 (en) * 2014-05-26 2015-12-03 Ebios Futura S.R.L. Method of prenatal diagnosis
WO2015184404A1 (en) * 2014-05-30 2015-12-03 Verinata Health, Inc. Detecting fetal sub-chromosomal aneuploidies and copy number variations
EP3149640B1 (en) * 2014-05-30 2019-09-04 Sequenom, Inc. Chromosome representation determinations
US20180173845A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
WO2016011428A1 (en) 2014-07-17 2016-01-21 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods of treating cells containing fusion genes
TWI758011B (zh) 2014-07-18 2022-03-11 香港中文大學 Ｄｎａ混合物中之組織甲基化模式分析
GB201412834D0 (en) * 2014-07-18 2014-09-03 Cancer Rec Tech Ltd A method for detecting a genetic variant
CN107002122B (zh) 2014-07-25 2023-09-19 华盛顿大学 确定导致无细胞dna的产生的组织和/或细胞类型的方法以及使用其鉴定疾病或紊乱的方法
US11783911B2 (en) 2014-07-30 2023-10-10 Sequenom, Inc Methods and processes for non-invasive assessment of genetic variations
EP3177740B1 (en) * 2014-08-06 2021-01-13 Nugen Technologies, Inc. Digital measurements from targeted sequencing
US20160053301A1 (en) 2014-08-22 2016-02-25 Clearfork Bioscience, Inc. Methods for quantitative genetic analysis of cell free dna
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
ES2989276T3 (es) 2014-12-05 2024-11-25 Found Medicine Inc Análisis multigénico de muestras tumorales
WO2016090584A1 (zh) * 2014-12-10 2016-06-16 深圳华大基因研究院 确定肿瘤核酸浓度的方法和装置
DK3230469T3 (da) * 2014-12-12 2019-07-15 Verinata Health Inc Anvendelse af cellefri DNA-fragmentstørrelse til bestemmelse af kopiantalsvariationer
WO2016095093A1 (zh) * 2014-12-15 2016-06-23 天津华大基因科技有限公司 肿瘤筛查方法、目标区域变异检测方法和装置
US10006910B2 (en) 2014-12-18 2018-06-26 Agilome, Inc. Chemically-sensitive field effect transistors, systems, and methods for manufacturing and using the same
US9618474B2 (en) 2014-12-18 2017-04-11 Edico Genome, Inc. Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids
US9857328B2 (en) 2014-12-18 2018-01-02 Agilome, Inc. Chemically-sensitive field effect transistors, systems and methods for manufacturing and using the same
US9859394B2 (en) 2014-12-18 2018-01-02 Agilome, Inc. Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids
US10429342B2 (en) 2014-12-18 2019-10-01 Edico Genome Corporation Chemically-sensitive field effect transistor
US10020300B2 (en) 2014-12-18 2018-07-10 Agilome, Inc. Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids
JP2018502602A (ja) * 2014-12-29 2018-02-01 カウンシル，インコーポレーテッド 相同性の高い領域において遺伝子型を決定する方法
WO2016109452A1 (en) 2014-12-31 2016-07-07 Guardant Health , Inc. Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results
US10364467B2 (en) 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
DK3256605T3 (da) * 2015-02-10 2022-03-14 Univ Hong Kong Chinese Påvisning af mutationer til cancerscreening og føtal analyse
WO2016160454A1 (en) 2015-03-27 2016-10-06 Exact Sciences Corporation Detecting esophageal disorders
EP3288455B1 (en) 2015-05-01 2023-12-06 Guardant Health, Inc. Diagnostic methods
EP4428863A3 (en) 2015-05-11 2024-12-11 Natera, Inc. Methods and compositions for determining ploidy
US10395759B2 (en) * 2015-05-18 2019-08-27 Regeneron Pharmaceuticals, Inc. Methods and systems for copy number variant detection
EP3298169B1 (en) 2015-05-18 2024-10-02 Karius, Inc. Compositions and methods for enriching populations of nucleic acids
WO2016201142A1 (en) * 2015-06-09 2016-12-15 Life Technologies Corporation Methods, systems, compositions, kits, apparatus and computer-readable media for molecular tagging
SG11201707649SA (en) * 2015-06-24 2017-10-30 Samsung Life Public Welfare Foundation Method and device for analyzing gene
HK1252804B (zh) * 2015-07-07 2020-02-28 远见基因组系统公司 用於基於测序的变型检测的方法和系统
AU2016293025A1 (en) * 2015-07-13 2017-11-02 Agilent Technologies Belgium Nv System and methodology for the analysis of genomic data obtained from a subject
JP7074661B2 (ja) * 2015-07-21 2022-05-25 ガーダント ヘルス， インコーポレイテッド 融合遺伝子を捕捉するためのロックド核酸
US10453556B2 (en) 2015-07-23 2019-10-22 The Chinese University Of Hong Kong Analysis of fragmentation patterns of cell-free DNA
WO2017020024A2 (en) * 2015-07-29 2017-02-02 Progenity, Inc. Systems and methods for genetic analysis
CN108350500A (zh) 2015-07-29 2018-07-31 普罗格尼迪公司 用于检测染色体异常的核酸和方法
CA2994848C (en) 2015-08-07 2021-08-10 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Methods for predicting prostate cancer relapse
US11286531B2 (en) 2015-08-11 2022-03-29 The Johns Hopkins University Assaying ovarian cyst fluid
JP6871926B2 (ja) 2015-08-31 2021-05-19 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチＭａｙｏ Ｆｏｕｎｄａｔｉｏｎ ｆｏｒ Ｍｅｄｉｃａｌ Ｅｄｕｃａｔｉｏｎ ａｎｄ Ｒｅｓｅａｒｃｈ 胃の新生物を検出すること
US11302416B2 (en) * 2015-09-02 2022-04-12 Guardant Health Machine learning for somatic single nucleotide variant detection in cell-free tumor nucleic acid sequencing applications
AU2016321204B2 (en) * 2015-09-08 2022-12-01 Cold Spring Harbor Laboratory Genetic copy number determination using high throughput multiplex sequencing of smashed nucleotides
JP6991134B2 (ja) 2015-10-09 2022-01-12 ガーダント ヘルス， インコーポレイテッド 無細胞ｄｎａを使用する集団ベースの処置レコメンダ
KR101848438B1 (ko) 2015-10-29 2018-04-13 바이오코아 주식회사 디지털 pcr을 이용한 산전진단 방법
CA3002196C (en) * 2015-10-30 2024-05-14 Exact Sciences Development Company, Llc Multiplex amplification detection assay and isolation and detection of dna from plasma
EP3889257A1 (en) 2015-11-11 2021-10-06 Resolution Bioscience, Inc. High efficiency construction of dna libraries
WO2017087510A1 (en) * 2015-11-16 2017-05-26 Mayo Foundation For Medical Education And Research Detecting copy number variations
WO2017100441A1 (en) 2015-12-08 2017-06-15 Twinstrand Biosciences, Inc. Improved adapters, methods, and compositions for duplex sequencing
SG11201805119QA (en) * 2015-12-17 2018-07-30 Guardant Health Inc Methods to determine tumor gene copy number by analysis of cell-free dna
WO2017127741A1 (en) * 2016-01-22 2017-07-27 Grail, Inc. Methods and systems for high fidelity sequencing
EP4779643A2 (en) 2016-02-02 2026-07-22 Guardant Health, Inc. Cancer evolution detection and diagnostic
US10095831B2 (en) 2016-02-03 2018-10-09 Verinata Health, Inc. Using cell-free DNA fragment size to determine copy number variations
US11479878B2 (en) 2016-03-16 2022-10-25 Dana-Farber Cancer Institute, Inc. Methods for genome characterization
KR102326769B1 (ko) 2016-03-25 2021-11-17 카리우스, 인코포레이티드 합성 핵산 스파이크-인
US11384382B2 (en) 2016-04-14 2022-07-12 Guardant Health, Inc. Methods of attaching adapters to sample nucleic acids
WO2017181146A1 (en) 2016-04-14 2017-10-19 Guardant Health, Inc. Methods for early detection of cancer
JP7280044B2 (ja) 2016-04-15 2023-05-23 ナテラ， インコーポレイテッド 肺癌の検出方法
ITUA20162640A1 (it) * 2016-04-15 2017-10-15 Menarini Silicon Biosystems Spa Metodo e kit per la generazione di librerie di dna per sequenziamento massivo parallelo
US20170298422A1 (en) 2016-04-18 2017-10-19 The Board Of Trustees Of The Leland Stanford Junior University Simultaneous single-molecule epigenetic imaging of dna methylation and hydroxymethylation
US11078475B2 (en) 2016-05-03 2021-08-03 Sinai Health System Methods of capturing cell-free methylated DNA and uses of same
AU2017260630B2 (en) 2016-05-05 2023-07-13 Exact Sciences Corporation Detection of lung neoplasia by analysis of methylated DNA
WO2017201081A1 (en) 2016-05-16 2017-11-23 Agilome, Inc. Graphene fet devices, systems, and methods of using the same for sequencing nucleic acids
CA3024630A1 (en) 2016-05-16 2017-11-23 Accuragen Holdings Limited Method of improved sequencing by strand identification
JP2019521673A (ja) * 2016-06-07 2019-08-08 ザ リージェンツ オブ ザ ユニヴァーシティー オブ カリフォルニア 疾患および状態の分析のためのセルフリーｄｎａメチル化パターン
WO2018005811A1 (en) 2016-06-30 2018-01-04 Grail, Inc. Differential tagging of rna for preparation of a cell-free dna/rna sequencing library
CN107577917A (zh) * 2016-07-05 2018-01-12 魏霖静 一种生物信息学高性能信息化管理系统及数据处理方法
ES2967443T3 (es) 2016-07-06 2024-04-30 Guardant Health Inc Procedimientos de perfilado de fragmentoma de ácidos nucleicos sin células
US10600499B2 (en) 2016-07-13 2020-03-24 Seven Bridges Genomics Inc. Systems and methods for reconciling variants in sequence data relative to reference sequence data
CN109563543B (zh) 2016-07-15 2022-08-30 加利福尼亚大学董事会 产生核酸库的方法
US11200963B2 (en) 2016-07-27 2021-12-14 Sequenom, Inc. Genetic copy number alteration classifications
KR102505122B1 (ko) 2016-08-25 2023-03-08 레졸루션 바이오사이언스, 인크. Dna 샘플 중 게놈 카피 변화의 검출을 위한 방법
KR102711907B1 (ko) * 2016-09-22 2024-09-27 일루미나, 인코포레이티드 체세포 복제수 변이 검출
US9850523B1 (en) 2016-09-30 2017-12-26 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
EP3792922A1 (en) 2016-09-30 2021-03-17 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
US20200048711A1 (en) 2016-10-12 2020-02-13 Bellwether Bio, Inc Determining cell type origin of circulating cell-free dna with molecular counting
TWI797095B (zh) 2016-10-24 2023-04-01 美商格瑞爾有限責任公司 腫瘤檢測之方法及系統
WO2018081465A1 (en) * 2016-10-26 2018-05-03 Pathway Genomics Corporation Systems and methods for characterizing nucleic acid in a biological sample
CN106566877A (zh) * 2016-10-31 2017-04-19 天津诺禾致源生物信息科技有限公司 检测基因突变的方法和装置
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
CA3042434A1 (en) 2016-11-15 2018-05-24 Personal Genome Diagnostics Inc. Non-unique barcodes in a genotyping assay
IL266347B2 (en) 2016-11-30 2025-01-01 Univ Hong Kong Chinese Analysis of cell-free DNA in urine and other samples
US10011870B2 (en) * 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
CN110383385B (zh) * 2016-12-08 2023-07-25 生命科技股份有限公司 从肿瘤样品中检测突变负荷的方法
US20180166170A1 (en) * 2016-12-12 2018-06-14 Konstantinos Theofilatos Generalized computational framework and system for integrative prediction of biomarkers
IL302912A (en) 2016-12-22 2023-07-01 Guardant Health Inc Methods and systems for analyzing nucleic acid molecules
CN106701956A (zh) * 2017-01-11 2017-05-24 上海思路迪生物医学科技有限公司 ctDNA的数字化深度测序技术
CA3198931A1 (en) 2017-01-20 2018-07-26 Sequenom, Inc. Methods for non-invasive assessment of genetic alterations
CA3207879C (en) 2017-01-24 2026-06-16 Sequenom, Inc. Methods and processes for assessment of genetic variations
WO2018137685A1 (en) 2017-01-25 2018-08-02 The Chinese University Of Hong Kong Diagnostic applications using nucleic acid fragments
AU2018211956B2 (en) 2017-01-27 2024-06-20 Exact Sciences Corporation Detection of colon neoplasia by analysis of methylated DNA
CA3049139A1 (en) 2017-02-21 2018-08-30 Natera, Inc. Compositions, methods, and kits for isolating nucleic acids
CN106755547A (zh) * 2017-03-15 2017-05-31 上海亿康医学检验所有限公司 一种膀胱癌的无创检测及其复发监测方法
EP3998350B1 (en) 2017-03-17 2025-05-07 Sequenom, Inc. Methods and processes for assessment of genetic mosaicism
WO2018183942A1 (en) 2017-03-31 2018-10-04 Grail, Inc. Improved library preparation and use thereof for sequencing-based error correction and/or variant identification
US12492430B2 (en) 2017-04-11 2025-12-09 Tecan Genomics, Inc. Library quantitation and qualification
CA3059370C (en) 2017-04-12 2022-05-10 Karius, Inc. Methods for concurrent analysis of dna and rna in mixed samples
US11342047B2 (en) * 2017-04-21 2022-05-24 Illumina, Inc. Using cell-free DNA fragment size to detect tumor-associated variant
US11535896B2 (en) * 2017-05-15 2022-12-27 Katholieke Universiteit Leuven Method for analysing cell-free nucleic acids
CN118711654A (zh) * 2017-05-16 2024-09-27 夸登特健康公司 无细胞dna的体细胞来源或种系来源的鉴定
CN110914911B (zh) 2017-05-16 2023-09-22 生命科技股份有限公司 压缩分子标记的核酸序列数据的方法
KR102145417B1 (ko) * 2017-05-24 2020-08-19 지니너스 주식회사 무세포 핵산으로부터 수득된 서열 분석 데이터에 대한 배경 대립인자의 빈도 분포를 생성하는 방법 및 이를 이용하여 무세포 핵산으로부터 변이를 검출하는 방법
EP3635133B1 (en) * 2017-06-09 2026-08-05 Bellwether Bio, Inc. Determination of cancer type in a subject by probabilistic modeling of circulating nucleic acid fragment endpoints
WO2018236911A1 (en) * 2017-06-20 2018-12-27 Illumina, Inc. Methods and systems for decomposition and quantification of dna mixtures from multiple contributors of known or unknown genotypes
US12054711B2 (en) 2017-07-14 2024-08-06 City Of Hope Meta-stable oligonucleotides junctions for delivery of therapeutics
EP3431611A1 (en) 2017-07-21 2019-01-23 Menarini Silicon Biosystems S.p.A. Improved method and kit for the generation of dna libraries for massively parallel sequencing
WO2019020057A1 (en) 2017-07-26 2019-01-31 The Chinese University Of Hong Kong ENHANCING CANCER SCREENING WITH ACELLULAR VIRAL NUCLEIC ACIDS
US11646100B2 (en) 2017-08-04 2023-05-09 Billiontoone, Inc. Target-associated molecules for characterization associated with biological targets
AU2018312117B2 (en) 2017-08-04 2022-05-12 Billiontoone, Inc. Sequencing output determination and analysis with target-associated molecules in quantification associated with biological targets
US11519024B2 (en) 2017-08-04 2022-12-06 Billiontoone, Inc. Homologous genomic regions for characterization associated with biological targets
KR20250047324A (ko) 2017-08-07 2025-04-03 더 존스 홉킨스 유니버시티 암을 평가하고 치료하기 위한 방법 및 재료
CN111630166B (zh) 2017-08-10 2024-04-19 希望之城 条件性-siRNA及其在治疗心肌肥大中的用途
WO2019033083A1 (en) 2017-08-10 2019-02-14 City Of Hope CONDITIONAL RNAIDS AND THEIR USES IN THE TREATMENT OF ACUTE MYELOID LEUKEMIA
KR20240157126A (ko) 2017-09-20 2024-10-31 가던트 헬쓰, 인크. 체세포 및 생식세포계열 변이체를 구별하기 위한 방법 및 시스템
CN107688726B (zh) * 2017-09-21 2021-09-07 深圳市易基因科技有限公司 基于液相捕获技术判定单基因病相关拷贝数缺失的方法
US11099202B2 (en) 2017-10-20 2021-08-24 Tecan Genomics, Inc. Reagent delivery system
EP3704268B1 (en) 2017-11-03 2025-01-22 Guardant Health, Inc. Normalizing tumor mutation burden
CN111542616A (zh) 2017-11-03 2020-08-14 夸登特健康公司 脱氨引起的序列错误的纠正
CA3081027A1 (en) 2017-11-08 2019-05-16 Twinstrand Biosciences, Inc. Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters
JP7054133B2 (ja) 2017-11-09 2022-04-13 国立研究開発法人国立がん研究センター 配列解析方法、配列解析装置、参照配列の生成方法、参照配列生成装置、プログラム、および記録媒体
KR102667912B1 (ko) 2017-11-16 2024-05-21 일루미나, 인코포레이티드 미세부수체 불안정성을 결정하기 위한 시스템 및 방법
CN111742059B (zh) * 2017-11-28 2024-07-09 格瑞尔有限责任公司 用于靶向测序的模型
EP3622522A1 (en) 2017-12-01 2020-03-18 Illumina, Inc. Methods and systems for determining somatic mutation clonality
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
WO2019118926A1 (en) 2017-12-14 2019-06-20 Tai Diagnostics, Inc. Assessing graft suitability for transplantation
CN108197428B (zh) * 2017-12-25 2020-06-19 西安交通大学 一种并行动态规划的下一代测序技术拷贝数变异检测方法
CN109979529B (zh) * 2017-12-28 2021-01-08 北京安诺优达医学检验实验室有限公司 Cnv检测装置
SG11202006110UA (en) 2018-01-05 2020-07-29 Billiontoone Inc Quality control templates for ensuring validity of sequencing-based assays
US12590326B2 (en) 2018-01-10 2026-03-31 Guardant Health, Inc. Methods for fragmentome profiling of cell-free nucleic acids
US11584929B2 (en) 2018-01-12 2023-02-21 Claret Bioscience, Llc Methods and compositions for analyzing nucleic acid
EP3737773B1 (en) 2018-01-12 2023-04-12 Natera, Inc. Novel primers and uses thereof
WO2019140402A1 (en) * 2018-01-15 2019-07-18 Illumina, Inc. Deep learning-based variant classifier
CN108268752B (zh) * 2018-01-18 2019-02-01 东莞博奥木华基因科技有限公司 一种染色体异常检测装置
KR102036609B1 (ko) * 2018-02-12 2019-10-28 바이오코아 주식회사 디지털 pcr을 이용한 산전진단 방법
WO2019161244A1 (en) 2018-02-15 2019-08-22 Natera, Inc. Methods for isolating nucleic acids with size selection
EP3762512A1 (en) 2018-03-06 2021-01-13 Cancer Research Technology Limited Improvements in variant detection
US12626780B2 (en) 2018-03-13 2026-05-12 Grail, Inc. Method and system for selecting, managing, and analyzing data of high dimensionality
GB201804642D0 (en) * 2018-03-22 2018-05-09 Inivata Ltd Methods of labelling nucleic acids
US11203782B2 (en) 2018-03-29 2021-12-21 Accuragen Holdings Limited Compositions and methods comprising asymmetric barcoding
CA3302676A1 (en) 2018-04-02 2026-05-13 Grail, Inc. Methylation markers and targeted methylation probe panels
US12322476B2 (en) 2018-04-13 2025-06-03 Guardant Health, Inc. Methods for detecting and suppressing alignment errors caused by fusion events
DK3781714T3 (da) 2018-04-14 2026-03-30 Natera Inc Fremgangsmåder til cancerpåvisning og -overvågning ved personlig påvisning af cirkulerende tumor-dna
CA3097146A1 (en) * 2018-04-16 2019-10-24 Memorial Sloan Kettering Cancer Center Systems and methods for detecting cancer via cfdna screening
JP7590954B2 (ja) * 2018-04-20 2024-11-27 バイオファイア・ダイアグノスティクス，リミテッド・ライアビリティ・カンパニー シーケンシングデータの正規化および定量化のための方法
CA3097992A1 (en) * 2018-04-24 2019-10-31 Grail, Inc. Systems and methods for using pathogen nucleic acid load to determine whether a subject has a cancer condition
CN112888459B (zh) 2018-06-01 2023-05-23 格里尔公司 卷积神经网络系统及数据分类方法
US20190385700A1 (en) 2018-06-04 2019-12-19 Guardant Health, Inc. METHODS AND SYSTEMS FOR DETERMINING The CELLULAR ORIGIN OF CELL-FREE NUCLEIC ACIDS
WO2019236726A1 (en) 2018-06-06 2019-12-12 The Regents Of The University Of California Methods of producing nucleic acid libraries and compositions and kits for practicing same
KR20210035167A (ko) 2018-06-11 2021-03-31 파운데이션 메디신 인코포레이티드 게놈 변경을 평가하기 위한 조성물 및 방법
CN109192246B (zh) * 2018-06-22 2020-10-16 深圳市达仁基因科技有限公司 检测染色体拷贝数异常的方法、装置和存储介质
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
EP3619712B1 (en) * 2018-07-11 2024-02-14 Illumina, Inc. Deep learning-based framework for identifying sequence patterns that cause sequence-specific errors
US12073922B2 (en) 2018-07-11 2024-08-27 Illumina, Inc. Deep learning-based framework for identifying sequence patterns that cause sequence-specific errors (SSEs)
AU2019300172A1 (en) 2018-07-12 2021-01-28 Twinstrand Biosciences, Inc. Methods and reagents for characterizing genomic editing, clonal expansion, and associated applications
CN120193081A (zh) 2018-07-23 2025-06-24 夸登特健康公司 用于通过肿瘤分数和覆盖率调整肿瘤突变负荷的方法和系统
US20210292851A1 (en) * 2018-07-27 2021-09-23 Roche Sequencing Solutions, Inc. Method of monitoring effectiveness of immunotherapy of cancer patients
CN113227396A (zh) 2018-08-06 2021-08-06 十亿至一公司 用于定量生物靶的稀释标签
JP7566741B2 (ja) 2018-08-10 2024-10-15 シティ・オブ・ホープ プログラム可能なｓｉＲＮＡ及びその使用
CN113574602A (zh) * 2018-08-22 2021-10-29 加利福尼亚大学董事会 从循环无细胞核酸中灵敏地检测拷贝数变异(cnv)
KR20210052501A (ko) 2018-08-30 2021-05-10 가던트 헬쓰, 인크. 샘플 사이의 오염을 검출하기 위한 방법 및 시스템
US20200075123A1 (en) 2018-08-31 2020-03-05 Guardant Health, Inc. Genetic variant detection based on merged and unmerged reads
JP7539367B2 (ja) 2018-08-31 2024-08-23 ガーダント ヘルス， インコーポレイテッド 無細胞ｄｎａにおけるマイクロサテライト不安定性の検出
US20200075124A1 (en) 2018-09-04 2020-03-05 Guardant Health, Inc. Methods and systems for detecting allelic imbalance in cell-free nucleic acid samples
EP3850631A1 (en) * 2018-09-14 2021-07-21 The Jackson Laboratory Method and apparatus for detecting copy number variations in a genome
EP3856903A4 (en) 2018-09-27 2022-07-27 Grail, LLC METHYLATION MARKER AND TARGETED METHYLATION PROBE PANEL
EP3815005A4 (en) 2018-10-08 2022-03-30 Freenome Holdings, Inc. Transcription factor profiling
CN109523520B (zh) * 2018-10-25 2020-12-18 北京大学第三医院 一种基于深度学习的染色体自动计数方法
CA3116176A1 (en) 2018-10-31 2020-05-07 Guardant Health, Inc. Methods, compositions and systems for calibrating epigenetic partitioning assays
EP4700161A3 (en) 2018-11-21 2026-03-11 Karius, Inc. Direct-to-library methods, systems, and compositions
CN109584961A (zh) * 2018-12-03 2019-04-05 元码基因科技（北京）股份有限公司 基于二代测序技术检测血液微卫星不稳定的方法
US11581062B2 (en) 2018-12-10 2023-02-14 Grail, Llc Systems and methods for classifying patients with respect to multiple cancer classes
US20200202975A1 (en) * 2018-12-19 2020-06-25 AiOnco, Inc. Genetic information processing system with mutation analysis mechanism and method of operation thereof
CN113454218A (zh) 2018-12-20 2021-09-28 夸登特健康公司 用于改进核酸分子的回收的方法、组合物和系统
CN109712671B (zh) * 2018-12-20 2020-06-26 北京优迅医学检验实验室有限公司 基于ctDNA的基因检测装置、存储介质及计算机系统
CN111383714B (zh) * 2018-12-29 2023-07-28 安诺优达基因科技(北京)有限公司 模拟目标疾病仿真测序文库的方法及其应用
EP4567131A3 (en) 2019-01-31 2025-09-03 Guardant Health, Inc. Compositions and methods for isolating cell-free dna
CN109841265B (zh) * 2019-02-22 2021-09-21 清华大学 使用片段化模式确定血浆游离核酸分子组织来源的方法和系统及应用
AU2020228058B2 (en) 2019-02-27 2025-03-27 Guardant Health, Inc. Computational modeling of loss of function based on allelic frequency
WO2020176659A1 (en) 2019-02-27 2020-09-03 Guardant Health, Inc. Methods and systems for determining the cellular origin of cell-free dna
CN111755075B (zh) * 2019-03-28 2023-09-29 深圳华大生命科学研究院 对免疫组库高通量测序样本间序列污染进行过滤的方法
WO2020206170A1 (en) 2019-04-02 2020-10-08 Progenity, Inc. Methods, systems, and compositions for counting nucleic acid molecules
EP3723096A1 (en) * 2019-04-12 2020-10-14 European Molecular Biology Laboratory Comprehensive detection of single cell genetic structural variations
US12497662B2 (en) 2019-04-16 2025-12-16 Grail, Inc. Systems and methods for tumor fraction estimation from small variants
CN110299185B (zh) * 2019-05-08 2023-07-04 西安电子科技大学 一种基于新一代测序数据的插入变异检测方法及系统
EP3976822A1 (en) * 2019-05-31 2022-04-06 Guardant Health, Inc. Methods and systems for improving patient monitoring after surgery
US12305235B2 (en) 2019-06-06 2025-05-20 Natera, Inc. Methods for detecting immune cell DNA and monitoring immune system
EP3983558A4 (en) * 2019-06-12 2023-06-28 Ultima Genomics, Inc. Methods for accurate base calling using molecular barcodes
US12437840B2 (en) 2019-07-02 2025-10-07 International Business Machines Corporation Determining cell, tissue, or lesion representations in cell-free DNA
EP3795685A1 (en) 2019-09-20 2021-03-24 Sophia Genetics S.A. Methods for dna library generation to facilitate the detection and reporting of low frequency variants
EP4041919A1 (en) 2019-09-30 2022-08-17 Guardant Health, Inc. Compositions and methods for analyzing cell-free dna in methylation partitioning assays
EP4040946A1 (en) * 2019-10-10 2022-08-17 Carlsberg A/S Methods for preparing mutant plants
CN110578002A (zh) * 2019-10-10 2019-12-17 广州燃石医学检验所有限公司 用于检测循环肿瘤dna突变的质控品及其制备方法
WO2021072275A1 (en) 2019-10-11 2021-04-15 Guardant Health, Inc. Use of cell free bacterial nucleic acids for detection of cancer
WO2021077411A1 (zh) * 2019-10-25 2021-04-29 苏州宏元生物科技有限公司 染色体不稳定性检测方法、系统及试剂盒
EP4775688A2 (en) 2019-10-25 2026-07-15 Guardant Health, Inc. Methods for 3' overhang repair
CN114467144B (zh) * 2019-10-25 2025-06-20 首尔大学校产学协力团 减少测序平台特异性错误的体细胞突变检测装置及方法
AU2020378435B2 (en) 2019-11-06 2026-07-30 The Board Of Trustees Of The Leland Stanford Junior University Methods and systems for analyzing nucleic acid molecules
ES3031713T3 (en) 2019-11-26 2025-07-10 Guardant Health Inc Methods, compositions and systems for improving the binding of methylated polynucleotides
KR102184277B1 (ko) * 2020-01-16 2020-11-30 성균관대학교산학협력단 초음파 진단 및 dna 검사 일체형 ai 자가 건강 관리 장치 및 이를 이용한 원격 의료 진단 방법
EP3851542A1 (en) 2020-01-20 2021-07-21 Tecan Genomics, Inc. Depletion of abundant uninformative sequences
CN115428087A (zh) 2020-01-31 2022-12-02 夸登特健康公司 克隆水平缺乏靶变体的显著性建模
CN113275053A (zh) 2020-02-03 2021-08-20 帝肯基因组学公司 试剂存储系统
WO2021163546A1 (en) 2020-02-14 2021-08-19 The Johns Hopkins University Methods and materials for assessing nucleic acids
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
ES3040741T3 (en) 2020-02-24 2025-11-04 Univ Leland Stanford Junior Methods of analyzing cell free nucleic acids and applications thereof
EP4118653B1 (en) 2020-03-11 2024-07-17 Guardant Health, Inc. Methods for classifying genetic mutations detected in cell-free nucleic acids as tumor or non-tumor origin
CN111445950B (zh) * 2020-03-19 2022-10-25 西安交通大学 一种基于滤波策略的高容错基因组复杂结构变异检测方法
CN113436679B (zh) * 2020-03-23 2024-05-10 北京合生基因科技有限公司 确定待测核酸样本变异率的方法和系统
WO2021222828A1 (en) 2020-04-30 2021-11-04 Guardant Health, Inc. Methods for sequence determination using partitioned nucleic acids
JP7842700B2 (ja) 2020-05-14 2026-04-08 ガーダント ヘルス， インコーポレイテッド 相同組換え修復欠損の検出
US20230183811A1 (en) * 2020-05-14 2023-06-15 Georgia Tech Research Corporation Methods of detecting the efficacy of anticancer agents
WO2021228418A1 (en) 2020-05-15 2021-11-18 Universal Diagnostics, S.L. Methods and systems for identifying methylation biomarkers
US12592321B2 (en) * 2020-06-19 2026-03-31 University Health Network Cancer detection and classification using methylome analysis
EP4407042A3 (en) 2020-07-10 2024-09-18 Guardant Health, Inc. Methods of detecting genomic rearrangements using cell free nucleic acids
WO2023282916A1 (en) 2021-07-09 2023-01-12 Guardant Health, Inc. Methods of detecting genomic rearrangements using cell free nucleic acids
ES3018032T3 (en) 2020-07-30 2025-05-14 Guardant Health Inc Methods for isolating cell-free dna
DE112021004478T5 (de) 2020-08-25 2023-09-14 Seer, Inc. Zusammensetzungen und verfahren zur bestimmung von proteinen und nukleinsäuren
WO2022046947A1 (en) 2020-08-25 2022-03-03 Guardant Health, Inc. Methods and systems for predicting an origin of a variant
EP4205122A2 (en) 2020-08-27 2023-07-05 Guardant Health, Inc. Computational detection of copy number variation at a locus in the absence of direct measurement of the locus
JP2023544720A (ja) 2020-09-30 2023-10-25 ガーダント ヘルス， インコーポレイテッド Ｄｎａメチル化分配アッセイのシグナル対ノイズ比を改善するための方法およびシステム
WO2022087309A1 (en) 2020-10-23 2022-04-28 Guardant Health, Inc. Compositions and methods for analyzing dna using partitioning and base conversion
EP4251765A1 (en) 2020-11-30 2023-10-04 Guardant Health, Inc. Compositions and methods for enriching methylated polynucleotides
EP4267757A1 (en) 2020-12-23 2023-11-01 Guardant Health, Inc. Methods and systems for analyzing methylated polynucleotides
CN116583906A (zh) * 2020-12-28 2023-08-11 松下电器（美国）知识产权公司 信息处理方法、信息处理装置以及信息处理程序
CN112735516A (zh) * 2020-12-29 2021-04-30 上海派森诺生物科技股份有限公司 一种无参考基因组的群体变异检测分析方法
CN112908411B (zh) * 2021-01-12 2024-05-14 广州市金域转化医学研究院有限公司 一种线粒体变异位点数据库及其建立方法和应用
WO2022174109A1 (en) 2021-02-12 2022-08-18 Guardant Health, Inc. Methods and compositions for detecting nucleic acid variants
KR20230156364A (ko) 2021-03-05 2023-11-14 가던트 헬쓰, 인크. 분자 반응을 분석하기 위한 방법 및 관련 측면
EP4305200A1 (en) 2021-03-09 2024-01-17 Guardant Health, Inc. Detecting the presence of a tumor based on off-target polynucleotide sequencing data
WO2022204730A1 (en) 2021-03-25 2022-09-29 Guardant Health, Inc. Methods and compositions for quantifying immune cell dna
CN113130005B (zh) * 2021-04-12 2022-11-22 中国科学院东北地理与农业生态研究所 一种基于m2群体的候选因果突变位点基因定位的方法
US11783912B2 (en) 2021-05-05 2023-10-10 The Board Of Trustees Of The Leland Stanford Junior University Methods and systems for analyzing nucleic acid molecules
EP4348249A1 (en) 2021-05-28 2024-04-10 Guardant Health, Inc. Compositions and methods for assaying circulating molecules
CN113284555B (zh) * 2021-06-11 2023-08-22 中山大学 一种基因突变网络的构建方法、装置、设备及存储介质
WO2022271730A1 (en) 2021-06-21 2022-12-29 Guardant Health, Inc. Methods and compositions for copy-number informed tissue-of-origin analysis
US20250191692A1 (en) * 2021-07-06 2025-06-12 Switch Therapeutics Inc. Methods of designing conditional-activatable small interfering rna sensors
EP4385021A4 (en) * 2021-08-10 2025-08-06 Univ Cornell ULTRASENSITIVE LIQUID BIOPSY BY PLASMA WHOLE GENOME SEQUENCING USING DEEP LEARNING
WO2023056065A1 (en) 2021-09-30 2023-04-06 Guardant Health, Inc. Compositions and methods for synthesis and use of probes targeting nucleic acid rearrangements
EP4413151A4 (en) * 2021-10-04 2025-08-13 Univ Hong Kong Chinese Viral DNA sequencing to predict disease relapse
JP2024540168A (ja) 2021-11-02 2024-10-31 ガーダント ヘルス， インコーポレイテッド 品質管理方法
WO2023097325A2 (en) * 2021-11-29 2023-06-01 Mammoth Biosciences, Inc. Systems and methods for identifying genetic phenotypes using programmable nucleases
CN114703263B (zh) * 2021-12-20 2023-09-22 北京科迅生物技术有限公司 一种群组染色体拷贝数变异检测方法及装置
WO2023122623A1 (en) 2021-12-21 2023-06-29 Guardant Health, Inc. Methods and systems for combinatorial chromatin-ip sequencing
WO2023122740A1 (en) 2021-12-23 2023-06-29 Guardant Health, Inc. Compositions and methods for detection of metastasis
WO2023183812A2 (en) 2022-03-21 2023-09-28 Billion Toone, Inc. Molecule counting of methylated cell-free dna for treatment monitoring
JP2025513786A (ja) 2022-04-07 2025-04-30 ガーダント ヘルス， インコーポレイテッド 無細胞核酸分子のメチル化状態に基づいた腫瘍の存在の検出
CN114724628B (zh) * 2022-04-24 2022-11-08 华中农业大学 一种对多物种进行多核苷酸变异鉴定和注释的方法
US20230360725A1 (en) 2022-05-09 2023-11-09 Guardant Health, Inc. Detecting degradation based on strand bias
JP2025522763A (ja) 2022-06-30 2025-07-17 ガーダント ヘルス， インコーポレイテッド 異常にメチル化されたｄｎａの富化
US20240191290A1 (en) 2022-07-21 2024-06-13 Guardant Health, Inc. Methods for detection and reduction of sample preparation-induced methylation artifacts
EP4587843A1 (en) 2022-09-16 2025-07-23 Guardant Health, Inc. Compositions and methods for analyzing soluble proteins
JP2025532196A (ja) 2022-09-27 2025-09-29 ガーダント ヘルス， インコーポレイテッド 免疫細胞ｄｎａを定量するための方法
EP4619985A1 (en) 2022-11-15 2025-09-24 Guardant Health, Inc. Method of predicting non-small cell lung cancer (nsclc) patient drug response or time until death or cancer progression from circulating tumor dna (ctdna) utilizing signals from both baseline ctdna level and longitudinal change of ctdna level over time
US12606872B2 (en) 2022-11-16 2026-04-21 Universal Diagnostics, S.A. Methods for stratification and early detection of advanced adenoma and/or colorectal cancer using DNA methylation markers
KR20250111338A (ko) 2022-11-17 2025-07-22 가던트 헬쓰, 인크. 무세포 dna 액체 생검 검정에서 비-종양 변이체를 분류하기 위한 생물정보학적 모델의 검증
AU2023409008A1 (en) 2022-12-21 2025-06-26 Guardant Health, Inc. Detecting homologous recombination deficiences based on methylation status of cell-free nucleic acid molecules
WO2024137880A2 (en) 2022-12-22 2024-06-27 Guardant Health, Inc. Methods involving methylation preserving amplification with error correction
WO2024138180A2 (en) 2022-12-22 2024-06-27 Guardant Health, Inc. Integrated targeted and whole genome somatic and dna methylation sequencing workflows
WO2024151825A1 (en) 2023-01-11 2024-07-18 Guardant Health, Inc. Joint modeling of longitudinal and time-to-event data to predict patient survival
WO2024159053A1 (en) 2023-01-25 2024-08-02 Guardant Health, Inc. Nucleic acid methylation profiling method
CN115798580B (zh) * 2023-02-10 2023-11-07 北京中仪康卫医疗器械有限公司 基于基因型填补和低深度测序的一体化基因组分析方法
US20250078955A1 (en) 2023-04-07 2025-03-06 Guardant Health, Inc. Detecting the presence of a tumor based on methylation status of cell-free nucleic acid molecules
JP2026514005A (ja) 2023-04-12 2026-05-01 ガーダント ヘルス， インコーポレイテッド プロモーターメチル化の検出
EP4705514A1 (en) 2023-05-01 2026-03-11 Guardant Health, Inc. Quality control method for enzymatic conversion procedures
WO2024229433A1 (en) 2023-05-03 2024-11-07 Guardant Health, Inc. Methods for analysis of dna methylation
WO2024233502A1 (en) 2023-05-05 2024-11-14 Guardant Health, Inc. Cell-free dna blood-based test for cancer screening
WO2024259251A1 (en) 2023-06-15 2024-12-19 Guardant Health, Inc. Method for hrd detection in targeted cfdna samples using de novo mutational signatures
WO2024264065A1 (en) 2023-06-23 2024-12-26 Guardant Health, Inc. Methods and compositions for quantifying immune cell nucleic acids
WO2025007034A1 (en) 2023-06-29 2025-01-02 Guardant Health, Inc. Methods for determining surveillance and therapy for diseases
WO2025029475A1 (en) 2023-07-28 2025-02-06 Guardant Health, Inc. Methods to enrich nucleotide variants by negative selection
EP4758267A1 (en) 2023-08-11 2026-06-17 Guardant Health, Inc. Methylated enrichment methods for single-molecule genetic and epigenetic sequencing
US20250084469A1 (en) 2023-09-12 2025-03-13 Guardant Health, Inc. Methods for analyzing nucleic acids using sequence read family size distribution
EP4781415A1 (en) 2023-09-19 2026-07-29 Guardant Health, Inc. Detecting the presence of a tumor based on methylation status of cell-free nucleic acid molecules
EP4784800A1 (en) 2023-09-29 2026-08-05 Guardant Health, Inc. Genotyping cyp2d6
WO2025076452A1 (en) 2023-10-06 2025-04-10 Guardant Health, Inc. Detecting tumor-related information based on methylation status of cell-free nucleic acid molecules
CN122003508A (zh) 2023-10-06 2026-05-08 夸登特健康公司 用于预测拷贝数丢失/基因缺失的基因组和甲基化生物标志物
WO2025079958A1 (ko) * 2023-10-11 2025-04-17 고려대학교 산학협력단 높은 처리량의 돌연변이 특이적 아답터 리게이션 방법
WO2025085784A1 (en) 2023-10-18 2025-04-24 Guardant Health, Inc. Genomic and methylation biomarkers for determining patient risk of heart disease and novel genomic and epigenomic drug targets to decrease risk of heart disease and/or improve patient outcome after myocardial infarction or cardiac injury
WO2025090954A1 (en) 2023-10-26 2025-05-01 Guardant Health, Inc. Methods for detecting nucleic acid variants
WO2025090956A1 (en) 2023-10-26 2025-05-01 Guardant Health, Inc. Methods for detecting nucleic acid variants using capture probes
WO2025090646A1 (en) 2023-10-27 2025-05-01 Guardant Health, Inc. Monitoring molecular response by allelic imbalance
WO2025106275A1 (en) 2023-11-15 2025-05-22 Guardant Health, Inc. Minimum residual disease (mrd) detection in early stage cancer using urine
WO2025106263A1 (en) 2023-11-15 2025-05-22 Guardant Health, Inc. Joint modeling of longitudinal and time-to-event data to predict patient survival
WO2025137620A1 (en) 2023-12-21 2025-06-26 Guardant Health, Inc. Methods for high quality and high accuracy methylation sequencing
WO2025137389A2 (en) 2023-12-22 2025-06-26 Guardant Health, Inc. Methods for targeted single-molecule genetic and epigenetic sequencing
WO2025160433A1 (en) * 2024-01-24 2025-07-31 Guardant Health, Inc. Methods for analyzing sequencing reads
WO2025179170A2 (en) 2024-02-22 2025-08-28 Canal Biosciences, Inc. Single-stranded end preserving adaptors
WO2025207817A1 (en) 2024-03-26 2025-10-02 Guardant Health, Inc. Method of determining the likelihood of a disease by combining biomarkers and imaging
WO2025207788A1 (en) 2024-03-27 2025-10-02 Guardant Health, Inc. Inferring cnvs from the distribution of molecules in hyper partition
WO2025208044A1 (en) 2024-03-28 2025-10-02 Guardant Health, Inc. Methods for cancer detection using molecular patterns
WO2025207921A1 (en) 2024-03-28 2025-10-02 Guardant Health, Inc. Methods for methylation enrichment using cpg-specific deamination
WO2025212664A1 (en) 2024-04-01 2025-10-09 Guardant Health, Inc. Small variant calling with error-rate based model
WO2025235602A1 (en) 2024-05-07 2025-11-13 Guardant Health, Inc. Predictive, prognostic signatures for immuno-oncology using liquid biopsy
WO2025235889A1 (en) 2024-05-10 2025-11-13 Guardant Health, Inc. Methods involving multiplexed pooled pcr
WO2025245131A1 (en) * 2024-05-21 2025-11-27 SAGA Dx, Inc. Tumor marker selection and detection
WO2025250544A1 (en) 2024-05-31 2025-12-04 Guardant Health, Inc. Methods for analyzing chromatin architecture in tissue to boost detection of cancer associated signals in cell-free dna
US12467087B1 (en) 2024-06-25 2025-11-11 Guardant Health, Inc. Sequencing methods with partitioning
WO2026015607A1 (en) 2024-07-09 2026-01-15 Guardant Health, Inc. Methods for partitioning hyper-, hypo-, and non-methylated dna
WO2026015794A1 (en) 2024-07-12 2026-01-15 Guardant Health, Inc. Methods for modifying dna using cpg-specific deamination and uracil base excision
WO2026024817A1 (en) 2024-07-24 2026-01-29 Guardant Health, Inc. Methods and compositions for anchored multiplex ngs workflows
WO2026024692A1 (en) 2024-07-24 2026-01-29 Guardant Health, Inc. Direct methylation single-base resolution sequencing of enriched unmethylated dna
WO2026024956A1 (en) 2024-07-24 2026-01-29 Guardant Health, Inc. Selecting low technical noise biomarkers for sensitive molecular diagnostics
WO2026043702A1 (en) 2024-08-21 2026-02-26 Guardant Health, Inc. Methods and approaches for personalized identification and monitoring of extrachromosomal circular dna
WO2026043718A1 (en) 2024-08-21 2026-02-26 Guardant Health, Inc. Methods to monitor patients treated with a cancer vaccine
WO2026050179A1 (en) 2024-08-26 2026-03-05 Guardant Health, Inc. Tumor fraction (tf) is associated with real-world progression-free survival (rwpfs) in non-small-cell lung cancer (nsclc) patients treated with platinum-based chemotherapy (chemo)
WO2026050287A1 (en) 2024-08-27 2026-03-05 Guardant Health, Inc. Methylation biomarkers for osimertinib treatment management
WO2026060266A1 (en) 2024-09-13 2026-03-19 Guardant Health, Inc. Use of copy number variants for the identification of false positive tumor calls
WO2026064529A2 (en) 2024-09-18 2026-03-26 Guardant Health, Inc. Methods for detecting nucleic acid variants using primers and ligation substrates
WO2026073140A1 (en) 2024-09-27 2026-04-02 Guardant Health, Inc. Framework to identify genomic regions indicative of one or more biological conditions
WO2026076332A1 (en) 2024-10-03 2026-04-09 Guardant Health, Inc. Methods involving multi-modal tumor variant identification and tracking of tumor molecules
WO2026080838A2 (en) 2024-10-11 2026-04-16 Guardant Health, Inc. Methods for detecting nucleic acid variants
WO2026090570A1 (en) 2024-10-24 2026-04-30 Guardant Health, Inc. Detecting the presence of a biological condition based on a nucleic acid sample data analysis
WO2026096358A1 (en) 2024-10-28 2026-05-07 Guardant Health, Inc. Screening approaches for high cancer risk individuals
WO2026096627A1 (en) 2024-10-29 2026-05-07 Guardant Health, Inc. Methods for high-plexity extracellular vesicle protein characterization through immunopcr/ngs
WO2026096657A1 (en) 2024-10-29 2026-05-07 Guardant Health, Inc. Methods for highly multi-plexed detection and quantification of co-localized membrane surface proteins
WO2026102107A1 (en) 2024-11-07 2026-05-15 Guardant Health, Inc. Methods for detecting somatic variants
WO2026102110A1 (en) 2024-11-07 2026-05-15 Guardant Health, Inc. Individualized mrd assay type selection to maximize per patient sensitivity based on comprehensive tumor variant profiling
WO2026107204A1 (en) 2024-11-14 2026-05-21 Guardant Health, Inc. Methods for analyzing low-depth genome sequencing data to detect minimal residual disease
WO2026107359A2 (en) 2024-11-15 2026-05-21 Guardant Health, Inc. Methods for detecting extracellular vesicle-associated molecules
WO2026112439A1 (en) 2024-11-21 2026-05-28 Guardant Health, Inc. Promoter methylation
WO2026112640A1 (en) 2024-11-25 2026-05-28 Guardant Health, Inc. Tumor-specific methylation-based multi-omic method for detecting gene deletions and driver mutations from plasma and tissue dna
WO2026117723A1 (en) 2024-11-26 2026-06-04 Guardant Health, Inc. Methods of nucleic acid analysis involving size separation
WO2026136560A1 (en) 2024-12-17 2026-06-25 Guardant Health, Inc. Methods for cfdna methylation data modeling using transformer neural network architecture
WO2026136937A1 (en) 2024-12-20 2026-06-25 Guardant Health, Inc. Methods for identifying and/or detecting somatic variants
WO2026136701A1 (en) 2024-12-20 2026-06-25 Guardant Health, Inc. Compositions and methods for analyzing dna using a methylation-discriminating nuclease and conversion
WO2026136756A1 (en) 2024-12-20 2026-06-25 Guardant Health, Inc. Compositions and methods for enriching dna using selection protection and a methylation-discriminating nuclease
WO2026161859A1 (en) 2025-01-27 2026-07-30 Guardant Health, Inc. Personalized models trained on synthetic cancer data
WO2026165101A1 (en) 2025-01-29 2026-08-06 Guardant Health, Inc. Copy number allelic strand determination
WO2026165372A1 (en) 2025-01-31 2026-08-06 Guardant Health, Inc. Methods for measuring line-1 hypomethylation
WO2026165504A1 (en) 2025-01-31 2026-08-06 Guardant Health, Inc. Methods for detecting nucleic acids from cancer cells

Family Cites Families (279)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US604804A (en) * 1898-05-31 Shuttle for looms
US4725536A (en) 1985-09-19 1988-02-16 Genetics Institute, Inc. Reagent polynucleotide complex with multiple target binding regions, and kit and methods
US6150517A (en) 1986-11-24 2000-11-21 Gen-Probe Methods for making oligonucleotide probes for the detection and/or quantitation of non-viral organisms
US4942124A (en) 1987-08-11 1990-07-17 President And Fellows Of Harvard College Multiplex sequencing
US5149625A (en) 1987-08-11 1992-09-22 President And Fellows Of Harvard College Multiplex analysis of DNA
US5656731A (en) 1987-10-15 1997-08-12 Chiron Corporation Nucleic acid-amplified immunoassay probes
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5871928A (en) 1989-06-07 1999-02-16 Fodor; Stephen P. A. Methods for nucleic acid analysis
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6551784B2 (en) 1989-06-07 2003-04-22 Affymetrix Inc Method of comparing nucleic acid sequences
US6309822B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US5925525A (en) 1989-06-07 1999-07-20 Affymetrix, Inc. Method of identifying nucleotide differences
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5200314A (en) 1990-03-23 1993-04-06 Chiron Corporation Polynucleotide capture assay employing in vitro amplification
DE69132905T2 (de) 1990-12-06 2002-08-01 Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) Detektion von Nukleinsäuresequenzen
US6582908B2 (en) 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
US5981179A (en) 1991-11-14 1999-11-09 Digene Diagnostics, Inc. Continuous amplification reaction
US5424413A (en) 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US6020124A (en) 1992-04-27 2000-02-01 Trustees Of Dartmouth College Detection of soluble gene sequences in biological fluids
US5981176A (en) 1992-06-17 1999-11-09 City Of Hope Method of detecting and discriminating between nucleic acid sequences
JP3954092B2 (ja) 1993-06-25 2007-08-08 アフィメトリックス インコーポレイテッド 核酸配列のハイブリダイゼーションと配列決定
US5500356A (en) 1993-08-10 1996-03-19 Life Technologies, Inc. Method of nucleic acid sequence selection
US6309823B1 (en) 1993-10-26 2001-10-30 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same
US5681697A (en) 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
CH686982A5 (fr) 1993-12-16 1996-08-15 Maurice Stroun Méthode pour le diagnostic de cancers.
US20030017081A1 (en) 1994-02-10 2003-01-23 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5714330A (en) 1994-04-04 1998-02-03 Lynx Therapeutics, Inc. DNA sequencing by stepwise ligation and cleavage
US6013445A (en) 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US5846719A (en) 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US5695934A (en) 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
US5604097A (en) 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US6600996B2 (en) 1994-10-21 2003-07-29 Affymetrix, Inc. Computer-aided techniques for analyzing biological sequences
EP0709466B1 (en) 1994-10-28 2006-09-27 Gen-Probe Incorporated Compositions and methods for the simultaneous detection and quantification of multiple specific nucleic acid sequences
US5648245A (en) 1995-05-09 1997-07-15 Carnegie Institution Of Washington Method for constructing an oligonucleotide concatamer library by rolling circle replication
US5968740A (en) 1995-07-24 1999-10-19 Affymetrix, Inc. Method of Identifying a Base in a Nucleic Acid
GB9516636D0 (en) 1995-08-14 1995-10-18 Univ London In-situ nucleic acid amplification and detection
US5763175A (en) 1995-11-17 1998-06-09 Lynx Therapeutics, Inc. Simultaneous sequencing of tagged polynucleotides
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
EP0929694A4 (en) 1996-03-15 2002-05-02 Penn State Res Found DETECTION OF TUMOR-RELATED EXTRACELLULAR NUCLEIC ACID USING PLASMA OR BLOOD SERUM USING NUCLEIC ACID AMPLIFICATION TESTS
CA2250118C (en) 1996-03-26 2009-09-29 Michael S. Kopreski Method enabling use of extracellular rna extracted from plasma or serum to detect, monitor or evaluate cancer
US6458530B1 (en) 1996-04-04 2002-10-01 Affymetrix Inc. Selecting tag nucleic acids
US6300077B1 (en) 1996-08-14 2001-10-09 Exact Sciences Corporation Methods for the detection of nucleic acids
US5935793A (en) 1996-09-27 1999-08-10 The Chinese University Of Hong Kong Parallel polynucleotide sequencing method using tagged primers
US6124092A (en) 1996-10-04 2000-09-26 The Perkin-Elmer Corporation Multiplex polynucleotide capture methods and compositions
US6117631A (en) 1996-10-29 2000-09-12 Polyprobe, Inc. Detection of antigens via oligonucleotide antibody conjugates
US6046005A (en) 1997-01-15 2000-04-04 Incyte Pharmaceuticals, Inc. Nucleic acid sequencing with solid phase capturable terminators comprising a cleavable linking group
JP4294740B2 (ja) 1997-05-23 2009-07-15 ソレクサ・インコーポレイテッド 分析物の系列的プロセシングのためのシステムおよび装置
AU1603199A (en) 1997-12-03 1999-06-16 Curagen Corporation Methods and devices for measuring differential gene expression
WO2000012687A1 (en) 1998-08-28 2000-03-09 Invitrogen Corporation System for the rapid manipulation of nucleic acid sequences
US6653077B1 (en) 1998-09-04 2003-11-25 Lynx Therapeutics, Inc. Method of screening for genetic polymorphism
US6503718B2 (en) 1999-01-10 2003-01-07 Exact Sciences Corporation Methods for detecting mutations using primer extension for detecting disease
WO2000046402A1 (en) 1999-02-05 2000-08-10 Amersham Pharmacia Biotech Uk Limited Genomic analysis method
US6629040B1 (en) 1999-03-19 2003-09-30 University Of Washington Isotope distribution encoded tags for protein identification
CA2366459A1 (en) 1999-03-26 2000-10-05 Affymetrix, Inc. Universal arrays
US6964846B1 (en) 1999-04-09 2005-11-15 Exact Sciences Corporation Methods for detecting nucleic acids indicative of cancer
EP1046717B1 (en) 1999-04-20 2010-10-06 National Institute of Advanced Industrial Science and Technology Method and probes for determining a concentration of target nucleic acid molecules and method for analyzing data obtained by the method
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
US6242186B1 (en) 1999-06-01 2001-06-05 Oy Jurilab Ltd. Method for detecting a risk of cancer and coronary heart disease and kit therefor
US6326148B1 (en) 1999-07-12 2001-12-04 The Regents Of The University Of California Detection of copy number changes in colon cancer
US6440706B1 (en) 1999-08-02 2002-08-27 Johns Hopkins University Digital amplification
US6849403B1 (en) 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
US6586177B1 (en) 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
ATE458831T1 (de) 1999-12-07 2010-03-15 Exact Sciences Corp Verfahren zum nachweis von lungenneoplasmen in fäkalen proben
US6489114B2 (en) 1999-12-17 2002-12-03 Bio Merieux Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby
JP2003521252A (ja) 2000-02-07 2003-07-15 イルミナ インコーポレイテッド ユニバーサルプライミングを用いる核酸検出方法
US20020072058A1 (en) 2000-03-24 2002-06-13 Voelker Leroy L. Method for amplifying quinolone-resistance-determining-regions and identifying polymorphic variants thereof
US20030207300A1 (en) 2000-04-28 2003-11-06 Matray Tracy J. Multiplex analytical platform using molecular tags
EP1158055A1 (fr) 2000-05-26 2001-11-28 Xu Qi University of Teaxs Laboratoire de Leucémie Chen Méthode pour le diagnostic de cancers
DE60131903T2 (de) 2000-10-24 2008-11-27 The Board of Trustees of the Leland S. Stanford Junior University, Palo Alto Direkte multiplex charakterisierung von genomischer dna
US20020142345A1 (en) 2000-12-22 2002-10-03 Nelsen Anita J. Methods for encoding and decoding complex mixtures in arrayed assays
US20030049616A1 (en) 2001-01-08 2003-03-13 Sydney Brenner Enzymatic synthesis of oligonucleotide tags
US6428964B1 (en) 2001-03-15 2002-08-06 Exact Sciences Corporation Method for alteration detection
CA2344599C (en) 2001-05-07 2011-07-12 Bioneer Corporation Selective polymerase chain reaction of dna of which base sequence is completely unknown
US7406385B2 (en) 2001-10-25 2008-07-29 Applera Corporation System and method for consensus-calling with per-base quality values for sample assemblies
DK1342794T3 (da) 2002-03-05 2006-04-24 Epigenomics Ag Fremgangsmåde og anordning til at bestemme vævsspecificitet af fritflydende DNA i legemsvæsker
US20030186251A1 (en) 2002-04-01 2003-10-02 Brookhaven Science Associates, Llc Genome sequence tags
US7727720B2 (en) 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
US7822555B2 (en) 2002-11-11 2010-10-26 Affymetrix, Inc. Methods for identifying DNA copy number changes
EP1578994A2 (en) 2002-11-11 2005-09-28 Affymetrix, Inc. Methods for identifying dna copy number changes
US10229244B2 (en) 2002-11-11 2019-03-12 Affymetrix, Inc. Methods for identifying DNA copy number changes using hidden markov model based estimations
US7704687B2 (en) 2002-11-15 2010-04-27 The Johns Hopkins University Digital karyotyping
US20040209299A1 (en) 2003-03-07 2004-10-21 Rubicon Genomics, Inc. In vitro DNA immortalization and whole genome amplification using libraries generated from randomly fragmented DNA
US20040259118A1 (en) 2003-06-23 2004-12-23 Macevicz Stephen C. Methods and compositions for nucleic acid sequence analysis
US8048627B2 (en) 2003-07-05 2011-11-01 The Johns Hopkins University Method and compositions for detection and enumeration of genetic variations
DE60328193D1 (de) 2003-10-16 2009-08-13 Sequenom Inc Nicht invasiver Nachweis fötaler genetischer Merkmale
DE10348407A1 (de) 2003-10-17 2005-05-19 Widschwendter, Martin, Prof. Prognostische und diagnostische Marker für Zell-proliferative Erkrankungen von Brustgeweben
US20070111233A1 (en) 2003-10-30 2007-05-17 Bianchi Diana W Prenatal diagnosis using cell-free fetal DNA in amniotic fluid
US20080261204A1 (en) 2004-01-23 2008-10-23 Lingvitae As Polynucleotide Ligation Reactions
JP2007521833A (ja) 2004-02-12 2007-08-09 コンパス ジェネティクス エルエルシー 配列特異的分類による遺伝的分析
US20100216153A1 (en) 2004-02-27 2010-08-26 Helicos Biosciences Corporation Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities
US20060046258A1 (en) 2004-02-27 2006-03-02 Lapidus Stanley N Applications of single molecule sequencing
WO2005111242A2 (en) 2004-05-10 2005-11-24 Parallele Bioscience, Inc. Digital profiling of polynucleotide populations
US7276720B2 (en) 2004-07-19 2007-10-02 Helicos Biosciences Corporation Apparatus and methods for analyzing samples
US20060035258A1 (en) 2004-08-06 2006-02-16 Affymetrix, Inc. Methods for identifying DNA copy number changes
US7937225B2 (en) 2004-09-03 2011-05-03 New York University Systems, methods and software arrangements for detection of genome copy number variation
EP1647600A3 (en) 2004-09-17 2006-06-28 Affymetrix, Inc. (A US Entity) Methods for identifying biological samples by addition of nucleic acid bar-code tags
WO2006047787A2 (en) 2004-10-27 2006-05-04 Exact Sciences Corporation Method for monitoring disease progression or recurrence
US7424371B2 (en) 2004-12-21 2008-09-09 Helicos Biosciences Corporation Nucleic acid analysis
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
ITRM20050068A1 (it) 2005-02-17 2006-08-18 Istituto Naz Per Le Malattie I Metodo per la rivelazione di acidi nucleici di agenti patogeni batterici o di parassiti nelle urine.
WO2006099604A2 (en) 2005-03-16 2006-09-21 Compass Genetics, Llc Methods and compositions for assay readouts on multiple analytical platforms
EP1861512A4 (en) 2005-03-18 2009-12-09 Fluidigm Corp THERMAL REACTION DEVICE AND USE METHOD THEREFOR
DE602005009324D1 (de) 2005-04-06 2008-10-09 Maurice Stroun Methode zur Krebsdiagnose mittels Nachweis von DNA und RNA im Kreislauf
US20070020640A1 (en) 2005-07-21 2007-01-25 Mccloskey Megan L Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
CA2910861C (en) 2005-09-29 2018-08-07 Michael Josephus Theresia Van Eijk High throughput screening of mutagenized populations
WO2007087312A2 (en) * 2006-01-23 2007-08-02 Population Genetics Technologies Ltd. Molecular counting
US20070172839A1 (en) 2006-01-24 2007-07-26 Smith Douglas R Asymmetrical adapters and methods of use thereof
US8383338B2 (en) 2006-04-24 2013-02-26 Roche Nimblegen, Inc. Methods and systems for uniform enrichment of genomic regions
US7702468B2 (en) 2006-05-03 2010-04-20 Population Diagnostics, Inc. Evaluating genetic disorders
US8700335B2 (en) 2006-05-18 2014-04-15 Caris Mpi, Inc. System and method for determining individualized medical intervention for a disease state
WO2008111990A1 (en) 2006-06-14 2008-09-18 Cellpoint Diagnostics, Inc. Rare cell analysis using sample splitting and dna tags
FR2904833A1 (fr) 2006-08-11 2008-02-15 Bioquanta Sarl Procede de dosage d'acide nuclieque par fluorescence
WO2008061193A2 (en) 2006-11-15 2008-05-22 Biospherex Llc Multitag sequencing and ecogenomics analysis
WO2008070144A2 (en) 2006-12-06 2008-06-12 Duke University Imprinted genes and disease
US9090693B2 (en) 2007-01-25 2015-07-28 Dana-Farber Cancer Institute Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease
US20080293055A1 (en) 2007-03-13 2008-11-27 Daniel Freeman K-ras mutations and anti-EGFr antibody therapy
WO2008148072A2 (en) 2007-05-24 2008-12-04 The Brigham And Women's Hospital, Inc. Disease-associated genetic variations and methods for obtaining and using same
CN101720359A (zh) 2007-06-01 2010-06-02 454生命科学公司 从多重混合物中识别个别样本的系统和方法
US8182993B2 (en) * 2007-06-06 2012-05-22 Pacific Biosciences Of California, Inc. Methods and processes for calling bases in sequence by incorporation methods
US12054776B2 (en) 2007-07-23 2024-08-06 The Chinese University Of Hong Kong Diagnosing fetal chromosomal aneuploidy using massively parallel genomic sequencing
US12180549B2 (en) 2007-07-23 2024-12-31 The Chinese University Of Hong Kong Diagnosing fetal chromosomal aneuploidy using genomic sequencing
US20090053719A1 (en) 2007-08-03 2009-02-26 The Chinese University Of Hong Kong Analysis of nucleic acids by digital pcr
ES2380844T3 (es) 2007-09-07 2012-05-18 Fluidigm Corporation Determinación de la variación en el número de copias, métodos y sistemas
US20100173294A1 (en) 2007-09-11 2010-07-08 Roche Molecular Systems, Inc. Diagnostic test for susceptibility to b-raf kinase inhibitors
WO2009085473A2 (en) 2007-11-21 2009-07-09 Cosmosid Inc. Genome identification system
MX2010008820A (es) 2008-02-12 2010-09-07 Novartis Ag Metodo para aislar acidos nucleicos fetales o apoptoticos libres de celulas.
US8216789B2 (en) 2008-02-27 2012-07-10 University Of Washington Diagnostic panel of cancer antibodies and methods for use
US20110003701A1 (en) 2008-02-27 2011-01-06 454 Life Sciences Corporation System and method for improved processing of nucleic acids for production of sequencable libraries
WO2009120808A2 (en) 2008-03-26 2009-10-01 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
JP2011515102A (ja) 2008-03-28 2011-05-19 パシフィック バイオサイエンシーズ オブ カリフォルニア， インコーポレイテッド 核酸シーケンシング用組成物及び方法
US20110160290A1 (en) 2008-05-21 2011-06-30 Muneesh Tewari Use of extracellular rna to measure disease
US20090298709A1 (en) 2008-05-28 2009-12-03 Affymetrix, Inc. Assays for determining telomere length and repeated sequence copy number
DE102008025656B4 (de) 2008-05-28 2016-07-28 Genxpro Gmbh Verfahren zur quantitativen Analyse von Nukleinsäuren, Marker dafür und deren Verwendung
EP2310524A4 (en) 2008-07-10 2013-07-24 Versitech Ltd METHODS OF CARTOGRAPHY OF NUCLEIC ACIDS AND IDENTIFICATION OF FINE STRUCTURAL VARIATIONS IN NUCLEIC ACIDS
US20100041048A1 (en) 2008-07-31 2010-02-18 The Johns Hopkins University Circulating Mutant DNA to Assess Tumor Dynamics
US20100062494A1 (en) 2008-08-08 2010-03-11 President And Fellows Of Harvard College Enzymatic oligonucleotide pre-adenylation
WO2010021936A1 (en) 2008-08-16 2010-02-25 The Board Of Trustees Of The Leland Stanford Junior University Digital pcr calibration for high throughput sequencing
EP3216874A1 (en) 2008-09-05 2017-09-13 TOMA Biosciences, Inc. Methods for stratifying and annotating cancer drug treatment options
US8383345B2 (en) 2008-09-12 2013-02-26 University Of Washington Sequence tag directed subassembly of short sequencing reads into long sequencing reads
WO2010033578A2 (en) 2008-09-20 2010-03-25 The Board Of Trustees Of The Leland Stanford Junior University Noninvasive diagnosis of fetal aneuploidy by sequencing
EP2607496B1 (en) 2008-12-23 2014-07-16 Illumina, Inc. Methods useful in nucleic acid sequencing protocols
JP2012514977A (ja) 2009-01-13 2012-07-05 キージーン・エン・フェー 新規ゲノム配列決定戦略
US20100323348A1 (en) 2009-01-31 2010-12-23 The Regents Of The University Of Colorado, A Body Corporate Methods and Compositions for Using Error-Detecting and/or Error-Correcting Barcodes in Nucleic Acid Amplification Process
US20120165202A1 (en) 2009-04-30 2012-06-28 Good Start Genetics, Inc. Methods and compositions for evaluating genetic markers
US9085798B2 (en) 2009-04-30 2015-07-21 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
US20130143747A1 (en) 2011-12-05 2013-06-06 Myriad Genetics, Incorporated Methods of detecting cancer
US9524369B2 (en) 2009-06-15 2016-12-20 Complete Genomics, Inc. Processing and analysis of complex nucleic acid sequence data
CA2765949C (en) 2009-06-25 2016-03-29 Fred Hutchinson Cancer Research Center Method of measuring adaptive immunity
EP2456885A2 (en) 2009-07-20 2012-05-30 Bar Harbor Biotechnology, Inc. Methods for assessing disease risk
EP2494065B1 (en) 2009-10-26 2015-12-23 Lifecodexx AG Means and methods for non-invasive diagnosis of chromosomal aneuploidy
CN102597272A (zh) 2009-11-12 2012-07-18 艾索特里克斯遗传实验室有限责任公司 基因座的拷贝数分析
US20110237444A1 (en) 2009-11-20 2011-09-29 Life Technologies Corporation Methods of mapping genomic methylation patterns
US9023769B2 (en) 2009-11-30 2015-05-05 Complete Genomics, Inc. cDNA library for nucleic acid sequencing
US9752187B2 (en) 2009-12-11 2017-09-05 Nucleix Categorization of DNA samples
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US9315857B2 (en) 2009-12-15 2016-04-19 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse label-tags
DK2516680T3 (en) 2009-12-22 2016-05-02 Sequenom Inc Method and kits to identify aneuploidy
US8965076B2 (en) 2010-01-13 2015-02-24 Illumina, Inc. Data processing system and methods
US20120010085A1 (en) * 2010-01-19 2012-01-12 Rava Richard P Methods for determining fraction of fetal nucleic acids in maternal samples
US20120100548A1 (en) * 2010-10-26 2012-04-26 Verinata Health, Inc. Method for determining copy number variations
US9260745B2 (en) 2010-01-19 2016-02-16 Verinata Health, Inc. Detecting and classifying copy number variation
US20110177512A1 (en) 2010-01-19 2011-07-21 Predictive Biosciences, Inc. Method for assuring amplification of an abnormal nucleic acid in a sample
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
ES2704701T3 (es) 2010-01-19 2019-03-19 Verinata Health Inc Nuevo protocolo de preparación de bibliotecas de secuenciación
AU2011207544A1 (en) 2010-01-19 2012-09-06 Verinata Health, Inc. Identification of polymorphic sequences in mixtures of genomic DNA by whole genome sequencing
WO2011103236A2 (en) 2010-02-18 2011-08-25 The Johns Hopkins University Personalized tumor biomarkers
US9140689B2 (en) 2010-03-14 2015-09-22 Translational Genomics Research Institute Methods of determining susceptibility of tumors to tyrosine kinase inhibitors
CN101967517B (zh) 2010-03-19 2012-11-07 黄乐群 一种无需借助pcr的基因检测方法
US10047397B2 (en) 2010-04-16 2018-08-14 Chronix Biomedical Breast cancer associated circulating nucleic acid biomarkers
US9255291B2 (en) 2010-05-06 2016-02-09 Bioo Scientific Corporation Oligonucleotide ligation methods for improving data quality and throughput using massively parallel sequencing
WO2011142836A2 (en) * 2010-05-14 2011-11-17 Fluidigm Corporation Assays for the detection of genotype, mutations, and/or aneuploidy
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
CA2801468C (en) 2010-06-04 2018-09-04 Chronix Biomedical Prostate cancer associated circulating nucleic acid biomarkers
EP2580351B1 (en) 2010-06-09 2018-08-29 Keygene N.V. Combinatorial sequence barcodes for high throughput screening
EP2400035A1 (en) 2010-06-28 2011-12-28 Technische Universität München Methods and compositions for diagnosing gastrointestinal stromal tumors
WO2012006291A2 (en) * 2010-07-06 2012-01-12 Life Technologies Corporation Systems and methods to detect copy number variation
SG10201505723UA (en) 2010-07-23 2015-09-29 Harvard College Methods for detecting signatures of disease or conditions in bodily fluids
WO2012014877A1 (ja) 2010-07-29 2012-02-02 Toto株式会社 光触媒塗装体および光触媒コーティング液
EP2601609B1 (en) 2010-08-02 2017-05-17 Population Bio, Inc. Compositions and methods for discovery of causative mutations in genetic disorders
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
US11031095B2 (en) * 2010-08-06 2021-06-08 Ariosa Diagnostics, Inc. Assay systems for determination of fetal copy number variation
EP2426217A1 (en) 2010-09-03 2012-03-07 Centre National de la Recherche Scientifique (CNRS) Analytical methods for cell free nucleic acids and applications
AU2011299088B2 (en) 2010-09-09 2015-12-24 Traxxsson, Llc Combination methods of diagnosing cancer in a patient
EP2619327B1 (en) 2010-09-21 2014-10-22 Population Genetics Technologies LTD. Increasing confidence of allele calls with molecular counting
AU2011305445B2 (en) 2010-09-24 2017-03-16 The Board Of Trustees Of The Leland Stanford Junior University Direct capture, amplification and sequencing of target DNA using immobilized primers
WO2012042374A2 (en) 2010-10-01 2012-04-05 Anssi Jussi Nikolai Taipale Method of determining number or concentration of molecules
US9902950B2 (en) 2010-10-08 2018-02-27 President And Fellows Of Harvard College High-throughput single cell barcoding
US8725422B2 (en) 2010-10-13 2014-05-13 Complete Genomics, Inc. Methods for estimating genome-wide copy number variations
DK2630263T4 (da) 2010-10-22 2022-02-14 Cold Spring Harbor Laboratory Varital tælling af nucleinsyrer for at opnå information om antal genomiske kopier
WO2012066451A1 (en) 2010-11-15 2012-05-24 Pfizer Inc. Prognostic and predictive gene signature for colon cancer
KR102040307B1 (ko) 2010-11-30 2019-11-27 더 차이니즈 유니버시티 오브 홍콩 암과 연관된 유전적 또는 분자적 이상들의 검출
AU2011348100B2 (en) 2010-12-22 2016-08-25 Natera, Inc. Methods for non-invasive prenatal paternity testing
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
WO2012088348A2 (en) 2010-12-23 2012-06-28 Sequenom, Inc. Fetal genetic variation detection
EP3225697A3 (en) 2010-12-30 2017-11-22 Foundation Medicine, Inc. Optimization of multigene analysis of tumor samples
US20140011694A1 (en) 2011-01-11 2014-01-09 Via Genomes, Inc. Methods, systems, databases, kits and arrays for screening for and predicting the risk of an identifying the presence of tumors and cancers
US20120190021A1 (en) 2011-01-25 2012-07-26 Aria Diagnostics, Inc. Detection of genetic abnormalities
JP6153874B2 (ja) 2011-02-09 2017-06-28 ナテラ， インコーポレイテッド 非侵襲的出生前倍数性呼び出しのための方法
US20120238464A1 (en) 2011-03-18 2012-09-20 Baylor Research Institute Biomarkers for Predicting the Recurrence of Colorectal Cancer Metastasis
US9260753B2 (en) 2011-03-24 2016-02-16 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
AU2012236200B2 (en) 2011-03-30 2015-05-14 Verinata Health, Inc. Method for verifying bioassay samples
EP2670866A4 (en) * 2011-04-05 2015-09-02 Translational Genomics Res Inst BIOMARKERS AND METHOD OF APPLICATION THEREFOR
EP3246416B1 (en) 2011-04-15 2024-06-05 The Johns Hopkins University Safe sequencing system
US9411937B2 (en) 2011-04-15 2016-08-09 Verinata Health, Inc. Detecting and classifying copy number variation
WO2014014498A1 (en) 2012-07-20 2014-01-23 Verinata Health, Inc. Detecting and classifying copy number variation in a fetal genome
JP2014512826A (ja) 2011-04-25 2014-05-29 バイオ−ラド ラボラトリーズ インコーポレイテッド 核酸分析のための方法および組成物
EP2705157B1 (en) 2011-05-06 2017-02-01 New England Biolabs, Inc. Ligation enhancement
SG10201605049QA (en) 2011-05-20 2016-07-28 Fluidigm Corp Nucleic acid encoding reactions
US9752176B2 (en) 2011-06-15 2017-09-05 Ginkgo Bioworks, Inc. Methods for preparative in vitro cloning
US9340826B2 (en) 2011-08-01 2016-05-17 Celemics, Inc. Method of preparing nucleic acid molecules
US10704164B2 (en) 2011-08-31 2020-07-07 Life Technologies Corporation Methods, systems, computer readable media, and kits for sample identification
US9834766B2 (en) 2011-09-02 2017-12-05 Atreca, Inc. DNA barcodes for multiplexed sequencing
US8712697B2 (en) 2011-09-07 2014-04-29 Ariosa Diagnostics, Inc. Determination of copy number variations using binomial probability calculations
US20130079241A1 (en) 2011-09-15 2013-03-28 Jianhua Luo Methods for Diagnosing Prostate Cancer and Predicting Prostate Cancer Relapse
WO2013052913A2 (en) 2011-10-06 2013-04-11 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP2764458B1 (en) 2011-10-06 2021-04-07 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20130102485A1 (en) 2011-10-19 2013-04-25 Inhan Lee Method of Determining a Diseased State in a Subject
WO2013066641A1 (en) 2011-10-21 2013-05-10 Chronix Biomedical Colorectal cancer associated circulating nucleic acid biomarkers
NO3051026T3 (pl) 2011-10-21 2018-07-28
US20130122499A1 (en) 2011-11-14 2013-05-16 Viomics, Inc. System and method of detecting local copy number variation in dna samples
US10214775B2 (en) 2011-12-07 2019-02-26 Chronix Biomedical Prostate cancer associated circulating nucleic acid biomarkers
CA2858688A1 (en) 2011-12-08 2013-06-13 Five3 Genomics, Llc Mdm2-containing double minute chromosomes and methods therefore
CN104334739A (zh) 2012-01-13 2015-02-04 Data生物有限公司 通过新一代测序进行基因分型
SMT202100154T1 (it) 2012-02-17 2021-05-07 Hutchinson Fred Cancer Res Composizioni e metodi per identificare precisamente mutazioni
WO2013130512A2 (en) 2012-02-27 2013-09-06 The University Of North Carolina At Chapel Hill Methods and uses for molecular tags
EP3321378B1 (en) 2012-02-27 2021-11-10 Becton, Dickinson and Company Compositions for molecular counting
EP3287531B1 (en) 2012-02-28 2019-06-19 Agilent Technologies, Inc. Method for attaching a counter sequence to a nucleic acid sample
US9890429B2 (en) 2012-02-29 2018-02-13 Dana-Farber Cancer Institute, Inc. Compositions, kits, and methods for the identification, assessment, prevention, and therapy of cancer
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
US9862995B2 (en) 2012-03-13 2018-01-09 Abhijit Ajit Patel Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing
WO2013142389A1 (en) 2012-03-20 2013-09-26 University Of Washington Through Its Center For Commercialization Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing
WO2013142213A1 (en) 2012-03-20 2013-09-26 Wake Forest University Health Sciences Methods, systems, and computer readable media for tracking and verifying receipt of contents of a delivery within an organization
AU2013240088B2 (en) 2012-03-26 2017-02-02 The Johns Hopkins University Rapid aneuploidy detection
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
US10385396B2 (en) 2012-04-19 2019-08-20 The Medical College Of Wisconsin, Inc. Highly sensitive surveillance using detection of cell free DNA
WO2013173394A2 (en) 2012-05-14 2013-11-21 Cb Biotechnologies, Inc. Method for increasing accuracy in quantitative detection of polynucleotides
AU2013267609C1 (en) 2012-05-31 2019-01-03 Board Of Regents, The University Of Texas System Method for accurate sequencing of DNA
AU2013274366A1 (en) 2012-06-11 2015-01-22 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US11261494B2 (en) 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
WO2014004726A1 (en) 2012-06-26 2014-01-03 Caifu Chen Methods, compositions and kits for the diagnosis, prognosis and monitoring of cancer
US20140066317A1 (en) 2012-09-04 2014-03-06 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
PL2893040T3 (pl) 2012-09-04 2019-05-31 Guardant Health Inc Sposoby wykrywania rzadkich mutacji i wariantu liczby kopii
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
CN105531375B (zh) 2012-12-10 2020-03-03 分析生物科学有限公司 靶向基因组分析的方法
CA2897190C (en) 2013-01-05 2023-06-13 Foundation Medicine, Inc. System and method for outcome tracking and analysis
CA2898326C (en) 2013-01-18 2022-05-17 Foundation Medicine, Inc. Methods of treating cholangiocarcinoma
WO2014152990A1 (en) 2013-03-14 2014-09-25 University Of Rochester System and method for detecting population variation from nucleic acid sequencing data
WO2014145078A1 (en) 2013-03-15 2014-09-18 Verinata Health, Inc. Generating cell-free dna libraries directly from blood
US9890425B2 (en) 2013-03-15 2018-02-13 Abbott Molecular Inc. Systems and methods for detection of genomic copy number changes
ES2980689T3 (es) * 2013-03-15 2024-10-02 Guardant Health Inc Métodos para la secuenciación de polinucleótidos libres de células
US20160032396A1 (en) 2013-03-15 2016-02-04 The Board Of Trustees Of The Leland Stanford Junior University Identification and Use of Circulating Nucleic Acid Tumor Markers
WO2014144495A1 (en) * 2013-03-15 2014-09-18 Abvitro, Inc. Single cell bar-coding for antibody discovery
WO2014148557A1 (ja) 2013-03-19 2014-09-25 凸版印刷株式会社 Ｅｇｆｒ阻害剤感受性予測方法
US10059989B2 (en) 2013-05-23 2018-08-28 The Board Of Trustees Of The Leland Stanford Junior University Transposition of native chromatin for personal epigenomics
JP6525473B2 (ja) 2013-11-13 2019-06-05 ニューゲン テクノロジーズ， インコーポレイテッド 複製物配列決定リードを同定するための組成物および方法
JP2015096049A (ja) 2013-11-15 2015-05-21 凸版印刷株式会社 Ｖｅｇｆ阻害剤長期奏功性予測方法
CN111534580B (zh) 2013-12-28 2024-06-04 夸登特健康公司 用于检测遗传变异的方法和系统
SI4026917T1 (sl) 2014-04-14 2024-05-31 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Ltd. Metoda in komplet za določanje smrti celic ali tkiva oz. izvora DNK tkiva ali celice z analizo metilacije DNK
RU2717641C2 (ru) 2014-04-21 2020-03-24 Натера, Инк. Обнаружение мутаций и плоидности в хромосомных сегментах
WO2015175705A1 (en) 2014-05-13 2015-11-19 Board Of Regents, The University Of Texas System Gene mutations and copy number alterations of egfr, kras and met
CN107002122B (zh) 2014-07-25 2023-09-19 华盛顿大学 确定导致无细胞dna的产生的组织和/或细胞类型的方法以及使用其鉴定疾病或紊乱的方法
US20180082012A1 (en) 2014-07-25 2018-03-22 Bgi Genomics Co., Ltd. Method and device for determining fraction of cell-free nucleic acids in biological sample and use thereof
US20160053301A1 (en) 2014-08-22 2016-02-25 Clearfork Bioscience, Inc. Methods for quantitative genetic analysis of cell free dna
EP3192047A4 (en) 2014-09-10 2018-03-28 Pathway Genomics Corporation Health and wellness management methods and systems useful for the practice thereof
WO2016040901A1 (en) 2014-09-12 2016-03-17 The Board Of Trustees Of The Leland Stanford Junior University Identification and use of circulating nucleic acids
DK3256605T3 (da) 2015-02-10 2022-03-14 Univ Hong Kong Chinese Påvisning af mutationer til cancerscreening og føtal analyse
US10844428B2 (en) 2015-04-28 2020-11-24 Illumina, Inc. Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS)
WO2017100441A1 (en) 2015-12-08 2017-06-15 Twinstrand Biosciences, Inc. Improved adapters, methods, and compositions for duplex sequencing
US10597717B2 (en) 2016-03-22 2020-03-24 Myriad Women's Health, Inc. Combinatorial DNA screening
WO2017181146A1 (en) 2016-04-14 2017-10-19 Guardant Health, Inc. Methods for early detection of cancer

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